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The entry examines the immunosuppresive effects of metabolites. Isozyme-selective inducers and inhibitors have been developed in order to detect immunotoxicants requiring metabolic activation by cytochrome P450s. Drug-metabolizing enzymes such as cytochrome P450s play a role in activating human carcinogens therefore it can be speculated that certain immunotoxicants might require metabolic activation in humans.

A reference entry for "CYP enzyme" is presented. It refers to cytochrome P-450 isozymes, a superfamily of monooxygenases, which are mostly found in liver. It has many subfamiles and each has different affinity and metabolizes in different ways. These enzymes oxidize various chemicals. It is linked with P450 Mono-oxygenase System.

A definition of the term "metabolite" is presented. It refers to a product of xenobiotic biotransformation. Some drug-metabolizing enzymes can produce reactive metabolites such as cytochrome P450 which can cause immunotoxicity.

The article presents an encyclopedia entry for cytochrome P450s, which are heme-containing proteins that absorb light when carbon monoxide binds to the proteins. Cytochrome P450 proteins ranks first as phase I biotransforming enzymes for its characteristics.

A reference entry for the term "cytochrome P450 2D6" is presented. It refers to a mixed-function oxidase localized in the endoplasmic reticulum which is responsible for the biotransformation of several tricyclic antidepressants, antipsychotics, betablockers, opioids, and many other drugs. It is also called debrisoquine-sparteine hydroxylase.

The article presents an encyclopedia entry for cytochrome P450 induction. It refers to a process whereby cellular and tissue levels of one of more cytochrome P450 enzymes are increased in response to treatment of cells, or a whole organism, with certain drugs or environmental chemicals referred to as P450 inducers.

A reference entry for the term "cytochrome P450 2C9" is presented. It refers to a mixed-function oxidase localized in the endoplasmic reticulum which is responsible for the biotransformation of several nonsteroidal anti-inflammatory drugs, S-warfarin, several sulfonylurea antidiabetics and other drugs.

A reference entry for "cytochrome P450 (CYP)" is presented. It refers to a is a family of hemeprotein monooxygenase enzymes that plays a central role in the oxidative metabolism of structurally diverse lipophilic steroids, fatty acids, drugs and environmental chemicals. It is involved in the biotransformation of drugs.