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Background: Different intensities of exercise may have a different effect on the level of brain-derived neurogenic factor (BDNF). Hence, this study aimed to determine the effect of sprint interval training with short repetitions on hippocampal BDNF level, spatial learning and memory in adult rats. Materials and Methods: Sixteen Wistar rats were randomly divided into the control (CO, n=8) and exercise (EX, n=8) groups. The exercise was performed for 8 weeks, 3 sessions per week, 4-9 repetitions of 10 seconds sprints, and 1-minute rest. At the end of the training period, the learning and memory of the animals were evaluated by Y maze and shuttle box tests. 48 hours after the test, the rats were anesthetized and the hippocampal tissue was isolated. BDNF levels were measured in hippocampal tissue homogeneity. The independent t-test was used to analyze the data at the alpha level of 0.05. Results: Statistical analysis of the data showed that the level of BDNF in EX hippocampus was significantly higher than that of CO (P

Background: Different intensities of exercise may have a different effect on the level of brain-derived neurogenic factor (BDNF). Hence, this study aimed to determine the effect of sprint interval training with short repetitions on hippocampal BDNF level, spatial learning and memory in adult rats. Materials and Methods: Sixteen Wistar rats were randomly divided into the control (CO, n=8) and exercise (EX, n=8) groups. The exercise was performed for 8 weeks, 3 sessions per week, 4-9 repetitions of 10 seconds sprints, and 1-minute rest. At the end of the training period, the learning and memory of the animals were evaluated by Y maze and shuttle box tests. 48 hours after the test, the rats were anesthetized and the hippocampal tissue was isolated. BDNF levels were measured in hippocampal tissue homogeneity. The independent t-test was used to analyze the data at the alpha level of 0.05. Results: Statistical analysis of the data showed that the level of BDNF in EX hippocampus was significantly higher than that of CO (P

Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for further investigation including cancer prevention. Methods: Fruits of Apium graveolens L. (celery), Bunium persicum (Boiss.) B.Fedtsch. (black cumin), Petroselinum crispum (Mill.) Fuss (parsley), Pimpinella anisum L. (anise), Trachyspermum ammi (L.) Sprague (ajwain), Coriandrum sativum L. (coriander), Foeniculum vulgare Mill. (fennel), Anethum graveolens L. (dill), Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall. (Persian hogweed), Ferula assa-foetida L. (asafoetida), Cuminum cyminum L. (cumin) and Daucus carota L. (carrot) were extracted with 80 % methanol and fractionated by petroleum ether, chloroform, ethyl acetate and methanol, respectively. For different fractions and total extract of all 12 samples, cytotoxicity by brine shrimp test (BST) and MTT assay against cancer and normal cell (foreskin fibroblast cells), antioxidant effects by FRAP, and total phenols by Folin-Ciocalteu method were measured. Results: The general toxicity of ethyl acetate fractions (mean of data) was higher than others in the brine shrimp test (P < 0.05). The most cytotoxic fractions against colon carcinoma (HT-29), breast adenocarcinoma (MDA-MB-231) and alveolar basal epithelial adenocarcinoma (A549) cell lines were from Ammineae and Peucedaneae tribes while fruits fractions with high phenol contents and antioxidant powers were from Ammineae tribe. Conclusion: The Apiaceae fruits have significant biological effects, therefore the isolation of phytochemical compounds from active fractions with cytotoxicity is suggested in future studies.