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The association between relational victimization and risk-taking development in children is understudied. Also, it is not clear how the social classroom norm may affect this link. The aim of this study was, therefore, to investigate the link between relational victimization and risk-taking behavior in elementary schoolchildren, and the potential moderating role of the classroom norm salience toward risk-taking. We expected that relationally victimized children would show an increase in risk-taking behavior in classrooms that are unfavorable toward risk-taking as a way to provoke and act against the classroom norm. However, alternatively, relationally victimized children could show an increase in risk-taking behavior in classrooms that are favorable toward risk-taking as a way to fortify the feeling of belonging to the classroom. Participants were 1,009 children (50% boys) in 69 classrooms of 13 mainstream elementary schools, followed annually across ages 7-11 (Grade 1-5). Risk-taking was assessed using the Balloon Analogue Risk Task. Relational victimization was assessed using teacher reports. The classroom norm salience toward risk-taking was based on the within-classroom correlation of risk-taking with children's social preference score among peers. Results from multilevel modeling showed that there was no significant main effect of relational victimization on risk-taking behavior. However, the classroom norm salience toward risk-taking significantly moderated the effect of relational victimization on risk-taking. Relational victimization was related to relative increases in risk-taking when classroom norms were unfavorable toward risk-taking. In classrooms where risk-taking was favored, relational victimization was related to relative decreases in risk-taking. These findings suggest that children who are relationally victimized may engage in norm-defying behavior in their classroom. Implications for further research are discussed.

Several occurrences of the word 'schizophrenia' have been re-worded as 'liability to schizophrenia' or 'schizophrenia risk', including in the title, which should have been "GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability," as well as in Supplementary Figures 1-10 and Supplementary Tables 7-10, to more accurately reflect the findings of the work.

Background and aimsCannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi-substance use and dependence. This study estimated the heritability of age at first cannabis use and identified associations with genetic variants.MethodsA twin-based heritability analysis using 8055 twins from three cohorts was performed. We then carried out a genome-wide association meta-analysis of age at first cannabis use in a discovery sample of 24 953 individuals from nine European, North American and Australian cohorts, and a replication sample of 3735 individuals.ResultsThe twin-based heritability for age at first cannabis use was 38% [95% confidence interval (CI) = 19-60%]. Shared and unique environmental factors explained 39% (95% CI = 20-56%) and 22% (95% CI = 16-29%). The genome-wide association meta-analysis identified five single nucleotide polymorphisms (SNPs) on chromosome 16 within the calcium-transporting ATPase gene (ATP2C2) at P  0.8), with the strongest association at the intronic variant rs1574587 (P = 4.09E-09). Gene-based tests of association identified the ATP2C2 gene on 16q24.1 (P = 1.33e-06). Although the five SNPs and ATP2C2 did not replicate, ATP2C2 has been associated with cocaine dependence in a previous study. ATP2B2, which is a member of the same calcium signalling pathway, has been associated previously with opioid dependence. SNP-based heritability for age at first cannabis use was non-significant.ConclusionAge at cannabis initiation appears to be moderately heritable in western countries, and individual differences in onset can be explained by separate but correlated genetic liabilities. The significant association between age of initiation and ATP2C2 is consistent with the role of calcium signalling mechanisms in substance use disorders.

Background: Deficits in error processing are reflected in an inability of people with externalizing problems to adjust their problem behaviour. The present study contains 2 meta-analyses, testing whether error processing--indexed by the event-related potentials error-related negativity (ERN) and error positivity (Pe)--is reduced in children and adults with externalizing problems and disorders compared to healthy controls. Methods: We conducted a systematic search in PubMed (1980 to December 2018), PsycInfo (1980 to December 2018) and Scopus (1970 to December 2018), identifying 328 studies. We included studies that measured error processing using the Eriksen flanker task, the go/no-go task or the stop-signal task in healthy controls and in adults or children with clearly described externalizing behavioural problems (e.g., aggression) or a clinical diagnosis on the externalizing spectrum (e.g., addiction). Results: Random-effect models (ERN: 23 studies, 1739 participants; Pe: 27 studies, 1456 participants) revealed a reduced ERN amplitude (Hedges' g = 0.44, 95% confidence interval [CI] 0.29 to 0.58) and a reduced Pe amplitude (Hedges' g = -0.27, 95% CI -0.44 to -0.09) during error processing in people with externalizing problems or disorders compared to healthy controls. Type of diagnosis, age and the presence of performance feedback or comorbidity did not moderate the results. The employed cognitive task was a moderator for Pe but not for ERN. The go/no-go task generated a greater amplitude difference in Pe than the Eriksen flanker task. Small-sample assessment revealed evidence of publication bias for both event-related potentials. However, a p curve analysis for ERN showed that evidential value was present; for Pe, the p curve analysis was inconclusive. Limitations: The moderators did not explain the potential heterogeneity in most of the analysis, suggesting that other disorder- and patient-related factors affect error processing. Conclusion: Our findings indicate the presence of compromised error processing in externalizing psychopathology, suggesting diminished activation of the prefrontal cortex during performance monitoring., Introduction Externalizing problem behaviour has been associated with problems in cognitive control, (1) of which error processing is an important component. (2,3) People with externalizing problems or disorders are characterized [...]

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

One particular developmental task during adolescence is to regulate fluctuating moods to successfully transition through this period. The aim of this person-centered study was to identify distinct developmental trajectories of adolescent mood variability and to compare adolescents in different trajectories on changes in depressive symptoms, delinquency, and alcohol consumption in early to middle (ages 13-16) and middle to late adolescence (ages 16-20). Dutch adolescents (n = 482, 57.1% male) rated their daily emotions three weeks per year for five years using Internet daily diaries (ages 13-18). Day-to-day mood changes were calculated as an indicator of mood variability. Adolescents provided annual reports on depressive symptoms, delinquent acts, and alcohol consumption (ages 13-20). Results showed that most adolescents (88%) followed a trajectory characterized by decreases in mood variability (i.e., more stable moods). However, a minority (12%) followed a trajectory of increases in mood variability with a peak during middle adolescence. Adolescents with an increasing mood variability trajectory showed stable depressive and delinquency symptoms in early to middle adolescence compared with adolescents with a decreasing mood variability trajectory, who showed a decline in these symptoms. At age 16, there was a significant difference between the groups in depressive and delinquency symptoms, which stayed stable toward late adolescence. Although the two groups did not differ concerning alcohol consumption in early to middle adolescence, adolescents from the increasing mood variability class experienced less steep increases in alcohol use from middle to late adolescence compared with adolescents from the decreasing mood variability class.

This 4-year, multi-informant longitudinal study (N = 480, initial age: 15) investigated the interplay between parental support, behavioral and psychological control, and adolescents' emotion regulation development. We examined reciprocal effects between parents and children, mothers' versus fathers' unique roles in emotion regulation development, and sex differences. Multi-informant data allowed us to compare effects of adolescent-perceived and parent-reported parenting. Finally, innovative analyses allowed us to disentangle between-family differences from within-family predictive processes. Parenting and emotion regulation were associated at the between-family and within-family levels, especially according to adolescent reports. Support primarily played a role between mothers and adolescents, and perceived behavioral control between fathers and adolescents. Sex moderation revealed that support played a more prominent role in mother-daughter than mother-son relationships, and that daughters experienced greater behavioral control. Child effects outnumbered parent effects, which might reflect the increasing equality of adolescent-parent relationships. Finally, adolescent-perceived parenting was a stronger correlate of emotion regulation than parent-reports, suggesting that adolescents' perceptions are a relevant source of information for research and practice. Consistent with the self-determination theory perspective on parenting, emotion regulation flourished when adolescents felt like mothers provided support, and fathers loosened behavioral control. These results are in line with the notion that mother-child relationships are supportive attachment relationships, whereas fathers provide "activation" relationships, challenging adolescents to regulate emotions autonomously by providing less explicit structure.

Students exhibiting challenging externalizing behaviors may benefit from supportive interactions with teachers. However, if students show high levels of externalizing behaviors, this may negatively impact on student-teacher interactions, and vice versa. We therefore examined bidirectional developmental links between student-teacher interactions and externalizing behavior of male adolescents placed in special education because of psychiatric disabilities. Participants were 584 adolescents (M[subscript age] = 15.0 years, SD = 1.7) and their teachers from 14 Dutch special education schools. At 3 time points, student-reports of student-teacher interactions and teacher-reports of adolescents' externalizing behavior were collected. Using autoregressive cross-lagged models, results indicate that externalizing behavior predicted decreases in supportive interactions (ß = -0.09, p = 0.02), but not in negative interactions. Student-teacher interactions did not show a significant influence on externalizing behavior. Our results highlight externalizing behavior as an important target for interventions intended to improve student-teacher interactions.

The aim of this study was to examine developmental links between disobedience and teacher-child closeness in a sample of boys with psychiatric disorders (i.e., emotional and behavioral disorders (EBD) and autism spectrum disorders (ASD)) and special educational needs who are placed in special education. More specifically, this study examined whether developmental links were different between boys with EBD (n = 150) versus boys with ASD (n = 122). Developmental links between disobedience and teacher-child closeness were investigated by incorporating a multi-informant perspective using teacher, child, and peer ratings and analyzed using autoregressive cross-lagged models across three waves within one school year. Results showed that in general, developmental links between teacher-child closeness and disobedience were stronger for boys with EBD than for boys with ASD. Specifically, boys with EBD experiencing less teacher-child closeness showed more disobedience, which in turn negatively affected their relationship development according to teacher ratings. Surprisingly, for boys with ASD, higher levels of disobedience predicted higher levels of teacher-rated teacher-child closeness during the school year. Our results offer more insight into the differential impact of teacher-child closeness on the behavioral problems for children with EBD and ASD.

This study tested effects of a program that offers teachers universal classroom management strategies, on teachers' burnout symptoms and self-efficacy, and their teaching behaviors. Data were collected from 147 teachers (mean age = 38.4 years, SD = 10.8) in 15 special secondary education schools for students with emotional and behavioral problems, at the start and end of the school year. Schools were randomly assigned to the experimental condition or a care-as-usual condition. Results show that the program impacted beneficially on self-reported levels of emotional exhaustion, and self-efficacy in engaging students and in classroom management, but not on teaching behaviors. Implications of this study for the professional development of teachers in special education and research are discussed.

Adolescent delinquency and identity formation have both been described in relation to the confusion, doubt, and need for individuation and autonomy faced by adolescents. While theoretical conceptualizations (e.g., Erikson, 1968; Moffitt, 1993) suggest that delinquency and identity formation might be developmentally intertwined across adolescence, this link had yet to be longitudinally examined. This study tested whether delinquency and identity are related and whether we could determine a developmental order considering both between- and within-person associations across adolescence. We examined these associations in a multi-informant sample of 497 Dutch adolescents followed for 5 annual waves from age 14-18. Between-person cross-lagged models showed that adolescents who scored higher on delinquency relative to their peers, scored lower on commitment and higher on reconsideration, 1 year later. Within-person cross-lagged models showed that when adolescents reported above their own average on delinquency, they reported decreased commitment and increased reconsideration 1 year later. Additionally, within-persons, when adolescents reported an increase in in-depth exploration compared with their own average they reported decreased delinquency 1 year later. From these results we can conclude that delinquency and personal identity are indeed related across adolescence. Experimenting with delinquency hampers identity formation by increasing reconsideration and decreasing commitment. Within-person results suggest that interventions tailored to increase in-depth exploration in adolescents may help to prevent adolescent delinquency.

We examined cross-cultural differences in (1) sibling power balance and (2) the associations between sibling power balance and internalizing and externalizing problems in three separate cross-cultural studies (early childhood, late childhood, and adolescence). The "early childhood samples" consisted of 123 Turkish and 128 Dutch mothers (mean age for children was 4.9 years). In the "late childhood samples," self-report data were collected from 124 Indian and 129 Dutch children (mean age 10.9 years). In the "adolescent samples" self-report data were collected from 165 ethnic Moroccan and 165 ethnic Dutch adolescents (mean age 15.2 years). In all studies, questionnaire data on sibling power imbalance and internalizing and externalizing problems were collected. Results showed only one significant cross-cultural difference in sibling power imbalance: The Indian sample reported more sibling power imbalance than the Dutch. Links between sibling power imbalance and problem behavior were highly similar between the different cultural samples. The only significant difference was a stronger impact of sibling power imbalance on externalizing problems for the Dutch compared to the Turkish sample. Concluding, few cross-cultural differences were found in sibling power imbalance. Across cultures and age groups, more sibling power imbalance was linked to more internalizing and externalizing problems.

Teaching children with psychiatric disorders can be a challenging task. The purpose of this study was to examine the impact of the Good Behavior Game (GBG) in children with psychiatric disorders, and their teachers, in special education. Teachers were trained by licensed school consultants to implement positive behavior support strategies to elicit desired behavior in students. A total of 389 children and their 58 teachers at 11 schools for special primary education were included in the study. Using a cluster randomized controlled design, special education schools were assigned to an intervention condition or an education as usual condition. An increase in emotional and behavioral problems was found in the control group, whereas no change was seen in the intervention group, indicating a modest intervention effect. No effects were found on children's relationships with teachers or peers. The GBG affected teachers' sense of self-efficacy in engaging students in schoolwork, but no effects were found on teachers' self-efficacy in classroom management or on teachers' burnout symptoms. Thus, although children with psychiatric disorders and their teachers in special education can benefit from the GBG, given the partial effects and modest effect sizes, a longer duration program complemented with additional elements is recommended.

Difficulties in peer acceptance during elementary school have been associated with emotional and behavioural problems. This study used a randomized controlled intervention design to test whether improvements in peer acceptance mediated reduced rates of emotional and behavioural problems in intervention compared to control-group children. A total of 615 elementary school children in the Netherlands were followed annually from kindergarten through second grade. Intervention children showed reductions in emotional and behavioural problems, and improved peer acceptance compared to controls. Improved peer acceptance mediated reductions in emotional and behavioural problem development. However, this mediation pathway held only for boys with low receptive vocabulary skills. These results indicate poor peer acceptance as a common underlying factor in emotional and behavioural problem development, particularly for children who are at risk for developing problems.

This longitudinal study explores differences between native Dutch and immigrant Moroccan adolescents in the relationship between internalizing and externalizing problems across time. By using generalized estimating equations (GEE), the strength and stability of associations between internalizing and externalizing problems in 159 Moroccan and 159 Dutch adolescents was studied over a period of 4 years. No differences in strength of co-occurring problems were found between Moroccan and Dutch adolescents. However, for Moroccan adolescents, associations between problems increased over time, whereas in Dutch adolescents, associations remained stable. The increase of co-occurring problems may be a result of undertreatment and increasing complexity of problems in Moroccans during adolescence. The results of this study imply that investigating processes leading to co-occurring problems in subgroups of adolescents, such as immigrant youths, is needed to optimize prevention and intervention efforts.

This 4-year study examined longitudinal interplays between adolescents' and mothers' self-reported empathic concern (EC) and perspective taking (PT). We investigated (a) whether adolescents' EC predicted rank-order change in their PT over time, or vice versa; (b) whether mothers' empathy predicted relative increases in adolescents' empathy; (c) whether adolescent gender moderated the over-time links from mothers' to adolescents' empathy; and (d) whether the rank-order stability of EC and PT over time differed within and between respondents. Adolescents' EC positively predicted their PT over time, but not vice versa. Mothers' PT positively predicted adolescent PT over time for girls, but not for boys. The rank-order stability of adolescents' EC was greater than their PT. Maternal PT and EC were equally stable and were more stable than in adolescents. This study contributes the first empirical evidence that the developmental order of adolescents' empathy runs from affective to cognitive empathy, in contrast to prior theoretical and experimental literature that has emphasized the reverse direction. It further provides the 1st longitudinal evidence of intergenerational empathy transmission. These findings support the notion that adolescence is a developmentally sensitive period for PT.

Empathy is an important social skill and is believed to play an essential role in moral development (Hoffman, 2000). In the present longitudinal study, the authors investigated adolescents' development of perspective taking and empathic concern from age 13 to 18 years (mean age at Wave 1 = 13 years, SD = 0.46) and examined its association with pubertal status. Adolescents (283 boys, 214 girls) reported for 6 consecutive years on their dispositional perspective taking and empathic concern and for 4 consecutive years on pubertal status. Latent growth curve modeling revealed gender differences in levels and developmental trends. Gender differences in perspective taking emerged during adolescence, with girls' increases being steeper than those of the boys. Girls also showed higher levels of empathic concern than did boys. Whereas girls' empathic concern remained stable across adolescence, boys showed a decrease from early to middle adolescence with a rebound to the initial level thereafter. Boys who were physically more mature also reported lower empathic concern than did their less physically developed peers. The current study supports theoretical notions that perspective taking develops during adolescence as a result of cognitive development. Moreover, the results suggest that pubertal maturation plays a role in boys' development of empathic concern.

This study aimed to understand how relationships with peers and teachers contribute to the development of internalizing problems via children's social self-concept. The sample included 570 children aged 7 years 5 months (SD = 4.6 months). Peer nominations of peer rejection, child-reported social self-concept, and teacher-reported internalizing problems were assessed longitudinally in the fall and spring of Grades 2 and 3. Teacher reports of support to the child were assessed in Grade 2. Results showed that peer rejection impeded children's social self-concept, which in turn affected the development of internalizing problems. Partial support was found for individual (but not classroom-level) teacher support to buffer the adverse effects of peer problems on children's self-concept, thereby mitigating its indirect effects on internalizing problems.

Background: It is well documented that friends' externalizing problems and negative parent-child interactions predict externalizing problems in adolescence, but relatively little is known about the role of siblings. This four-wave, multi-informant study investigated linkages of siblings' externalizing problems and sibling-adolescent negative interactions on adolescents' externalizing problems, while examining and controlling for similar linkages with friends and parents. Methods: Questionnaire data on externalizing problems and negative interactions were annually collected from 497 Dutch adolescents ("M" = 13.03 years, "SD" = 0.52, at baseline), as well as their siblings, mothers, fathers, and friends. Results: Cross-lagged panel analyses revealed modest unique longitudinal paths from sibling externalizing problems to adolescent externalizing problems, for male and female adolescents, and for same-sex and mixed-sex sibling dyads, but only from older to younger siblings. Moreover, these paths were above and beyond significant paths from mother-adolescent negative interaction and friend externalizing problems to adolescent externalizing problems, 1 year later. No cross-lagged paths existed between sibling-adolescent negative interaction and adolescent externalizing problems. Conclusions: Taken together, it appears that especially older sibling externalizing problems may be a unique social risk factor for adolescent externalizing problems, equal in strength to significant parents' and friends' risk factors. (Contains 3 tables, 1 figure, and 2 notes.)

The role of children's on-task behavior in the prevention of aggressive behavior was assessed among 570 Dutch speaking children followed from second- to third-grade elementary school in Flanders, Belgium. A first objective was to investigate whether individual level variation of on-task behavior moderated the impact of a universal preventive intervention, the Good Behavior Game (GBG), on aggression development, controlling for classroom levels of on-task behavior. The second goal was to study whether improved on-task behavior or reductions in peer rejection mediated intervention impact on children's aggression. Second-grade classrooms were randomly assigned to the GBG or a control condition. Results showed that intervention impact was found only among children who had low-level on-task behavior at baseline. These children showed a decrease in aggression when in the GBG condition, which was not found among control group children. The reduction in aggression among low on-task children was mediated by reductions in peer rejection. No mediation effect of on-task behavior was found. These results suggest that the effect of a universal preventive intervention may depend upon initial levels of on-task behavior and that improvements in social relations with peers may explain the reductions in aggression among these low-on task children. (Contains 2 tables and 4 figures.)

Heightened sensation-seeking is related to the development of delinquency. Moreover, sensation-seeking, or biological correlates of sensation-seeking, are suggested as factors linking victimization to delinquency. Here, we focused on epigenetic correlates of sensation-seeking. First, we identified DNA methylation (DNAm) patterns related to sensation-seeking. Second, we investigated the association between sensation-seeking related DNAm and the development of delinquency. Third, we examined whether victimization was related to sensation-seeking related DNAm and the development of delinquency. Participants (N = 905; 49% boys) came from the Avon Longitudinal Study of Parents and Children. DNAm was assessed at birth, age 7 and age 15–17. Sensation-seeking (self-reports) was assessed at age 11 and 14. Delinquency (self-reports) was assessed at age 17–19. Sensation-seeking epigenome-wide association study revealed that no probes reached the critical significance level. However, 20 differential methylated probes reached marginal significance. With these 20 suggestive sites, a sensation-seeking cumulative DNAm risk score was created. Results showed that this DNAm risk score at age 15–17 was related to delinquency at age 17–19. Moreover, an indirect effect of victimization to delinquency via DNAm was found. Sensation-seeking related DNAm is a potential biological correlate that can help to understand the development of delinquency, including how victimization might be associated with adolescent delinquency. [ABSTRACT FROM AUTHOR]