Search

The morbidity and mortality of myocardial infarction (MI) are increasing worldwide. Mesenchymal stem cells (MSCs) are multipotent stem cells with self-renewal and differentiation capabilities that are essential in tissue healing and regenerative medicine. However, the low implantation and survival rates of transplanted cells hinder the widespread clinical use of stem cells. Exosomes are naturally occurring nanovesicles that are secreted by cells and promote the repair of cardiac function by transporting noncoding RNA and protein. In recent years, MSC-derived exosomes have been promising cell-free treatment tools for improving cardiac function and reversing cardiac remodeling. This review describes the biological properties and therapeutic potential of exosomes and summarizes some engineering approaches for exosomes optimization to enhance the targeting and therapeutic efficacy of exosomes in MI. [ABSTRACT FROM AUTHOR]

Vocabulary knowledge is one of the most important aspects of language development. For bilingual students, early vocabulary development often predicts their future bilingual success. This paper examines early bilingual receptive vocabulary knowledge of ethnic minority children (N=135) from two large ethnic language communities (Uyghur and Kazak) in three national-level poverty-stricken counties in Xinjiang, China. The children's bilingual vocabulary knowledge was assessed using translated versions of the Peabody Picture Vocabulary Test-IV (PPTV-IV) in Putonghua (PTH) and their mother tongue (MT) Uyghur or Kazak. Data were analyzed through four General Linear Models (GLM). The analyses showed that both groups scored higher in MT vocabulary knowledge than that in their PTH, although the Kazak students' MT vocabulary scores were lower than those of the Uyghurs. While gender, age, L1, or residence location were not significant factors in differences across the two groups in PTH, among the Kazak children, the main effect of age was significant in MT; and among Uyghur children, residence location had a significant effect. The two groups also differed in patterns of acquisition in different parts of speech (nouns, verbs, and attributes) with Uyghur children performing strongest in MT and PTH verbs. The findings have important implications for ensuring the quality of early bilingual education among impoverished Chinese minority communities. [ABSTRACT FROM AUTHOR]

This paper reports on a study of 148 Sibe youths and their parents from the Charbuchar Sibe Autonomous County of Xinjiang, North-western China, investigating their attitudes toward their mother tongue. Language attitude questionnaires that looked into the youths' and their parents' perceptions of their mother tongue's solidarity (friendliness, beautifulness, usefulness and learnability), status (significance in the country, in economic development, in daily life and in cultural wealth) and vitality (including linguistic, extralinguistic and related factors) were used to collect data. The results show that Sibe youth were more pessimistic than their parents about the solidarity and vitality of the Sibe language, but shared their parents' optimistic perceptions of the Sibe language's status. Parents' attitudes differed by education, income, profession and residence, with high-income, highly educated parents in urban centres holding more pessimistic attitudes than low-income, rural parents. Students' attitudes also varied by gender and grade levels, with girls being more positive than boys. The findings suggest that concerted efforts in school, home, and communities, especially in urban communities, must be devoted to bridging the intergenerational gaps in language attitudes. Emphasis should also be placed on supporting youths,' especially boys,' ethnic identity and affirmation. [ABSTRACT FROM AUTHOR]

Background: To explore the application of nursing practice combined with scene simulation teaching mode in standardized training and teaching for newly recruited nurses in Post Anesthesia Care Unit (PACU) and its impact on their emergency response ability and competence., Methods: From Jan 2019 to Jan 2020, a total of 120 PACU nurses with professional qualification certificates in West China Hospital Sichuan University, Chengdu, China were enrolled and randomized into group A (n=60) and group B (n=60). Conventional standardized PACU training and teaching was applied in group B, and nursing practice combined with scene simulation teaching mode was applied in group A. After training for 12 weeks, the examination scores, competence and emergency response ability in the two groups were compared., Results: After training, the scores of theoretical examination, comprehensive scene simulation and nursing document in group A were conspicuously higher than those in group B ( P <0.001). After training, the competence and emergency response ability in group A were significantly higher than those in group B ( P <0.001)., Conclusion: With a better training effect, nursing practice combined with scene simulation teaching mode can enhance the emergency response ability and competence for nurses in PACU, which should be promoted in practice., Competing Interests: Conflict of interest The authors declare that there is no conflict of interest., (Copyright © 2022 Guo et al. Published by Tehran University of Medical Sciences.)

Objective: This study is on mental health status of anesthesiologists and its influencing factors., Methods: Electronic questionnaires were given out to anesthesiologists through online platforms such as WeChat for information sharing among anesthesiologists. The included anesthesiologists were encouraged to distribute this platform to other anesthesiologists. Psychological survey was carried out using the Huaxi Emotional-distress Index (HEI). A total of 480 valid questionnaires were collected., Results: Anesthesiologists had different degrees of bad moods, 37.9% of whom had poor mental health. Ordinal logistic regression analysis suggested that there were statistically significant differences in gender, marital status, job title, position, hospital type, and the amount of overtime work per week in relation to mood (all P < 0.05). Age, nationality, number of children, number of anesthesiologists and the daily amount of anesthesia operations on average in the hospital was not significantly different in regard to mental health (all P > 0.05)., Conclusion: The mental state of anesthesiologists is often at a poor level, and measures should be taken to improve the mental health of anesthesiologists and improve their quality of life., Competing Interests: None., (AJTR Copyright © 2021.)

During the COVID-19 pandemic, ensuring the gradual recovery of anesthesia nursing unit and avoiding cross-infection between surgical patients and staff are difficult problems for hospital managers. We outlined the emergency response measures and the transition to normal operation of the anesthesia nursing unit in West China Hospital, which is a large teaching hospital. This mainly included hospital and operating room channel management, three-level screening management of patients and medical staff, classification management of patients undergoing anesthesia and recovery, training management of medical personnel, strict environmental management, and online teaching management., (Copyright © 2020 Zheng, Zhou, Yin, Yin, Mao, Wang, Ye and Zhu.)

The purpose of our study was to determine the safety and tolerability of early oral hydration (EOH) compared with delayed oral hydration (DOH) after general anesthesia. One thousand anesthesiology (ASA) I to III adult patients undergoing non-gastrointestinal surgery with general anesthesia were randomized assigned into two groups: DOH (n=500, patients were given water 4 h after general anesthesia), EOH (n=500, patients were given 0.5 ml/kg water once recovered from general anesthesia.) in the postanesthesia care unit (PACU). Patients were evaluated for nausea, vomiting, drink desire, thirsty scale, oropharyngeal discomfort scale, and satisfaction scale. Statistical analysis was performed with Student's t and Chi-Square tests. Complete data were available for 983 patients (EOH=488, DOH=495). Twenty minutes after receiving water the incidence of vomiting in EOH group was very low. And there was no significant difference between the two groups at the same time point (p > 0.05). Compared with DOH group, after receiving water there was a significant decrease of patients' thirsty scales (p < 0.0001) and oropharyngeal discomfort scales (p < 0.0001) in EOH group. Significantly more patients' satisfaction were reported in EOH group (p < 0.001). No serious adverse effects were reported during the study period. For patients undergoing non-gastrointestinal surgery, early oral hydration after recovery from general anesthesia was safe, with lower thirsty scale and oropharyngeal discomfort scales, and higher satisfaction.

Objective: To investigate the predictive value of cardiac magnetic resonance (CMR) on outcome of patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing percutaneous transluminal septal myocardial ablation (PTSMA)., Methods: A total of 38 consecutive HOCM patients underwent CMR imaging before PTSMA in Fuwai hospital From March 2010 to September 2012 were included in this retrospective study. The efficacy was defined as >30 mmHg (1 mmHg = 0.133 kPa) reduction of echocardiography derived left ventricular outflow tract gradient (LVOTG) at 6 months post operation. The relationship between CMR imaging derived parameters and effect of PTSMA was analyzed. Receiver operating curve (ROC) was applied to assess the predicting effectiveness of related CMR parameters., Results: The effective rate of PTSMA was 65.8% (25/38). The thickness of basal anterior wall (r = 0.505, P = 0.001), basal anteroseptal wall (0.500, P = 0.001) and the sum of the two segments (r = 0.656, P < 0.001) was positively correlated to the post-procedure reduction of LVOTG. The area under the ROC curve of the thickness of basal anterior wall, basal anteroseptal wall and the sum of the two segments was 0.806, 0.675 and 0.834, respectively. The sensitivity was 84.6% and specificity was 84.0% to predict the efficacy of PTSMA using the sum of left ventricular basal anterior wall and basal anteroseptal wall thickness 49.6 mm as cut-off value., Conclusions: LVOTG reduction post PTSMA positively correlates to pre-procedure left ventricular basal anterior wall, basal anteroseptal wall and the total thickness of these two segments in patients with HOCM. The total thickness of these two segments is a superior parameter for predicting efficacy of PTSMA in HOCM patients.