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Managed treatment wetlands technology is now used around the world to treat wastewater and stormwater by removing nutrients and other contaminants to obtain a desired water quality. In this paper we present a brief review of a large-scale application of the nature-based technology known as stormwater treatment areas (STAs). These STAs were constructed to treat agricultural and urban runoff to reduce outflow total phosphorus (TP) concentrations to <20 μg P L−1, which is required to protect downstream water quality and preserve the remaining Everglades ecosystem. Five STAs with a total area of approximately 25,000 ha were built at strategic locations to reduce TP loads to the Everglades Protection Area. For the past three decades, these Everglades STAs have done remarkable job by 70 to 85% TP load reduction, with an average outflow TP concentrations of 15-40 μg P L−1. In this Everglades STAs special issue, we present research findings on the influence of both external and internal drivers influencing STA performance and potential adaptive management strategies to enhance treatment efficiency to further reduce outflow TP concentrations. • Introduction of the Everglades STAs – largest constructed treatment wetland network in the world. • Everglades STAs serve as 'kidneys' of the Everglades ecosystem by reducing phosphorus loads to downstream waterbodies. • Phosphorus loading is one of the key drivers regulating treatment efficiency STAs. [ABSTRACT FROM AUTHOR]