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Histamine has tremendous influence over a variety of pathophysiological processes through the activation of four receptors: H1, H2, H3 and H4 and is known to participate in allergic, inflammation, gastric acid secretion, immunomodulation and neurotransmission. In recent years, accumulating evidences have witnessed the importance of histamine-cytokine and histamine-antibody network in immunoregulation. Moreover, histamine immunobiology pertaining to histamine-receptors is elementary in the existing literature in contrast to increasing frequency of allergic diseases. In this chapter, we tried to elaborate the newer discoveries in the current field and also discussed our recent studies on the immunobiology of histamine receptors. We hope that this article would stimulate discussions and active research on this important aspect. [ABSTRACT FROM AUTHOR]