1. Natural and Synthetic Bioactives for Skin Health, Disease and Management.
- Author
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Chamcheu, Jean Christopher, Chamcheu, Jean Christopher, Noubissi-Kamdem, Felicite, and Walker, Anthony L.
- Subjects
Biology, life sciences ,Research & information: general ,3-isobutyl-1-methylxanthine ,3D cell culture ,B16/F10 melanoma cell ,Cornus officinalis ,DNA repair ,FLG ,Lactobacillus helveticus ,Lactobacillus plantarum CJLP55 ,Lithospermum erythrorhizon ,NC/Nga ,Nigella sativa ,Perilla frutescens ,Planktochlorella nurekis ,Sorghum bicolor ,TRPV ,Th1 ,Th17 ,Th2 ,Th22 ,Thymocid® ,UV ,UV radiation ,UVB irradiation ,acne vulgaris ,acyl-ceramide ,anti-inflammatory activity ,anti-melanogenesis ,antioxidant activity ,antioxidants ,ascorbic acid ,atopic dermatitis ,bioactive substances ,black cumin ,borage oil ,cell proliferation ,collagen ,collagenase ,corneocyte lipid envelope ,cornified envelope proteins ,cosmeceutical ,cosmetics ,cutaneous lymphomas ,dopachrome tautomerase ,ear-inflammation ,eggshell membrane ,elastase ,epidermis ,epigallocatechin ,essential oils ,fungal infections ,glycation ,glycosaminoglycans ,holothuroids ,human embryonic fibroblasts ,human epidermal primary melanocytes ,human high-affinity IgE receptors ,hydration ,hydroxyoctadecadienoic acid ,immune balance ,inflammation ,keratinocyte differentiation ,keratinocytes ,konjac glucomannan ,lotus seedpod extract ,matrix metalloproteinase-1 ,melanin ,melanogenesis ,microalgae ,microphthalmia-associated transcription factor ,molecular docking ,mycosis fungoides ,n/a ,nanohydrogel ,nutraceuticals ,phosphoinositide 3-kinase ,phytonutrients ,polysaccharide ,proliferation ,propolis ,proteomics ,rutin ,sebum ,senescence ,skin ,skin aging ,skin barrier function ,skin care ,skin cells ,skin health ,skin thickness ,triacylglycerol metabolism ,tyrosinase ,tyrosinase-related protein 1 ,ultraviolet B ,ultraviolet radiation ,urine bacterial extracellular vesicles ,whey ,α-MSH ,α-melanocyte-stimulating hormone - Abstract
Summary: In recent years, researchers have shown a special interest in natural products as alternative methods for the prevention, treatment, and/or management of various skin illnesses and disorders, primarily due to their natural availability, efficacity, reduced cost, and minimal toxicity. In a similar vein, synthetic bioactives, as well as small molecules, have been studied in vitro, in vivo, and in clinical studies as potential drugs or supplements. This Special Issue of Nutrients comprises an array of literature reviews, original communications, and studies on the roles of natural products, synthetic bioactives, and small molecules in a variety of skin disorders and diseases, such as aging, atopic dermatitis, cutaneous T-cell lymphomas, melanoma, allergies, hyperpigmentation, inflammation, and more, which were investigated through in vitro and ex vivo approaches, preclinical trials, cell-based assays, and animal models. The mechanisms of action of certain compounds are proposed, while others are currently under investigation. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of skin disorders, the wealth of information published in this Special Issue can act as a springboard for the development of new preventive and therapeutic modalities for the management of skin diseases.