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Cancer vaccines represent a promising form of immunotherapy employed in the treatment of cancer. However, their efficiency in eliciting immune responses is limited, and satisfactory results have yet to be achieved. Optimizing adjuvants and antigens is an important approach to promoting the anti‐tumor efficacy of cancer vaccines. Here, a novel nanoadjuvant (LNP/siRNA) designed to silence T‐cell immunoglobulin and mucin‐domain containing‐3 (TIM3) and activate Toll‐like receptors (TLRs) is presented. The LNP/siRNA demonstrates significant potential in promoting dendritic cell (DC) maturation and enhancing the anti‐tumor response. Furthermore, desialylated cancer cell membrane is utilized as antigens, providing a variety of tumor antigens for DCs and enhancing their function. Additionally, they are integrated to create a core‐shell structured nanovaccine (dClip‐LNP/siRNA) through coextrusion, which collectively enhances the cross‐presentation ability of DCs, thus achieving a dual enhancement strategy. The dClip‐LNP/siRNA significantly silences TIM3 expression in DCs and promotes antigen presentation by DCs. Besides, dClip‐LNP/siRNA significantly promotes the activation of T cells in lymph nodes and induces robust and durable anti‐tumor immunity in tumor sites to eliminate established B16‐OVA tumors, prevent tumor occurrence, and suppress tumor lung metastasis. The dClip‐LNP/siRNA is also suitable for combination with adoptive OT‐I cell therapy to enhance cancer immunotherapy. The dClip‐LNP/siRNA represents a robust vaccine platform for personalized cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Context: Cross-project defect prediction (CPDP), due to the potential of adaption by industry in realistic scenarios, had gained significant attention from the research community. Currently, existing CPDP studies use static statistical features designed by experts, which might not capture the semantic and structural aspects of software, resulting in low accuracy in defect prediction. Meanwhile, they tend to overlook the valuable iterative information brought about by version updates in mature software projects. Objective: This paper introduces DETECTOR, a novel CPDP approach based on coDE semanTic and cross-vErsion struCTural infORmation to leverage cross-versions features of the software and improve the performance of CPDP. Methods: DETECTOR parses source code to exploit Abstract Syntax Trees (ASTs) and cross-version software network (Cross-SN) that consists of internal class dependency network and cross-version class dependency edges. It utilizes Attention-based Bi-LSTM and simplified graph convolutional neural networks to automatically extract software features from ASTs and Cross-SN. The extracted features are fused using gate(⋅) to generate more effective cross-version features. Finally the source project is selected to carry out the data used to train the classifier to predict the defects. Results: Empirical studies on seven open-source Java projects, the experiment results show that: (1) DETECTOR outperforms the state-of-the-art models in CPDP; (2) our proposed cross-version dependent edges positively contribute to DETECTOR performance; (3) gate(⋅) outperforms existing strategies in fusion features; (4) more multi-versions information enhance DETECTOR's performance. Conclusion: DETECTOR can predict more defects in CPDP and improve the accuracy and effectiveness of prediction. [ABSTRACT FROM AUTHOR]

Global human‐induced warming has intensified water circulation in the atmospheric environment and altered the streamflow generation regime. The VIC hydrological model approach for impact assessment of climate change and human activities mainly focuses on variations in streamflow, but ignores other critical flooding characteristics induced by extreme streamflow, especially bivariate flooding characteristics. In this work, the copula functions are employed to structure the flooding risk under the shared socioeconomic pathway (SSP) across the Yellow River basin (YRB). This is based on the multi‐model ensemble (MME) and Delta downscaling outputs (Delta‐MME) of the CMIP6 global climate models (GCMs), as well as the flooding characteristics simulated by VIC hydrological model. Compared to the reference period (1995–2014), Delta‐MME reveals a significant warming and humidifying trend under three SSPs over the YRB. Despite uncertainties originating from climate variables and hydrological model, multiple findings underscore the substantial influence of climate change on the flooding generation regime in YRB. This includes: (a) an increase in the streamflow under all SSPs; (b) a larger flooding peak (Q) and volume (W) under SSP585, with Q and W at the Huayuankou hydrologic station (HYK) increasing by 52.7% and 44.8%, respectively; (c) an advancement in the bivariate flooding risk, particularly in SSP585 where flooding co‐occurrence return period at HYK may be more than 50 times earlier. This study underscores that the urgent need to enhance social resilience to climate change in the YRB. Plain Language Summary: The YRB, as the second‐longest river in China, is confronted with the threat of catastrophic flooding hazards. The CMIP6, representing the latest climate prediction products, was developed by Earth System Grid Federation. This research aims to propose a novel perspective for predicting future flooding risks along the YRB under all SSPs. The findings of this research could hold great potential for informing mitigation and adaptation policies regarding flooding hazards in the YRB. Key Points: The VIC hydrologic model is employed to simulate flooding magnitude to climate change over the Yellow River basinFlooding magnitude over the Yellow River basin become more fluctuating under three SSPsFuture return period levels for flooding peak and volume have reduced significantly from the historical period, with the co‐occurrence return period being more prominent than the joint return period [ABSTRACT FROM AUTHOR]

The correction practice of scientific publications is usually used to correct publication errors by issuing correction notices, and it is less explored compared to retraction practice. The aim of this study is to present an overview of correction practice and to explore the citation situation of correction notices in library and information science (LIS) journals, using 720 correction notices in the Web of Science from 2001–2020. Through bibliometrics and content analysis, we found the correcting rate of LIS was relatively low. The main types of corrected errors occurred in authorship, figure or table, references, etc. Most corrected errors were trivial or minor. The citation situation of correction notices was more complex than expected and could be classified into five types. It was relatively rare to cite both the corrected paper and correction notice in a standardized manner. The remaining four types of citation were unreasonable, which could influence citation practice and reduce the citations of corrected papers. We concluded that the appearance of the correction notice had affected the citation of the corrected papers to some extent, and researchers and databases needed to pay attention to this problem. We also provided some suggestions for improving correction practice. [ABSTRACT FROM AUTHOR]

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The hydrological cycle across the source regions of the Yellow River (SRYR) affects water supply for 324 million people across the Yellow River basin (YRB), and the scarcity of meteorological stations leads to great challenges for the estimation of hydrologic and energy balance. Therefore, our work employs multisource precipitation products across the YRB to develop a new integrated precipitation product with the optimized Bayesian mean algorithm (OBMA). It investigates the performance and hydrological utility of the optimal Bayesian integrated precipitation product (OBIPP). This study found that the OBIPP improved by 14.08% in overall performance relative to the optimal precipitation product across the SRYR, respectively. Meanwhile, the variable infiltration capacity (VIC) model, driven by daily OBIPP, can drastically improve the accuracy of runoff simulation compared with other precipitation products across the SRYR. According to the VIC model driven by daily OBIPP, the average precipitation and runoff depth across the SRYR were approximately 621 mm and 64 mm from 2001 to 2019, respectively, showing a spatial trend increasing from northwest to southeast. Overall, OBIPP is characterized by smaller uncertainty of simulation and higher simulation performance across the SRYR, which should provide a scientific basis for accurate prediction and assessment of water resources in areas where meteorological data are scarce. [ABSTRACT FROM AUTHOR]

Due to the uneven temperature field and temperature gradient introduced by an efficient cooling structure, the analysis of the stress field is necessary. In this study, the cooling characteristics and stress characteristics such as the thermal stress and thermomechanical stress of an impingement/effusion cooling system were investigated by employing a fluid–thermal-structure coupling simulation method. The effects of film hole injection angle (30°–90°) and blowing ratio (0.5–2.0) were studied. The results showed that the film hole shape and the non-uniform temperature field introduced by the cooling structure had a great influence on the stress field distribution. With the increase in the blowing ratio, not only the overall cooling effectiveness of the cooling system increased, but the maximum thermal stress and thermomechanical stress near film holes also increased. The cases with a smaller inclination angle could provide a better cooling performance, but caused a more serious stress concentration of the film hole. However, the thermal stress difference at the leading and trailing edges of the film hole increased with a decreasing inclination angle. The cases with a = 30° and 45° showed serious thermal stress concentration near the hole's acute region. [ABSTRACT FROM AUTHOR]

In the context of global warming, relevant studies have shown that China will experience the largest temperature rise in the Qinghai–Tibet Plateau and northwestern regions in the future. Based on MOD10A2 and MYD10A2 snow products and snow depth data, this study analyzes the temporal and spatial evolution characteristics of the snow cover fraction, snow depth, and snow cover days in the three stable snow cover areas in China, and combines 15 modes in CMIP6 snow cover data in four different scenarios with three kinds of variables, predicting the spatiotemporal evolution pattern of snow cover in China's three stable snow cover areas in the future. The results show that (1) the mean snow cover fraction, snow depth, and snow cover days in the snow cover area of Northern Xinjiang are all the highest. Seasonal changes in the snow cover areas of the Qinghai–Tibet Plateau are the most stable. The snow cover fraction, snow depth, and snow cover days of the three stable snow cover areas are consistent in spatial distribution. The high values are mainly distributed in the southeast and west of the Qinghai–Tibet Plateau, the south and northeast of Northern Xinjiang, and the north of the snow cover area of Northeast China. (2) The future snow changes in the three stable snow cover areas will continue to decline with the increase in development imbalance. Snow cover fraction and snow depth decrease most significantly in the Qinghai–Tibet Plateau and the snow cover days in Northern Xinjiang decrease most significantly under the SSPs585 scenario. In the future, the southeast of the Qinghai–Tibet Plateau, the northwest of Northern Xinjiang, and the north of Northeast China will be the center of snow cover reduction. (3) Under the four different scenarios, the snow cover changes in the Qinghai–Tibet Plateau and Northern Xinjiang are the most significant. Under the SSPs126 and SSPs245 scenarios, the Qinghai–Tibet Plateau snow cover has the most significant change in response. Under the SSPs370 and SSPs585 scenarios, the snow cover in Northern Xinjiang has the most significant change. [ABSTRACT FROM AUTHOR]

Mobile crowdsensing (MCS) offers a novel paradigm for large-scale sensing with the proliferation of smartphones. Task assignment is a critical problem in mobile crowdsensing (MCS), where service providers attempt to recruit a group of brilliant users to complete the sensing task at a limited cost. However, selecting an appropriate set of users with high quality and low cost is challenging. Existing works of task assignment ignore the data redundancy of large-scale users and the individual preference of service providers, resulting in a significant workload on the sensing platform and inaccurate assignment results. To tackle this issue, we propose a task assignment method based on user-union clustering and individual preferences, which considers the influence of clustering data quality and preference-based sensing cost. Firstly, we design a user-union clustering algorithm (UCA) by defining user similarity and setting user scale, which aims to balance user distribution, reduce data redundancy, and improve the accuracy of high-quality user aggregation. Then, we consider individual preferences of service providers and construct a preference-based task assignment algorithm (PTA) to achieve the diversified sensing cost control needs. To evaluate the performance of the proposed solutions, extensive simulations are conducted. The results demonstrate that our proposed solutions outperform the baseline algorithm, which realizes the individual preference-based task assignment under the premise of ensuring high-quality data. [ABSTRACT FROM AUTHOR]

Background: Similarities in the biology of pulmonary hypertension and cancer suggest that anticancer therapies, such as sanguinarine, may also be effective in treating pulmonary hypertension. This, along with underlying biochemical pathways, is investigated in this study. Methods: Rats were subjected to 4-week hypoxia (or control) with or without sanguinarine treatment. In addition, pulmonary artery smooth muscle cells (PASMCs) were examined after 24–48 h hypoxia (with normoxic controls) and with or without sanguinirine. Pulmonary artery pressures and plasma survivin levels were measured in vivo. Ex vivo tissues were examined histologically with appropriate staining. mRNA and protein levels of survivin, HIF-1α, TGFb1, BMPR2, Smad3, P53, and Kv 1.2, 1.5, 2.1 were determined by real-time PCR and Western blot in PASMCs and distal PAs tissue. PASMC proliferation and changes of TGFb1 and pSmad3 induced by sanguinarine were studied using MTT and Western blot. Electrophysiology for Kv functions was measured by patch-clamp experiments. Results: Four-week hypoxia resulted in an increase in serum survivin and HIF-1α, pulmonary artery pressures, and pulmonary vascular remodeling with hypertrophy. These changes were all decreased by treatment with sanguinarine. Hypoxia induced a rise of proliferation in PASMCs which was prevented by sanguinarine treatment. Hypoxic PASMCs had elevated TGFb1, pSmad3, BMPR2, and HIF1α. These increases were all ameliorated by sanguinarine treatment. Hypoxia treatment resulted in reduced expression and function of Kv 1.2, 1.5, 2.1 channels, and these changes were also modulated by sanguinarine. Conclusion: Sanguinarine is effective in modulating hypoxic pulmonary vascular hypertrophy via the survivin pathway and Kv channels. [ABSTRACT FROM AUTHOR]

Purpose: In ambulant patients with lower limb DVT managed with Warfarin, there is a need for initial treatment and short time "bridging" with a rapidly acting anticoagulant until there is a stable therapeutic INR. In this study, results from bridging with subcutaneous low molecular weight heparin (LMWH) or oral Rivaroxaban were compared. Methods: One hundred and twenty‐four patients received LMWH and 98 patients received Rivaroxaban, both in addition to Warfarin. Patients were assessed at 1 and 4 weeks after treatment initiation for thrombus progression, bleeding, clinic attendance and INR. Findings: The treatment groups were well matched. There were no significant differences between the treatment groups for any of the end‐points at either 1 week or 4 weeks. Implications: In ambulant patients with DVT treated with Warfarin both Rivaroxaban and LMWH are suitable for use in the early phase of Warfarin treatment until therapeutic INR is achieved. Rivaroxaban is a suitable alternative to LMWH for patients who prefer not to have injections. [ABSTRACT FROM AUTHOR]

Mobile Crowdsensing (MCS) has evolved into an effective and valuable paradigm to engage mobile users to sense and collect urban-scale information. However, users risk their location privacy while reporting data with actual sensing locations. Existing works of location privacy-preserving are primarily based on single-region location information, which rely on a trusted and centralized sensing platform and ignore the impact of regional differences on user privacy-preserving demands. To tackle this issue, we propose a Location Difference-Based Privacy-Preserving Framework (LDPF), leveraging the powerful edge servers deployed between users and the sensing platform to hide and manage users according to regional user characteristics. More specifically, for popular regions, based on the edge servers and the k-anonymity algorithm, we propose a Coordinate Transformation and Bit Commitment (CTBC) privacy-preserving method that effectively guarantees the privacy of location data without relying on a trusted sensing platform. For remote regions, based on a more realistic distance calculation mode, we design a Paillier Encryption Data Coding (PDC) privacy-preserving method that realizes the secure computation for users' location and prevents malicious users from deceiving. The theoretical analysis and simulation results demonstrate the security and efficiency of the proposed framework in location difference-based privacy-preserving. [ABSTRACT FROM AUTHOR]

Growing evidence indicates that circular RNAs (circRNAs) are promising biomarkers, as they play significant roles in the development of various cancers. The circular RNA MYLK (circMYLK) has been reported to be involved in the development of malignant tumours, including liver, prostate and bladder cancers. Nevertheless, the biological function of circMYLK in renal cell carcinoma (RCC) remains unclear. In this study, we observed that circMYLK is notably up‐regulated in RCC. Increased circMYLK expression led to a larger tumour size, distant metastasis and poor prognosis of RCC patients. Moreover, circMYLK silencing repressed RCC growth and metastasis in vitro and in vivo. Mechanistically, circMYLK can capture miR‐513a‐5p to facilitate VEGFC expression and further promote the tumorigenesis of RCC cells. In summary, our findings demonstrate that circMYLK has an oncogenic role in RCC growth and metastasis by modulating miR‐513a‐5p/VEGFC signalling. Thus, circMYLK has potential as a diagnostic biomarker and therapeutic target in the treatment of RCC. [ABSTRACT FROM AUTHOR]

Long non-coding RNAs (lncRNAs) are a class of transcriptional RNA molecules with a length of greater than 200 nucleotides that function as regulatory factors in many human diseases. Studies have shown that lncRNAs are involved in multiple cellular processes, including proliferation, apoptosis, migration, and invasion. In this report, a long non-coding RNA-ATB that is overexpressed in various tumor tissues and cell lines was investigated. Recent evidence suggests that ATB is dysfunctional in a variety of cancers, including hepatocellular carcinoma, gastric cancer (GC), colorectal cancer (CRC), breast cancer (BC), prostate cancer, renal cell carcinoma, non-small cell lung cancer (NSCLC), pancreatic cancer, osteosarcoma, and glioma. The high expression of ATB is associated with clinicopathological features of cancer patients. In addition, overexpression of lncRNA-ATB can promote tumor proliferation, migration, and invasion. LncRNA-ATB induces epithelial-mesenchymal transition (EMT) by competitively binding to miRNAs, thus promoting tumor progression. Biological functions and mechanisms of ATB in human cancers are discussed here, concluding that lncRNA-ATB may provide a new biomarker for use in diagnosis and prognosis of cancer. [ABSTRACT FROM AUTHOR]

Understanding historical and future drought patterns is crucial to acclimation and the mitigation of drought. The negative impact of China's droughts on the social economy has attracted attention; however, there is still no comprehensive or long-term monitoring pattern for future droughts. Here we evaluated the precipitation and temperature simulation capability of Coupled Model Intercomparison Project Phase 6 (CMIP6) and evaluated the temporal and spatial pattern of droughts during 1961–2099 across China. The results show that the multi-model ensemble mean (MME) is more representative of the observed precipitation and temperatures across China than the single climate model. China experienced an overall drying trend in the historical period. After 1991, the drought frequency (DF), drought duration (DD), and drought intensity (DI) in the northwest of the Inland River Basin and in the Yangtze River Basin increased significantly. Compared with the historical period, China will suffer more frequent drought events, although the DD and DI will be weakened under SSP1-2.6 and SSP2-4.5, while China will experience longer DD and more serious drought events under SSP3-7.0 and SSP5-8.5. The Hai River Basin and Huai River Basin are expected to have more serious drought trends in summer. Compared with historical periods, the drought trend will increase by 2.9–5.7 times and 1.1–4.2 times, respectively. The results can be used for decision making regarding future drought control. [ABSTRACT FROM AUTHOR]

The development pattern of agriculture and energy exploitation in the southern marginal area of the Loess Plateau is widespread in the northern part of China. As a typical example, the fragile ecological area in the Weibei region is greatly affected by human factors, which makes the local ecological environment and social sustainability disturbed to varying degrees. Taking the Weibei region as the study area, through the comprehensive analysis of social, economic, and climate data, an index system suitable for the ecological security assessment of the Weibei region was constructed. The ecological security of this region was quantitatively evaluated by spatial principal component analysis (SPCA), and its ecological security partition was divided and analyzed. There were five zones at different levels, and I to V represented the development of ecological security from a low level to a high level. The results showed that from 1997 to 2017, the ecological security of different districts and counties in the Weibei region showed different trends. For example, the ecological security index of Tongguan County, Chengcheng County, and Pucheng County continued to decrease, but the overall index value was still high, and the ecological security index of Dali County, Fuping County, and Hancheng County increased. During this period, the ecological security of regions I and II continued to increase, while regions IV and V first decreased and then increased. At the same time, the area of the ecological security buffer region increased year by year. This study can provide a feasible method for assessing ecological security of the current regional model of mixed agriculture and energy extraction industry. [ABSTRACT FROM AUTHOR]

• Cooking technique influences the chemical composition of soup. • Stewed soup had small particle size. • Stewed soup had low fat and total triglycerides levels. • Stewed soup had more flavor characteristics. • Stewed soup had more taste characteristics. Meat soup is an important diet with desirable taste and abundant nutrients. Unveiling the chemical composition of soup will help to understand the health effects. In this work, pork ribs and Silkie chicken were used to prepare soups by boiling, steaming and four-stage stewing, respectively. The chemical composition and sensory qualities of these soups were obviously influenced by the cooking technique. Silkie chicken and pork rib soups prepared by four-stage stewing technique had particle size smaller than 850 nm, smaller chromatic aberration, higher stability, higher levels of free amino acids, lower levels of fat and total triglycerides than the other two techniques. More abundant flavor and taste characteristics were also detected. The high temperature boiling technique could promote the accumulation of the mineral elements in soup. According to healthy and sensory concerns, stewing was the best choice for preparing soups of pork rib and Silkie chicken. [ABSTRACT FROM AUTHOR]

Melanoma is one of the most aggressive types of cancer and is prone to metastasis, making current clinical treatment quite difficult. The usage of the first-line medication dacarbazine (DTIC) for melanoma is limited due to harsh side effects, limited water solubility, and a short half-life. To tackle these disadvantages, polylactic acid-hydroxyacetic acid copolymer nanoparticles (NPs) loaded with dacarbazine and ursolic acid (NPs) were fabricated, which were further encapsulated with a red blood cell membrane (RNPs). MTT, apoptosis assay, wound healing assay, colony formation assay, and immunohistochemistry were used to assess the antitumor effect of NPs and RNPs. Ferroptosis evaluation was implemented using GSH detection and the malondialdehyde assay. We found that RNPs exhibited stability and biosafety in vitro and in vivo and achieved superior anticancer ability against xenograft tumors compared with single agents and NPs, which indicated the synergistic and biomimetic efficacy. Furthermore, ferroptotic activity was observed in RNPs-treated tumor cells, and ferroptosis inhibition could partially rescue melanoma cells from RNPs-induced cell death. Collectively, this study evaluated the potential of RNPs as a novel biomimetic nanomedicine for synergistic melanoma therapy by eliciting ferroptosis in tumor cells with both anticancer activity and biosafety., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease that eventually leads to heart failure (HF) and subsequent fatality if left untreated. Right ventricular (RV) function has proven prognostic values in patients with a variety of heart diseases including PAH. PAH is predominantly a right heart disease; however, given the nature of the continuous circulatory system and the presence of shared septum and pericardial constraints, the interdependence of the right and left ventricles is a factor that requires consideration. Accurate and timely assessment of ventricular function is very important in the management of patients with PAH for disease outcomes and prognosis. Non-invasive modalities such as cardiac magnetic resonance (CMR) and echocardiography (two-dimensional and three-dimensional), and nuclear medicine, positron emission tomography (PET) play a crucial role in the assessment of ventricular function and disease prognosis. Each modality has its own strengths and limitations, hence this review article sheds light on (i) ventricular dysfunction in patients with PAH and RV-LV interdependence in such patients, (ii) the strengths and limitations of all available modalities and parameters for the early assessment of ventricular function, as well as their prognostic value, and (iii) lastly, the challenges faced and the potential future advancement in these modalities for accurate and early diagnosis of ventricular function in PAH., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Ahmad, Zou, Zhang, Li, Wang, Wang and Fan.)

Background: The coronavirus disease 2019 (COVID-19) outbreak within China has been well controlled and stabilized since early April 2020. Therefore, the current major focus in China is to prevent the introduction of COVID into China from international arrivals. To achieve this, pre-Hospital COVID-19 Response Teams (pHCRTs) have been established., Context: The pHRCTs were established in Xi'an, China in early 2020. During the 12 months covered in this report, there were 356 international flight arrivals with over 5,000 COVID-19 Nucleic Acid Test (NAT) positive people, 500 of them with symptomatic COVID-19 and requiring admission to special hospitals. All other arrivals were managed in dedicated facilities by pHRCTs. The outcome measure of this report was the number of positive cases among the pHRCT members., Details: Four hundred forty-two staff worked in the pHCRTs during the reporting period. Despite multiple throat swab PCR tests during their pHRCTs tour of duty, and the subsequent mandatory 14-day quarantine required before return to the general community, no staff became NAT positive., Conclusion: The prevention of community transmission from imported cases is a vital part of the strategy to maintain the low numbers of cases in countries which have achieved control, or suppression of local internal cases. The program of pHCRTs described in this article gives successful protocols for transportation of patients who are infectious based on the minimal transmission of virus and staff safety. The strategies employed may prove useful in future pandemics., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Zou, Zou, Dart, Zhang, Wang and Fan.)

Long non-coding RNAs account for large proportion of non-coding transcripts in human genomes. Though they lack of open reading framework and cannot encode protein, they can control endogenous gene expression though regulating cell life activities. They serve as transcriptional modulator, posttranscriptional processor, chromatin remodeler and splicing regulator during the process of gene modification. Moreover, long non-coding RNAs were regarded as potential tumor markers for cancer diagnosis and prognosis. BANCR was identified as a cancer-promoting long non-coding RNA in melanoma tissues. Since then, increasing studies about BANCR in cancer progression were reported. BANCR was dysregulated in various cancers including melanoma, colorectal cancer, retinoblastoma, lung carcinoma and hepatocellular carcinoma, and increased BANCR expression cause poor prognosis and shorter survival rate of cancer patients. Furthermore, the functions and mechanisms of BANCR in cancer cells have been clarified. Here, we focus on the current research on the role of BANCR in the clinical management, progression and molecular mechanisms in human cancer., Competing Interests: CONFLICTS OF INTEREST The authors declare that they have no competing interests.

Background: Acupuncture and moxibustion has been widely applied to hyperlipidemia treatment in clinical practice in China, serving as an alternative treatment to statins. Warm-needling acupuncture and medicinal cake-separated moxibustion have been separately reported with potential therapeutic effects on hyperlipidemia treatment in several studies but with limitations in study methodology. Combining these two modalities may provide a more advantageous strategy in treating hyperlipidemia. Therefore, a strict evaluation through well-designed randomized controlled trials (RCT) is necessary to determine their efficacy and safety on hyperlipidemia., Methods: The study a multicenter, open-label, randomized, stratified, active-controlled, noninferiority trial with two parallel groups. Subjects with hyperlipidemia will be stratified into different groups by risk levels of heart diseases. They then will be instructed to the Therapeutic Lifestyle Change (TLC) diet. Those who have not reached the target lipid level will be randomly assigned to the treatments of either acupuncture and moxibustion or simvastatin with a 1:1 allocation. One hundred and thirty subjects are aimed to be recruited. The duration of intervention for this study will be 12 weeks, followed by another 4 weeks for post-treatment assessment. The primary outcome is percentage change from baseline to the end of the study in low-density lipoprotein cholesterol (LDL-C). Other indicators in lipid change, safety and adherence will also be assessed secondarily. The repeated measures, linear mixed-effects model will be applied to the analysis., Discussion: Acupuncture and moxibustion could be a potentially effective treatment alternative for hyperlipidemia. A study with careful design is developed to evaluate the efficacy and safety of combined acupuncture and moxibustion, by integrating the traditional Chinese Medicine (TCM) regimens with the standardized Western medicine appraisal approach., Trial Registration: ClinicalTrials.gov, NCT02269046 . Registered on 26 September 2014.