1. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
- Author
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Yan Li, De-Qiang Feng, You-Kai Xu, Shang-Gao Liao, Mao-Juan Zhang, Bing Liu, and Kai-Long Ji
- Subjects
Uncaria sessilifructus ,uncarilic acid ,secouncarilic acid ,triterpenoids ,Organic chemistry ,QD241-441 - Abstract
Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
- Published
- 2013
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