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Chemotherapy, a medical procedure used to treat cancer, may result in partial or complete hair loss (alopecia) side effects. It heightens psychological pain, which might lead some patients to decline therapy. Chemotherapy effects on the hair follicles. This paper aims to develop and produce scalp cooling systems that are equipped with sensors for better control to prevent hair loss in cancer patients, the approach involves reducing scalp temperatures to minimize blood flow to the scalp area before, during, and after chemotherapy. The Peltier and a radiator are used in place of the compressor and condenser in the cooling system to turn from mechanic to electronic, which was a new idea because no one had previously used a Peltier to manufacture the device, so explain the cooling system is designed and fabricated for production and display the circulating coolant through Peltier who responsible on the cooling entire scalp area. The system consists of two main components: the cap part and the cooling part. The components of the cap are the cap is comprised of several components, including an inner silicone layer, an aluminum cover, and an insulated cap cover. On the other hand, the cooling system consists of various elements such as a microcontroller, smart touch screen, voltage step-down module, power supply, fan, radiator, water pump, relay 1ch, and timer. It tested on many volunteers for almost an hour and then made the results as curves. The system was effectively implemented at a low cost, and the results demonstrate temperature levels within an acceptable range of (8-15) °C, which aligns with findings from previous studies. [ABSTRACT FROM AUTHOR]