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4. CSF-Phospho-tau (181P) as a Promising Marker for Discriminating Alzheimer's Disease from Dementia with Lewy Bodies

Author

Vanmechelen, E., primary, Van Kerschaver, E., additional, Blennow, K., additional, De Deyn, P. P., additional, Galasko, D., additional, Parnetti, L., additional, Sindic, C. J. M., additional, Arai, H., additional, Riemenschneider, M., additional, Hampel, H., additional, Pottel, H., additional, Valgaeren, A., additional, Hulstaert, F., additional, and Vanderstichele, H., additional

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5. CSF-Phospho-tau (181P) as a Promising Marker for Discriminating Alzheimer's Disease from Dementia with Lewy Bodies.

Author

Vanmechelen, E., Van Kerschaver, E., Blennow, K., De Deyn, P. P., Galasko, D., Parnetti, L., Sindic, C. J. M., Arai, H., Riemenschneider, M., Hampel, H., Pottel, H., Valgaeren, A., Hulstaert, F., and Vanderstichele, H.

Subjects
DEMENTIA, NEUROBEHAVIORAL disorders, LEWY body dementia, ALZHEIMER'S disease, BIOMARKERS, CEREBROSPINAL fluid
Abstract

Increased levels of the microtuble-associated protein tau in cerebrospinal fluid is a consistent finding in more than 80% of patients with Alzheimer's disease. As tau protein accumulates in the Alzheimer's disease brain in a hyperphosphorylated form, the determination of phosphorylated tau in cerebrospinal fluid as opposed to total tau might increase the assay specificity. Several recent studies suggest, but do not yet clearly demonstrate, that assays based on phospho-tau are more specific for Alzheimer's disease than those based on total tau. For this reason, the phospho-tau (181P-specific assay) was evaluated in Alzheimer's disease and closely related dementia. Since the relative absence of phosphorylated tau biochemically distinguishes senile dementia with Lewy bodies from Alzheimer's disease, our primary aim was to determine whether there is a significant difference in phospho-tau levels between these two forms of dementia. [ABSTRACT FROM PUBLISHER]

Published
2001

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