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Your search keyword '"Sloan, Andrew E."' showing total 9 results
Start Over Author "Sloan, Andrew E." Publication Type Books
9 results on '"Sloan, Andrew E."'

2. List of Contributors

Author

Agro, Lauren, primary, Bao, Shideng, additional, Chang, Chi-Hsuan, additional, Chan, Keith Syson, additional, Cheshier, Samuel H., additional, Chopra, Avijeet S., additional, Chumakova, Anastasia, additional, Clarke, Michael F., additional, Condello, Salvatore, additional, Donahue, Leanne R., additional, Esparza, Rogelio, additional, Fang, Fang, additional, Fillmore Brainson, Christine, additional, Gurney, Austin, additional, Haller, Andrew, additional, Haynes, Jennifer, additional, Heiser, Diane, additional, He, Joy Q., additional, Hitomi, Masahiro, additional, Hoey, Timothy, additional, Hseih, Jason K., additional, Hutter, Gregor, additional, Jarrar, Awad, additional, Kim, Carla F., additional, Kozminsky, Molly, additional, Kurtova, Antonina V., additional, Lathia, Justin D., additional, Leung, Cherry, additional, Lima-Fernandes, Evelyne, additional, Liu, Huiping, additional, Liu, Xia, additional, Lobo, Neethan A., additional, Matei, Daniela, additional, Mitra, Siddhartha S., additional, Moon, Hyeongsun, additional, Nagrath, Sunitha, additional, Nephew, Kenneth P., additional, O’Brien, Catherine A., additional, Petritsch, Claudia, additional, Puri, Akshita, additional, Qian, Dalong, additional, Rehman, Sumaiyah, additional, Reizes, Ofer, additional, Rosen, Jeffrey M., additional, Rycaj, Kiera, additional, Saunthararajah, Yogen, additional, Shen, Xiling, additional, Sloan, Andrew E., additional, Spike, Benjamin T., additional, Sundar, Swetha J., additional, Tang, Dean G., additional, Thiagarajan, Praveena S., additional, van Weele, Linda J., additional, Wang, Yadong, additional, Wang, Yinu, additional, Weissman, Irving, additional, White, Andrew C., additional, Wright, James, additional, Zabala, Maider, additional, and Zhou, Wenchao, additional

Published
2016
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3. Spinal Metastasis

Author

Lo, Simon S., primary, Sloan, Andrew E., additional, Machtay, Mitchell, additional, Teh, Bin S., additional, Sahgal, Arjun, additional, Chao, Samuel T., additional, and Chang, Eric L., additional

Published
2011
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6. Medulloblastoma

Author

Barger, Geoffrey R., primary, Douglas, James G., additional, Kupsky, William J., additional, Sloan, Andrew E., additional, and Zak, Imad T., additional

Published
2005
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8. Spinal Metastasis.

Author

Lo, Simon S., Sloan, Andrew E., Machtay, Mitchell, Teh, Bin S., Sahgal, Arjun, Chao, Samuel T., and Chang, Eric L.

Published
2012
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9. RNAi-based Approaches to the Treatment of Brain Tumors.

Author

Mathupala, Saroj P., Mittal, Sandeep, Guthikonda, Murali, and Sloan, Andrew E.

Abstract

The discovery of RNA interference (RNAi) as an alternate mode of gene regulation utilized by eukaryotes has greatly expanded the arsenal of molecular tools that a biomedical researcher can employ to target tumors. Thus, it will be natural to extend this methodology from bench to the bedside as a novel mode of clinical intervention against intracranial tumors, as these are frequently refractive to conventional therapies, i.e. surgery, radiotherapy, and chemotherapy. Induction of RNAi in the targeted tumor can be multifaceted, with two primary modes of therapeutic intervention postulated to date; delivery of in silico designed and in vitro synthesized non-coding RNA molecules to the tumor, or the pharmacological perturbation of non-coding RNA molecules that are endogenously expressed by the tumor. Both modes silence gene expression, but via somewhat different molecular pathways. Two key non-coding RNA molecules that are known to impart RNAi are small interfering RNA and microRNA. Both are currently under investigation in pre-clinical and clinical settings for their potential utility against tumors, with small interfering RNA already proving their efficacy in several small-scale clinical trials. However, despite demonstration of excellent potential as an anti-cancer therapy at the bench, the current inability to deliver therapeutically significant levels of RNAi into the diseased tissue remains a primary hurdle that needs to be overcome for widespread utility at the bedside. This chapter presents an update on both the latest methodologies that have been utilized for induction of RNAi in brain tumors, both in pre-clinical and clinical settings, as well as descriptions of the molecular pathways that have been targeted via RNAi. The pioneering RNAi-based clinical trials that have been tested against brain tumors are also described to illustrate both the utility and the impact of this novel mode of brain tumor therapy at the bedside. [ABSTRACT FROM AUTHOR]

Published
2011
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