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4. Contributors

Author

Aguilar, Ethan George, primary, Alatrash, Gheath, additional, Anasetti, Claudio, additional, Arvindam, Upasana Sunil, additional, Blazar, Bruce R., additional, Bousso, Philippe, additional, Byersdorfer, Craig, additional, Chilkulwar, Abhishek R., additional, Coghill, James M., additional, Cooke, Kenneth R., additional, Crain, Alyssa K., additional, Drobyski, William R., additional, Dudakov, Jarrod A., additional, Edinger, Matthias, additional, Felices, Martin, additional, Fry, Terry J., additional, Fowler, Daniel H., additional, Goulmy, Els, additional, Hanash, Alan M., additional, Hill, Geoffrey R., additional, Hoffmann, Petra, additional, Holler, Ernst, additional, Holtan, Shernan, additional, Jacoby, Elad, additional, Jenq, Robert R., additional, Kean, Leslie, additional, Levy, Robert B., additional, Markey, Kate A., additional, Martin, Paul J., additional, Michonneau, David, additional, Miller, Jeffrey, additional, Molldrem, Jeffrey J., additional, Murphy, William, additional, Mutis, Tuna, additional, Negrin, Robert S., additional, Paczesny, Sophie, additional, Penack, Olaf, additional, Petersdorf, Effie, additional, Piper, Clint, additional, Reddy, Pavan, additional, Ritz, Jerome, additional, Sarantopoulos, Stefanie, additional, Serody, Jonathan S., additional, Socié, Gérard, additional, Takashima, Shuichiro, additional, van den Brink, Marcel R.M., additional, Weber, Daniela, additional, Wu, Yongxia, additional, Yu, Xue-Zhong, additional, and Zeiser, Robert, additional

Published
2019
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13. Polymorphisms Within Epithelial Receptors.

Author

Walker, John M., Beksac, Meral, Brenmoehl, Julia, Holler, Ernst, and Rogler, Gerhard

Abstract

Genetic risk assessment in the setting of allogeneic stem cell transplantation is one of the major goals to optimise future prophylaxis and treatment of patients: our group has focused on analysis of single-nucleotide polymorphisms (SNPs) within the intracytoplasmatic receptor NOD2/CARD15, which recognizes the bacterial cell wall compound muramyl-dipeptide and induces nuclear factor-KB-mediated inflammation. By performing TaqMan PCR of the three major SNPs also identified as risk factors in Crohn's disease in donors and recipients, we were able to demonstrate a major association of NOD2/CARD15 SNPs with the occurrence of severe graft-vs-host disease and resulting treatment-related mortality following human leukocyte antigen-identical sibling transplantation. Although these data need confirmation in further prospective trials, this association may not only be used for risk assessment but also point to a major pathophysiological interaction of dysregulated activation of the innate immune system and specific alloreaction. [ABSTRACT FROM AUTHOR]

Published
2007
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