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Interface dermatitis is characterized by damage to the epidermis from the inflammatory infiltrate. Microscopically, this is characterized by basal vacuolization with or without necrotic keratinocytes. Interface dermatitis can be broadly grouped into two subgroups based on the pattern of the inflammatory infiltrate: (1) lichenoid, or band-like, in which, the infiltrate forms a dense layer parallel to the overlying epidermis (Fig. 4.1) and (2) perivascular, in which the infiltrate is concentrated around blood vessels in either a superficial or superficial and deep distribution (Fig. 4.2). [ABSTRACT FROM AUTHOR]