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1,296 results on '"Wu, Xiaolin"'

8. Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma

Author

Kacar, Zeynep, Slud, Eric, Levy, Doron, Candia, Julián, Budhu, Anuradha, Forgues, Marshonna, Wu, Xiaolin, Raziuddin, Arati, Tran, Bao, Shetty, Jyoti, Pomyen, Yotsawat, Chaisaingmongkol, Jittiporn, Rabibhadana, Siritida, Pupacdi, Benjarath, Bhudhisawasdi, Vajarabhongsa, Lertprasertsuke, Nirush, Auewarakul, Chirayu, Sangrajrang, Suleeporn, Mahidol, Chulabhorn, Ruchirawat, Mathuros, and Wang, Xin Wei

Published
2024
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16. Research on Ultra-high Rotary Bending Fatigue Strength of Flexible Bearing Steels for Robot Harmonic Speed Reducer

Author

Liu Ye, Gui Yulin, Yin Qing, Wu Xiaolin, Miao Xinde

Subjects
harmonic speed reducer； flexible bearing steel； grain size； non-metallic inclusions； rotary bending fa tigue； ultra-high cycle fatigue, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

The flexible bearing steel with long fatigue life using for robot harmonic speed reducer has been successfully de⁃ veloped by applying EAF process technology. The ratio of scrap to hot metal was controlled more than 80%. This paper compared the metallurgical quality of flexible bearings and traditional rolling bearings in terms of non-metallic inclusions， austenite grain size and carbide banding structure， the fatigue strength of steel used for flexible bearing and traditional roll⁃ ing bearing under 107 cycles was tested by the method of rotary bending fatigue test. The O content of steel used for flexible bearings of robot harmonic reducer was less than 0. 000 4%， the Ti content was much less than 0. 001%， non-metal inclu⁃ sions of class A sulfide≤1. 0 grade， non-metal inclusions of class B and D oxide ≤0. 5 grade. The size of the maximum spherical inclusion was less than 30 μm. The test results show that the flexible bearings have ultra-high purity. By increas⁃ ing Al and N chemical composition in the smelting process， the austenite grain size was 10 grade in the flexible bearing steel， much higher than 8. 5 grade in the traditional rolling bearing steel. The proportion of carbide banding structure of 7. 1 and 7. 2 grade was higher than that of traditional bearing steel in the means of extending the high temperature diffusion time. The ultra-high austenite grain size and the decrease of the width of carbide banding structure showed that the flexible bearing steel had an ultra-high structure uniformity. In addition， the rotary bending fatigue strength of the flexible bearing steels was 1 016 MPa， its fatigue life was slightly higher than that of the traditional rolling bearing steels.

Published
2024
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25. Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model

Author

Uchida, Naoya, Stasula, Ulana, Demirci, Selami, Germino-Watnick, Paula, Hinds, Malikiya, Le, Anh, Chu, Rebecca, Berg, Alexander, Liu, Xiong, Su, Ling, Wu, Xiaolin, Krouse, Allen E., Linde, N. Seth, Bonifacino, Aylin, Hong, So Gun, Dunbar, Cynthia E., Lanieri, Leanne, Bhat, Anjali, Palchaudhuri, Rahul, Bennet, Bindu, Hoban, Megan, Bertelsen, Kirk, Olson, Lisa M., Donahue, Robert E., and Tisdale, John F.

Published
2023
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29. AN ANALYSIS OF INFLUENCING FACTORS FOR SHORT-TERM PROGNOSIS AFTER ENDOVASCULAR TREATMENT IN ELDERLY PATIENTS WITH POSTERIOR CIRCULATION INFARCTION

Author

CAO Qieyan, LIU Xindong, WU Xiaolin, FENG Qiong, LIU Man

Subjects
brain infarction, endovascular procedures, prognosis, root cause analysis, logistic models, Medicine
Abstract

Objective To explore the influencing factors for short-term prognosis after endovascular treatment in elderly patients with posterior circulation infarction (POCI). Methods A retrospective analysis was performed on the clinical data of 50 elderly patients with POCI who received endovascular treatment in the Nuclear Industry 416 Hospital from January 2019 to December 2020. The clinical data included patients’ preoperative general status (age, sex, smoking history, and alcohol abuse history), past disease history (diabetes, hypertension, hyperuricemia, and transient ischemic attack), post-onset indicators [onset-to-door time (ODT), door-to-needle time (DNT), NIH Stroke Scale (NIHSS) on admission], and postoperative conditions (immediate postoperative NIHSS, revascularization, and postoperative complications). The patients were divided into good prognosis group and poor prognosis group according to modified Rankin Scale (mRS) score 90 d after endovascular treatment and were analyzed for the differences in the above indicators. Meanwhile, a multivariate logistic regression analysis was performed on the influencing factors for patients’ short-term prognosis after endovascular treatment. Results There were 20 and 30 patients in the good prognosis group and poor prognosis group, respectively, demonstrating significant differences between the two groups in nine indicators [systolic blood pressure, glycosylated hemoglobin (HbA1c), serum uric acid, total cholesterol, postoperative modified Thrombolysis in Cerebral Infarction (mTICI) grade, preoperative NIHSS score, immediate postoperative NIHSS score, ODT, and postoperative stroke-related pneumonia] (t=2.30-4.13,χ2=6.35,7.07,P

Published
2023
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37. Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency

Author

De Ravin, Suk See, Liu, Siyuan, Sweeney, Colin L, Brault, Julie, Whiting-Theobald, Narda, Ma, Michelle, Liu, Taylor, Choi, Uimook, Lee, Janet, O’Brien, Sandra Anaya, Quackenbush, Priscilla, Estwick, Tyra, Karra, Anita, Docking, Ethan, Kwatemaa, Nana, Guo, Shuang, Su, Ling, Sun, Zhonghe, Zhou, Sheng, Puck, Jennifer, Cowan, Morton J, Notarangelo, Luigi D, Kang, Elizabeth, Malech, Harry L, and Wu, Xiaolin

Subjects
Clinical Trials and Supportive Activities, Biotechnology, Stem Cell Research, Regenerative Medicine, Clinical Research, Gene Therapy, Transplantation, Genetics, Stem Cell Research - Nonembryonic - Human, Hematology, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Antigens, CD34, Clone Cells, Genetic Therapy, Genetic Vectors, Humans, Lentivirus, X-Linked Combined Immunodeficiency Diseases
Abstract

X-linked Severe Combined Immunodeficiency (SCID-X1) due to IL2RG mutations is potentially fatal in infancy where 'emergency' life-saving stem cell transplant may only achieve incomplete immune reconstitution following transplant. Salvage therapy SCID-X1 patients over 2 years old (NCT01306019) is a non-randomized, open-label, phase I/II clinical trial for administration of lentiviral-transduced autologous hematopoietic stem cells following busulfan (6 mg/kg total) conditioning. The primary and secondary objectives assess efficacy in restoring immunity and safety by vector insertion site analysis (VISA). In this ongoing study (19 patients treated), we report VISA in blood lineages from first eight treated patients with longer follow up found a > 60-fold increase in frequency of forward-orientated VIS within intron 3 of the High Mobility Group AT-hook 2 gene. All eight patients demonstrated emergence of dominant HMGA2 VIS clones in progenitor and myeloid lineages, but without disturbance of hematopoiesis. Our molecular analysis demonstrated a cryptic splice site within the chicken β-globin hypersensitivity 4 insulator element in the vector generating truncated mRNA transcripts from many transcriptionally active gene containing forward-oriented intronic vector insert. A two base-pair change at the splice site within the lentiviral vector eliminated splicing activity while retaining vector functional capability. This highlights the importance of functional analysis of lentivectors for cryptic splicing for preclinical safety assessment and a redesign of clinical vectors to improve safety.

Published
2022

44. The crystal structure of catena-poly[diaqua-m2-dicyanido-κ2 C:N-dicyanido-κ1 C-bis(4-(pyridin-4-yl)benzaldehyde-κ1N)iron(II)-platinum(II), C28H22N6O4PtFe

Author

Lu Jitao, Wu Xiaolin, Zhang Youwei, and Xiao Yufang

Subjects
2261330, Physics, QC1-999, Crystallography, QD901-999
Abstract

(C28H22N6O4PtFe)n, triclinic, P 1‾ $\overline{1}$ (no. 2), a = 7.9137(6) Å, b = 8.5766(13) Å, c = 10.970(3) Å, α = 70.266(19)° $70.266(19){}^{\circ}$ , β = 81.258(14)° $81.258(14){}^{\circ}$ , γ = 78.728(11)° $78.728(11){}^{\circ}$ , V = 684.3(2) Å3, Z = 1, R gt(F) = 0.0408, wR ref(F 2) = 0.0657, T = 293 K.

Published
2023
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46. Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy

Author

Budhu, Anuradha, Pehrsson, Erica C., He, Aiwu, Goyal, Lipika, Kelley, Robin Kate, Dang, Hien, Xie, Changqing, Monge, Cecilia, Tandon, Mayank, Ma, Lichun, Revsine, Mahler, Kuhlman, Laura, Zhang, Karen, Baiev, Islam, Lamm, Ryan, Patel, Keyur, Kleiner, David E., Hewitt, Stephen M., Tran, Bao, Shetty, Jyoti, Wu, Xiaolin, Zhao, Yongmei, Shen, Tsai-Wei, Choudhari, Sulbha, Kriga, Yuliya, Ylaya, Kris, Warner, Andrew C., Edmondson, Elijah F., Forgues, Marshonna, Greten, Tim F., and Wang, Xin Wei

Published
2023
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47. Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Author

Patro, Sean C, Brandt, Leah D, Bale, Michael J, Halvas, Elias K, Joseph, Kevin W, Shao, Wei, Wu, Xiaolin, Guo, Shuang, Murrell, Ben, Wiegand, Ann, Spindler, Jonathan, Raley, Castle, Hautman, Christopher, Sobolewski, Michele, Fennessey, Christine M, Hu, Wei-Shau, Luke, Brian, Hasson, Jenna M, Niyongabo, Aurelie, Capoferri, Adam A, Keele, Brandon F, Milush, Jeff, Hoh, Rebecca, Deeks, Steven G, Maldarelli, Frank, Hughes, Stephen H, Coffin, John M, Rausch, Jason W, Mellors, John W, and Kearney, Mary F

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Immunology, Medical Microbiology, Infectious Diseases, HIV/AIDS, 2.2 Factors relating to the physical environment, Aetiology, Infection, Anti-Retroviral Agents, Base Sequence, Cell Line, DNA, Viral, Drug Resistance, Viral, HIV Infections, HIV-1, Humans, Leukocytes, Mononuclear, Lymph Nodes, Mutation, Proviruses, Virus Integration, Virus Replication, HIV persistence, proviral structure, integration site analysis
Abstract

Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populations; however, until recently, there was no way to link integration sites to their cognate proviral sequences. Here, we used multiple-displacement amplification (MDA) of cellular DNA diluted to a proviral endpoint to obtain full-length proviral sequences and their corresponding sites of integration. We applied this method to lymph node and peripheral blood mononuclear cells from 5 ART-treated donors to determine whether groups of identical subgenomic sequences in the 2 compartments are the result of clonal expansion of infected cells or a viral genetic bottleneck. We found that identical proviral sequences can result from both cellular expansion and viral genetic bottlenecks occurring prior to ART initiation and following ART failure. We identified an expanded T cell clone carrying an intact provirus that matched a variant previously detected by viral outgrowth assays and expanded clones with wild-type and drug-resistant defective proviruses. We also found 2 clones from 1 donor that carried identical proviruses except for nonoverlapping deletions, from which we could infer the sequence of the intact parental virus. Thus, MDA-SGS can be used for "viral reconstruction" to better understand intrapatient HIV-1 evolution and to determine the clonality and structure of proviruses within expanded clones, including those with drug-resistant mutations. Importantly, we demonstrate that identical sequences observed by standard SGS are not always sufficient to establish proviral clonality.

Published
2019

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