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In Western world, the prevalence of chronic diseases is highly increasing due to the increase in the life expectancy. Besides, cardiovascular diseases (CVD) are the leading source of death, causing 45% of all deaths and Heart Failure (HF), the paradigm of CVD, mainly affects people older than 65. This paper focuses on the latest advances in the design and development of the user interaction system to manage Heart Failure Management in a mobile environment, based on daily monitoring of Vital Body Signals, with wearable and information technologies, for the continuous assessment of this chronic disease. [ABSTRACT FROM AUTHOR]