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Can subjective replication generate valid and worthwhile knowledge? A theory of multimedia systems development (MSD) generated using a content analysis method is tested using a grounded theory method. The theory—that two distinct communities of software engineers and graphic designers exist within MSD—is confirmed. In fact, the test finds more differences and less commonalities. This finding has implications for the development of MSD methodologies, and for the education and training of MSD practitioners. The conclusion is that subjective replication is worthwhile but must be done carefully because of problems with the application of methods in this relatively unexplored information systems research space. [ABSTRACT FROM AUTHOR]

Resilience, defined as the capacity for continuous reconstruction, is based on Hamel’s earlier work on core competencies. We deploy the resilience concept to explain the performance differentials of small information technology companies. Our interviews with owner-managers suggest that the resilience concept is insufficient to account for competitive advantage and suggest that a sole focus on core competencies can even create competitive disadvantage. In particular, those managers that focused too much on their own core competencies and ignored market developments and other stakeholders created competitive disadvantages. We therefore suggest that resilience can only be a source of competitive advantage if it is extended with the option of replacing core competencies. In addition, core competencies frequently have to be supplemented by competencies of partners or customers in order to achieve competitive advantage. [ABSTRACT FROM AUTHOR]

The increased number of drug targets and compounds demands novel high-throughput screening technologies that could be used for parallel analysis of many genes and proteins. Protein microarrays are evolving promising technologies for the parallel analysis of many proteins with respect to their abundance, location, modifications, and interactions with other biological and chemical molecules. This chapter specifically describes the fabrication of G protein-coupled receptor (GPCR) microarrays, a unique subset of protein microarrays, using contact-pin printing technology. The bioassays and potential applications of GPCR microarrays for the determination of compound affinities and potencies are also included. [ABSTRACT FROM AUTHOR]