Search

An encyclopedia entry for the term "insulin-like growth factors" (IGF) is presented. IGF is a family of insulin growth factors related proteins that are structurally and functionally related to insulin. Protein members of IGF include binding proteins and cell surface receptors. IGF is important in development during embryonic stage and in post-natal growth and development.

A definition of the term "somatomedins" is presented. It refers to polypeptide mediators that are created in response to growth hormone in the liver. Insulin-like growth factors are an example of somatomedins. The main mediator of growth hormone action is identified, which is IGF-1.

An encyclopedia entry for "insulin-like growth factor" is presented. Insulin-like growth factor IGF1 and IGF2 are widely expressed peptides with sequence homology to insulin. Both factors bind to specific receptors. The IGF1 receptor is a receptor tyrosine kinase with the same structure and molecular function to the insulin receptor.

A definition of the term "insulin-like growth factor-1 receptor," which refers to a large protein found on many cells that bind insulin-like growth factors, is presented.

A definition of the term "insulin-like binding proteins" is presented. These are large molecular proteins seen in local tissue environments and in circulation. Insulin-like binding proteins tie up insulin-like growth factors (IGF). These proteins tie up IGF to regulate their half-life and functions.

An encyclopedia entry for "IGFR" is presented. The acronym stands for insulin-like growth factor receptors.