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Your search keyword '"Weinstock, George M"' showing total 27 results
Start Over Author "Weinstock, George M" Publication Type Books
27 results on '"Weinstock, George M"'

1. Identification of a Novel Gene on 10q22.1 Causing Autosomal Dominant Retinitis Pigmentosa (adRP)

Author

Daiger, Stephen P., primary, Sullivan, Lori S., additional, Bowne, Sara J., additional, Koboldt, Daniel C., additional, Blanton, Susan H., additional, Wheaton, Dianna K., additional, Avery, Cheryl E., additional, Cadena, Elizabeth D., additional, Koenekoop, Robert K., additional, Fulton, Robert S., additional, Wilson, Richard K., additional, Weinstock, George M., additional, Lewis, Richard A., additional, and Birch, David G., additional

Published
2015
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3. Application of Next-Generation Sequencing to Identify Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa (adRP)

Author

Daiger, Stephen P., primary, Bowne, Sara J., additional, Sullivan, Lori S., additional, Blanton, Susan H., additional, Weinstock, George M., additional, Koboldt, Daniel C., additional, Fulton, Robert S., additional, Larsen, David, additional, Humphries, Peter, additional, Humphries, Marian M., additional, Pierce, Eric A., additional, Chen, Rui, additional, and Li, Yumei, additional

Published
2014
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7. Enterococcus faecalis

Author

Murray, Barbara E., primary, Jiang, Liangxia, additional, Xiao, Jianguo, additional, Qin, Xiang, additional, Singh, Kavindra V., additional, de Kok, Aart, additional, Claiborne, Al, additional, Courvalin, Patrice, additional, and Weinstock, George M., additional

Published
1998
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13. Treponema pallidum subsp. pallidum (Nichols)

Author

Norris, Steven J., primary, Walker, Eldon M., additional, Howell, Jerrilyn K., additional, You, Yun, additional, Hoffmaster, Alex R., additional, Heath, Joe Don, additional, and Weinstock, George M., additional

Published
1998
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14. Rhodobacter sphaeroides 2.4.1T

Author

Mackenzie, Christopher, primary, Choudhary, Madhusudan, additional, Nereng, Kirsten S., additional, Sodergren, Erica, additional, Chidambaram, Monjula, additional, Weinstock, George M., additional, and Kaplan, Samuel, additional

Published
1998
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23. Application of Next-Generation Sequencing to Identify Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa (adRP).

Author

Daiger, Stephen P., Bowne, Sara J., Sullivan, Lori S., Blanton, Susan H., Weinstock, George M., Koboldt, Daniel C., Fulton, Robert S., Larsen, David, Humphries, Peter, Humphries, Marian M., Pierce, Eric A., Chen, Rui, and Li, Yumei

Abstract

The goal of our research is to identify genes and mutations causing autosomal dominant retinitis pigmentosa (adRP). For this purpose we established a cohort of more than 250 independently ascertained families with adRP in the Houston Laboratory for Molecular Diagnosis of Inherited Eye Diseases. Affected members of each family were screened for disease-causing mutations in genes and gene regions that are commonly associated with adRP. By this approach, we detected mutations in 65 % of the families, leaving 85 families that are likely to harbor mutations outside of the ˵common″ regions or in novel genes. Of these, 32 families were tested by several types of next-generation sequencing (NGS), including (a) targeted polymerase chain reaction (PCR) NGS, (b) whole exome NGS, and (c) targeted retinal-capture NGS. We detected mutations in 11 of these families (31 %) bringing the total detected in the adRP cohort to 70 %. Several large families have also been tested for linkage using Afymetrix single nucleotide polymorphism (SNP) arrays. [ABSTRACT FROM AUTHOR]

Published
2014
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25. Preparation of BAC Libraries From Bacterial Genomes by In Vitro Packaging.

Author

Walker, John M., Shaying Zhao, Stodolsky, Marvin, Pal, Sangita, Mak, Solida, and Weinstock, George M.

Abstract

Genomic libraries represent a powerful resource for genetic studies of bacteria. Large-insert libraries in bacterial artificial chromosome (BAC) vectors are particularly important not only for genome-sequencing projects, but for comparative and functional genomic studies once a complete sequence is known. Cloned DNA can be introduced into bacterial cells in two different ways. One way is to have cells take up naked DNA; this is known as transformation (1). The other way is to package the recombinant DNA inside bacteriophage particles in vitro using a phage such as λ. This process, known as in vitro packaging, allows DNA to be introduced by infection (2). Although transformation allows DNA of any size to be introduced, DNA uptake occurs at very low frequency. On the other hand, in vitro packaging limits the size of the DNA based on the phage head stability. However, in vitro package is the most efficient method for introducing large-insert clones. [ABSTRACT FROM AUTHOR]

Published
2004
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26. Construction of Small Genome BAC Library for Functional and Genomic Applications.

Author

Walker, John M., Shaying Zhao, Stodolsky, Marvin, Šmajs, David, Norris, Steven J., and Weinstock, George M.

Abstract

The use of genetic approaches to study bacteria is limited by the following considerations: first, the bacteria must be easy to culture and nonpathogenic; and, second, a broad spectrum of genetic techniques for the particular bacteria being studied must be available. For other bacteria, such as the syphilis-causing spirochete, Treponema pallidum, genetic studies are highly limited because the bacterium cannot be continuously grown in the laboratory, because of its high virulence and a total lack of genetic tools to study this organism. [ABSTRACT FROM AUTHOR]

Published
2004
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