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Start Over Descriptor "Pufa" Publication Type Books
2 results on '"Pufa"'

1. Functional Foods as a New Therapeutic Strategy.

Author

Cruz-Chamorro, Ivan and Cruz-Chamorro, Ivan

Subjects
Medicine, Basidiomycetes-X (BDM-X), COVID-19, Ceraceomyces tessulatus, Coriandrum sativum L., European black elderberry extract, Mibyou, Mibyou-care functional food, PUFA, RBL-2H3 cell, SARS-CoV-2, SARS-CoV-2 variants of concern, Shirayukidake, aging theories, agricultural waste, alginate, alginate oligosaccharides, anthocyanin, anthocyanins, anti-allergy, anti-inflammation, antibacterial, antioxidant, antioxidant activity, antioxidants, antiviral, application in agriculture, athlete, berries, bilberry, biological properties, buckwheat, cardiovascular diseases, carotenoids, cedar pollen, chitosan, chronic disease, chronic diseases, cohort study, colon simulation, comfort, coriander leaf, coronavirus, degranulation, diabetes, docosahexaenoic acid, dyslipidemia, ecological functions, fava bean, flour fortification, food, fruit, functional food, functional foods, genes, goji berry, health, health promotion, healthy diet, healthy lifespan expenditure, hemp, high-fat diet, human and animal health-promoting properties, hyperlipidemia, intestinal microbiota, longevity, microalgae, microbial metabolites, mitochondria, mucilages, natural substance, nutraceuticals, nutritional components, obesity, oxidative stress, pectin, phenolic compounds, phenols, polymeric conjugate, polyphenols, prebiotic, quercetin, reactive oxygen species, senescence, short-chain fatty acids, soft fruit, sterols, sugar, testa, vitamins
Abstract

Summary: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases.

2. Why Is the Nervous System Vulnerable to Oxidative Stress?

Author

Friedman, Joseph

Abstract

The nervous system is especially vulnerable to reactive oxygen species (ROS)-mediated injury for the following reasons. (1) High oxygen consumption of the brain for high energy needs, that is, high O2 consumption, results in excessive ROS produced. (2) Neuronal membranes are rich in polyunsaturated fatty acids (PUFA), which are particularly vulnerable to free radical attack. (3) The ratio of membrane surface area to cytoplasmic volume is high. (4) Specialized neuronal conduction and synaptic transmission activity depend on efficient membrane function. (5) Extended axonal morphology is prone to peripheral injury. (6) Neuronal anatomic network is vulnerable to disruptions. (7) The excitotoxic glutamate is the major effector that causes oxidative stress (OS). (8) The high Ca2+ traffic across neuronal membranes and interference of ion transport increase intracellular Ca2+, often leading to OS. (9) Auto-oxidation of neurotransmitters can generate O2 and quinones that reduce glutathione. (10) Iron is formed throughout the brain, and brain damage readily releases iron ions capable of catalyzing free radical reactions. (11) Antioxidant defense mechanisms are modest, in particular, low levels of catalase, glutathione peroxidase, and vitamin E. (12) ROS directly downregulate proteins of tight junctions and indirectly activate matrix metalloproteinases (MMP) that contribute to open the blood–brain barrier (BBB). (13) Activated microglia produce ROS and cytokines in a perpetual process. (14) Cytochrome P450 produces ROS. (15) Loss of trophic support can activate NADPH oxidase, which increases ROS. (16) The presence of hemoglobin within the neural tissues secondary to spontaneous, iatrogenic, or traumatic causes is neurotoxic. Heme and iron are released and promote ROS. (17) Neuronal mitochondria generate O2. (18) The interaction of NO with superoxide can be implicated also in neuronal degeneration. (19) Neuronal cells are nonreplicating and thus are sensitive to ROS. In comparison with other organs, the neuronal network may be especially vulnerable to ROS-mediated injury because of the following anatomic, physiological, and biochemical properties of the brain. [ABSTRACT FROM AUTHOR]

Published
2011
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