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2. Factors that determine the loss of control when reducing therapy by steps in the treatment of moderate-severe asthma in standard clinical practice: A multicentre Spanish study

Author

López, Jesús Jiménez, Orenes, Miguel Ángel Moscardó, Montaño, Patricia Prieto, Toro, Miguel Torrecillas, Oliver, Begoña Cueva, Torres, Ángel Ferrer, Delgado, Purificación González, Rodríguez, Teodorikez Wilfox Jiménez, Auli, Brian Vila, Yebenes, Juan José Zapata, Berasategui, María Teresa Audicana, Jiménez, Marta Frias, Ruibio, Nieves Hurtado De Mendoza, Azagra, Marta Velasco, Fernández, Jose Antonio Álvarez, Sainz, Sara Acero, González, Rosa Mª Blanco, Nieves, María Estela Gómez, Carpio, Diego Aisa, Sellés, Núria Angrill, García, Cristina Berastegui, Lessmann, Astrid Crespo, Carrillo, David De La Rosa, Pla, Jordi Juanola, Giraldo, Alejandra López, Sánchez, Olga Luengo, Rivera, Carlos Martínez, Olondris, Pilar Martínez, Gall, Xavier Muñoz, Nogués, Ester Pinto, Coimerma, Francisco Planas, Carroz, Karina Portillo, Blanch, Antoni Riba, Ortún, Mª Luisa Rivera, Berenguer, Dan Sánchez, Batlles, Joan Serra, Mitjà, Pere Serra, Sagardía, Ana Sogo, Retes, Lorena Soto, Combas, Joan Valldeperas, Giralte, Xavier Vila, Zubeldia, Ignacio Ansotegui, Ercoreca, Ignacio Antepara, Peña, Miguel Herrerías, Pascual, María Milagros Iriberri, Michelena, Carmen Jaca, Castro, Adolfo Lahuerta, Legarreta, Amaia Laita, Llorente, Paula Losada, Prieto, Joaquina Prieto, Lorenzo, Vanessa Zorrilla, Gil, Lidia Alonso, Muñoz, Juan Pablo García, Durantez, Marisa Marcos, Miguel, Teresa Peña, Ahmida, Tahar, Izquierdo, María Isabel Alvarado, Olbah, Michael Alwakil, Muñoz, Aurelio Arnedillo, Núñez, Ignacio García, Fernández, Diego Gutiérrez, Camacho, Antonio Letran, Pellon, Luis Fernández, Miguel, Eva Maria Morchon, Portal, Félix Ortiz, Raducan, Isabela, Prats, Juan Antonio Royo, Segarra, María Dolores Salvador, Soler, Frederic Tatay, Naon, Alberto Levy, Bonilla, Pedro Galindo, Muñoz, Francisco Luis Gil, Calderón, Patricia Mata, Costa, Luis Manuel Entrenas, Aparicio, Marina Blanco, Pazos, Jose Manuel García, Paz, Vanessa García, Barcala, Francisco-Javier González, Sotes, Pilar Iriarte, Rodríguez, Pedro Jorge Marcos, Nieto, Fernando Molina, Orjales, Ramón Nuñez, Martín, Carracedo Sevillano, Antelo, Juan Suárez, Rodríguez, Julia Tábara, Español, Santiago Aparicio, Nieto, Carlos Sabadell, Talaverano, Gladis Sabater, Rodríguez, Mª Mar Escribano, López, José Fernando Florido, Jiménez, María Ángeles Lara, Vílchez, María José Rojas, Palacín, Susana Chic, Quintana, Silvia Dorronsoro, Echeverria, Jose Antonio Navarro, Guardia, Eduardo Figueroa De La, Jara, Belén Hinojosa, García, Victoria Moreno, Vazquez, Lucía Valverde, De Sus, Joaquín Cegoñino, Santonio, Jose, López, Juan Alfonso Almagro, Campillo, Eduardo Arcalá, Molina, Compaired Villa Jose María Cruz, Venegas, Antonia Dolores Soto, Martínez, Patricia Benito, Reinosa, Begoña Blanco, Parra, Beatriz Fernández, García, Domingo Fernández, Gutiérrez, Virginia Serrano, Lobera, Adolfo Velez Ruiz De, Alcon, Silvia Lara, González, Francisco Carballada, Fernández, Teresa González, Lázaro, Joaquín Martín, Macenlle, Noemí Mengual, Viteri, Soledad Alonso, Amerigo, Darío Antolín, Bobolea, Irina, Aguirre, M Del Puerto Cano, Contreras, Remedios Cardenas, Arias, Fernando Carrillo, Álvarez, Mercedes Cimarra, Martínez, Eva Belén De Higes, Campos, Rocío Magdalena Díaz, Cano, María Del Mar Gandolfo, Rodríguez, Leticia García, Tejada, Jose Andrés García Romero De, Mancebo, Eloina González, Seco, Emma González, Torralba, Fernando González, Santana, Aythamy Henríquez, Herrera, Pilar De Lys Herráez, Mosquete, María Ruth Herrero, Rodríguez, Pedro Landete, Ballesteros, Belén López-Muñiz, Vicente, Ester Mohedano, Chacón, Beatriz Morales, Fernández, Antonio Moreno, García, Esther Muñoz, Castillejo, Elena Ojeda, Serrano, Fernando Pedraza, Acevedo, Yesenia Peña Acevedo, Rojo, Raquel Pérez, Ruiz-Rico, Natividad Quílez, Pinedo, Ángela Ramos, Jiménez, Beatriz Rodríguez, Rodríguez, Mercedes Rodríguez, Ingelmo, Ana Rosado, Peña, Antonio Ruiz, González, María José Sánchez, Trujillo, María Jesús Trujillo, Fuertes, Laura Vázquez, Albelda, Concepción Vila, Meniz, Alexandra Yago, Grovas, Ricardo Ismael Aguilar Perez, Ramírez, José Alcázar Ramírez Alcázar, Muñoz, José Manuel Barceló, Manzanares, Miguel Bentabol, Martínez, Gustavo De Luiz, Luna, Francisco Linde De, Paez, Alfonso Miranda, Tejada, Ezequiel Ortega Sáenz De, Galo, Alicia Padilla, Cornejo, Manuel Pérez Estrada, Esojo, Carmen Soria, Alemán, Ángel Francisco Abellán, Rumayor, María Consuelo Alcalde, Espinosa, Rubén Andújar, Mora, Roberto Bernabeu, Lancharro, Francisco Javier Campano, Urra, Tamara Gutiérrez, Martín, Sonia Herrero, Lizaldre, Alfredo Resano, Quintas, R. Dacal, Martínez-Moragón, E., Delgado, J., Mogrovejo, S., and Fernández-Sánchez, T.

Published
2020
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3. Factores que condicionan la pérdida de control al reducir escalones terapéuticos en el tratamiento del asma moderada-grave en la práctica clínica habitual: estudio español multicéntrico

Author

Martínez-Moragón, E., Delgado, J., Mogrovejo, S., Fernández-Sánchez, T., Jesús, Jiménez López, Ángel, Moscardó Orenes Miguel, Patricia, Prieto Montaño, Miguel, Torrecillas Toro, Begoña, Cueva Oliver, Ángel, Ferrer Torres, Purificación, González Delgado, Wilfox, Jiménez Rodríguez Teodorikez, Brian, Vila Auli, José, Zapata Yebenes Juan, Teresa, Audicana Berasategui María, Marta, Frias Jiménez, Nieves, Hurtado de Mendoza Ruibio, Marta, Velasco Azagra, Antonio, Álvarez Fernández Jose, Sara, Acero Sainz, Rosa, Blanco González M., Estela, Gómez Nieves María, Diego, Aisa Carpio, Núria, Angrill Sellés, Cristina, Berastegui García, Astrid, Crespo Lessmann, David, De La Rosa Carrillo, Jordi, Juanola Pla, Alejandra, López Giraldo, Olga, Luengo Sánchez, Carlos, Martínez Rivera, Pilar, Martínez Olondris, Xavier, Muñoz Gall, Ester, Pinto Nogués, Francisco, Planas Coimerma, Karina, Portillo Carroz, Antoni, Riba Blanch, Luisa, Rivera Ortún M., Dan, Sánchez Berenguer, Joan, Serra Batlles, Pere, Serra Mitjà, Ana, Sogo Sagardía, Lorena, Soto Retes, Joan, Valldeperas Combas, Xavier, Vila Giralte, Ignacio, Ansotegui Zubeldia, Ignacio, Antepara Ercoreca, Miguel, Herrerías Peña, Milagros, Iriberri Pascual María, Carmen, Jaca Michelena, Adolfo, Lahuerta Castro, Amaia, Laita Legarreta, Paula, Losada Llorente, Joaquina, Prieto Prieto, Vanessa, Zorrilla Lorenzo, Lidia, Alonso Gil, Pablo, García Muñoz Juan, Marisa, Marcos Durantez, Teresa, Peña Miguel, Tahar, Ahmida, Isabel, Alvarado Izquierdo María, Michael, Alwakil Olbah, Aurelio, Arnedillo Muñoz, Ignacio, García Núñez, Diego, Gutiérrez Fernández, Antonio, Letran Camacho, Luis, Fernández Pellon, Maria, Morchon Miguel Eva, Félix, Ortiz Portal, Isabela, Raducan, Antonio, Royo Prats Juan, Dolores, Salvador Segarra María, Frederic, Tatay Soler, Alberto, Levy Naon, Pedro, Galindo Bonilla, Luis, Gil Muñoz Francisco, Patricia, Mata Calderón, Manuel, Entrenas Costa Luis, Marina, Blanco Aparicio, Manuel, García Pazos Jose, Vanessa, García Paz, Francisco-Javier, González Barcala, Pilar, Iriarte Sotes, Jorge, Marcos Rodríguez Pedro, Fernando, Molina Nieto, Ramón, Nuñez Orjales, Carracedo, Sevillano Martín, Juan, Suárez Antelo, Julia, Tábara Rodríguez, Santiago, Aparicio Español, Carlos, Sabadell Nieto, Gladis, Sabater Talaverano, Mar, Escribano Rodríguez M., Fernando, Florido López José, Ángeles, Lara Jiménez María, José, Rojas Vílchez María, Susana, Chic Palacín, Silvia, Dorronsoro Quintana, Antonio, Navarro Echeverria Jose, Eduardo, Figueroa de la Guardia, Belén, Hinojosa Jara, Victoria, Moreno García, Lucía, Valverde Vazquez, Joaquín, Cegoñino de Sus, Santonio, Compaired Villa Jose, Alfonso, Almagro López Juan, Eduardo, Arcalá Campillo, María, Cruz Molina Jose, Dolores, Soto Venegas Antonia, Patricia, Benito Martínez, Begoña, Blanco Reinosa, Beatriz, Fernández Parra, Domingo, Fernández García, Virginia, Serrano Gutiérrez, Adolfo, Velez Ruiz de Lobera, Silvia, Lara Alcon, Francisco, Carballada González, Teresa, González Fernández, Joaquín, Martín Lázaro, Noemí, Mengual Macenlle, Soledad, Alonso Viteri, Darío, Antolín Amerigo, Irina, Bobolea, Puerto, Cano Aguirre M. del, Remedios, Cardenas Contreras, Fernando, Carrillo Arias, Mercedes, Cimarra Álvarez, Belén, De Higes Martínez Eva, Magdalena, Díaz Campos Rocío, Mar, Gandolfo Cano María del, Leticia, García Rodríguez, Andrés, García Romero de Tejada Jose, Eloina, González Mancebo, Emma, González Seco, Fernando, González Torralba, Aythamy, Henríquez Santana, Lys, Herráez Herrera Pilar de, Ruth, Herrero Mosquete María, Pedro, Landete Rodríguez, Belén, López-Muñiz Ballesteros, Ester, Mohedano Vicente, Beatriz, Morales Chacón, Antonio, Moreno Fernández, Esther, Muñoz García, Elena, Ojeda Castillejo, Fernando, Pedraza Serrano, Yesenia, Peña Acevedo Acevedo, Raquel, Pérez Rojo, Natividad, Quílez Ruiz-Rico, Ángela, Ramos Pinedo, Beatriz, Rodríguez Jiménez, Mercedes, Rodríguez Rodríguez, Ana, Rosado Ingelmo, Antonio, Ruiz Peña, José, Sánchez González María, Jesús, Trujillo Trujillo María, Laura, Vázquez Fuertes, Concepción, Vila Albelda, Alexandra, Yago Meniz, Ismael, Aguilar Perez Grovas Ricardo, José, Alcázar Ramírez Alcázar Ramírez, Manuel, Barceló Muñoz José, Miguel, Bentabol Manzanares, Gustavo, De Luiz Martínez, Francisco, Linde de Luna, Alfonso, Miranda Paez, Ezequiel, Ortega Sáenz de Tejada, Alicia, Padilla Galo, Manuel, Pérez Estrada Cornejo, Carmen, Soria Esojo, Francisco, Abellán Alemán Ángel, Consuelo, Alcalde Rumayor María, Rubén, Andújar Espinosa, Roberto, Bernabeu Mora, Javier, Campano Lancharro Francisco, Tamara, Gutiérrez Urra, Sonia, Herrero Martín, Alfredo, Resano Lizaldre, and Raquel, Dacal Quintas

Published
2020
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10. Towards a Data Governance Framework for Third Generation Platforms.

Author

Yebenes, Juan and Zorrilla, Marta

Subjects
SOFTWARE architecture, INDUSTRY 4.0, MANUFACTURING processes, CLOUD computing
Abstract

The fourth industrial revolution considers data as a business asset and therefore this is placed as a central element of the software architecture (data as a service) that will support the horizontal and vertical digitalization of industrial processes. The large volume of data that the environment generates, its heterogeneity and complexity, as well as its reuse for later processes (e.g. analytics, IA) requires the adoption of policies, directives and standards for its right governance. Furthermore, the issues related to the use of resources in the cloud computing must be taken into account with the aim of meeting the requirements of performance and security of the different processes. This article, in the absence of frameworks adapted to this new architecture, proposes an initial schema for developing an effective data governance programme for third generation platforms, that means, a conceptual tool which guides organizations to define, design, develop and deploy services aligned with its vision and business goals in I4.0 era. [ABSTRACT FROM AUTHOR]

Published
2020
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11. Towards a Data Governance Framework for Third Generation Platforms.

Author

Yebenes, Juan and Zorrilla, Marta

Subjects
SOFTWARE architecture, INDUSTRY 4.0, MANUFACTURING processes, CLOUD computing
Abstract

The fourth industrial revolution considers data as a business asset and therefore this is placed as a central element of the software architecture (data as a service) that will support the horizontal and vertical digitalization of industrial processes. The large volume of data that the environment generates, its heterogeneity and complexity, as well as its reuse for later processes (e.g. analytics, IA) requires the adoption of policies, directives and standards for its right governance. Furthermore, the issues related to the use of resources in the cloud computing must be taken into account with the aim of meeting the requirements of performance and security of the different processes. This article, in the absence of frameworks adapted to this new architecture, proposes an initial schema for developing an effective data governance programme for third generation platforms, that means, a conceptual tool which guides organizations to define, design, develop and deploy services aligned with its vision and business goals in I4.0 era. [ABSTRACT FROM AUTHOR]

Published
2019
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12. Risk Factors for Noninvasive Ventilation Failure in Critically 111 Subjects With Confirmed Influenza Infection.

Author

Rodríguez, Alejandro, Ferri, Cristina, Martin-Loeches, Ignacio, Díaz, Emili, Masclans, Joan R., Gordo, Federico, Sole-Violán, Jordi, Bodí, María, Avilés-Jurado, Francesc X., Trefler, Sandra, Magret, Monica, Moreno, Gerard, Reyes, Luis F., Marin-Corral, Judith, Yebenes, Juan C., Esteban, Andres, Anzueto, Antonio, Aliberti, Stefano, and Restrepo, Marcos I.

Subjects
INFLUENZA complications, ADULT respiratory distress syndrome treatment, ALGORITHMS, APACHE (Disease classification system), CHI-squared test, CONFIDENCE intervals, DECISION trees, FISHER exact test, PROBABILITY theory, RESEARCH funding, T-test (Statistics), LOGISTIC regression analysis, SECONDARY analysis, TREATMENT effectiveness, SEVERITY of illness index, POSITIVE pressure ventilation, HOSPITAL mortality, KAPLAN-Meier estimator, ODDS ratio, MANN Whitney U Test
Abstract

BACKGROUND: Despite wide use of noninvasive ventilation (NIV) in several clinical settings, the beneficial effects of NIV in patients with hypoxemic acute respiratory failure (ARF) due to influenza infection remain controversial. The aim of this study was to identify the profile of patients with risk factors for NIV failure using chi-square automatic interaction detection (CHAID) analysis and to determine whether NIV failure is associated with ICU mortality. METHODS: This work was a secondary analysis from prospective and observational multi-center analysis in critically ill subjects admitted to the ICU with ARF due to influenza infection requiring mechanical ventilation. Three groups of subjects were compared: (1) subjects who received NIV immediately after ICU admission for ARF and then failed (NIV failure group); (2) subjects who received NIV immediately after ICU admission for ARF and then succeeded (NIV success group); and (3) subjects who received invasive mechanical ventilation immediately after ICU admission for ARF (invasive mechanical ventilation group). Profiles of subjects with risk factors for NIV failure were obtained using CHAID analysis. RESULTS: Of 1,898 subjects, 806 underwent NIV, and 56.8% of them failed. Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, infiltrates in chest radiograph, and ICU mortality (38.4% vs 6.3%) were higher (P < .001) in the NIV failure than in the NIV success group. SOFA score was the variable most associated with NIV failure, and 2 cutoffs were determined. Subjects with SOFA ≥ 5 had a higher risk of NIV failure (odds ratio = 3.3, 95% CI 2.4-4.5). ICU mortality was higher in subjects with NIV failure (38.4%) compared with invasive mechanical ventilation subjects (31.3%, P = .018), and NIV failure was associated with increased ICU mortality (odds ratio = 11.4, 95% CI 6.5-20.1). CONCLUSIONS: An automatic and non-subjective algorithm based on CHAID decision-tree analysis can help to define the profile of patients with different risks of NIV failure, which might be a promising tool to assist in clinical decision making to avoid the possible complications associated with NIV failure. [ABSTRACT FROM AUTHOR]

Published
2017
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13. Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review.

Author

Campins, Lluis, Camps, Marcella, Riera, ariadna, Pleguezuelos, Eulogio, Yebenes, Juan Carlos, and Serra-Prat, Mateu

Subjects
ORAL medication, SARCOPENIA, HORMONE therapy, DISEASE progression, AGE of onset, THERAPEUTICS
Abstract

Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can include genetic influence, immobility or disuse, endocrine factors, inflammation and nutritional deficiencies. These disorders involve an imbalance between anabolic and catabolic pathways that rules muscle mass. Many drugs taken regularly for common conditions may interact with some mechanisms that can alter the balance between protein synthesis and degradation. This may lead to a harmful or a beneficial effect on muscle mass and strength. Widely prescribed drugs could play an important role during the time of onset and development of sarcopenia. In this paper, we reviewed the current understanding of how can drugs contribute positively or negatively on sarcopenia and muscle wasting. We decided to focus this review on oral common drugs, which are usually prescribed in older adults, leaving aside other drugs as hormone therapy. [ABSTRACT FROM AUTHOR]

Published
2017
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17. Risk Factors for Noninvasive Ventilation Failure in Critically Ill Subjects With Confirmed Influenza Infection.

Author

Rodríguez A, Ferri C, Martin-Loeches I, Díaz E, Masclans JR, Gordo F, Sole-Violán J, Bodí M, Avilés-Jurado FX, Trefler S, Magret M, Moreno G, Reyes LF, Marin-Corral J, Yebenes JC, Esteban A, Anzueto A, Aliberti S, and Restrepo MI

Subjects
APACHE, Adult, Aged, Chi-Square Distribution, Critical Illness mortality, Female, Hospital Mortality, Humans, Influenza, Human mortality, Intensive Care Units statistics & numerical data, Male, Middle Aged, Noninvasive Ventilation methods, Organ Dysfunction Scores, Prospective Studies, Respiration, Artificial methods, Respiration, Artificial mortality, Respiratory Insufficiency mortality, Respiratory Insufficiency virology, Risk Factors, Treatment Failure, Influenza, Human complications, Noninvasive Ventilation mortality, Respiratory Insufficiency therapy
Abstract

Background: Despite wide use of noninvasive ventilation (NIV) in several clinical settings, the beneficial effects of NIV in patients with hypoxemic acute respiratory failure (ARF) due to influenza infection remain controversial. The aim of this study was to identify the profile of patients with risk factors for NIV failure using chi-square automatic interaction detection (CHAID) analysis and to determine whether NIV failure is associated with ICU mortality., Methods: This work was a secondary analysis from prospective and observational multi-center analysis in critically ill subjects admitted to the ICU with ARF due to influenza infection requiring mechanical ventilation. Three groups of subjects were compared: (1) subjects who received NIV immediately after ICU admission for ARF and then failed (NIV failure group); (2) subjects who received NIV immediately after ICU admission for ARF and then succeeded (NIV success group); and (3) subjects who received invasive mechanical ventilation immediately after ICU admission for ARF (invasive mechanical ventilation group). Profiles of subjects with risk factors for NIV failure were obtained using CHAID analysis., Results: Of 1,898 subjects, 806 underwent NIV, and 56.8% of them failed. Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, infiltrates in chest radiograph, and ICU mortality (38.4% vs 6.3%) were higher ( P < .001) in the NIV failure than in the NIV success group. SOFA score was the variable most associated with NIV failure, and 2 cutoffs were determined. Subjects with SOFA ≥ 5 had a higher risk of NIV failure (odds ratio = 3.3, 95% CI 2.4-4.5). ICU mortality was higher in subjects with NIV failure (38.4%) compared with invasive mechanical ventilation subjects (31.3%, P = .018), and NIV failure was associated with increased ICU mortality (odds ratio = 11.4, 95% CI 6.5-20.1)., Conclusions: An automatic and non-subjective algorithm based on CHAID decision-tree analysis can help to define the profile of patients with different risks of NIV failure, which might be a promising tool to assist in clinical decision making to avoid the possible complications associated with NIV failure., (Copyright © 2017 by Daedalus Enterprises.)

Published
2017
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