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Your search keyword '"Yu, Junjie"' showing total 511 results
Start Over Author "Yu, Junjie" Publication Type Academic Journals
511 results on '"Yu, Junjie"'

1. The Collider

Author

Fang, Ke, Shi, Danqing, Qian, Yunzi, Li, Yin, and Yu, Junjie

Published
2019

35. Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma

Author

Yu Junjie and Pajvani Utpal B.

Subjects
hepatocellular carcinoma, non-alcoholic steatohepatitis, tumorigenesis, Medicine
Abstract

Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand the genetic change and the immune microenvironment of HCC, and the remaining questions. Based on the current study, NASH-HCC is likely to have novel mechanism, which needs more investigation in future.

Published
2023
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46. Path Planning of Robot Based on Improved Multi-Strategy Fusion Whale Algorithm.

Author

You, Dazhang, Kang, Suo, Yu, Junjie, and Wen, Changjun

Subjects
METAHEURISTIC algorithms, OPTIMIZATION algorithms, ROBOTIC path planning, INDUSTRIAL robots, GRIDS (Cartography), POTENTIAL field method (Robotics)
Abstract

In logistics and manufacturing, smart technologies are increasingly used, and warehouse logistics robots (WLR) have thus become key automation tools. Nonetheless, the path planning of mobile robots in complex environments still faces the challenges of excessively long paths and high energy consumption. To this end, this study proposes an innovative optimization algorithm, IWOA-WLR, which aims to optimize path planning and improve the shortest route and smoothness of paths. The algorithm is based on the Whale Algorithm with Multiple Strategies Fusion (IWOA), which significantly improves the obstacle avoidance ability and path optimization of mobile robots in global path planning. First, improved Tent chaotic mapping and differential dynamic weights are used to enhance the algorithm's optimization-seeking ability and improve the diversity of the population. In the late stage of the optimization search, the positive cosine inertia threshold and the golden sine are used to perform adaptive position updating during the search strategy to enhance the global optimal search capability. Secondly, the fitness function of the path planning problem is designed, and the path length is taken as the objective function, the path smoothness as the evaluation index, and the multi-objective optimization is realized through the hierarchical adjustment strategy and is applied to the global path planning of WLR. Finally, simulation experiments on raster maps with grid sizes of 15 × 15 and 20 × 20 compare the IWOA algorithm with the WOA, GWO, MAACO, RRT, and A* algorithms. On the 15 × 15 maps, the IWOA algorithm reduces path lengths by 3.61%, 5.90%, 1.27%, 15.79%, and 5.26%, respectively. On the 20 × 20 maps, the reductions are 4.56%, 5.83%, 3.95%, 19.57%, and 1.59%, respectively. These results indicate that the improved algorithm efficiently and reliably finds the global optimal path, significantly reduces path length, and enhances the smoothness and stability of the path's inflection points. [ABSTRACT FROM AUTHOR]

Published
2024
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47. The Central Conserved Peptides of Respiratory Syncytial Virus G Protein Enhance the Immune Response to the RSV F Protein in an Adenovirus Vector Vaccine Candidate.

Author

Chai, Pengdi, Shi, Yi, Yu, Junjie, Liu, Xiafei, Li, Dongwei, Li, Jinsong, Li, Lili, Li, Dandi, and Duan, Zhaojun

Subjects
RESPIRATORY syncytial virus infection vaccines, VIRAL proteins, RESPIRATORY syncytial virus infections, RESPIRATORY syncytial virus, G proteins
Abstract

Respiratory syncytial virus (RSV) is a serious human respiratory pathogen that commonly affects children, older adults, and immunocompromised individuals. At present, the design of licensed vaccines focuses on the incorporation of the pre-fusion protein (PreF protein) of RSV, as this protein has the ability to induce antibodies that offer a high level of protection. Moreover, the G protein contains the CX3C motif that binds the chemokine receptor CX3CR1 in respiratory epithelial cells, which plays an essential role in viral infection. Therefore, incorporating the G antigen into vaccine design may prove more advantageous for RSV prevention. In this study, we developed a human adenoviral vector-based RSV vaccine containing highly neutralizing immunogens, a modified full-length PreF protein fused with the central conserved peptides of the G protein (Gcc) from both RSV subgroups trimerized via a C-terminal foldon, and evaluated its immune response in mice through intranasal (i.n.) immunization. Our results showed that immunization with Ad5-PreF-Qa-Gcc elicited a balanced Th1/Th2 immune response and robust mucosal immunity with higher neutralizing antibody titers against RSV Long and RSV B1. Importantly, immunization with Ad5-PreF-Qa-Gcc enhanced CD4+ CD25+ FoxP3+ Treg cell response and protected the mice against RSV infection. Our data demonstrate that the combination of Gcc and the PreF antigen is a viable strategy for developing effective RSV vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Genome-Wide Identification of Zn2Cys6 Class Fungal-Specific Transcription Factors (ZnFTFs) and Functional Analysis of UvZnFTF1 in Ustilaginoidea virens

Author

Song Tianqiao, Zhang Xiong, Zhang You, Liang Dong, Yan Jiaoling, Yu Junjie, Yu Mina, Cao Huijuan, Yong Mingli, Pan Xiayan, Qi Zhongqiang, Du Yan, Zhang Rongsheng, and Liu Yongfeng

Subjects
Zn2Cys6-type fungal-specific transcription factor, Ustilaginoidea virens, rice pathogen, Gene silencing, RNA-Seq, Metabolism pathway, Plant culture, SB1-1110
Abstract

Transcription factors (TFs) orchestrate the regulation of cellular gene expression and thereby determine cell functionality. In this study, we analyzed the distribution of TFs containing domains, which named as ZnFTFs, both in ascomycete and basidiomycete fungi. We found that ZnFTFs were widely distributed in these fungal species, but there was more expansion of the ZnFTF class in Ascomycota than Basidiomycota. We identified 40 ZnFTFs in Ustilaginoidea virens, and demonstrated the involvement of UvZnFTF1 in vegetative growth, conidiation, pigment biosynthesis and pathogenicity. RNA-Seq analysis suggested that UvZnFTF1 may regulate different nutrient metabolism pathways, the production of secondary metabolites, and the expression of pathogen-host interaction genes and secreted protein- encoding genes. Analysis of the distribution of different fungal TFs in U. virens further demonstrated that UvZnFTFs make up a large TF family and may play essential biological roles in U. virens.

Published
2021
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