Search

Your search keyword '"Graham, Kenneth"' showing total 50 results
Start Over Author "Graham, Kenneth" Publication Type Books
50 results on '"Graham, Kenneth"'

11. Ophthalmic Product Development for Biologics

Author

Sharma, Gitanjali, primary, Zhou, Chen, additional, Wadhwa, Saurabh, additional, Parenky, Ashwin C., additional, Graham, Kenneth S., additional, Bhalla, Amardeep S., additional, Liu, Dingjiang, additional, Chen, Hunter H., additional, and Shameem, Mohammed, additional

Published
2021
Full Text
View/download PDF

18. Study Skills Handbook: A Guide for All Teachers.

Author

ERIC Clearinghouse on Reading and Communication Skills, Urbana, IL., International Reading Association, Newark, DE., Graham, Kenneth G., Robinson, H. Alan, Graham, Kenneth G., Robinson, H. Alan, ERIC Clearinghouse on Reading and Communication Skills, Urbana, IL., and International Reading Association, Newark, DE.

Abstract

Intended for elementary and secondary school teachers, this handbook provides practical instruction for the development of students' study strategies. Each of the four chapters begins with a study guide and closes with a reaction guide, thus illustrating for the reader an excellent study strategy that teachers may use with text materials in their classes. The first chapter discusses the nature of readers, reading processes, and specific study skills. The remaining three chapters discuss study strategies useful before, during, and after reading. (HTH)

Published
1984

36. Explosions

Author

Kinney, Gilbert Ford, primary and Graham, Kenneth Judson, additional

Published
1985
Full Text
View/download PDF

48. Automated C-Terminal Protein Sequence Analysis Using the Alkylated-Thiohydantoin Method.

Author

Walker, John M., Smith, Bryan John, Dupont, David R., Yuen, Sylvia W., and Graham, Kenneth S.

Abstract

The alkylated-thiohydantoin (ATH) method for C-terminal sequence analysis, which exploits some unique properties of the thiohydantoin (TH) ring system, was first described in 1992 (1). The ATH method incorporates alkylation of the C-terminal TH with an aralkylbromide reagent. The resulting ATH is a better leaving group than the unmodified TH, eliminating the need for strongly acidic or strongly nucleophilic cleavage conditions and minimizing ring opening of the TH and hydrolysis of the protein. The ATH is readily cleaved under mildly acidic conditions by nucleophilic displacement with thiocyanate ion, [NCS]", conditions that simultaneously form the penultimate (C-1) TH. This is a key advantage of the ATH method over other methods for C-terminal sequence analysis. Combination of ATH-cleavage and TH-derivatization into one step eliminates the need for activation of the C-terminal amino acid before each cycle of sequencing. Therefore, any new C-termini arising from fragmentation of peptide bonds in the protein can not form TH. This prevents detection of amino acid background resulting from internal cleavage of the protein. In other methods for C-terminal sequence analysis, internal cleavage followed by repeated C-terminal activation can produce a rising TH-background, making accurate sequence calling difficult. In the ATH method, each alkylation of the proteinyl-TH, followed by cleavage and derivatization with [NCS]-, comprises one cycle of sequencing. [ABSTRACT FROM AUTHOR]

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results