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OBJECTIVE: This study aimed to determine the morbidity and comorbidity of glucolipid metabolic multiple noncommunicable diseases in a Chinese natural population and associated risk factors. SUBJECTS AND METHODS: A cross-sectional survey with randomized sampling was conducted on a typical sample of 4,002 residents (aged 26-76 years) in the Pinggu District of Beijing. They were subjected to a questionnaire survey, physical examination, and laboratory examination to collect data. Multivariable analysis was used to establish the association between various risk factors and multiple noncommunicable diseases. RESULTS: The overall prevalence rate of chronic glucolipid metabolic noncommunicable diseases was 84.28%. The most common type of noncommunicable diseases was dyslipidemia, abdominal obesity, hypertension, obesity, and type 2 diabetes. The prevalence rate of multiple noncommunicable diseases was 79.60%. Participants with dyslipidemia were at higher risk for underlying chronic diseases. Younger men and women after menopause were more likely to have multiple noncommunicable diseases compared to their older and younger counterparts, respectively. The results of multivariate logistic regression indicated that age above 50, male sex, high household income, low education level, and harmful alcohol consumption were independent risk factors for multiple noncommunicable diseases. CONCLUSIONS: The prevalence of chronic glucolipid metabolic noncommunicable diseases in Pinggu was higher than at the national level. Men with multiple noncommunicable diseases were younger, while women after menopause were more likely to suffer from multiple noncommunicable diseases and the prevalence rate was higher than in men. Intervention programs that aim to target risk factors by sex and region-specific are urgently needed. [ABSTRACT FROM AUTHOR]

The low-lying electronic states of Yb isolated in a solid Ar matrix grown at 4.2 K are characterized through absorption and emission spectroscopy. Yb atoms are found to occupy three distinct thermally stable trapping sites labeled "red," "blue," and "violet" according to the relative positions of the absorption features they produce. Classical simulations of the site structure and relative stability broadly reproduced the experimentally observed matrix-induced frequency shifts and thus identified the red, blue, and violet sites as due to respective single substitutional (SS), tetravacancy (TV), and hexavacancy (HV) occupation. Prolonged excitation of the ¹S → ¹P transition was found to transfer the Yb population from HV sites into TV and SS sites. The process showed reversibility in that annealing to 24 K predominantly transferred the TV population back into HV sites. Population kinetics were used to deduce the effective rate parameters for the site transformation processes. Experimental observations indicate that the blue and violet sites lie close in energy, whereas the red one is much less stable. Classical simulations identify the blue site as the most stable one. [ABSTRACT FROM AUTHOR]

The structure, magnetic transitions, and magnetostriction of TbxDyyNdz(Fe0.9Co0.1)1.93 polycrystalline compounds have been investigated, with the ratio of x, y, and z spanning the line of minimum magnetic anisotropy. Anisotropy compensation with lower Tb content was realized in Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 compound. The spin configuration diagram accompanied with different crystal structures was constructed to illustrate the arrangement for the easy magnetization direction and crystal structure. An optimized effect on magnetostriction especially at the relatively low field of 1 kOe (197 ppm) was observed in Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 compound, which is about two times larger than that of the sample free of Nd (62 ppm). Meanwhile, the polycrystalline saturation magnetostriction (λs=945 ppm) of Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 is even much larger than that of the Ho-doped multicomponent single crystal compound Tb0.2Dy0.22Ho0.58Fe2 (λs=530 ppm). Low content of heavy rare earth Tb, high Curie temperature, and large ratio between magnetostriction and the absolute value of the first anisotropy constant λa/|K1| were obtained in Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 compound, which may make it a potential material for magnetostrictive application. [ABSTRACT FROM AUTHOR]

Due to being affected by the rapid development of open science and the increasing popularity of mobile devices (e.g., smartphones), remote sensing data as frequently used data sources are broadly applied to our daily life. At the same time, remote sensing data collection also presents a trend of popularization. To improve the utilization efficiency and availability of the obtained diversified remote sensing data, we propose a novel evaluation method based on information theory and scatterplot mapping model, i.e., geometrical mapping entropy (GME). The goal is to construct a unified model of measurement to be much more effectively and accurately evaluate the information content and quality of remotely sensed imagery. Different experimental data are used to verify the performance of the proposed method, i.e., a group of the dataset that contains different four types of images; the other group of image data contains the images with different modalities and different imaging times (2016–05, 2017–08, 2018–04, and 2018–06). Experimental results indicate that the proposed approach can better characterize the spectrum features and spatial structural features contained in images and visual perception information. Additionally, it can also reflect the difference in the quality of different modality images, especially the effect for the images that contain clouds or poor lighting conditions, is better. [ABSTRACT FROM AUTHOR]

In vector landcover database, there are a lot of complex polygons with many holes, even nesting holes. In the incremental updating (i.e., using the change-only information to update the land cover database), a new changed parcel usually has 2-dimensional intersections (e.g., overlap, cover, equal and inside, etc.) with several existing regions, automatic updating operations need to identify the affected objects for the new changes at first. If the existing parcels include complex polygons (i.e., the polygon with holes), it is still needed to determine if there are 2-dimensional intersections between the new changed polygon and each holes of the involved complex polygons. The relation between the complex polygon and its holes has not been presented in the current spatial data indexing methods, only the MBB (Minimum Bounding Box) of the exterior ring of the complex polygon has been stored, the non-involved holes can not be filtered at the first step of spatial access methods. As the refinement geometric operation is costly, therefore the updating process for the complex polygons is very complicated and low efficient using the current spatial data indexing methods. In order to solve this problem, an improved quadtree spatial index method is presented in this paper. In this method, the polygons is divided to two categories according to the relations with the quadrant axes, i.e., disjoint to the axes and intersect with the axes. The intersect polygons are still divided to 5 cases according to the intersection position among the polygons and the different level quadrant axes. The intersection polygons are stored in the different level root nodes in our index tree, and five buckets denoted as XpB, XnB, YpB, YnB, XYB are used to store the polygons intersecting the different level quadrant axes respectively. The polygons disjoint to all quadrant axes are stored in the leaf nodes in this method. The authors developed the spatial index structure with inclusion relations and the algorithms of the corresponding index operations (e.g., insert, delete and query) for the complex polygons. The effectiveness of the improved index is verified by an experiment of land cover data incremental updating. Experimental results show that the proposed index method is significantly more efficient than the traditional quadtree index in terms of spatial query efficiency, and the time efficiency of the incremental updating is increased about 3 times using the proposed index method than that using the traditional quadtree index. [ABSTRACT FROM AUTHOR]

Based on prior work, a cellulase from glycosyl hydrolase family 7 (GHF7) was identified and found to be expressed at a high level in Coptotermes formosanus. To determine the function of GHF7 family members in vivo, we used RNA interference (RNAi) to functionally analyse the exoglucanase gene Pseudotrichonympha grassii cellobiohydrolase gene (PgCBH), which was highly expressed in Pseudotrichonympha grassii, a flagellate found in the hindgut of C. formosanus. In this study, the expression level of PgCBH was down-regulated by RNAi, causing the death of P. grassii, but no effect was observed for other flagellates found in C. formosanus. RNAi also resulted in significantly reduced exoglucanase activity, and no effect was observed for endoglucanase and β-glucosidase activities. This result demonstrated that the PgCBH gene plays a role in the protist lignocellulolytic process and is also important for host survival. PgCBH can be used as a target gene and has potential as a bioinsecticide for use against termites. [ABSTRACT FROM AUTHOR]

Replanting with seedlings or regenerating with coppice in second rotation is a major forestry management regime in short rotation forestry (SRF), but little is known about its effects on understorey vegetation conservation, timber production and economic benefits. To evaluate the effects of second rotation seedlings and coppice regime on the composition, structure and biomass of understorey vegetation, timber production and economic benefits of Eucalyptus plantations, a long-term (14 years) comparative study was conducted using three rotation regimes: (1) the first rotation planted with seedlings (FRs), (2) second rotation replanted with seedlings (SRs) and (3) another second rotation regenerated with coppice (SRc). Both successive rotation regimes significantly decreased the species richness, diversity and evenness of the total understorey vegetation. SRs did not affect the abundance of understorey species but significantly decreased the coverage and biomass of understorey vegetation. SRc significantly increased the abundance of the understorey plant species and maintained the coverage and biomass of the understorey vegetation equivalent to FRs. SRs showed the highest stand volume and net present value, however the highest internal rate of return occurred in SRc due to the reduced establishment and management costs. This suggested regenerating with coppice should be a more suitable successive rotation regime for increasing economic benefits as well as biodiversity conservation in south China. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate the level of hormone variation between the peripheral blood and spermatic vein plexus in patients with varicoceles. A total of 23 patients diagnosed with varicoceles were enrolled in the study. All patients underwent a testicular artery-sparing microsurgical varicocelectomy. During the operation, a blood sample from the ipsilateral spermatic vein plexus and a peripheral blood sample were collected. A radioimmunoassay was performed to determine the total testosterone, free testosterone, dihydrotestosterone and oestradiol levels. An enzyme-linked immunosorbent assay was performed to determine the albumin level. The mean age of the patients was 32.3 ± 9.3 years. Compared with the hormone level in the peripheral blood, the total testosterone, free testosterone, dihydrotestosterone, and oestrogen levels were significantly increased in the left or right spermatic vein plexus ( P < 0.05). There were no differences in the albumin levels in the peripheral blood and spermatic vein plexus ( P > 0.05). The mean total testosterone, free testosterone, dihydrotestosterone, and oestradiol levels in the left spermatic vein plexus were 10.8-fold, 29.0-fold, 2.0-fold, and 26.6-fold those of the peripheral blood. The hormone concentration in the spermatic vein plexus was significantly higher than that in the peripheral blood in patients with varicoceles. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The application of intravenous immune globulin (IVIG) has been recommended for treating hemolysis in neonates for several years. But in clinical work, more than one study reported that IVIG treatment maybe increased the risk of NEC in hemolytic patients. In light of this situation, we performed this meta-analysis. MATERIALS AND METHODS: We searched in PubMed, Embase, Cochrane databases for English references, and inWanfang,VIP, Cnki databases for Chinese references (all last launched on 2015/12/18). Ultimately, 5 studies (Including 4 Chinese articles) were incorporated into this metaanalysis. Odds ratio (OR) and weighted mean difference (WMD) were calculated using a random-effects or fixed-effects model, depending on the data type and heterogeneity of the included studies. RESULTS: (1) Baseline data including gestational age, gender and TBil between IVIG and control groups were compared in hemolytic infants, and showed no significance. (2) With respect to possible inducement of NEC, SGA and formula feeding were found no significance between IVIG and control groups. In contrast, birth weight was found significantly different between the two groups (WMD = 33.35; 95% CI, 20.70- 46.01; p < 0.00001). (3) Regarding the incidence of NEC and mortality, the result showed that there was a significant difference between the IVIG and the control groups in the risk of NEC (OR: 4.53; 95% CI, 2.34-8.79; p < 0.00001). CONCLUSIONS: Our results indicate that IVIG treatment for hemolysis may increase the risk of NEC in infants. But it does not increase the risk of final mortality. [ABSTRACT FROM AUTHOR]

To explore the aetiology of obstructive azoospermia ( OA) in Chinese infertility patients, 133 OA patients was included in this study diagnosed and evaluated by one major specialist trained urological infertility. We retrospected the medical records to collect relative information. All of the patients had been underwent physical examination, ultrasound scan to the urogenital system, serum hormone tests, genetic tests and two separate semen analyses. The mean age of all 133 patients was 32.7 ± 6.8 years. A total of 266 reproductive tract units (two/patient) were classified into four categories: no causes (Idiopathic) for 74 units (27.8%), single cause for 173 units (65.0%), double causes for 17 units (6.4%) and triple causes for two units (0.8%). As to single cause of OA, there were four types: trauma for 0 unit (0%), infection for 125 units (47.0%), dysplasia for 11 units (4.1%) and surgeries for 37 units (13.9%). As to total cause of OA, there were five types: infection for 144 units (54.1%), orchitis for 51 units (19.2%), epididymitis for 54 units (20.3%), gonorrhoea for 28 units (10.5%) and inguinal hernia repair surgery for 18 units (6.8%). The most frequent cause of obstructive azoospermia was infection revealed in these Chinese infertility populations, followed by idiopathic reason. [ABSTRACT FROM AUTHOR]

Annually, the extreme climate and special geological environments lead to frequent natural disasters, e.g., earthquakes, floods, etc. The disasters often bring serious casualties and enormous economic losses. Post-disaster surveying is very important for disaster relief and assessment. As the Unmanned Aerial Vehicle (UAV) remote sensing with the advantage of high efficiency, high precision, high flexibility, and low cost, it is widely used in emergency surveying in recent years. As the UAVs used in emergency surveying cannot stop and wait for the happening of the disaster, when the disaster happens the UAVs usually are working at everywhere. In order to improve the emergency surveying efficiency, it is needed to track the UAVs and assign the emergency surveying task for each selected UAV. Therefore, a UAV tracking and scheduling method for post-disaster survey is presented in this paper. In this method, Global Positioning System (GPS), and GSM network are used to track the UAVs; an emergency tracking UAV information database is built in advance by registration, the database at least includes the following information, e.g., the ID of the UAVs, the communication number of the UAVs; when catastrophe happens, the real time location of all UAVs in the database will be gotten using emergency tracking method at first, then the traffic cost time for all UAVs to the disaster region will be calculated based on the UAVs' the real time location and the road network using the nearest services analysis algorithm; the disaster region is subdivided to several emergency surveying regions based on DEM, area, and the population distribution map; the emergency surveying regions are assigned to the appropriated UAV according to shortest cost time rule. The UAVs tracking and scheduling prototype is implemented using SQLServer2008, ArcEnginge 10.1 SDK, Visual Studio 2010 C#, Android, SMS Modem, and Google Maps API. [ABSTRACT FROM AUTHOR]

The distribution of root length density of maize in ridge culture under alternate partial root-zone furrow irrigation (APFI) and conventional furrow irrigation (CFI) was investigated, and two-dimensional models of root length density and root uptake were developed to investigate the water use efficiencies under different furrow irrigation modes. Results indicated that APFI increased root depth and horizontal extended distance of maize, as well as water use efficiency (WUE). Values of the mean absolute error (MAE), the root mean square error (RMSE), and the index of agreement (di) between measured and simulated values of root length density of maize under APFI ranged from 0.26 to 0.68, 0.03 to 1.51, and 0.64 to 0.85 cm m-3, respectively; and the coefficient of determination (R2) was greater than 0.80. Values of MAE, RMSE, and di between measured and simulated values of root length density of maize under CFI ranged from 0.01 to 0.26, 0.01 to 0.60, and 0.61 to 0.96 cm m-3, respectively; and R2 was higher than 0.86. Dynamics of root uptake at different sites were simulated using the model of root water uptake. Root growth of maize under furrow irrigation was modeled using the 2D model of root length density with reasonable accuracy. Compared with CFI, water consumption rate of the maize in APFI was lower in key water requirement period, root uptake rate was higher in the end period, and WUE in APFI was higher by 5% than that in CFI. [ABSTRACT FROM AUTHOR]

The magnetic phase transitions in MnNiGe1 − xGa x ( x = 0.0725, 0.080, and 0.085) compounds were investigated by dc magnetization measurements. Due to the introduction of Ga, all the compounds crystallized in Ni2In-type structure at room temperature instead of TiNiSi-type structure for their parent compound MnNiGe. With increasing temperature, each compound goes through two magnetic phase transitions, i.e. magnetostructural phase transitions from antiferromagnetic (AFM) TiNiSi-type phase to ferromagnetic (FM) Ni2In-type phase and ferromagnetic to paramagnetic (FM-PM) transition of Ni2In-type phase. It was found that the magnetostructural phase transition temperatures Tt decreased with the increase of Ga content, while the FM-PM transition temperature TC almost did not change. Large inverse magnetic entropy Δ SM in the vicinity of Tt following a conventional one around TC was observed for each sample. [ABSTRACT FROM AUTHOR]

Multiple applications of fungicides are used to manage anthracnose caused by Colletotrichum orbiculare and gummy stem blight caused by Didymeila bryoniae, the two most common and destructive diseases on watermelon (Citrullus lanatus) in the mid-Atlantic region of the United States. To develop a sustainable, nonchemical management option, a split-plot experiment was conducted over 3 years to evaluate the effects of a no-till hairy vetch (Vicia villosa) cover crop on disease severity, plant growth, and fruit yield compared with two conventional bedding systems and fungicide application. The main plots were bedding strategies consisting of bare ground, polyethylene covering, or a hairy vetch cover crop that was planted in the fall, killed the following spring, and left on the soil surface as an organic mulch. The subplots were a nonfungicide control or a weekly application of a standard fungicide program. Hairy vetch mulch provided greater than a 65% reduction in the area under the disease progress curves of anthracnose and gummy stem blight and greater than an 88% decrease in diseased fruit compared with bare ground or polyethylene mulch. The reductions were comparable with those achieved by fungicide applications. Watermelon vine lengths in plots with hairy vetch were similar to or greater than those in plots with polyethylene or bare ground that were treated with fungicides. Marketable fruit in plots with hairy vetch was higher compared with bare ground in 2 of 3 years and was similar to that in plots treated with fungicides in all 3 years. Addition of fungicide application to hairy vetch treatment further reduced anthracnose in 1 year and gummy stem blight in 2 years but did not significantly increase fruit yield in all 3 years. This is the first demonstration that a no-till hairy vetch production system can reduce anthracnose and gummy stem blight on watermelon and that the production system has the potential to mitigate damage caused by these diseases. [ABSTRACT FROM AUTHOR]

The aims of this study were to create a copy number variant (CNV) profile of human chromosome 22 and to establish a genotype-phenotype correlation for patients with genomic abnormalities on chromosome 22. Thus, 1,654 consecutive pediatric patients with a diversity of clinical findings were evaluated by high-resolution chromosomal microarray analysis (CMA). We identified 25 individuals with abnormal CNVs on chromosome 22, representing 1.5% of the cases analyzed in this cohort. Meanwhile, we detected 1,298 benign CNVs on this chromosome in these individuals. Twenty-one of the 25 abnormal CNVs and the majority of the benign CNVs occurred through involvement of the 8 unstable genomic regions enriched with low copy repeats (LCR22A-H). The highly dynamic status of LCR22s within the 22q11 region facilitates the formation of diverse genomic abnormalities. This CNV profile provides a general perspective of the spectrum of chromosome 22 genomic imbalances and subsequently improves the CNV-phenotype correlations. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Eighty-eight isolates of Fusariunt oxysporum f. sp. niveum, collected from wilted watermelon plants and infested soil in Maryland and Delaware, were characterized by cross pathogenicity to muskmelon, race, and vegetative compatibility. Four isolates (4.5%) were moderately pathogenic to ≥2 of 18 muskmelon cultivars in a greenhouse test, and one representative isolate also was slightly pathogenic in field microplots. The four isolates all were designated as race 2, and were in vegetative compatibility group (VCG) 0082. Of the 74 isolates to which a VCG could be assigned, 41 were in VCG 0080, the VCG distributed most widely; 27 were in VCG 0082, and were distributed in half of the 20 watermelon fields surveyed; and 6 were in the newly described VCG 0083, and were restricted to three fields. Among the isolates in VCG 0080, 8 were designated as race 0, 21 as race 1, and 12 as race 2. Of the isolates in VCG 0082, 6 were designated as race 0, 11 as race 1, and 10 as race 2. All isolates in VCG 0083 were designated as race 2. Isolates from more than one race within the same VCG or isolates from more than one VCG were recovered from single plants and fields. No differences in aggressiveness on differential watermelon cultivars were observed among isolates from different VCGs of the same race. A diverse association between virulence and VCG throughout the Mid-Atlantic region suggests that the pathotypes of E oxysporum f. sp. niveum may be of local origin or at least long existent in the region. [ABSTRACT FROM AUTHOR]

Hairy vetch (Vicia villosa) used as a soil amendment is a newly described potential management tool for the suppression of Fusarium wilt of watermelon (Citrullus lanatus). However, the effect of inoculum density and the level of resistance in the host on the level of suppression are not understood. In this study, hairy vetch-induced wilt suppression was evaluated in the greenhouse on 12 watermelon cultivars with different levels of wilt resistance and in 16 naturally infested soil samples collected from commercial watermelon fields. Wilt suppression occurred in all but two cultivars and with the trend that suppression increased as the level of resistance in cultivars increased. Fusarium wilt suppression was 22, 53, and 63% in hairy vetch-amended soil compared with nonamended soil on cultivars ranked as susceptible, moderately resistant, and highly resistant, respectively. Suppression also occurred in nine of the soils that contained populations of Fusarium oxysporum f. sp. niveum below 1,100 CFU/g of soil. However, at this level or higher, significant wilt suppression was not observed. The magnitude of disease suppression decreased with the increase of inoculum in the soils. The induced wilt suppression appeared to be correlated with an increase in bacterial populations in soil. Hairy vetch-induced suppression to Fusarium wilt in watermelon is dependent on the resistance level of cultivars and is overcome by high inoculum level of E oxysporum f. sp. niveum in soil. [ABSTRACT FROM AUTHOR]

Hairy vetch (Vicia villosa Roth) as a soil amendment was evaluated for suppression of Fusarium wilt of watermelon and soil populations of Fusarium oxysporum f sp. niveum in greenhouses microplot, and field studies. When mixed at 1 or 5% (wt/wt) in a loamy sand soil that was artificially or naturally infested with race 2 of F oxysporum f. sp. niveum, pulverized dry hairy vetch, crab shell, and urea provided the best suppression (53 to 87% reduction) of Fusarium wilt on watermelon seedlings among 13 plant and animal residues screened. Soil amended with hairy vetch at 0.25 or 0.5% (wt/wt) in microplots resulted in 54 to 69% decreased wilt incidence and 100 to 220% increase of watermelon plant biomass. Hairy vetch winter cover crop incorporated into field plots under black plastic provided 42 to 48% reduction of wilt incidence, 64 to 100% increase of plant biomass, and a 34 to 68% increase in weight of fruit, comparable to improvements achieved by the soil fumigants methyl bromide or 1,3-dichloropropene plus 35% chloropicrin. Soil amendment with hairy vetch also increased the sugar content of watermelon fruit 10 to 15%. Significant reductions in the populations of F. oxysporum f. sp. niveum were not observed in hairy vetch-amended soil in microplots and field plots, but were observed in green-house pot soil amended with 5% (wt/wt) hairy vetch, which was attributed primarily to increased levels of fungicidal ammonia produced during decomposition. Incorporating hairy vetch into mulched soil can be an alternative or supplement to cultivar resistance and crop rotation for management of Fusarium wilt of watermelon. [ABSTRACT FROM AUTHOR]

The entire magnetization process of TlCuCl3 has been experimentally investigated up to 100 T employing the single-turn technique. The upper critical field Hc2 is observed to be 86.1 T at 2 K. A convex slope of the M-H curve between the lower and upper critical fields (Hc1 and Hc2) is clearly observed, which indicates that a particle-hole symmetry is broken in TlCuCl3. By quantum Monte Carlo simulation and the bond-operator theory method, we find that the particle-hole symmetry breaking results from strong interdimer interactions. [ABSTRACT FROM AUTHOR]

A large-scale carbon nanotube/CoFe2O4 (CNTs/CoFe2O4) spinel nanocomposite has been fabricated by a chemical vapor deposition method using CoFe2O4 nanoparticles as catalysts. A uniform mixture of CNTs and CoFe2O4 nanoparticles was obtained simultaneously. The structure and chemical composition of the product were investigated using various techniques, such as x-ray diffraction, high-resolution transmission electron microscopy, and electron energy loss spectroscopy. It was found that the particles functionalized on CNTs were cubic phase CoFe2O4. Microwave absorption of the CNT/CoFe2O4 nanocomposites at 2–18 GHz is evidently enhanced, as compared with that of both pure CNTs and CoFe2O4 nanoparticles. The enhancement mechanism is discussed based on magnetization hysteresis loop measurement and electromagnetic theory. [ABSTRACT FROM AUTHOR]

In September 2015, the United Nations adopted "Transforming Our World: the 2030 Agenda for Sustainable Development" as a new ambitious global development plan to end extreme poverty, fight inequality and injustice, and combat climate change. Comprising 17 Sustainable Development Goals (SDGs) with 169 associated targets, the agenda recognizes the complex and diverse challenges that the world of today faces. It has been proposed by the United Nations Committee of Experts on Global Geospatial Information Management (UN-GGIM) that it is impossible to measure and monitor the SDGs without the use of accurate, reliable and up-to-date geospatial data. Therefore, establishing a dynamic SDGs monitoring mechanism based on geospatial data is a critical issue for international communities.This ISPRS and GEO workshop aimed at providing a focus forum to discuss the opportunities and challenges of geospatial-enabled SDGs monitoring (GI4SDGs), to present the recent R&D progress on relevant topics (including global mapping and collaborative crowd-sourced cloud mapping), and to explore future collaborations. The workshop was organized in conjunction with ISPRS IC WG IV/III (Global mapping: updating, verification and interoperability), ISPRS WG IV/4 (Collaborative Crowdsourced Cloud Mapping), GEO Community Activity (Land Cover and Land Cover Change), Central South University and National Geomatics Center of China.The workshop received 26 submissions, which were all reviewed by the scientific and organizing committees. According to the review results, 17 full papers were accepted and published in ISPRS Archives. There were 28 oral presentations including invited presentations in the workshop. We hope these contributions would trigger new interesting ideas or solutions for monitoring the SDGs with geospatial data in the near future.At last, we cordially thank all the authors/speakers for their contributions and all reviewers for their constructive and valuable comments. [ABSTRACT FROM AUTHOR]

Facilitative interactions occur between the plants in intercropping systems, however, the underlying allelopathy mechanisms are poorly understood. We determined the effects of potato-onion (Allium cepa var. agrogatum Don.) intercrop on root morphology of tomato (Lycopersicon esculenum L.) through volatile organic compounds (VOCs). There were four treatments as (i) Tomato/tomato without VOCs interaction (-TT), (ii) Tomato/tomato with VOCs interaction (+TT, control), (iii) Potato-onion/tomato without VOCs interaction (-OT) and (iv) Potato-onion/tomato with VOCs interaction +(OT) in glasshouses. As compared to tomato, VOCs from potato-onion significantly increased the number of root tips total length but decreased the root diameter of tomato, however significantly the increase the tomato root length (0-0.5 mm mean diameter). These results indicated that the tomato root morphology has influenced by aboveground secreted VOCs from neighboring plants in potato-onion intercropping system. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinicopathological characteristics of rashes in monkeypox patients through a series of skin biopsies, and examine their pathological features and the most effective tests. Methods: Patients with monkeypox virus infection admitted to Beijing Ditan Hospital from June to August 2023 were identified. Among them, 24 patients underwent skin biopsies for clinical pathological study that were included in this study. Clinical information, rash pictures, and nucleic acid test results were analyzed using histopathology, immunohistochemistry, RNAscope ® hybridization and electron microscopy. Results: All 24 patients were male, including 14 patients with concurrent human immunodeficiency virus infection. Their average age was (32.3±5.4) years. The nucleic acid test confirmed monkeypox virus infection. The clinical feature of monkeypox rashes was solitary rather than clustered distribution, with rashes occurring in similar phase, distinguishing it from herpesvirus. The rashes in these patients were mostly scattered, with an average of (13.0±11.8) rashes, and most commonly present in the perineum, face, limbs, and trunk. The three main pathological features of these rashes were ballooning degeneration of the epidermal spinous cell layer, the characteristic intra-cytoplasmic Guarnieri's bodies and significant infiltration of inflammatory cells in whole dermal layer. Immunohistochemistry, RNAscope ® hybridization, and electron microscopy can all effectively detect the monkeypox virus. Electron microscopy showed viral replication in various types of skin cells. Conclusions: The study describes the pathological features of monkeypox virus rashes. Pathological examination of skin biopsy samples is helpful to diagnose these rashes. The study suggests that the monkeypox virus has a unique epitheliotropic affinity and can infect various types of cells in the skin.

The seed serves as the primary source for establishing microbial populations in plants across subsequent generations, influencing plant growth and overall health. Cropping conditions, especially farming practices, can influence the composition and functionality of the seed microbiome. Very little is known about the differences in seed microbiome between organic and conventional production systems. In this study, we characterized the endophytic microbial populations in seeds of rice grown under organic and conventional management practices through culture-dependent and -independent analyses. The V4 region of 16S rRNA was used for bacterial taxa identification, and the ITS1 region was used for the identification of fungal taxa. Our results revealed significantly higher Shannon and Simpson indices for bacterial diversity in the conventional farming system, whereas the fungal diversity was higher for observed, Shannon, and Simpson indices in the organic farming system. The cultivable endophytic bacteria were isolated and identified using the full-length 16S rRNA gene. There was no difference in culturable endophytic bacterial isolates in rice seeds grown under both conventional and organic farming systems. Among 33 unique isolates tested in vitro , three bacteria- Bacillus sp. ST24, Burkholderia sp. OR5, and Pantoea sp. ST25-showed antagonistic activities against Marasmius graminum, Rhizoctonia solani AG4, and R. solani AG11, the fungal pathogens causing seedling blight in rice., Importance: In this paper, we studied the differences in the endophytic microbial composition of rice seeds grown in conventional and organic farming systems. Our results demonstrate a greater bacterial diversity in conventional farming, while organic farming showcases a higher fungal diversity. Additionally, our research reveals the ability of seed bacterial endophytes to inhibit the growth of three fungal pathogens responsible for causing seedling blight in rice. This study provides valuable insights into the potential use of beneficial seed microbial endophytes for developing a novel microbiome-based strategy in the management of rice diseases. Such an approach has the potential to enhance overall plant health and improve crop productivity., Competing Interests: The authors declare no conflict of interest.

Objective: To investigate the clinicopathological features and differential diagnosis of primary mucosal CD30-positive T-cell lymphoproliferative disorders (pmCD30 + TLPD). Methods: Eight cases of pmCD30 + TLPD diagnosed from 2013 to 2023 at the Department of Pathology, Beijing Friendship Hospital Affiliated to Capital Medical University and Beijing Ludaopei Hospital were retrospectively collected. The immunophenotype, EBV infection status and T-cell receptor (TCR) clonability of tumor cells were examined. The clinicopathological features were analyzed and related literatures were reviewed. Results: There were 5 females and 3 males, aged 28 to 73 years, without B symptoms, lack of trauma and autoimmune diseases. Seven cases occurred in oral mucosa and one in anal canal mucosa. Submucosal nodules with ulcerations were presented in all cases except one, which only submucosal nodule. Morphologically, there was different distribution of allotypic lymphocytes in inflammatory background. Four cases showed "kidney-shaped", "embryonic" and "horseshoe-shaped" cells, and one case resembled Hodgkin and Reed/Sternberg (HRS) cells. Allotypic lymphocytes expressed CD3 (7/8), CD4+/CD8-(7/8) and CD4-/CD8-(1/8). CD30 was uniformly strongly positive while ALK and CD56 were negative. In situ hybridization of EBER was negative in five cases (5/5). Clonal TCR gene rearrangement was positive in two cases. Four patients did not receive radiotherapy or chemotherapy. All the seven patients survived without disease except one died due to concurrent leukopenia. Conclusions: pmCD30 + TLPD had a broad morphological spectrum and could be easily confused with primary cutaneous CD30 + TLPD and systemic ALK-negative anaplastic large cell lymphoma involving mucosa, which may lead to misdiagnosis. Although the majority of the cases had a favorable prognosis, a few cases relapsed or progressed to lymphoma.

Objective: To study the clinicopathological features of Sjogren's syndrome (SS) with liver injury and to improve the understanding of this disease. Methods: Forty-nine patients with SS complicated with liver injury were collected from Beijing Ditan Hospital, Capital Medical University from October 2008 to January 2022. All patients underwent ultrasound-guided liver biopsy, and all specimens were stained with HE. The histopathologic characteristics were observed and the pathologic indexes were graded. Immunohistochemical stains for CK7, CK19, CD38, MUM1 and CD10 were performed by EnVision method; and special histochemical stains for reticulin, Masson's trichrome, Rhodanine, Prussian blue, periodic acid Schiff (PAS) and D-PAS stains were conducted . Results: The age of patients ranged from 31 to 66 years, including 3 males and 46 females. SS combined with drug-induced liver injury was the most common (22 cases, 44.9%), followed by autoimmune liver disease (13 cases, 26.5%, including primary biliary cholangitis in eight cases, autoimmune hepatitis in 3 cases, and PBC-AIH overlap syndrome in 2 cases), non-alcoholic fatty liver disease (NAFLD, 9 cases, 18.4%) and other lesions (5 cases, 10.2%; including 3 cases of nonspecific liver inflammation, 1 case of liver amyloidosis, and 1 case of porto-sinusoidal vascular disease). Among them, 28 cases (57.1%) were associated with obvious interlobular bile duct injury, mainly in SS combined with PBC group and drug-induced liver injury group. Twenty-three cases (46.9%) were associated with hepatocyte steatosis of varying degrees. In SS with autoimmune liver disease group, ISHAK score, degree of fibrosis bile duct injury, bile duct remodeling, lymphocyte infiltration of portal area, and plasma cell infiltration, MUM1 and CD38 expression; serum ALP and GGT, IgM; elevated globulin; positive AMA, proportion of AMA-M2 positive and IgM positive were all significantly higher than those in other groups(all P <0.05). Serum ALT, direct bilirubin and SSA positive ratio in SS combined with drug liver group were significantly higher than those in other groups(all P <0.05). The serum total cholesterol level in SS combined with PBC group ( P= 0.006) and NALFD group ( P= 0.011) were significantly higher than those in other groups ( P <0.05). Conclusions: The pathologic manifestations of SS patients with liver injury are varied. The inflammatory lesions of SS patients with autoimmune liver disease are the most serious, and the inflammatory lesions of SS patients with non-alcoholic fatty liver disease and non-specific inflammation are mild. Comprehensive analysis of liver histopathologic changes and laboratory findings is helpful for the diagnosis of SS complicated with different types of liver injury.

Objective: To investigate the clinical and pathologic features and diagnosis of follicular lymphoma (FL) with a predominantly diffuse growth pattern (DFL) with 1p36 deletion. Methods: Eight cases of DFL with 1p36 deletion diagnosed at Department of Pathology, Beijing Friendship Hospital, Capital Medical University ( n =5) and the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital ( n =3) from January 2017 to January 2023 were included. Their clinicopathologic features and follow-up data were analyzed. Immunohistochemistry and fluorescence in situ hybridization (FISH) were performed. Results: There were five males and three females, with a median age of 67 years, and inguinal lymphadenopathy was found as the main symptom. Histologically, similar morphologic features were sheared among all cases, with effaced nodal structure and characterized by proliferation of centrocytes in a diffuse pattern, with or without follicular components. The germinal center-related markers such as CD10 and/or bcl-6 were expressed in the tumor cells, and 1p36 deletion but not bcl-2 translocation was appreciable in these cases. Conclusions: DFL with 1p36 deletion is a rare subtype of FL, with some overlaps with other types of FL or indolent B-cell lymphomas in their pathologic features. An accurate diagnosis requires comprehensive considerations based on their clinical, pathologic, immunohistochemical, and molecular features.

Objective: To investigate the clinicopathologic features of progressively transformed germinal center-like follicular T-cell lymphoma (PTGC-like FTCL). Methods: The clinicopathologic data of 14 PTGC-like FTCL cases that were diagnosed at the Beijing Friendship Hospital Affiliated to the Capital Medical University from January 2017 to January 2022 were retrospectively collected. Clinicopathological features, immunophenotype, and Epstein-Barr virus (EBV) infection status were analyzed in these cases. Polymerase chain reaction (PCR) was performed to detect the clonal gene rearrangements of T cell receptor (TCR) and the immunoglobulin (Ig) in 10 and 8 cases, respectively. Results: The male to female ratio was 5∶2. The median age was 61 years (range 32-70 years). All patients had lymphadenopathy at the time of diagnosis. By using the Ann Arbor system staging, seven cases were classified as stage Ⅰ-Ⅱ, and seven cases as stage Ⅲ-Ⅳ. Seven cases had B symptoms, four cases had splenomegaly, and two cases had skin rash and pruritus. Previously, three cases were diagnosed as classic Hodgkin's lymphoma, three cases as small B-cell lymphoma, two cases as atypical lymphoid hyperplasia unable to exclude angioimmunoblastic T-cell lymphoma (AITL), one case as EBV-associated lymphoproliferative disorder, and one case as peripheral T-cell lymphoma (PTCL) associated with the proliferation of B cells. All the 14 cases showed that the large nodules were composed of mature CD20+, IgD+B lymphocytes admixed with small aggregates of neoplastic cells with pale to clear cytoplasm. Moreover, hyperplastic germinal centers (GCs) and Hodgkin/Reed-Sternberg-like (HRS-like) cells were seen within these nodules in two and five cases, respectively. The neoplastic cells expressed CD3 (14/14), CD4 (14/14), PD1 (14/14), ICOS (14/14), CD10 (9/14), bcl-6 (12/14), CXCL13 (10/14), and CD30 (10/14). The HRS-like cells in five cases expressed CD20 (2/5), PAX5 (5/5), CD30 (5/5), CD15 (2/5), LCA (0/5), OCT2 (5/5) and BOB1 (2/5). Moreover, neoplastic T cells formed rosettes around HRS-like cells. EBV-encoded RNA (EBER) in situ hybridization showed scattered, small, positive bystander B lymphocytes in 8/14 cases, including 3/5 cases containing HRS-like cells. All tested cases (including five with HRS-like cells) showed monoclonal TCR gene rearrangement and polyclonal Ig gene rearrangement. Conclusions: PTGC-like FTCL is a rare tumor originated from T-follicular helper cells. It could be distinguished from angioimmunoblastic T-cell lymphoma by the formation of follicular structure, and lack of follicular dendritic cell proliferation outside the follicles and the polymorphous inflammatory background. In addition, it should be differentiated from lymphocyte-rich classical Hodgkin's lymphoma and low-grade B cell lymphoma.

Objective: To investigate the clinical, pathological and immunophenotypic features, molecular biology and prognosis of fibrin-associated large B-cell lymphoma (LBCL-FA) in various sites. Methods: Six cases of LBCL-FA diagnosed from April 2016 to November 2021 at the Beijing Friendship Hospital, Capital Medical University, Beijing, China and the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China were collected. The cases were divided into atrial myxoma and cyst-related groups. Clinical characteristics, pathological morphology, immunophenotype, Epstein Barr virus infection status, B-cell gene rearrangement and fluorescence in situ hybridization of MYC, bcl-2, bcl-6 were summarized. Results: The patients' mean age was 60 years. All of them were male. Three cases occurred in atrial myxoma background, while the others were in cyst-related background, including adrenal gland, abdominal cavity and subdura. All cases showed tumor cells located in pink fibrin clot. However, three cyst-related cases showed the cyst wall with obviously fibrosis and inflammatory cells. All cases tested were non germinal center B cell origin, positive for PD-L1, EBER and EBNA2, and were negative for MYC, bcl-2 and bcl-6 rearrangements, except one case with MYC, bcl-2 and bcl-6 amplification. All of the 5 cases showed monoclonal rearrangement of the Ig gene using PCR based analysis. The patients had detailed follow-ups of 9-120 months, were treated surgically without radiotherapy or chemotherapy, and had long-term disease-free survivals. Conclusions: LBCL-FA is a group of rare diseases occurring in various sites, with predilection in the context of atrial myxoma and cyst-related lesions. Cyst-related lesions with obvious chronic inflammatory background show more scarcity of lymphoid cells and obvious degeneration, which are easy to be missed or misdiagnosed. LBCL-FA overall has a good prognosis with the potential for cure by surgery alone and postoperative chemotherapy may not be necessary.

Objective: To investigate the clinicopathological features of angioimmunoblastic T-cell lymphoma pattern Ⅰ (AITL Pattern Ⅰ). Methods: The clinicopathological data of 11 AITL Pattern Ⅰ cases that were diagnosed at the Beijing Friendship Hospital Affiliated to Capital Medical University (10 cases) and Beijing Lu Daopei Hospital (1 cases) from January 2019 to October 2021 were retrospectively collected. Immunophenotype, Epstein-Barr virus infection status and T cell receptor (TCR) clonality of the tumor cells were tested, and clinicopathological features of cases were analyzed. Results: Among the 11 AITL Pattern Ⅰ cases, the male to female ratio was 1.2∶1.0. The median age was 59 years (range 47-78 years). Seven cases had B symptoms, while eleven cases presented with systemic lymphadenopathy. According to Ann Arbor system staging, two cases were classified as stage Ⅰ-Ⅱ, and 9 cases as stage Ⅲ-Ⅳ. Hepatosplenomegaly was present in two cases (2/11), three cases (3/11) had skin rash and pruritus, and two cases (2/11) had pleural effusion. Previously, 6 cases (6/11) were diagnosed as reactive hyperplasia, 1 case (1/11) as EBV-associated lymphoproliferative disorder, and 4 cases (4/11) as hyperplasia of lymphoid tissue, which was unable to exclude lymphoma. Histologically, all the 11 cases showed hyperplastic follicles in the paracortical regions with well-formed germinal centers. The hyperplastic follicles showed ill-defined borders and attenuated mantle zones in 7 cases. Mantle zones completely disappeared in 4 cases. The follicles were surrounded by a thin layer of atypical lymphocytes with bright or faintly stained cytoplasm. In 2 cases, the clear cells were located between the germinal centers and the thin residual mantle cell layers, showing a circular growth pattern. The cells were medium in size, with irregular karyotype, coarse chromatin and indistinct nucleoli. Immunohistochemically, CD21 staining showed that the meshworks of follicular dendritic cells(FDC)were mainly confined to the follicles. There was a subtle expansion of the meshworks of FDC in 4 cases with ill-defined borders. The atypical cells surrounding the follicles expressed CD3 (11/11), CD4 (11/11), PD-1 (11/11), CXCL13 (6/11), ICOS (10/11) and CD10 (7/11). PD-1 staining showed a strong perifollicular pattern, and a small number of positive cells were scattered around the high endothelial veins in the interfollicular region. CXCL13, ICOS and CD10 showed similar distribution patterns. EBV-encoded small RNA probe (EBER) in situ hybridization showed that EBER positive B lymphocytes were scattered in the interfollicular region (5-20/HPF) in all cases. T cell receptor gene rearrangement was monoclonal in all cases. Conclusions: Diagnosing AITL Pattern Ⅰ may be challenging and requires comprehensive analysis of clinical manifestations, histological morphology, immunophenotype and gene rearrangement results.

Objective: To investigate the clinicopathological features and prognosis of cytotoxic T-cell lymphoma (CTL). Methods: The clinicopathological data of 134 CTL patients in Beijing Friendship Hospital Affiliated to Capital Medical University, the 989 Hospital of PLA Joint Logistics Support force (formerly the 152 Hospital) and the Fourth Hospital of Hebei Medical University from 2008 to 2020 were retrospectively collected. Immunophenotype, Epstein-Barr virus infection status and T cell receptor (TCR) clonality of tumor cells were assessed, and clinicopathological features and prognosis of patients were analyzed. Results: Among the 134 CTL patients, the male to female ratio was 1.7∶1.0, the median age was 49.5 years (range 3-83 years), and 100 cases (74.6%) were under 60 years old. Forty-six point nine percent of the patients (53/113) had B symptoms. Most of the patients presented with systemic superficial lymphadenopathy. According to the Ann Arbor staging system, 36.8% (39/106) of the patients were in stage Ⅰ-Ⅱ, and 63.2% (67/106) in stage Ⅲ-Ⅳ. The rate of extranodal involvement was 51.6% (66/128). Spleen was involved in 24.2% (31/128) of the cases. Morphology showed diffuse growth of abnormal lymphocytes, infiltrating and destroying normal tissue structure. Immunohistochemical staining showed that tumor cells expressed T cell antigens (CD2, CD3, CD5, and CD7), and 72.0% (77/107) of them had decreased or lost expression of one or more antigens. According to the numbers of CD4 and CD8 expression in tumor cells, 70 cases (52.2%) were grouped into CD8 + >CD4 + group. The expression rates of TIA-1 and granzyme B were 99.2% (119/120) and 79.8% (95/119), respectively. CD20 abnormal expression rate was 27.6% (37/134) and CD56 was negative in all cases. The median Ki-67 proliferative index was 45.0% (range 5%-80%). In situ hybridization of small RNA encoded by Epstein-Barr virus was negative. Clonal TCR gene rearrangement analysis was performed on 49 cases and was positive in all cases. Ninety-one patients were followed up for a median of 36 months (range, 1 to 240 months), and 40 of the 91 patients (44.0%) died. The twenty-three patients were in complete remission (including 13 cases with localized single extranodal mass). The 3-year and 5-year overall survival rates were 53.5% and 49.4%, respectively. Univariate analysis showed that B symptom, spleen involvement, extranodal involvement, clinical stage, CD8 + >CD4 + phenotype, abnormal expression of CD20 and Ki-67 proliferation index (>60%) were associated with overall survival ( P <0.05). The multivariate Cox regression analyses showed that spleen involvement and CD8 + >CD4 + phenotype were independent prognostic factors for overall survival in CTL patients. Conclusions: CTL are more commonly found in adult males under 60 years old, often accompanied by B symptom, with a high proportion of extranodal involvement and more CD8 positive phenotypes. Spleen involvement and CD8 + >CD4 + phenotype are independent predictors of CTL overall survival. Some patients with localized extranodal CTL may have a good prognosis.

Objective: To investigate the clinicopathological features and prognosis of skeletal-muscle cytotoxic T-cell lymphoma (CTL). Methods: The clinical data of 14 cases of skeletal muscle CTL and 47 cases of non-skeletal muscle extranodal CTL patients in Beijing Friendship Hospital Affiliated to Capital Medical University and the 989 Hospital of the joint logistics support force of the people's Liberation Army (the former 152 hospital) from 2008 to 2019 were collected retrospectively. Immunophenotype, EBV infection status and T-cell receptor (TCR) clonality of tumor cells were evaluated. The clinicopathological features and prognosis of the two groups were compared. Results: Skeletal-muscle CTL accounted for 23.0% (14/61) of extranodal CTL in the same period. The median age of the patients was 42.3 years (range 11-76 years), including six males and eight females. The main clinical manifestations were painless masses. Two patients (2/14) had B symptoms. The tumors occurred in the cheek (7 cases), the tongue (4 cases), the lower lip (3 cases) and the left upper arm (2 cases), and in two cases had two sites. Ten cases were of stage ⅠE and four cases stage ⅡE. Compared with non-skeletal-muscle extranodal CTL, many patients of skeletal-muscle CTL did not have B symptoms, the clinical stage was lower, and the tumor mainly involved the oral cavity (cheek, tongue and lip, P <0.05). Morphologically, the tumor showed diffuse infiltration of heterotypic lymphocytes in skeletal muscle. Immunohistochemistry showed that in 11/14 cases, there were reduced or loss of expression of some the T cell antigens (CD2, CD3, CD5, CD7). TIA-1, Gr B and CD8 (CD8 + >CD4 + ) were expressed in all cases, and CD56 was negative. The median Ki-67 proliferation index was 35.0% (range 5%-60%). EBER in situ hybridization was negative in all cases. The results of TCR clonality analysis showed clonal TCR gene rearrangement were detected in eight cases. The median follow-up time was 40 months (range 10-67 months). Ten patients were tumor free; the 5-year survival rate of skeletal-muscle CTL was 100%. Compared with non-skeletal-muscle extranodal CTL (5-year overall survival rate was 35.9%), the difference was statistically significant (χ²=8.277, P =0.004). Conclusions: Skeletal-muscle CTL mostly occurs in the skeletal muscle of cheek and mouth. Tumor cells show morphologic characteristics of muscle invasion and myositis-like feature. It also shows CD8 + >CD4 + immunophenotype, cytotoxic molecular pattern and is associated with low clinical stage and good prognosis.

Objective: To investigate the translocations of MYC, bcl-2 and bcl-6 genes, the Epstein-Barr virus (EBV) status and the clinicopathological features of primary cardiac large B cell lymphoma (LBCL). Methods: Seven cases of primary cardiac LBCL were collected at Beijing Friendship Hospital, Capital Medical University, China from February 2013 to May 2019. The clinical feature, pathological morphology and immunophenotype were analyzed. The detections of EBV and gene rearrangements of MYC, bcl-2 and bcl-6 were conducted. The 2017 WHO classification of tumors of haematopoietic and lymphoid tissues was used to classify the tumors. Results: Four patients with right atrial lesions showed diffuse infiltration of medium size lymphoid cells with small vascular hyperplasia, without evidence of EBV infection. Without detectable gene rearrangements of MYC and bcl-2, 2 of the patients showed bcl-6 gene break-apart. The diagnosis was revised from diffuse LBCL to high-grade B-cell lymphoma, not otherwise specified (HGBL-NOS). There was a case of CD5 + diffuse LBCL involving the right atrium and ventricle and 2 cases of fibrin-associated diffuse LBCL located at left atrium without gene rearrangements of MYC, bcl-2 and bcl-6. However, EBER and EBNA2 were highly expressed in fibrin-associated diffuse LBCL. The patients were followed up for 10-71 months. Four cases of HGBL-NOS and a case of CD5 + diffuse LBCL received R-CHOP with/without autologous stem cell transplantation. All but two patients survived. Two cases of fibrin-associated diffuse LBCL were disease free without adjuvant chemotherapy and radiotherapy. Conclusions: Primary cardiac LBCL is heterogeneous, including at least HGBL-NOS. Primary cardiac HGBL-NOS most frequently occurs in the right atrium. Tumor cells of primary cardiac LBCL have the morphological characteristics similar to Burkitt lymphoma, lacking MYC and bcl-2 gene rearrangements, but usually show bcl-6 gene disruption. Fibrin-associated diffuse LBCL has a good prognosis and postoperative chemotherapy seems unnecessary.