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10. Synthetic Antibody Gene Libraries for In Vitro Affinity Maturation.

Author

Walker, John M., Paul, Sudhir, Deng, Su-jun, MacKenzie, C. Roger, and Narang, Saran A.

Abstract

The application of phage display to the screening of antibody V-gene libraries promises to replace animal immunization and hybridoma technology as a means of antibody generation (1,2). Synthetic libraries offer the potential for expanding the immune system repertoire and designing libraries for particular sets of antigens. We have developed a method for the generation of synthetic antibody gene libraries by which spiked oligonucleotides are assembled by a ligase chain reaction protocol (3). This is a synthetic adaptation of a reaction that was previously used as a diagnostic tool (4,5). [ABSTRACT FROM AUTHOR]

Published
1995
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