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The overexpression of programmed cell death-ligand 1(PD-L1) has been observed in gastric cancer (GC). However, whether the expression of PD-L1 in tumor cells or blood serum is associated with the prognosis of patients with GC remains unclear. Therefore, we performed a meta-analysis to evaluate the prognostic significance of PD-L1 expression in GC. Electronic databases were searched systematically. Studies that met the inclusion criteria were included in the meta-analysis. Data concerning the hazard ratio (HR) for overall survival and disease-free survival with a 95% confidence interval (CI) according to the expression status of PD-L1 evaluated by immunohistochemistry or enzyme-linked immunosorbent assay were extracted. The data were analyzed using a random effects model. Subgroup analyses were proposed. Our results showed that eight studies with 950 patients met the inclusion criteria and were included in the meta-analysis. The pooled HR for overall survival indicated that patients with PD-L1-positive expression had significantly shorter survival time compared with the PD-L1-negative group (HR 1.60, 95% CI 1.09-2.36, P=0.012). The pooled HR for disease-free survival demonstrated that the difference between the two groups was not statistically significant (HR 1.02, 95% CI 0.32-3.20, P=0.98). In conclusion, our results indicate that the evaluation of PD-L1 overexpression in GC tissue or blood serum may be useful in the future as a novel prognostic factor. [ABSTRACT FROM AUTHOR]

Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies. By using network analysis, the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe, even though they are geographically far away from each other. By further composite analysis, this study revealed that hot events first occurred in Eastern Europe, typically with a time lag of 3-4 days before the East Asian heatwave events. An eastward propagating atmospheric wave train, known as the circumglobal teleconnection (CGT) pattern, bridged the sequent occurrences of extreme events in these two remote regions. Atmospheric blockings, amplified by surface warming over Eastern Europe, not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low pressures. Subsequent downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation, thereby facilitating the formation of heatwaves over East Asia. Nearly half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave events. This investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves. [ABSTRACT FROM AUTHOR]

This article examines a transnational network of advocates for Kampō (traditional) medicine in Japan, occupied China, and Manchukuo during the Sino-Japanese War (1931–1945), shedding new light on collaborationism, Asianism, and the modernization of traditional medicine in East Asia. In the 1930s, despite deteriorating Sino-Japanese relations, the Kampō revival movement in Japan joined forces with the struggle to preserve traditional medicine in China. In 1938, the Association of East Asian Medicine was founded in Japan, gathering together Chinese, Korean, and Japanese advocates under the banner of 'East Asian medicine'. This article delineates the evolution of what I call 'medical Asianism' and how it was institutionalized in different parts of the Japanese empire. Participants in this network differed in their priorities and ideological commitments, yet they tactfully utilized the Japanese imperial infrastructure and wartime circumstances to promote traditional medicine. Their work laid important intellectual and institutional foundations for the postwar development of traditional medicine across East Asia. This study also contributes to a more nuanced understandings of collaborationism. The type of collaboration examined in this article was preceded by a long history of intellectual exchange, based on a shared body of knowledge and morals, motivated by mutual empathy, and for a cause that was much valued in postwar Asia. As a result, unlike most Chinese collaborators who were prosecuted as 'traitors', protagonists in this study continued to prosper professionally and became valuable assets in the postwar rebuilding of Sino-Japanese relations. [ABSTRACT FROM AUTHOR]

Meiyu occurs in Yangtze‐Huaihe River valley (YHRV) every summer. Its intensity, distribution, and intraseasonal variation are greatly influenced by atmospheric forcings from different directions, such as the monsoon southwesterlies from the south, the western Pacific subtropical high (WPSH) in the east, the atmospheric longwave activities in the north, the southwest vortex from the west, and so on. In this study, to explore the contributions of the atmospheric forcings from different directions to 2020 extreme Meiyu, Regional Climate Model version 4.6 (RegCM4.6) is employed. A series of sensitivity experiments are conducted with realistic or climatological averaged lateral boundary conditions. The results show that the monsoon westerlies from the south transport moisture and heat to YHRV, converge with the cold air brought by the frequent atmospheric longwave activities in the north, and result in this extreme Meiyu. The frequent cold air from the north can lift warm air, provide unstable conditions, and make the distribution of precipitation similar to the teleconnection pattern in East Asia. The stable WPSH in the east anchors the 2020 Meiyu rainband to the YHTV for a long time. In addition, the contributions of the atmospheric forcings from different directions to evolution of 2020 Meiyu change with time. Before 10 June, the WPSH in the east mainly contributes to the Meiyu evolution. From 11 June to 3 July, the combined effects of atmospheric forcings from the south and north are dominant. From 3 July to 10 July, the cold air from the north plays a major role. Plain Language Summary: The typical rainy season of the East Asian summer monsoon, Meiyu, occurs in Yangtze‐Huaihe River valley (YHRV) in China every summer. Its intensity, distribution and intraseasonal variation are greatly influenced by the monsoon southwesterlies from the south, the western Pacific subtropical high in the east, the atmospheric longwave activities in the north, the southwest vortex from the west and so on. In the summer of 2020, the record‐breaking Meiyu rainfall, featuring an early onset, delayed retreat, abundant precipitation, and frequent heavy rainstorm processes, appeared in the YHRV. However, the contributions and roles of atmospheric forcings from different directions to 2020 Meiyu have not been well analyzed. In this study, Regional Climate Model version 4.6 (RegCM4.6) is employed to simulate the 2020 Meiyu, and a series of sensitivity experiments are conducted. The results show that atmospheric forcings from different directions play different roles in the occurrence and movement of the Meiyu rain belt in 2020. In addition, the contributions of atmospheric forcings to the 2020 Meiyu from different directions change with time. The results improve the understanding of the occurrence and maintenance mechanisms of Meiyu. Key Points: The extreme Meiyu in 2020 occurs due to specific atmospheric forcings which are different from the climatological conditionsThe atmospheric forcings from different directions play different roles in the occurrence and evolution of the Meiyu rain belt in 2020The contributions of atmospheric forcings to the 2020 Meiyu from different directions change with time during the Meiyu period [ABSTRACT FROM AUTHOR]

This paper provides an overview of recent literature on the history of epidemics in East Asia, with a primary focus on modern and contemporary China, but including some discussion of the scholarship in English on epidemics in Korea and Japan. Key research strands are identified within the field: local and regional histories, disease biographies, histories of public health campaigns, global connections, and cultural representations. The paper argues that studies of epidemic disease have been central to debates about East Asian modernity, transformations of the state, the formation of a post-imperial citizenry, postcolonial science and technology studies, and East Asia's role in globalizing processes. The paper concludes by reflecting on the COVID-19 pandemic and the issues it raises for future research. [ABSTRACT FROM AUTHOR]

Dust direct radiative effect (DDRE) can modify the near‐surface air temperature, which can in turn influence dust emission. However, the feedback mechanism of DDRE on dust emission is poorly understood. In this study, the influence of DDRE on dust emission in Taklimakan Desert (TD) was investigated using comprehensive ground‐based observations. The results show that the near‐surface air temperature significantly decreased as a result of DDRE, corresponding to dust emission enhanced. Statistically, the contributions of DDRE to dust emission during light, moderate, and heavy dusty episodes were 5.0% (3.6%), 5.2% (2.8%), and 6.1% (3.3%) in spring (summer), respectively. From the perspective of mechanism, DDRE can induce an increase in air density by cooling the near‐surface, causing an enhancement of aerodynamic drag, promoting dust emission in TD. Such positive feedback of DDRE on dust emission may be a potential contributor to improving the dust emission scheme of numerical modeling in the future. Plain Language Summary: Taklimakan Desert (TD) is a significant dust source in China and East Asia, providing abundant dust aerosols that are suspended in the atmosphere over Tarim Basin. Currently, the feedback mechanism of the radiative effect of suspended dust on dust emission is poorly understood. By combining comprehensive ground‐based observations with reanalysis data, we investigated the influence of dust direct radiative effect (DDRE) on dust emission in TD. Due to the DDRE, the near‐surface air temperature during light, moderate and heavy dust pollution episodes decreased by 7.01 (4.38), 7.28 (3.51), and 8.50 K (4.06 K) in spring (summer), respectively. Such a distinct cooling effect decreased the threshold wind speed, leading to dust emission enhanced in TD. The contributions of DDRE to dust emission were 5.0%–6.1% (2.8%–3.6%) in spring (summer). According to the physical mechanism of sand movement, the near‐surface cooling effect caused by DDER induced an increase in air density, leading to the enhancement of aerodynamic drag, which resulted in more dust particles leaving from the surface. Therefore, DDER is responsible for the promotion of dust emissions in TD. The results are beneficial for improving dust emission schemes in future modeling. Key Points: Dust direct radiative effect (DDRE) and air pressure are presented as quadratic functionsContributions of DDRE to dust emission are 5.0%–6.1% (2.8%–3.6%) in spring (summer)Enhancement of aerodynamic drag is the primary cause of dust emission increased [ABSTRACT FROM AUTHOR]

Introduction: Hypsizygus marmoreus is an industrial mushroom that is widely cultivated in East Asia. Its long postripening stage before fruiting severely limits its industrialized production. Methods: Five different mycelial ripening times (30, 50, 70, 90, and 100 d) were chosen and primordia (30P, 50P, 70P, 90P, and 110P) were collected for comparative transcriptomic analyses. The corresponding substrates (30F, 50F, 70F, 90F, and 110F) were used for nutrient content and enzyme activity determination. Results: In pairwise comparisons between 110P and other primordia, a total of 1,194, 977, 773, and 697 differentially expressed genes (DEGs) were identified in 30P_110P, 50P_110P, 70P_110P, and 90P_110P, respectively. Gene Ontology (GO) and Kyoto Encyclopedia of Genes Genomes (KEGG) functional enrichment analyses revealed that the DEGs were mainly associated with amino acid metabolism, and lipid and carbohydrate metabolism pathways. Tyrosine, tryptophan, phenylalanine and histidine metabolism were enriched in all groups. Among the main carbon nutrients, the contents of cellulose and hemicellulose were high, and the lignin content decreased with the extension of the ripening time. Laccase had the highest activity, and acid protease activity decreased with the extension of the ripening time. Discussion: The highly enrichment for amino acid metabolic pathways in primordia reveals that these pathways are essential for fruiting body formation in H. marmoreus, and these results will provide a basis for the optimization of its cultivation. [ABSTRACT FROM AUTHOR]

Discrete element modelling (DEM) is a numerical method for examining the dynamic behavior of granular media. In order to build an accurate simulation model and provide more comprehensive soil characteristic parameters for the design and optimization of various soil contact machinery, in this paper, the discrete element simulation method (EDEM) combined with experimental approach is used to investigate the soil contact characteristic parameters in East Asia. In this study, Hertze-Mindlin (no slip) was used as a particle contact model by taking particle contact parameters and soil JKR (Johnson-Kendall-Roberts) surface energy as determinants, and repose angle, internal friction angle, and cohesive force as evaluation indexes. The method of Plackett-Burman, Stepest ascent, and Box-Behnken were used to gradually reduce the range of parameters needed for simulation until the most accurate value was determined. The results show that the restitution coefficient, static friction coefficient, and rolling friction coefficient between soil particles have significant effects on the DEM model, and their value of them are 0.596, 0.725, and 0.16, respectively. Based on these parameters used for the repose angle test and direct shear stress test, the value of repose angle is 31.97°, the internal friction angle is 27.61°, and the cohesive force is 33.06 kPa. The relative errors with the actual measured values are 9.54%, 1.87%, and 2.31%, respectively. In order to further test whether the simulation parameters of soil obtained by repose angle test and direct shear stress test are consistent with the real soil, comparison test between field test and discrete element simulation was used. The results show that the error in height of ridge between the simulated soil and the actual soil is 4.06%, which is within the acceptable range. It also indicates that the calibrated and optimized soil simulation model can accurately represent the real soil. The research provides theoretical basis and technical support for the study of soil contact parts by using the discrete element method, combined with repose angle test and direct shear stress test. [ABSTRACT FROM AUTHOR]

The cause of magmatic tempo in an active plate margin remains controversial, partly due to lack of structural analysis. During 130–105 Ma, the magmatism in the South China Block (SCB) was significantly reduced (lull) and restricted around the Changle‐Nan'ao Belt (CNB) while the magmatism was highly active (flare‐up) in North China. For unveiling the tectonic role on magmatism, a multidisciplinary study including field and microscopic structural observations, magnetic fabric measurement (AMS), and zircon/monazite dating was conducted on the plutons with oriented minerals in the CNB. Structural analysis and AMS results show a highly clustered NE‐striking vertical foliation developed during the emplacement indicating a syn‐emplacement NW‐SE shortening regime. The geochronology results confirm that the emplacement occurred during 130–105 Ma. Regional geologic correlation indicates that the collision between the Dangerous Grounds‐West Philippines Block and SCB was responsible for this shortening regime. The collected depleted zircon εHf(t) data suggest that a possible collision‐triggered slab break‐off caused the syn‐collisional magmatic activity around the CNB. This study shows that the magmatic lull in the SCB was coeval with a crustal shortening regime due to the arrival of a microcontinent carried by the subduction slab, while the magmatic flare‐up was coeval with an extensional regime due to the subduction roll‐back and retreat as evidenced by the Cretaceous evolution of the SCB before and after the collision and that of North China which is unaffected by the collision. The cause of magmatic tempo in the continental margin is largely due to the tectonic evolution of underlain subduction slabs. Plain Language Summary: Magmatic activity is closely connected to human life as it provides us with useful metals, releases greenhouse gases, triggers natural hazards. It is necessary to explore what controls a magmatic activity. Several previous studies considered that a shortening regime with thickened crust causes strong magmatism (flare‐up). The South China Block (SCB) featured by alternating magmatic flare‐up and lulls, provides an appropriate research target to test this hypothesis. During the Cretaceous, the SCB was dominated by an extensional regime caused by the Paleo‐Pacific oceanic slab subduction. However, our structural analyses on the SCB document a shortening regime caused by the collision between the SCB and a microcontinent carried by the Paleo‐Pacific oceanic slab in the period of the Cretaceous. During the collision, the SCB was generally featured by a magmatic lull, although magmatic activity was only observed around the Changle‐Nan'ao Belt, probably caused by the break‐off of the subducted Paleo‐Pacific oceanic slab. Before and after the collision, the extensional regime caused by Paleo‐Pacific oceanic slab subduction was coeval with magmatic flare‐up. This study questions the previous claims and proposes that the tectonic evolution of the subducting slab may control the magmatic flare‐up and lull in the overlain active continental margin. Key Points: The 130–105 Ma syn‐tectonic plutons intruded the Changle‐Nan'ao Belt in a NW‐SE shortening regime caused by a microcontinent collisionThe shortening/extension regimes were coeval with magmatic lull/flare‐up in the East Asia Continental Margin during the CretaceousThe collision causing break‐off can account for the plutonism in the Changle‐Nan'ao Belt during the magmatic lull of the South China Block [ABSTRACT FROM AUTHOR]

In June‐July 2020, the Middle and Lower Yangtze River Region (MLYR) encountered the most severe precipitation event over the past 60 years. The Indian Ocean Dipole (IOD) in the previous autumn of the unusual precipitation event was the main contributing factor. Nonetheless, not every strong IOD event could bring anomalously high precipitation in the MLYR. This study showed significantly enhanced influence of IOD on East Asia climate since 2000. The IOD's effect on MLYR summer precipitation has strengthened significantly with the correlation coefficient up to 0.55 during 2000–2020. The northward movement of East Asia–Pacific pattern associated with IOD since 2000 (as compared with before) was primarily responsible for the enhanced effect. Since 2000, the MLYR has been controlled by a deep baroclinic instability system with anomalous low pressure in the lower troposphere and anomalous high pressure (completely different from before). Furthermore, the western Pacific subtropical high shifted northward and westerly jets were significantly enhanced with eastward expansion. All of these patterns contributed to the water vapor convergence and precipitation generation in the MLYR, which was not the case in the past. The record‐breaking IOD in 2019 autumn and the enhanced IOD's climatic effect in 2000–2020 contribute to the extreme Meiyu in 2020 jointly. The significant change in the influence of IOD and the enhanced climate effect of IOD highlight exciting new avenues for improving climate predictions in the MLYR. Plain Language Summary: The excessive Meiyu rainfall over the Middle and Lower Yangtze River Region (MLYR) during summer 2020 was beyond expectations of meteorologists, because in the 2019/20 winter, the Niño3.4 index was marginal at only 0.5°C as compared to 2.4°C and 2.6°C in 1997/98 and 2015/16 winters, respectively. Researches pointed out that the severely positive Indian Ocean Dipole (IOD) in the previous season was the main contributing factor on 2020 extreme Meiyu event in the MLYR. Nonetheless, not every strong IOD event could bring anomalously high precipitation in the MLYR. Our study shows significantly enhanced influence of IOD on East Asia climate since 2000. The IOD's effect on MLYR summer precipitation has strengthened significantly with the correlation coefficient up to 0.55 during 2000–2020. The IOD‐induced circulation patterns, including East Asia–Pacific pattern, the western Pacific subtropical high, and westerly jets, shifted northward with stronger intensity since 2000 (as compared with before). These results help us to reconsider the influence of tropical Indian Ocean sea surface temperature when forecasting weather or the possible climate changes under global warming. Key Points: The impact of Indian Ocean Dipole (IOD) on the Yangtze precipitation has enhanced in recent decadesThe IOD‐induced East Asia–Pacific pattern moves northward since 2000The interdecadal change in IOD's climatic effect largely contributes to the extreme Meiyu in 2020 [ABSTRACT FROM AUTHOR]

Didymodon heilongjiangensis is described as a new species from Nianzishan District, Heilongjiang Province, China. It is mainly characterized by triangular to ovate‐lanceolate leaves that are erect to erect‐patent when moist, acute leaf apices, leaf margins recurved to near leaf apex, yellowish color in KOH, percurrent to short‐excurrent costa that is widened toward apex, laminal cells with low papillae over the transverse walls, which reach the two adjacent cells, and marginal basal cells with thickened transverse walls. A phylogenetic analysis based on DNA sequences of ITS, rps4, trnM‐trnV confirms that D. heilongjiangensis belongs to the genus Didymodon s.str. The new species is fully illustrated and its affinities are discussed in detail. [ABSTRACT FROM AUTHOR]

While research on new venture entrepreneurship has been predominantly conducted in Western countries, East Asian start-ups have gained global relevance in recent years. In this article, we systematically review studies on new venture entrepreneurship in East Asia published in Social Science Citation Index (SSCI)-listed journals between 2000 and 2020 and find that the number of papers annually published has been rapidly increasing. However, the research body is highly unbalanced, as most articles are single-country studies focused on China, apply a quantitative methodology, and concentrate on topics such as entrepreneurial strategies and new venture entrepreneurs' personal attributes and networks. Moreover, a majority of studies provides no or only a weak consideration of the national or subnational context. More strongly contextualized research on countries such as Japan and South Korea and on less studied themes such as culture, entrepreneurial financing, entrepreneurial teams, new venture internationalization and new venture entrepreneurial intention is desirable. [ABSTRACT FROM AUTHOR]

The sudden outbreak of the COVID-19 pandemic has changed people's long-standing group life, and "less gathering" has become a popular slogan during this period. People will probably feel lonely when they are physically, socially, or mentally distanced and isolated or excluded, and they usually perceive a deficiency in the quality or quantity of their social relationships. Although loneliness is easily conflated with solitude, loneliness as an emotion is generally regarded as negative while solitude can be positive. There are various causes and effects of loneliness during the COVID-19 pandemic, and loneliness has been found to have significant impacts on poorer physical and mental health. Religiosity and spirituality are specifically proven to have a great impact on handling loneliness during the COVID-19 pandemic. When regarding belongingness as the opposite of loneliness and social isolation, religious belonging means a feeling of being "at home" and "connected". In this paper, from a comparative approach, we attempt to investigate how the three most prominent traditions in East Asia, i.e., Confucianism, Daoism, and Buddhism, can help manage the feeling of loneliness. Due to different understandings of loneliness, their coping strategies for loneliness also vary. Through a preliminary study of "benevolence and rites," "wu-wei and freedom," and "mindfulness and spiritual realization," we can learn from the ancient wisdom about how to reduce loneliness and promote spiritual well-being during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

The model uncertainty, one of the major sources of projection uncertainty, is still a challenge in the climate change projection. In this study, the model uncertainty in simulating the East Asian summer monsoon rainfall and its physical link to the upper‐level jet streams and the western North Pacific subtropical high (WNPSH) are investigated from the Coupled Model Inter‐comparison Project Phase 6 (CMIP6) models. The results show that extracted by the inter‐model Empirical Orthogonal Function method, the leading inter‐model mode of the rainfall is characterized as a meridional pattern. The positive mode (a continent‐wet‐ocean‐dry pattern) is closely associated with a northward shift of the oceanic branch of the East Asian subtropical jet and a northward movement of the WNPSH, while the negative mode (a continent‐dry‐ocean‐wet pattern) is highly correlated with an enhanced East Asian polar‐front jet combined with a weakened land branch of the East Asian subtropical jet as well as a weakened and eastward recess of the WNPSH. This systematic link among the atmospheric circulations and the leading inter‐model mode is maintained by the negative phase of the Victoria Mode in the North Pacific and warming over the Atlantic Ocean in the positive mode, and the cooling over the Indian Ocean, Atlantic Ocean and the warming over the central Pacific in the negative mode. Our findings suggest that the physical linkage between the atmospheric circulations and monsoon rainfall is useful to understand the model uncertainty, which would be helpful in providing potential indicators of the East Asia summer monsoon change. Plain Language Summary: Monsoon rainfall has profound economic and social impacts, however large uncertainties lie in the climate model simulations. In this study, the inter‐model spread is used to extract the model uncertainty for the East Asian summer monsoon rainfall. The leading inter‐model mode is a meridional dipole pattern, which is closely associated with the concurrent variations of jet streams and the intensity and meridional movement of the western North Pacific subtropical high (WNPSH), but with the asymmetric response. The associated jet stream and the WNPSH variations are sustained by the oceanic conditions over the Atlantic Ocean, Pacific Ocean, and Indian Ocean, and therefore results in the inter‐model spread of the monsoon rainfall. Our findings suggest a useful metric to understand the traces of model uncertainties, focused on the physical linkage between the atmospheric circulations and the monsoon rainfall. Key Points: The leading inter‐model spread in East Asian summer monsoon rainfall is a meridional pattern from the Coupled Model Inter‐comparison Project Phase 6 modelsThe associated jet streams and western North Pacific subtropical high (WNPSH) variations exhibit asymmetric responses to this inter‐model spreadThe uncertainties in the north Pacific, Atlantic, and Indian Ocean have physically linked the jet stream and WNPSH variations to this inter‐model spread [ABSTRACT FROM AUTHOR]

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The Taihang–Lvliangshan region is located in the central part of the North China Craton (NCC), which has undergone significant reactivation and reconstruction during the Mesozoic–Cenozoic period. Documenting its long‐term uplift and exhumation history is critical for accurately characterizing the reformation extent of the NCC. In order to further reveal the Mesozoic and Cenozoic exhumation stages and spatial exhumation pattern of the Taihang–Lvliangshan, we present a comprehensive low‐temperature thermochronometric datasets from the region. The compilation revealed five distinct rapid exhumation episodes within the Taihang–Lvliangshan, including the Middle‐Late Jurassic (~160–150 Ma), Early Cretaceous (~120–110 Ma), Late Cretaceous (~100–60 Ma), Eocene (~50–40 Ma), and Late Oligocene–Early Miocene (~30–20 Ma). During the Middle–Late Jurassic, the Taihang–Lvliangshan underwent a strong thrusting deformation caused by the synthesis of northwestward subduction of the Palaeo‐Pacific Plate and southward subduction/collision of the Mongol–Okhotsk suture zone. Subsequently, rapid exhumation under an extensional tectonic environment occurred during the Early Cretaceous primarily owing to the subduction of the Palaeo‐Pacific Plate. During the Late Cretaceous, the collision between the Okhotomorsk Block and East Asia resulted in the regional northwest–southeast shortening and uplift of the Taihang–Lvliangshan. During the Eocene, normal fault activations were occurring throughout the range, likely owing to the change in the convergence rate and direction between the Palaeo‐Pacific Plate and East Asia. Another important exhumation event occurred during the Late Oligocene–Early Miocene period, which was likely attributed to the result of combined effects from both the India–Eurasia collision and Pacific Plate subduction. Furthermore, differential exhumation of the Taihang–Lvliangshan were clearly revealed according to the five separate E–W elevation–distance profiles of the Taihang–Lvliangshan. They displayed greater exhumation thicknesses at the southern regions than those along the northern regions, which can be explained by the development of the Shanxi Rift that began to form following the Oligocene–Miocene period. [ABSTRACT FROM AUTHOR]

It is well known that the El Niño‐Southern Oscillation (ENSO) has a profound impact on climate over southern China (SC). This study indicates that independent from the ENSO variability, a meridional tripolar sea surface temperature (SST) pattern over tropical‐North Pacific in February has a close relationship with interannual variations in the frequency of spring extreme consecutive dry days (extreme‐CDDs) over SC. Further analyses suggest that the tripolar SST pattern has a good persistence from February to the following spring and could influence the variations of SC extreme‐CDDs through two ways. On one hand, the extratropical SST anomalies of the tripolar pattern can cause the meridional shift of the North Pacific subarctic oceanic front, resulting in a meridional dipole atmospheric pattern over the region from the North Pacific to East Asia through eddy‐mean flow interaction. The meridional atmospheric pattern can influence the East Asian upper‐level jet and western Pacific subtropical high (WPSH), leading to anomalous vertical motion and moisture transport over SC. On the other hand, the SST anomalies of the tripolar pattern over the tropical western Pacific can excite an overturning circulation and influence the WPSH through the Matsuno‐Gill response, also contributing to anomalous vertical motion and moisture transport over SC. These physical processes are further confirmed by numerical simulations. Therefore, through the aforementioned two physical ways, the February tripolar SST pattern can influence the moisture and dynamical conditions associated with the occurrence of extreme‐CDDs, consequently providing a factor and predictor for the variations of SC spring extreme‐CDDs. Key Points: The interannual variations of spring southern China (SC) extreme consecutive dry days (extreme‐CDDs) are related to a tripolar sea surface temperature (SST) pattern over tropical‐North Pacific in FebruaryThe tripolar SST pattern affects SC extreme‐CDDs through mid‐latitude eddy‐mean flow interaction and tropical overturning circulationThe February tripolar SST pattern provides a prediction source for the interannual variations of SC spring extreme‐CDDs [ABSTRACT FROM AUTHOR]

Top‐down estimates using satellite data provide important information on the sources of air pollutants. We develop a sector‐based 4D‐Var framework based on the GEOS‐Chem adjoint model to address the impacts of co‐emissions and chemical interactions on top‐down emission estimates. We apply OMI NO2, OMI SO2, and MOPITT CO observations to estimate NOx, SO2, and CO emissions in East Asia during 2005–2012. Posterior evaluations with surface measurements show reduced normalized mean bias (NMB) by 7% (NO2)–15% (SO2) and normalized mean square error (NMSE) by 8% (SO2)–9% (NO2) compared to a species‐based inversion. This new inversion captures the peak years of Chinese SO2 (2007) and NOx (2011) emissions and attributes their drivers to industry and energy activities. The CO peak in 2007 in China is driven by residential and industry emissions. In India, the inversion attributes NOx and SO2 trends mostly to energy and CO trend to residential emissions. Plain Language Summary: Satellite observations are widely used to estimate air pollutant emissions and evaluate their trends. We design a new method based on Bayesian statistics to estimate emissions of major air pollutants in East Asia according to their sources (e.g., energy, industry, transportation, etc.). Results from this approach show better agreement with independent surface measurements than the previous estimates that use observations to optimize emissions by species and estimates that compile emissions using activity data and emission factors. This method provides a new perspective to analyze the trend of air pollutants by sources and is crucial for countries and regions that lack detailed and timely emission estimates for each source sector. Key Points: A new sector‐based multispecies inversion framework is developed to estimate NOx, SO2, and CO emissions using satellite observationsThe sector‐based inversion leads to smaller biases and errors in surface NO2 and SO2 simulations than a species‐based inversionThe framework provides a new perspective to analyze the trend of emissions by sectors and evaluates bottom‐up estimates [ABSTRACT FROM AUTHOR]

Low temperature can improve the quality and prolong the shelf life of perishable food effectively. East Asia has some special foods for its individual geography, climate, and culture, which need different low temperature preservation technologies to maintain their unique flavor. In this paper, the differences in food composition or cooking habits are briefly introduced in each section and then the low temperature preservation technologies developed for these special foods are mainly discussed. Also, the recommendations for future research are provided. Very fast chilling and controlled freezing/supercooling point are promising technologies for pre‐rigor fresh meat. Low temperature oxidation resistance and its combination with nonthermal sterilization can ensure the color, freshness, and safety of raw aquatic products. Low temperature rapid fermentation can effectively maintain the organoleptic property of pickles. The synergies of physical and biochemistry methods can reduce wrapper cracking and filling oxidation of frozen prepared foods. Novelty impact statement: Low temperature is an effective method for the preservation of food. Due to climate and cultural differences, people in different regions have different eating habits. To better meet people's requirements for the special flavor of food, the corresponding low temperature preservation technologies need to be studied and summarized. This review summarizes the low temperature preservation techniques of four representative special foods in East Asia and provides recommendations for future research. These positive results will be helpful to the research and application of food preservation technologies in the future. [ABSTRACT FROM AUTHOR]

The dust emission parameterization in the Chinese Academy of Sciences Earth System Model version 2 (CAS‐ESM2) is described with emphasis on the implementation process and simulations of global dust cycle and East Asia dust event statistics. The parameterization is based on the scheme of Shao (2004; http://doi.org/10.1029/2003JD004372) which considers two major dust emission mechanisms, namely, saltation bombardment and aggregation disintegration. Shao (2004; http://doi.org/10.1029/2003JD004372) scheme was well tested against field observations and has been widely used in regional dust modeling. Here this scheme is implemented into a global climate model for the first time and thus provides an independent solution for simulating global dust emissions. With this scheme, CAS‐ESM2 reasonably simulates the main dust emission regions in the Earth and reproduces the observations of dust deposition flux and surface dust concentrations at most stations. Compared to the synoptic records of dust events, the model also captures the general patterns and seasonal variations of dust activities in East Asia. However, the model underestimates the frequency of strong dust events (instantaneous surface dust concentrations >1,000 μg m−3) due to the weaker surface winds simulated by the model. The model tends to simulate much weaker and longer‐lasting dust events in Eastern Sources (35–49°N, 94–126.5°E) of northern China, suggesting the weaker and slower‐moving synoptic weather systems associated with dust events in the model. Overall CAS‐ESM2 performs well in simulating the key aspects of global dust distribution and East Asian dust events, yet some biases remain to be improved. Plain Language Summary: Dust emitted from the bare soil is an important aerosol type, and dust cycle links the various components of Earth System including atmosphere, land, and oceans. Therefore, dust emission is an essential part of Earth system. In this study, we develop a dust emission module for Chinese Academy of Sciences Earth System Model version 2 (CAS‐ESM2) to simulate the global dust emission. The module incorporates advanced mechanisms of dust emission physics. The results show that with this module, CAS‐ESM2 reproduces well the global distribution of dust aerosol. We also evaluate the model's ability in simulating the individual dust events in terms of dust event frequency, intensity, and duration. We find that the model can reproduce the key regions of dust emission and the highest frequency of dust event in spring in East Asia. However, because the model underestimates surface wind speeds, it simulates weaker and longer‐lasting dust events. Overall CAS‐ESM2 provides a new and promising solution to simulate global dust emission, although there are still some biases for further improvements. Key Points: Chinese Academy of Sciences Earth System Model version 2 (CAS‐ESM2) with a physically based dust emission scheme provides a new and promising solution to simulate global dust emissionsCAS‐ESM2 captures the main global dust emission regions and reproduces observed dust depositions and surface dust concentrationsThe weaker dust events are compensated by overestimated dust event frequency and duration to produce reasonable means in East Asia [ABSTRACT FROM AUTHOR]

A well‐constrained plate deformation model may lead to an improved understanding of sedimentary basin formation and the connection between subduction history and over‐riding plate deformation. Building quantitative models of basin kinematics and deformation remains challenging often due to the lack of comprehensive constraints. The Bohai Bay Basin (BBB) is an important manifestation of the destruction of the North China Craton, and records the plate kinematic history of East Asia during the Cenozoic. Although a number of interpretations of the formation of the BBB have been proposed, few quantitative basin reconstruction models have been built to test and refine previous ideas. Here, we developed a quantitative deformation reconstruction of the BBB constrained with balanced cross‐sections and structural, stratigraphic and depositional age data. Our reconstruction suggests that the basin formation process was composed of three main stages: Paleocene‐early Eocene (65–42 Ma) extension initiation, middle Eocene‐early Oligocene (42–32.8 Ma) extension climax and post‐Oligocene (32.8–0 Ma) post‐extensional subsidence. The deformation of the BBB is spatially heterogeneous, and its velocity directions rotated clockwise during the basin formation process. The reconstruction supports the interpretation that the BBB formed via strike‐slip faulting and orthogonal extension and that the basin is classified as a composite extensional‐transtensional basin. We argue that the clockwise rotation of the basin velocity field was driven by the counter‐clockwise rotation in the direction of Pacific Plate subduction. The kinematics of the BBB imply that the Pacific Plate may have been sufficiently coupled to the over‐riding East Asian Plate during the critical period of Pacific Plate reorganization. The new reconstruction provides a quantitative basis for studies of deformation processes not only in the vicinity of the BBB, but also more broadly throughout East Asia. [ABSTRACT FROM AUTHOR]

Important geological events that influenced the global environment occurred during the mid‐Cretaceous period. Dramatically increasing temperatures not only triggered oceanic anoxic events (OAEs) but also led to the aridity of terrestrial environments in East Asia. This study provides evidence for the aridity of a terrestrial East Asian environment during the mid‐Cretaceous and provides an example of the influence of the Cretaceous greenhouse climate on a terrestrial lake system in correspondence with the OAE 1a event. Palaeosalinity indexes (B, B/Ga, Sr/Ba, and Couch's palaeosalinity) and palaeoclimate proxies (Sr/Cu, Rb/Sr, Al2O3/MgO, and clay mineral compositions) of shale and mudstone from the Laiyang Group of the Jiaolai Basin in Eastern China were analysed. The results demonstrate that the palaeoclimate in the Wawukuang Formation was relatively warm and humid but became extremely dry and hot in the Shuinan Formation during the OAE 1a event before becoming warm and humid again in the Longwangzhuang and Qugezhuang formations. As a result, the palaeosalinity of the Jiaolai Basin increased from 4% in the Wawukuang Formation to 30% in the Shuinan Formation before decreasing to 0.48% in the Longwangzhuang and Qugezhuang formations. The following conclusions are from combining the distributional characteristics of the saliferous strata and its palaeontology, the palaeogeographic background, and the aeolian sandstone in eastern China. (a) The East Asian continental margin was influenced by the Cretaceous greenhouse climate, which resulted in the salinization of the Jiaolai Basin. (b) The significant increase of the palaeosalinity in the Shuinan Formation was an effect of the OAE 1a event on the terrestrial lake system, which further suggests the OAE 1a event was global. (c) Influences of the hothouse climate on the continental lakes changed the palaeosalinity of the water bodies. [ABSTRACT FROM AUTHOR]

The eastern Pacific (EP) El Niño‐Southern Oscillation (ENSO) is an important impact factor for the East Asian trough (EAT) variability during boreal winter. However, not all ENSO events can result in anomalous EAT events, which indicates that there could be some other factors modulating the relationship between ENSO and the EAT. The analysis of atmospheric circulations indicates that the intensity of the Asian Polar vortex (PV) plays an important role in the El Niño‐EAT connection. The strengthened Asian PV favours the wave‐train triggered by El Niño events propagates eastward from the North Pacific to East Asia and finally weakens the EAT. In contrast, during El Niño years with the weakened Asian PV, El Niño's influences are confined over western Siberia and the wave activity flux over Eurasia is weak, which consequently leads to a weak response of the EAT. For the La Niña‐EAT connection, the North Pacific Oscillation (NPO) is a potential modulating factor. The La Niña and negative‐phase NPO have a strengthened effect on the EAT, resulting in a strong response of the EAT to La Niña events. In contrast, the effects of La Niña and positive‐phase NPO on the EAT are offset, leading to a weak response of the EAT to La Niña events. The above results are further confirmed by a numerical simulation of the pre‐industrial Control experiment. Therefore, the simultaneous occurrence of the Asian PV and NPO should be a great concern when understanding and predicting the EAT based on ENSO information. [ABSTRACT FROM AUTHOR]

Low temperature is a major driver of the upper distributional limits of subtropical evergreen broadleaved forests in East Asia. The eco‐physiology of evergreen broadleaved trees at the upper limits could respond to both lower winter temperature and lower averaged annual temperature that covary with elevation. To analyze these responses, we assessed the variations in leaf chemical traits of Cyclobalanopsis gracilis with seasonality and along elevation in the ecotone from subtropical to temperate climate, and analyzed the relationships between traits of mature leaves and temperature. The study showed that the mass‐based nonstructural carbohydrate (NSC) content reached the highest level across elevations during winter; however, the winter NSC content did not differ between elevations. For mature leaves, leaf dry mass per area (LMA) tended to be higher approaching the upper limit. The leaf carbon to phosphorus ratio (C/P) showed an increasing trend with decreasing temperature, as did leaf carbon to nitrogen ratio (C/N) to some extent. The mass‐based P content showed a decreasing trend approaching the upper limit, whereas area‐based P content showed no significant variation. Our main results indicate that leaf NSC content is highest at all elevations in winter, and individuals at high elevations have high LMA and high nutrient use efficiency. The results suggest that for C. gracilis, an increasing leaf NSC results in a baseline protection to cope with cold in winter, which, at higher elevations is supplemented with increasing LMA and nutrient use efficiency to cope with associated low‐temperature stress. [ABSTRACT FROM AUTHOR]

Strain leavening power loss and product quality deterioration are the two main issues in frozen dough technology being used during Chinese steamed bread manufacture. Our study added soybean peptides (SP) in the Saccharomyces cerevisiae growth medium to restore its fermentative capability in dough and maintain the steamed bread qualities. When dough was not frozen, 0.1% (w/v) SP‐added group's fermenting rate was 4.6 times of the control with no SP. When dough was frozen at −20°C for 7 and 30 days prior to fermentation, respectively, fermenting speed of 0.1% SP group was 4.8 and 8 times of the control group. Bread from dough of the SP group also had better qualities. Adding 0.1% SP into medium also increased cells' extracellular enzyme activity to 50 times of the blank. This study demonstrates the possibility of using edible SP to maintain strain fermenting power and bread qualities for frozen dough technology. Practical applications: Chinese steamed bread is a widely consumed cereal product in East Asia, whose fermenting Saccharomyces cerevisiae has various claimed benefits to product quality. Keeping this yeast's fermenting power at low temperatures could be a challenge to industries when frozen dough technology is applied. Soybean peptides have been proved to promote fermenting microorganisms' growth at low temperatures in other food products. This study provided some evidences on how soybean peptides reserved the S. cerevisiae fermenting power during the dough freezing time frame while maintained the product organoleptic qualities; therefore, soybean peptides could have a potential application for Chinese steamed bread industries. [ABSTRACT FROM AUTHOR]

The atmospheric moisture transport processes are of great importance to the occurrence and intensity of precipitation extremes. In this paper, we review the linkage between processes, including the large‐scale atmospheric circulation, atmospheric moisture transport, and extreme precipitation events. We first summarize the thermodynamic and dynamic processes and moisture transport trackings for historical precipitation extremes. We then focus on the contribution of three major atmospheric moisture transport pathways, that is, atmospheric rivers, low‐level jets, and tropical cyclones, to the occurrence and intensity of regional precipitation extremes. Studies on large‐scale atmospheric circulation driving water vapor transport for precipitation extremes over East Asia and North America were specifically reviewed for the understanding of physical mechanisms and predictability of moisture transport and extreme precipitation events. We then pay more attention to the effects of global warming on atmospheric moisture transport, and thus regional precipitation extremes from the perspectives of thermodynamic and dynamic changes of the atmosphere. In the end, we summarize future research challenges on the physical mechanisms of atmospheric moisture transport that are associated with regional precipitation extremes, especially under a warming climate. This article is categorized under: Science of Water > Water ExtremesScience of Water > Hydrological Processes [ABSTRACT FROM AUTHOR]

Endo‐polygalacturonase II B (PgaB) from Aspergillus luchuensis was orthologous to endo‐polygalacturonase from Aspergillus niger with mutant sites Thr42Ser and Glu52Ala. Mature pgaB gene was cloned from the genomic DNA of A. luchuensis and secreted expressed with over 90% purity in Pichia Pastoris and reached 1.0 g/L after 144 hr culture. The recombinant PgaB was further purified by Ni‐NTA chromatography. Using polygalacturonic acid (PGA) as substrate, the optimal condition for PgaB activity was 40°C and pH 4.5, respectively. Km and Vmax of PgaB were 0.19 mmol/l and 103.58 μmol min−1 mg−1, respectively. The relative activity of PgaB remained more than 60% and 40% of maximum activity at 50 and 60°C for 7 hr. PgaB increased the light transmittance by 85% and showed high efficiency in juice clarification. The main product was galacturonic acid oligosaccharides with degrees of polymers (DP) 1–3. The PgaB is a potential pectinolytic enzyme in food industries. Practical applications: Endo‐polygalacturonase II B (PgaB) was identified from Aspergillus luchuensis, a filamentous fungus widely used in food and beverage fermentation in East Asia. PgaB still kept its most activity at 60°C for 7 hr. Polygalacturonic acid (PGA) can be digested effectively by the PgaB and the main products are galacturonic acid oligosaccharides with degrees of polymers (DP) 1–3. PgaB shows high efficiency in juice clarification. The PgaB is a potential pectinolytic enzyme for the applications in food industries. [ABSTRACT FROM AUTHOR]

This study aims to examine whether two country characteristics--book-tax conformity and law enforcement--affect the complementary level of financial and tax aggressiveness. Previous studies have produced inconclusive results for the relationship between financial and tax aggressiveness. This study fills the gap by examining the country-level determinants of the complementary level of financial and tax aggressiveness. It also develops a new measure of the complementary level of financial and tax aggressiveness. Using a sample of firms from 15 countries in East Asia and Europe from 2014 to 2016, this study finds that firms from countries with higher book-tax conformity and stronger law enforcement tend to have a lower complementary level of financial and tax aggressiveness. In an additional test, this study shows that in countries with lower book-tax conformity, the effect of law enforcement on the complementary level of financial and tax aggressiveness is stronger than in countries with higher book-tax conformity. These results suggest that country characteristics influence managers' decisions to either present financial statements and tax reporting aggressively at the same time or not. [ABSTRACT FROM AUTHOR]

Monochamus alternatus (Hope) is a severe wood‐boring pest in coniferous forests and a major vector of pine wilt disease in East Asia. Harmonic radar is a powerful tool for studying the dispersal behavior of insects and it could be applied to control pine wilt disease. In this study, we validated the application of harmonic radar for analyzing the dispersal behavior of M. alternatus beetles in a field environment. We determined the wing capacities of the beetles and the effects of electronic tagging and marking on their movement, flight ability, survivorship, and food consumption in the laboratory to confirm the suitability of this technique. The detection rate and recovery rate for beetles were analyzed separately using radar on caged pine stands and in the field environment. The results showed that the minimum wing capacity of the Japanese pine sawyer was 24.9 mg, which was seven times the weight of the electronic tag (3.5 mg). Marking and tagging the beetles had no significant adverse effects on their movement, flight capacity, food consumption, and survivorship. The detection rate using the radar system and recovery rate based on visual observations of the beetles in caged pines were both 95.6%. However, in the field environment, the detection and recovery rates were only 55.6% and 37.8% after one week, respectively, and 33.3% and 7.8% after two weeks. Harmonic radar is a promising technique for studying the dispersal behavior of the Japanese pine sawyer, but its performance is not satisfactory and major improvements are required for both the radar system and electronic tags. [ABSTRACT FROM AUTHOR]

The West Qinling Orogenic Belt (WQOB) is a major portion of the Qinling‐Dabie‐Sulu Orogen and holds essential information for understanding the protracted evolution of the north‐eastern branch of the Paleo‐Tethys in East Asia. In this study, we report our petrological, geochemical, and geochronological study on the five Triassic granitoid plutons of West Qinling with emphasis on the poorly studied Jiaochangba pluton with zircon U–Pb ages of 217.5 ± 1.6 Ma and 215.2 ± 1.2 Ma. The new data and the existing data on the other four plutons support the view that the West Qinling granitoids represent a magmatic response to the continental collision of the Yangtze Block (YB) with the North China Craton (NCC) in the Triassic. Like the other four plutons, the Jiaochangba pluton shows strong light rare earth element (REE) enrichment and weak heavy REE depletion ([La/Sm]N ≈ 7.14 ± 1.89; [Sm/Yb]N ≈ 4.63 ± 1.85) with varying negative Eu anomalies (Eu/Eu* ≈ 0.65 ± 0.20). In the N‐MORB normalized diagram, all the samples show relative enrichment in Rb, Pb, U, and K with negative Nb, Ta, P, and Ti anomalies, resembling those of the model continental crust. The Jiaochangba pluton has relatively lower (87Sr/86Sr)i (0.7062 to 0.7081), higher εNd(t) (−6.91 to −2.09), and εHf(t) (−5.57 to −0.14) than mature continental crust, which are consistent with their source being dominated by lower crust with significant mantle contributions. Mantle‐derived melt, which formed from partial melting of mantle wedge peridotite facilitated by dehydration of the subducted/subducting Mianlue ocean crust, provide the required heat for the crustal melting while also contributing to the compositions of these granitoids. Evolution of such parental magmas in open system crustal magma chambers with continued evolution/replenishment and crustal contamination and assimilation give rise to the observed petrological and geochemical characteristics of these granitoids. [ABSTRACT FROM AUTHOR]

The main advancements of the Beijing Climate Center (BCC) climate system model from phase 5 of the Coupled Model Intercomparison Project (CMIP5) to phase 6 (CMIP6) are presented, in terms of physical parameterizations and model performance. BCC-CSM1.1 and BCC-CSM1.1m are the two models involved in CMIP5, whereas BCC-CSM2-MR, BCC-CSM2-HR, and BCC-ESM1.0 are the three models configured for CMIP6. Historical simulations from 1851 to 2014 from BCC-CSM2-MR (CMIP6) and from 1851 to 2005 from BCC-CSM1.1m (CMIP5) are used for models assessment. The evaluation matrices include the following: (a) the energy budget at top-of-atmosphere; (b) surface air temperature, precipitation, and atmospheric circulation for the global and East Asia regions; (c) the sea surface temperature (SST) in the tropical Pacific; (d) sea-ice extent and thickness and Atlantic Meridional Overturning Circulation (AMOC); and (e) climate variations at different timescales, such as the global warming trend in the 20th century, the stratospheric quasi-biennial oscillation (QBO), the Madden–Julian Oscillation (MJO), and the diurnal cycle of precipitation. Compared with BCC-CSM1.1m, BCC-CSM2-MR shows significant improvements in many aspects including the tropospheric air temperature and circulation at global and regional scales in East Asia and climate variability at different timescales, such as the QBO, the MJO, the diurnal cycle of precipitation, interannual variations of SST in the equatorial Pacific, and the long-term trend of surface air temperature. [ABSTRACT FROM AUTHOR]

Background and Objective: 5-Fluorouracil plus cisplatin is the most commonly used chemotherapy regimen for nasopharyngeal carcinoma (NPC). The objective of this study was to establish an individualized 5-fluorouracil treatment model based on pharmacokinetic and pharmacodynamic analyses of 5-fluorouracil in East-Asian NPC patients.Methods: A total of 122 NPC patients were administered 5-fluorouracil plus cisplatin treatment. Blood samples were collected to calculate the area under the concentration-time curve (AUC) for 5-fluorouracil, and expressions of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) at both protein and messenger RNA (mRNA) levels were analyzed in the tumor tissues from 73 patients in the same cohort.Results: The results showed a wide (sevenfold) pharmacokinetic variability of 5-fluorouracil exposure (measured as AUC) based on body surface area (BSA) dosing. Pharmacokinetic analyses revealed that the 5-fluorouracil AUC range had a significant impact on the response of patients to 5-fluorouracil and related toxicities. Patients with 5-fluorouracil AUC <25 mg·h/L responded unsatisfactorily to 5-fluorouracil (overall response rate [ORR] 17.5 % lower than patients with AUC 25-35, p = 0.176; and 26.1 % lower than patients with AUC >35, p = 0.031). On the other hand, patients with 5-fluorouracil AUC >35 mg·h/L experienced more 5-fluorouracil-related toxicities (a grade 3 or higher toxicity rate 57.1 % higher than patients with AUC 25-35, p < 0.001; and 60.0 % higher than AUC >35, p < 0.001). The established 5-fluorouracil therapeutic window in head and neck cancer (HNC) [AUC 25-35 mg·h/L) was verified in our study. Pharmacodynamic analyses indicated a positive correlation between TS and DPD expression (p < 0.001) and, despite the pharmacokinetic influences, low expression of TS mRNA in tumor tended to have a better ORR (81.0 vs. 54.3 %, p = 0.051). No significant association was found between DPD expression and ORR.Conclusions: The therapeutic window of 5-fluorouracil for East-Asian NPC patients was verified as 25-35 mg·h/L based on lower toxicity and higher efficacy. TS mRNA expression showed potentially predictive value in 5-fluorouracil treatment, and personalized treatment based on pharmacokinetics and pharmacodynamics proved to be clinically beneficial and is worthy of further clinical studies. [ABSTRACT FROM AUTHOR]

Gross primary productivity (GPP) is a major component of carbon exchange between the atmosphere and terrestrial ecosystems and a key component of the terrestrial carbon cycle. Because of the large spatial heterogeneity and temporal dynamics of ecosystems, it is a challenge to estimate GPP accurately at global or regional scales. The 8-day MODerate resolution Imaging Spectroradiometer (MODIS) GPP product provides a near real time estimate of global GPP. However, previous studies indicated that MODIS GPP has large uncertainties, partly caused by biases in parameterization and forcing data. In this study, MODIS GPP was validated using GPP derived from the eddy covariance flux measurements at five typical forest sites in East Asia. The validation indicated that MODIS GPP was seriously underestimated in these forest ecosystems of East Asia, especially at northern sites. With observed meteorological data, fraction of photosynthetically active radiation absorbed by the plant canopy (fPAR) calculated using smoothed MODIS leaf area index, and optimized maximum light use efficiency ( ε) to force the MOD17 algorithm, the agreement between predicted GPP and tower-based GPP was significantly improved. The errors of MODIS GPP in these forest ecosystems of East Asia were mainly caused by uncertainties in ε, followed by those in fPAR and meteorological data. The separation of canopy into sunlit and shaded leaves, for which GPP is individually calculated, can improve GPP simulation significantly. [ABSTRACT FROM AUTHOR]

Background: In the studies incorporating worldwide sampling of A. thaliana populations, the samples from East Asia, especially from China, were very scattered; and the studies focused on global patterns of cpDNA genetic variation among accessions of A. thaliana are very few. In this study, chloroplast DNA sequence variability was used to infer phylogenetic relationships among Arabidopsis thaliana accessions from around the world, with the emphasis on samples from China. Results: A data set comprising 77 accessions of A. thaliana, including 19 field-collected Chinese accessions together with three related species (A. arenosa, A. suecica, and Olimarabidopsis cabulica) as the out-group, was compiled. The analysis of the nucleotide sequences showed that the 77 accessions of A. thaliana were partitioned into two major differentiated haplotype classes (MDHCs). The estimated divergence time of the two MDHCs was about 0.39 mya. Forty-nine haplotypes were detected among the 77 accessions, which exhibited nucleotide diversity (π) of 0.00169. The Chinese populations along the Yangtze River were characterized by five haplotypes, and the two accessions collected from the middle range of the Altai Mountains in China shared six specific variable sites. Conclusions: The dimorphism in the chloroplast DNA could be due to founder effects during late Pleistocene glaciations and interglacial periods, although introgression cannot be ruled out. The Chinese populations along the Yangtze River may have dispersed eastwards to their present-day locations from the Himalayas. These populations originated from a common ancestor, and a rapid demographic expansion began approximately 90,000 years ago. Two accessions collected from the middle range of the Altai Mountains in China may have survived in a local refugium during late Pleistocene glaciations. The natural populations from China with specific genetic characteristics enriched the gene pools of global A. thaliana collections. [ABSTRACT FROM AUTHOR]

In most of the world, there is a broad public interest in cross-national comparisons. Despite the myriad difficulties inherent in such comparisons, and despite the fact that most studies explicitly acknowledge limited generalizability, news media representatives, policy makers, politicians and educators often take the findings at face value as providing solid scientific evidence of the achievement of students in the countries studied. This often leads in turn to superficial commentaries and unhelpful recommendations. Our task as scholars of mathematics education is to demonstrate the nuanced complexity of such comparisons. The papers in this issue of ZDM succeed in this regard. Using a range of scholarly perspectives (mathematical, psychological and socio-cultural), the authors offer many insightful observations regarding curriculum and curriculum materials in East Asian countries (especially China) and the USA, with careful attention to the central role of curriculum in the teaching and learning of mathematics in schools. In this commentary study I discuss a few of these insights and develop one illustrative example of how cross-national comparative analyses such as these could be used to sensibly inform policy discussions related to changes in mathematics curriculum, teaching, or teacher preparation. [ABSTRACT FROM AUTHOR]

This article studies East Asian political economy from a regional perspective. The Asian financial crisis showed that East Asian economies are highly regionalized. However, the linkages among Asian economies, mostly informal in nature, often appear “invisible” to many in the West, who focus more on the states and formal institutions. Drawing on a broad set of literature mostly in Asian languages, this paper provides a systematic study of informal integration in East Asia, which consists of not only regional production networks, but also ethnic Chinese business networks and subregional economic zones. It finds that the three informal mechanisms have formed an interrelated pattern of regional integration in East Asia. The nature of the economic networks is very useful in explaining the Asian crisis and the different performances of East Asian economies in the crisis. The crisis has also resulted in profound changes in informal integration. While the Japanese–led production networks have been greatly weakened, the Chinese Economic Area is rising, driven by the ethnic Chinese business networks and subregional economic zones. As a result, the Japan–dominated “flying geese pattern” has been broken. The connections between Greater China and the United States have also been enhanced and are out–competing the Japanese production networks. Many of the new developments have been ignored in the West but they are key factors that will shape the future of Asian and World political economy. [ABSTRACT FROM AUTHOR]

The limited knowledge of Late Cretaceous terrestrial environments and their response to tectonic events in mid-latitudes can be addressed through continental basin deposits such as paleosols. Paleosols have been discovered in the Late Cretaceous Yaojia Formation in the southern Songlaio Basin and are recognized by evidence of soil structures controlled by pedogenesis. Sedimentary facies research on red paleosols was conducted on the Late Cretaceous Yaojia Formation in the outcrop of the southern Songliao Basin to interpret the depositional environments and tectonic significance of red paleosols during the greenhouse period. Mudflat, lake margin, and shallow lake depositional environments in a semi-arid climate are interpreted from the outcrops based on sedimentary descriptions and interpretation as well as geochemical and micromorphological analyses of paleosols in outcrops. We reconstructed the paleoenvironmental and paleoclimatic conditions through the paleosols in the mudflats and lake margin. The red paleosols in the mudflats and lake margin deposits formed in a stable landscape influenced by the tectonic uplift of the Songliao Basin, which is considered as new important evidence for tectonic uplift influenced by the collision of the Okhotomorsk Block with East Asia. The tectonic uplift process in East Asia is identified from the evolution of the depositional environments and drainage conditions inferred from different types of paleosols. Thus, the paleosols-bearing red bed deposits in outcrops provide an important contribution of the Late Cretaceous terrestrial paleoclimate and the tectonic setting research. [ABSTRACT FROM AUTHOR]

(1) Background: Detailed diversity information regarding terrestrial mosses in a tropical forest ecosystem and an understanding of the drivers behind moss distribution provide crucial data for the management and conservation of forest ecosystems. Mosses are critical components of tropical forest ecosystems due to their high diversity and biomass, and they also fulfill essential ecological functions. Here, we report the first study into the relative importance of vegetation types and elevational gradient for the diversity, distribution and community structure of terrestrial moss species in southern China. (2) Methods: Five elevations spaced 200 m apart in the tropical mountain forest on the northern aspect of Tai Mo Shan were selected. The diversity, distribution, and geographical patterns of terrestrial mosses in response to altitudinal changes were examined. Differences in the biotic variables of terrestrial mosses between elevations were tested using a one-way ANOVA. Curve estimation regression models were used to describe the responses of the biotic variables to the elevation gradient. Canonical correlation analysis (CCA) was performed to identify and measure the associations among biotic variables of terrestrial mosses and abiotic environmental factors. (3) Results: Fifty-three terrestrial moss species belonging to 20 families and 31 genera were recorded along the altitudinal gradient on Tai Mo Shan. Microclimate factors including dew point and rainfall were strongly associated with the cover and thickness of the ground moss species. There were no obvious richness changes of terrestrial mosses along the elevation gradient. In total, 33 of the 51 species were tropically distributed, 14 species were found across East Asia and the tropical regions, 10 species had an East Asian pattern and 8 were temperate species. (4) Conclusions: Vegetation types significantly affect the diversity and distribution of terrestrial moss species. Although they are influenced by the East Asian and temperate climate with frequent human activities, terrestrial mosses on Tai Mo Shan are primarily tropical in nature. Forest conservation and restoration should be implemented to sustain and improve the diversity of terrestrial mosses and understory plants on Tai Mo Shan, especially at higher elevations. [ABSTRACT FROM AUTHOR]