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Your search keyword '"Zhou, Xiangtian"' showing total 303 results
Start Over Author "Zhou, Xiangtian" Publication Type Academic Journals
303 results on '"Zhou, Xiangtian"'

4. IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

Author

Ostrin, Lisa A, Harb, Elise, Nickla, Debora L, Read, Scott A, Alonso-Caneiro, David, Schroedl, Falk, Kaser-Eichberger, Alexandra, Zhou, Xiangtian, and Wildsoet, Christine F

Subjects
Eye Disease and Disorders of Vision, Eye, Animals, Humans, Axial Length, Eye, Choroid, Bruch Membrane, Myopia, Models, Animal, Tomography, Optical Coherence, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry
Abstract

The choroid is the richly vascular layer of the eye located between the sclera and Bruch's membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject to modulation by a variety of physiologic and visual stimuli. In this review, the anatomy and function of the choroid are summarized and links between the choroid, eye growth regulation, and myopia, as demonstrated in animal models, discussed. Methods for quantifying choroidal thickness in the human eye and associated challenges are described, the literature examining choroidal changes in response to various visual stimuli and refractive error-related differences are summarized, and the potential implications of the latter for myopia are considered. This review also allowed for the reexamination of the hypothesis that short-term changes in choroidal thickness induced by pharmacologic, optical, or environmental stimuli are predictive of future long-term changes in axial elongation, and the speculation that short-term choroidal thickening can be used as a biomarker of treatment efficacy for myopia control therapies, with the general conclusion that current evidence is not sufficient.

Published
2023

9. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author

Bailey-Wilson, Joan E., Baird, Paul N., Barathi, Veluchamy A., Biino, Ginevra, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Haarman, Annechien E.G., Haller, Toomas, Hammond, Christopher J., Han, Xikun, Hayward, Caroline, He, Mingguang, Hewitt, Alex W., Hoang, Quan, Hysi, Pirro G., Iglesias, Adriana I., Igo, Robert P., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Khawaja, Anthony P., Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Metspalu, Andres, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Pärssinen, Olavi, Paterson, Andrew D., Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Saw, Seang-Mei, Simpson, Claire L., Stambolian, Dwight, Tai, E-Shyong, Tedja, Milly S., Tideman, J. Willem L., Tsujikawa, Akitaka, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Vitart, Veronique, Wang, Ningli, Wang, Ya Xing, Wedenoja, Juho, Wei, Wen Bin, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Yam, Jason C.S., Yamashiro, Kenji, Yap, Maurice K.H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Bunce, Catey, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon, Cipriani, Valentina, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John, Garway-Heath, David, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse A., Khaw, Peng Tee, Khawaja, Anthony, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James, Muthy, Zaynah, O'Sullivan, Eoin, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Tapp, Robyn, Thaung, Caroline, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen, Viswanathan, Ananth, Williams, Katie, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Choquet, Hélène, and Ohno-Matsui, Kyoko

Published
2023
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10. PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.

Author

Yu, Jialing, Liang, Xiaoyang, Ji, Yanchun, Ai, Cheng, Liu, Junxia, Zhu, Ling, Nie, Zhipeng, Jin, Xiaofen, Wang, Chenghui, Zhang, Juanjuan, Zhao, Fuxin, Mei, Shuang, Zhao, Xiaoxu, Zhou, Xiangtian, Zhang, Minglian, Wang, Meng, Huang, Taosheng, Jiang, Pingping, and Guan, Min-Xin

Subjects
Animals, Mice, Knockout, Humans, Mice, Optic Atrophy, Hereditary, Leber, Mitochondrial Proteins, Amino Acid Substitution, Mutation, Missense, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Female, Male, Adenosine Triphosphatases, LIM Domain Proteins, Genetic diseases, Genetics, Mitochondria, Molecular pathology, Ophthalmology, Eye Disease and Disorders of Vision, Neurosciences, Pediatric, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Medical and Health Sciences, Immunology
Abstract

Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye disease. X-linked nuclear modifiers were proposed to modify the phenotypic manifestation of LHON-associated mitochondrial DNA (mtDNA) mutations. By whole-exome sequencing, we identified the X-linked LHON modifier (c.157C>T, p.Arg53Trp) in PRICKLE3 encoding a mitochondrial protein linked to biogenesis of ATPase in 3 Chinese families. All affected individuals carried both ND4 11778G>A and p.Arg53Trp mutations, while subjects bearing only a single mutation exhibited normal vision. The cells carrying the p.Arg53Trp mutation exhibited defective assembly, stability, and function of ATP synthase, verified by PRICKLE3-knockdown cells. Coimmunoprecipitation indicated the direct interaction of PRICKLE3 with ATP synthase via ATP8. Strikingly, cells bearing both p.Arg53Trp and m.11778G>A mutations displayed greater mitochondrial dysfunction than those carrying only a single mutation. This finding indicated that the p.Arg53Trp mutation acted in synergy with the m.11778G>A mutation and deteriorated mitochondrial dysfunctions necessary for the expression of LHON. Furthermore, we demonstrated that Prickle3-deficient mice exhibited pronounced ATPase deficiencies. Prickle3-knockout mice recapitulated LHON phenotypes with retinal deficiencies, including degeneration of retinal ganglion cells and abnormal vasculature. Our findings provided new insights into the pathophysiology of LHON that were manifested by interaction between mtDNA mutations and X-linked nuclear modifiers.

Published
2020

17. Scleral hypoxia is a target for myopia control

Author

Wu, Hao, Chen, Wei, Zhao, Fei, Zhou, Qingyi, Reinach, Peter S., Deng, Lili, Ma, Li, Luo, Shumeng, Srinivasalu, Nethrajeith, Pan, Miaozhen, Hu, Yang, Pei, Xiaomeng, Sun, Jing, Ren, Ran, Xiong, Yinghui, Zhou, Zhonglou, Zhang, Sen, Tian, Geng, Fang, Jianhuo, Zhang, Lina, Lang, Jidong, Wu, Deng, Zeng, Changqing, Qu, Jia, and Zhou, Xiangtian

Published
2018

20. Myopia

Author

Baird, Paul N., Saw, Seang-Mei, Lanca, Carla, Guggenheim, Jeremy A., Smith III, Earl L., Zhou, Xiangtian, Matsui, Kyoko-Ohno, Wu, Pei-Chang, Sankaridurg, Padmaja, Chia, Audrey, Rosman, Mohamad, Lamoureux, Ecosse L., Man, Ryan, and He, Mingguang

Published
2020
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28. The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leberʼs hereditary optic neuropathy-associated mitochondrial DNA mutation

Author

Jiang, Pingping, Jin, Xiaofen, Peng, Yanyan, Wang, Meng, Liu, Hao, Liu, Xiaoling, Zhang, Zengjun, Ji, Yanchun, Zhang, Juanjuan, Liang, Min, Zhao, Fuxin, Sun, Yan-Hong, Zhang, Minglian, Zhou, Xiangtian, Chen, Ye, Mo, Jun Qin, Huang, Taosheng, Qu, Jia, and Guan, Min-Xin

Published
2016
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40. PDE4B Proposed as a High Myopia Susceptibility Gene in Chinese Population.

Author

Zhao, Fuxin, Chen, Wei, Zhou, Hui, Reinach, Peter S., Wang, Yuhan, Juo, Suh-Hang H., Yang, Zhenglin, Xue, Anquan, Shi, Yi, Liang, Chung-Ling, Zeng, Changqing, Qu, Jia, and Zhou, Xiangtian

Subjects
CHINESE people, MYOPIA, SINGLE nucleotide polymorphisms, REFRACTIVE errors, GENOME-wide association studies
Abstract

Myopia is the most common cause of refractive error worldwide. High myopia is a severe type of myopia, which usually accompanies pathological changes in the fundus. To identify high myopia susceptibility genes, DNA-pooling based genome-wide association analysis was used to search for a correlation between single nucleotide polymorphisms and high myopia in a Han Chinese cohort (cases vs. controls in discovery stage: 507 vs. 294; replication stage 1: 991 vs. 1,025; replication stage 2: 1,021 vs. 52,708). Three variants (rs10889602T/G, rs2193015T/C, rs9676191A/C) were identified as being significantly associated with high myopia in the discovery, and replication stage. rs10889602T/G is located at the third intron of phosphodiesterase 4B (PDE4B), whose functional assays were performed by comparing the effects of rs10889602T/T deletion of this risk allele on PDE4B and COL1A1 gene and protein expression levels in the rs10889602T/Tdel/del, rs10889602T/Tdel/wt, and normal control A549 cell lines. The declines in the PDE4B and COL1A1 gene expression levels were larger in the rs10889602T/T deleted A549 cells than in the normal control A549 cells (one-way ANOVA, p < 0.001). The knockdown of PDE4B by siRNA in human scleral fibroblasts led to downregulation of COL1A1. This correspondence between the declines in rs10889602 of the PDE4B gene, PDE4B knockdown, and COL1A1 protein expression levels suggest that PDE4B may be a novel high myopia susceptibility gene, which regulates myopia progression through controlling scleral collagen I expression levels. More studies are needed to determine if there is a correlation between PDE4B and high myopia in other larger sample sized cohorts. [ABSTRACT FROM AUTHOR]

Published
2022
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