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Your search keyword '"Zhong, Fei"' showing total 1,264 results
Start Over Author "Zhong, Fei" Publication Type Academic Journals
1,264 results on '"Zhong, Fei"'

19. Comprehensive analyses reveal the carcinogenic and immunological roles of ANLN in human cancers.

Author

Shi, Yanlong, Wang, Menglu, Lan, Sheng, Jian, Haokun, Wang, Yue, Wei, Qian, Zhong, Fei, and Ma, Xinyu

Subjects
Anillin, Biomarker, Cancer, Immune infiltration, Prognosis
Abstract

BACKGROUND: Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. Although previous studies have shown that ANLN is related to carcinogenesis, no pan-cancer analyses of ANLN have been reported. Accordingly, in this study, we evaluated the carcinogenic roles of ANLN in various cancer types using online databases. METHODS: We evaluated the potential carcinogenic roles of ANLN using TIMER2 and Gene Expression Omnibus databases with 33 types of cancers. We further investigated the associations of ANLN with patient prognosis, genetic alterations, phosphorylation levels, and immune infiltration in multiple cancers using GEPIA2, cBioPortal, UACLAN, and TIMER2 databases. Additionally, the potential functions of ANLN were explored using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. Reverse transcription quantitative polymerase chain reaction and immunohistochemistry were used to determine ANLN mRNA and protein expression in colorectal cancer (CRC), gastric cancer (GC), and hepatocellular carcinoma (HCC) cell lines. RESULTS: ANLN was overexpressed in various tumor tissues compared with corresponding normal tissues, and significant correlations between ANLN expression and patient prognosis, genetic alterations, phosphorylation levels, and immune infiltration were noted. Moreover, enrichment analysis suggested that ANLN functionally affected endocytosis, regulation of actin cytoskeleton, and oxytocin signaling pathways. Importantly, ANLN mRNA and protein expression levels were upregulated in gastrointestinal cancers, including CRC, GC, and HCC. CONCLUSIONS: Our findings suggested that ANLN participated in tumorigenesis and cancer progression and may have applications as a promising biomarker of immune infiltration and prognosis in various cancers.

Published
2022

34. The Effect of Classroom-Based Physical Activity Elements on Academic Performance in Children and Adolescents: A Meta-Analysis.

Author

Xu, Yongjin, Lin, Nan, Wu, Chunchun, Wen, Xu, Zhong, Fei, Yu, Kehong, Shu, Li, and Huang, Cong

Subjects
PERFORMANCE in children, ACADEMIC achievement, PHYSICAL activity, RANDOM effects model, METABOLIC equivalent
Abstract

Purpose: We investigated the effects of classroom-based physical activity (CBPA) interventions on academic performance and assessed the impact of different CBPA elements on academic performance. Methods: Relevant experimental studies in four databases were searched from their inception to September 2022. Random effects models were used to compute standardized mean differences (SMDs) and 95% confidence intervals. Results: A total of 13 studies were included. CBPA interventions could improve academic performance in children and adolescents (SMD = 0.17, p =.02). For the CBPA elements, low frequency (no more than three times per week; SMD = 0.19, p =.01), moderate intensity (SMD = 0.19, p =.01), long time (more than 20 min in each intervention; SMD = 0.14, p =.05), integrated physical activity (SMD = 0.18, p =.04), no more than 400 metabolic equivalents of energy-min/week (SMD = 0.33, p =.001), and more than 8-week interventions (SMD = 0.19, p =.04) tended to improve academic performance. Conclusions: CBPA may improve academic performance in children and adolescents. CBPA elements also have an impact on academic performance. [ABSTRACT FROM AUTHOR]

Published
2024
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