Oak Ridge National Laboratory (ORNL) has over 200 professionals engaged in measurement science research and development. This work includes transduction techniques, advanced microelectronics, signal and image processing, modeling and simulation, material synthesis and characterization, and system engineering issues for packaging, miniaturization, integration, and communications (e.g. wireless networks). ORNL is applying this expertise to detecting, preventing, and reversing the proliferation of weapons of mass destruction, deploying integrated systems for incident awareness, detection, and response, providing technology for detection of explosives, and delivering enhanced protection and new capabilities to first responders and warfighters. Sensor systems include micro- and nano-arrays, optical, chemical, and biological technologies. Electronics΄ research has focused on low-power, low-cost, and wireless functionality. Signal processing advancements encompass data flow with conversion to information and knowledge for intelligent decision making. [ABSTRACT FROM AUTHOR]