1. Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective.
- Author
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Duarte, Noelia and Duarte, Noelia
- Subjects
Cardiovascular medicine ,Medicine ,(−)-usnic acid ,2D NMR analyses ,7α-acetoxy-6β-hydroxyroyleanone ,Asphodelus ramosus ,Bursera graveolens ,Chagas disease ,Euphorbia ,Garcinia indica ,Hymenocardia acida ,IL-1β ,NAFLD ,NF-ĸB ,NMR spectroscopy ,PLGA ,Plectranthus ,Posidonia oceanica ,Sambucus nigra L. ,Smyrnium olusatrum L. ,TNF-α ,Thai herbal compress ,Trypanosoma ,UV-absorbing compounds ,adipogenesis ,alkaline extraction ,amphotericin B ,anthocyanins ,antibacterial activity ,anticancer activity ,antifungal activity ,antimicrobial activity ,antioxidant ,antioxidants ,antitumoral activity ,autophagy ,bioactivities ,bioavailability ,biological activity ,biosynthesis ,candidiasis ,cellulite ,chemotaxonomy ,collagenase inhibition ,cytotoxicity ,database ,diabesity ,dietary source ,endoplasmic reticulum stress ,ent-abietane ,essential oil ,ethosomes ,evernic acid ,flavonoids ,fructans ,fructooligosaccharide ,gel ,herbal medicine ,high-performance thin layer chromatography ,human African trypanosomiasis ,human American trypanosomiasis ,infrared spectroscopy ,inulin ,ischemic stroke ,isofuranodiene ,kidney ,kokum ,lichen extracts ,linarin ,lipid accumulation ,lipolysis ,mass spectrometry ,melatonin ,monoterpenes ,mycosporine-like amino acids (MAAs) ,mycosporines ,n/a ,nanoencapsulation ,nanoparticle ,pharmacological activities ,pharmacological activity ,photoprotective compounds ,phytochemistry ,plant extract ,propyl-propane-thiosulfinate ,propyl-propane-thiosulfonate ,root-tubers ,royleanone ,salazinic acid ,secondary metabolites ,skin compatibility ,sleeping disease ,structure-activity relationship ,terpenoids ,topical treatment ,vapor ,vasorelaxation ,wild mangosteen - Abstract
Summary: For centuries, nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays, natural-based treatments continue to be employed for primary health care, particularly playing a significant role in folk medicine. In addition, we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources, making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment, we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research, contributing to the scientific validation of their use and opening new perspectives in drug discovery