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Changes in land use types in alpine meadow areas have significant impacts on the ecological environment in alpine areas. Exploring land use change is crucial for land use management and optimization in alpine regions. Thus, it is necessary to analyze land use evolution and its drivers in alpine meadow regions from a production–living–ecology space (PLES) perspective by using remote sensing data. We first constructed the PLES evaluation system for Gannan. Then, we analyzed the spatial and temporal evolution characteristics and coupling degree of PLES in the study area. Finally, the driving factors affecting PLES were explored with geodetector. The conclusions of the study reveal that the distribution of productive and ecological spaces is large and concentrated, while the distribution of living spaces is more decentralized. The PLES was mainly concentrated in the area above 2500 m but below 4000 m and with a slope of 40° or less. During the study period, the area of production space showed a decreasing trend, while the areas of living and ecological space both showed increasing trends, primarily occurring at the expense of production space. DEM and GDP were the main factors affecting the distribution of PLES. The coupling level and the degree of coupling coordination were relatively stable in general, showing a pattern of "high in the east and low in the west". The study provides technical support and a theoretical basis for the future planning of land space and ecological environment optimization in the alpine meadow regions. [ABSTRACT FROM AUTHOR]

Single-cell RNA sequencing (scRNA-seq) experiments have become instrumental in developmental and differentiation studies, enabling the profiling of cells at a single or multiple time-points to uncover subtle variations in expression profiles reflecting underlying biological processes. Benchmarking studies have compared many of the computational methods used to reconstruct cellular dynamics; however, researchers still encounter challenges in their analysis due to uncertainty with respect to selecting the most appropriate methods and parameters. Even among universal data processing steps used by trajectory inference methods such as feature selection and dimension reduction, trajectory methods' performances are highly dataset-specific. To address these challenges, we developed Escort, a novel framework for evaluating a dataset's suitability for trajectory inference and quantifying trajectory properties influenced by analysis decisions. Escort evaluates the suitability of trajectory analysis and the combined effects of processing choices using trajectory-specific metrics. Escort navigates single-cell trajectory analysis through these data-driven assessments, reducing uncertainty and much of the decision burden inherent to trajectory inference analyses. Escort is implemented in an accessible R package and R/Shiny application, providing researchers with the necessary tools to make informed decisions during trajectory analysis and enabling new insights into dynamic biological processes at single-cell resolution. [ABSTRACT FROM AUTHOR]

The utilization of deep learning techniques for decoding visual perception images from brain activity recorded by functional magnetic resonance imaging (fMRI) has garnered considerable attention in recent research. However, reconstructed images from previous studies still suffer from low quality or unreliability. Moreover, the complexity inherent to fMRI data, characterized by high dimensionality and low signal-to-noise ratio, poses significant challenges in extracting meaningful visual information for perceptual reconstruction. In this regard, we proposes a novel neural decoding model, named the hierarchical semantic generative adversarial network (HS-GAN), inspired by the hierarchical encoding of the visual cortex and the homology theory of convolutional neural networks (CNNs), which is capable of reconstructing perceptual images from fMRI data by leveraging the hierarchical and semantic representations. The experimental results demonstrate that HS-GAN achieved the best performance on Horikawa2017 dataset (histogram similarity: 0.447, SSIM-Acc: 78.9%, Peceptual-Acc: 95.38%, AlexNet(2): 96.24% and AlexNet(5): 94.82%) over existing advanced methods, indicating improved naturalness and fidelity of the reconstructed image. The versatility of the HS-GAN was also highlighted, as it demonstrated promising generalization capabilities in reconstructing handwritten digits, achieving the highest SSIM (0.783±0.038), thus extending its application beyond training solely on natural images. [ABSTRACT FROM AUTHOR]

The reconstruction of visual stimuli from fMRI signals, which record brain activity, is a challenging task with crucial research value in the fields of neuroscience and machine learning. Previous studies tend to emphasize reconstructing pixel-level features (contours, colors, etc.) or semantic features (object category) of the stimulus image, but typically, these properties are not reconstructed together. In this context, we introduce a novel three-stage visual reconstruction approach called the Dual-guided Brain Diffusion Model (DBDM). Initially, we employ the Very Deep Variational Autoencoder (VDVAE) to reconstruct a coarse image from fMRI data, capturing the underlying details of the original image. Subsequently, the Bootstrapping Language-Image Pre-training (BLIP) model is utilized to provide a semantic annotation for each image. Finally, the image-to-image generation pipeline of the Versatile Diffusion (VD) model is utilized to recover natural images from the fMRI patterns guided by both visual and semantic information. The experimental results demonstrate that DBDM surpasses previous approaches in both qualitative and quantitative comparisons. In particular, the best performance is achieved by DBDM in reconstructing the semantic details of the original image; the Inception, CLIP and SwAV distances are 0.611, 0.225 and 0.405, respectively. This confirms the efficacy of our model and its potential to advance visual decoding research. [ABSTRACT FROM AUTHOR]

Featured Application: We propose an SPR sensor with high sensitivity and resolution based on the higher-order modes, which can be applied in the measurement of the refractive index. In this paper, we propose an approach to improve the sensitivity of an optical fiber surface plasmon resonance (SPR) sensor with a pure higher-order mode excited by a designed mode selective coupler (MSC). We calculate the proportion of the power of the higher-order mode in the cladding. Compared to the LP 01 mode, the power proportion of the LP 11 mode ( LP 21 mode) in the cladding theoretically improves by 100% (150%). To generate a relatively pure LP 11 mode or LP 21 mode, a mode selective coupler (MSC, 430–580 nm) is designed. The coupling efficiency of the LP 01 – LP 11 mode coupler is over 80%, and that of the LP 01 – LP 21 mode coupler is over 50%. The simulation results show that the sensitivity of the LP 11   mode and the LP 21 mode increases by approximately 330% and 360%, respectively, using the intensity modulation (n = 1.33–1.38, 430–580 nm); the resolution of the refractive indices of our sensor, using the LP 11 mode ( LP 21 mode), is 2.6 × 10 − 4 RIU ( 2.4 × 10 − 4 RIU). The higher sensitivity and resolution of our presented fiber SPR sensor containing a visible MSC make it a promising candidate for the measurement of refractive indices. [ABSTRACT FROM AUTHOR]