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In the future new power system, the multi-agent trusted transaction and information security in the virtual power plant (VPP) will be complex and challenging. The features of blockchain technology, such as information security, distribution decision, smart contract and tamper-proof, provide a new idea for VPP multi-subject trusted transaction. This paper focuses on the benefits maximization formed by multi-aggregator inside VPPs and the efficiency of trusted transaction matching. Firstly, according to the different demands of transaction subjects, a master and multi-slave hierarchical interactive control architecture is established to integrate blockchain technology with multi-agent system. Secondly, a credible transaction matching mechanism is designed under the demand of multi-aggregator peer to peer transaction, and non-cooperative game model is introduced to ensure the interests of multi-aggregator subjects. Then, the blockchain-based distributed particle swarm optimization algorithm proposes a consensus algorithm improved by delegated proof-of-authority (DPoA) to improve the security of the transaction. Finally, the rationality and feasibility of the strategy proposed in this paper are verified by an example analysis, which effectively enhances the matching efficiency and security of multi-agent transactions.

In the context of the dual-carbon goal, virtual power plants, microgrids and other forms of prosumers have emerged on a large scale. Energy sharing among multiple prosumers can improve the overall economic efficiency and new energy consumption. A collaborative operation mechanism for energy sharing among multiple prosumers under the weak centralization model is proposed. The mechanism considers the data privacy of each prosumer. Firstly, an internal scheduling model of prosumers with multiple distributed resources is constructed. The model considers the volatility and randomness of load demand and new energy output, quantifying the risk of uncertainty based on conditional value at risk (CVaR). Then, a weakly centralized tariff iteration mechanism for multiple prosumers is proposed, which uses the supply and demand relationship to guide the tariff update. Meanwhile, considering the privacy protection of prosumers, the power data aggregation method is designed based on Paillier homomorphic encryption algorithm and secret sharing principle. The method is able to obtain the system supply and demand information while ensuring the privacy of all parties. Finally, the effectiveness and rationality of the mechanism proposed in this paper is verified by an arithmetic example, and the overall cost of multiple prosumers is reduced by 12.6% after energy sharing.

Nanomaterials (NMs) have found extensive applications in the realm of ornamental plants due to their unique properties. This article comprehensively discusses four main aspects of NM utilization in ornamental plants: 1) providing new insights into challenging problems in tissue culture, 2) exploring their regulatory effects on the growth of ornamental plants, 3) enhancing the resistance to biotic and abiotic stressors, and 4) discussing their widespread application and mechanisms in cut flower harvesting. Furthermore, potential issues and future directions are explored, providing a deeper theoretical basis for the application of novel NMs in the realm of ornamental plants.

AIM: To investigate the clinical efficacy and safety of XEN drainage tube implantation combined with mitomycin C(MMC)for open angle glaucoma(OAG).METHODS:A total of 37 OAG patients(37 eyes)were retrospectively included, grouped by anti-glaucoma surgical treatment as the first choice or not, with 17 patients(17 eyes)in the group with primary surgical treatment, and 20 patients(20 eyes)in the group with the numerous surgeries. The intraocular pressure(IOP), kinds of IOP-lowering drugs, and complications were collected and analyzed in 1 a follow-up postoperatively.RESULTS:Upon the one-year follow-up, IOP had decreased from 27.56±9.94, 28.43±14.18 mmHg to 15.16±3.65, 17.18±5.83 mmHg in both groups, respectively, representing a reduction of 55.01% and 60.43%, respectively(t=4.863, P

In view of the shortage of conventional design methods of pressure curve in the anti-gravity precision casting and taking the structural characteristics of the casting with variable cross-sections into account, automatic calculation of cross-sectional areas was implemented for the casting and gating system by the secondary development of CAD software, and quantitatively describing the variable feature of cross-sections of casting was realized. Based on Bernoulli and flow conservation equations，the relationship between the filling pressure and the rising speed of metal liquid level was deduced. A new design method of pressure curve based on the automatic calculation of cross-sectional areas of the casting was proposed. The simulation results of anti-gravity casting for nickel-based superalloy demonstrate that, compared with the pressure curve of the conventional design method，the new curve can reduce the peak value of filling speed from 0.611 m/s to 0.439 m/s at the minimum cross-sectional area，the falling range of which is 28.15%. It meant that the new method can effectively avoid the shock and splash of liquid metal，meanwhile，shorten the filling time，then the filling process is fast and stable. The hydraulic experiment and pouring experiment show that the new pressure curve has a smoother filling liquid level and can effectively avoid casting defects. Therefore，it proves the effectiveness of the new pressure curve design method and provides a basis for rational design of anti-gravity pressure curve.

Large size nickel-based single crystal twin turbine guide vanes（TGVs）were prepared by grain continuator（GC）technology. Directional solidification was performed in a high-rate-solidification（HRS）Bridgman vacuum furnace. Then, the macro-etching test was carried out to reveal the single crystal integrality of TGVs. Scanning electron microscopy（SEM）, electron backscatter diffraction（EBSD）technology, and high temperature stress rupture experiment were applied to evaluate the actual properties of TGVs. Simultaneously, the professional finite element modeling（FEM）ProCAST software was used to simulate the directional solidification process of single crystal TGVs. The experimental results show that the formation of stray grain（SG）defect can be avoided effectively, and integrity large size single crystal twin TGVs can be prepared successfully by adopting GC technology. However, the low angle grain boundaries（LABs）defects are formed inevitably, and the boundaries angle between primary crystal and GC crystal in Vane 1 are 1.5° and 2.7° respectively. Despite the mechanical performance at high temperature degrades slightly（stress rupture life loss less than 15%, and elongation loss less than 7%）, the service performance of TGVs is still satisfied perfectly. According to the solidification process results of the large size twin TGVs simulated by ProCAST software, it is found that the initial solidification path of TGVs is optimized, meanwhile, and the undercooling condition at the leading edge of TGVs is improved by adding the GC structure. In addition, the nucleation probability of SG defect is reduced significantly, and the formation of SG defects is avoided effectively.

In this paper, we first studied the basic content of deep learning in college sports and explored the principles of physical education evaluation in colleges and universities in the context of deep learning. Then, the framework of the physical education evaluation index system is constructed, the indexes are screened and optimized by combining the Delphi method, and the weights of the indexes are calculated by using the fuzzy comprehensive evaluation method. Then, based on the expectation and satisfaction data of students in the sample colleges and universities, the gap is analyzed according to the perception-expectation matrix, and the SERVQUAL model is used to analyze each issue of the quality of physical education in colleges and universities one by one. The maximum value of the expectation of the quality of physical education in colleges and universities is 6.558 points, the minimum value is 6.348 points, the maximum value of the mean value of perception is 6.349 points, the minimum value is 5.797 points, and the scores are above 5 points, which makes the quality of education in colleges and universities better. This study further enriches the theory of quality evaluation of education in sports colleges and establishes the evaluation model and method with specific specifications.

as an important part of the digital economy, energy power data elements assets management related field is extensive, covers the industry digital, digital industrialization, data value multiple dimensions of content, contains both national laws and policies, domestic and foreign markets, and contains specific data assets, data pricing, data trading technology and "cloud big wisdom" technical support. This paper mainly starts from the two dimensions of digital economy, data transaction and asset management of data elements, in order to provide reference and reference for relevant energy and power enterprises to carry out the practice of asset management of power data elements.

Pure copper/copper alloy has excellent thermal and electrical conductivity, which is an important industrial material. Laser powder bed fusion, which represents the laser additive manufacturing technology, has excellent design freedom and forming accuracy, and is the mainstream development direction of additive manufacturing. Compared with traditional processing and manufacturing technology, the laser powder bed fusion of pure copper/copper alloy can give better play to the excellent performance of copper, and has broad application prospects in the fields of high thermal conductivity/electrical conductivity such as electrical and electronic, automotive, aerospace and other fields. The current research status of laser powder bed fusion of laser high-reflective materials represented by pure copper/copper alloys, the important problems they face, and the analysis of corresponding solutions were reviewed in this paper. On this basis, combined with the team's experience in the laser powder bed fusion process of pure copper/copper alloy, it was pointed out that the use of blue, green and other short-wavelength lasers for the powder bed laser fusion of pure copper/copper alloy and other highly reflective materials is a future study hot spots and development directions.

The main focus of this research work was to study the anti-cancer properties of 7,8-dihydromethysticin against HL-60 leukemia cells. Investigations were also performed to check its impact on the phases of the cell cycle, cell migration and invasion, JAK/STAT signalling pathway and intracellular mitochondrial membrane potential (MMP) and reactive oxygen species (ROS). Cell proliferation was assessed through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and effects on colony formation were examined via clonogenic assay. Flow cytometry and Western blott analysis were performed to investigate the distribution of cell cycle phases. Flow cytometric analysis was performed for the examination of MMP and ROS production. The effect on JAK/STAT signalling pathway was examined through Western blot analysis. Results depicted that 7,8-dihydromethysticin induced concentration- as well as time-dependent inhibition of cell proliferation in leukemia HL-60 cells. Clonogenic assay indicated potential suppression in leukemia HL-60 cell colonies. The 7,8-dihydromethysticin molecule also caused cell cycle arrest at G2/M-phase along with concentration-dependent inhibition of cyclin B1, D1 and E. ROS and MMP measurements indicated significant ROS enhancement and MMP suppression with increasing 7,8-dihydromethysticin concentrations. Additionally, 7,8-dihydromethysticin led to remarkable dose-reliant inhibition of cell invasion as well as cell migration. Therefore, 7,8-dihydromethysticin should be considered a valuable candidate for leukemia research and chemoprevention.

doi：10.3969/j.issn.1672⁃6731.2021.12.014

The recycled brick micropowder was formed after crushing and ball milling and waste clay bricks have great potential activity. It can replace some percentage of cement in the preparation of concrete through activation effects of excitation, and thus, reutilization of waste products is the objective of this study. This study analyzed the activation effects of mechanical excitation, chemical excitation, and high-temperature excitation on the activity of regenerated brick powder. The correlation between different excitation methods and the activity index was fitted, and the microstructure and mechanism of action of the material were analyzed and revealed using SEM and XRD techniques. The results show that after using mechanical excitation, chemical excitation, and high-temperature excitation to activate the brick powder, the activity index of the material was improved to varying degrees, and there is a good correlation between different excitation modes and the activity index. The study shows that the 45 min mechanical excitation of ball milling and the high-temperature excitation of 800 have better effects, with the highest activity index reaching 71%, and the highest activity index in the chemical excitation mode is 65%. Considering the excitation effect, energy consumption, economy, and practical operation feasibility, it is recommended to use the ball milling 45 min excitation method as the best activation method for the recycled brick micropowder.

BACKGROUND For the determination of P2O5 in complete silicate analysis of uranium-producing ore by alkali fusion-phosphovanoclonolybeate spectrophotometry with wavelength of 420nm, iron (Fe) was detected simultaneously, because Fe as the co-existing element complexed with ammonium vanadium molybdate and showed the same yellow with phosphovanoclonolybeate. Iron produced positive interference on the results of P2O5. OBJECTIVES To correct the interference of Fe on the determination of P2O5. METHODS Taking Fe2O3 as the assessment amount of Fe in complete silicate analysis, when detection wavelength was changed from 400nm to 480nm, the effects of different amounts of Fe2O3 (0.00 to 0.70mg/mL) on the absorption value of P2O5 with content of 0.20g/mL, 2.00g/mL and 8.00g/mL were investigated, respectively. RESULTS (1) It was found that when the detection wavelength of P2O5 was changed from 420nm to 450nm, the positive interference produced by Fe2O3 on the analysis results of P2O5 was corrected. Moreover, the contents of Fe2O3 and P2O5 in the sample was within the calibration range at the correction wavelength of 450nm when taking national standard materials GBW04117-GBW04122 of uranium-producing ore as verification samples. (2) When P2O5 in national standard material of uranium-producing rocks, basalts and argillaceous limestone was analyzed at 450nm, the results were within the error range. The method precision (RSD) was between 1.1% and 15.7%, which met requirements of analyzing P2O5 in other samples with a similar matrix such as silicate and uranium ores. CONCLUSIONS The corrected method is simple and easy to operate. It provides a supplementary method for accurate spectrophotometric determination of P2O5 during complete silicate analysis in uranium-producing ore.

As the existing belt tear detection method based on machine vision technology being used for images with complex background texture, it is easy to misjudge the defect areas with inconspicuous tear marks relative to the background texture as non-defects, and the detection results are noisy and difficult to identify. In order to solve the above problems, a belt tear detection method based on two-dimensional Gabor filter is proposed. The method uses Gabor filtering to process the belt images and obtain multiple Gabor filtered processing images. Through the Gabor optimization selection method, a new cost function is constructed based on the coefficient of variation, and the optimal filter channel is selected to highlight the texture characteristics of the tear area. The Sobel operator is used to extract the texture characteristics of the tear area in the horizontal and vertical directions respectively so as to obtain the gradient images of the two directions. The self-propagation normalization operation is applied on the obtained gradient images to enhance the texture information, and the pixel-weighted average method is used to fuse the two images. The obtained fused images are segmented by adaptive threshold binarization method, and morphological technology is used to perform belt tear detection on the images to be detected. The detection results show that the improved Gabor optimization selection method has a lower miss detection rate than the Gabor optimization selection method and the Sobel operator-based longitudinal tear detection method. The method can detect all defects in the belt defect images with complex background texture. The detection results are clear and the contour characteristics of the tear area are preserved relatively well.

In this study, the potato whole flour was added to wheat flour with wheat gluten was auxiliary added to make potato noodle. Three groups of the potato powder noodles with different total flour content were studied from three levels: texture characteristics, microstructure and physicochemical properties of noodles. It was found that the potato powder had a certain effect on the mechanical properties of dough, the formation and structure of gluten network, and the cooking parameters and appearance of noodles. The results showed that the overall index was the best when the total amount of the potato powder was 20% (g/g)and the amount of gluten was 0.03% (g/g). It was also found that the effect of the potato powder on dough was bidirectional. The effect of the potato starch on the dough was negative, but the polysaccharides and protein in the potato powder may have a positive effect on the dough and gluten network. At the same time,the addition of wheat gluten can improve the stability of dough and the quality of noodles.

In order to better explain the phenomenon of foundation pit inrush caused by confined water, the Hansbo non-Darcy seepage theory was introduced into the Terzaghi one-dimensional saturated soil consolidation equation. Finite difference methods were applied to the numerical solution of excess pore pressure caused by the fluctuation of confined water. Then, the numerical solution was reduced to Darcy seepage and compared with the analytical solution. The effects of non-Darcy parameters, fluctuation periods of confined water, and initial water levels on the variation of excess pore pressure in the aquitard were analyzed. The results show that the excess pore pressure in aquitard volatility increases over time under the fluctuation of confined water, and reaches a stable fluctuating state after several cycles. The greater the initial hydraulic gradient and test constant of non-Darcy, the more obvious the hysteresis phenomenon of excess pore pressure, and the smaller the amplitude. The longer period of pressure water fluctuation or the higher the initial water level, the greater the amplitude of excess pore pressure oscillation. In addition, when the base is subjected to higher levels of initial confined water, the excess pore pressure in aquitard becomes more susceptible to the change of confined water pressure. The application of a case indicates that the designed drawdown depth of the confined water level could be reduced if the non-Darcy factor is considered.

Objective To identify potential target genes for isocitrate dehydrogenase (IDH) mutations in cholangiocarcinoma. Methods DNA methylation 450K data and mRNA expression data of the TCGA CHOL project were downloaded. Probe-wise differential methylation analysis and differential expression analysis were performed through limma and DESeq2 in the IDH-mutant vs IDH-WT comparison. Then, Spearman correlation analysis was performed between the normalized expression levels of differentially expressed genes and the methylation levels of corresponding differentially methylated sites. Genes with high methylation, low expression, and strong negative correlation were screened for enrichment analysis to explore their functions. A protein interaction network was constructed and the core modules were found by MCODE. Results The analysis revealed 11 605 differentially methylated sites, of which 10 427 were hypermethylated; and 651 of the 735 differentially expressed genes were down-regulated. Among them, 143 down-regulated genes and 328 hypermethylation sites formed 330 strongly negatively correlated combinations. The above 143 genes are enriched in the regulation of epidermal growth factor receptor signaling pathway, cell extravasation and cell division. By constructing a protein-protein interaction (PPI) network, 10 genes of its core module were identified, which were involved in biological processes such as epithelial cell differentiation and development, and cellular protein localization. Conclusions By integrating the TCGA cholangiocarcinoma transcriptome and DNA methylation data, the potential target genes for IDH mutations are obtained and the core modules of their PPI network are identified, providing new clues for the role of IDH mutations in the development of cholangiocarcinoma.

Background At present, most of the contamination detection equipments for small items in domestic nuclear power plants are manually putting in and taking out the testing items, and the operation time is long and the steps are relatively tedious. According to the on-site demand of nuclear power and feedback on the use of similar imported equipment, contamination detection equipment based on the conveyor belt can effectively solve these drawbacks. Purpose This study aims to design a small item γ pollution measuring instrument that can be used to transmit items with a conveyor belt, hence effectively improve the detection efficiency and save the cost of manual operation. Methods Semi-automatic two-channel control design scheme was adopted, one through the motor driver to control the conveyor belt motor running mode, the other control the digital circuit of the radiation detector and the corresponding electrical parts through the main control board. Linkage of contamination monitoring status and item convey was achieved by the status control board associated with the motor drive. The background counting rate of the equipment in the background environment, the counting rate of the radioactive source at rest in the center of the measuring chamber and the dynamic counting rate of the radioactive source moving through the measuring chamber with the conveyor belt were tested and analyzed. Results The results show that the minimum net count value of the detector is 81.6% of the average count in the static state. The net value of the minimum peak value of the detector at motion state is 89.3% of the average peak count, and the minimum detectable limit is 111 Bq. Conclusions The test performance of prototype is better than the reference standard and meets the design requirements.

Storage and transportation are one of the primary restrictions on the approach involving hydrogen energy. The traditional hydrogen storage methods, including high-pressure gas cylinder and cryogenic liquid tank show unfavorable economy, thus hindering their further industrial application and development. Metal hydrides can reversibly react with hydrogen and accomplish the hydriding/dehydriding process under mild operation conditions, which feature advantages such as large hydrogen storage amount, low operation pressure and energy consumption. This process is expected to replace the conventional hydrogen storage and transportation. Meanwhile, considering the strong endothermal/exothermic effect during hydrogenation/dehydrogenation, the prompt heat removal/support inside the metal hydride reactor is a key parameter for H2 absorption/desorption rate and H2 storage efficiency. To improve the heat transfer and absorption/desorption rates of metal hydride reactor, comprehensive analysis and evaluation were conducted. Based on the heat and mass transfer intensification, a new elliptical spiral mini-tube bundle reactor (ESMBR) with high efficiency was designed and proposed; the reactor possesses numerous features, such as high heat transfer speed, compact structure, high reaction rate, and convenient operation. All the hydrogen storage reactor models were established, and both the model accuracy and effectiveness were experimentally validated. Numerical simulations of ESMBR, spiral mini-tube bundle reactor, and mini-tube bundle reactor were calculated and compared by COMSOL. ESMBR was proven to exhibit favorable heat and mass transfer performance during the H2 storage. Results of further analysis indicate that the sensitivity order of elliptical spiral structure parameters as follows: Dc > A > B > Pt > α. A multi-element valued model was used to evaluate the reactor schemes systematically, and the calculation results show the integrated superiority of ESMBR could achieve a value of 0.845. The comparison results indicate that the ESMBR presents an outstanding performance compared with other reactors and features a broad application prospect in the field of hydrogen energy.

BACKGROUND The analysis and testing process of high-phosphorus iron ore requires quality control of standard materials with similar matrix components, moderate content and fixed value components. At present, there are no certified reference materials available for high-phosphorus iron ore chemical composition analysis in China. The available iron ore reference materials in China and abroad have different matrix compositions and phosphorus contents. Phosphorus content is mostly less than 0.25%, while phosphorus content in high-phosphorus iron ore is higher than 0.25%. It is difficult to meet the analytical quality control requirements of high-phosphorus iron ore products with these reference materials. OBJECTIVES To develop three high-phosphorus iron ore reference materials with contents of iron and phosphorus forming a certain gradient and covering the content range of high phosphorus iron ore. CANDIDATES CHARACTERISTICS The sample GPFe-1 is composed of 40% metallic minerals, 25% quartz, 15% colloidal phosphate, 20% oolitic chlorite, clay mineral, apatite, carbonate minerals, rock debris and a small amount of organic matter. The metal minerals are hematite, limonite and pyrite.The contents of iron and phosphorus are 31%-37% and 0.1%-0.5%, respectively. The sample GPFe-2 consists of 40% hematite, 5% limonite, 55% gangue mineral, and minor collophanite and pyrite. The iron and phosphorus contents in GPFe-2 are 38%-44% and 0.6%-1.0%, respectively. The sample GPFe-3 is composed of 70% metallic minerals (hematite, limonite, pyrite), 5% quartz, 1% collophane, 3% chlorite, 1% cuttings, and minor apatite and calcite. The contents of iron and phosphorus in this sample are 48%-55% and 1.4%-2.0%, respectively. METHODS The samples of high-phosphorus iron ores were collected from the western Hubei Yelangping mining area in Zigui county of Yichang city, the Enshi Changling mining area (Wuhan iron and steel corporation mining area), and the Huoshaoping mining area in Changyang county of Yichang city (Bao Steel Group Changyang mining area). Uniformity and stability were tested for 25 components of SiO2, Al2O3, TiO2, P, K2O, Na2O, Fe, MnO, CaO, MgO, FeO, LOI, S, Cu, Pb, Zn, Cr, Ni, Co, Cd, Sr, Ba, V, As and Hg. Uniformity test was evaluated by variance analysis F test and relative standard deviation of test results. Stability test was evaluated by linear fitting and t-test. RESULTS Three samples were homogeneous and stable. The RSD of major elements and trace elements of 3 samples was less than 5%. The F value of variance test was less than the critical value F0.05(24, 25)=1.96, indicating that all the components of 3 samples were homogeneous. The stability test showed that the components of 3 samples had no directional change and statistically significant differences, indicating that the elements in the 3 samples were stable. The verified value was tested by 11 laboratories and by two or more different principles. The verified value components included 25 major elements and trace elements. Three components of Na2O, S and Hg of GPFe-1 had reference values, whereas other 22 components had certified values and uncertainties. The contents of iron and phosphorus in GPFe-1 were 35.18%±0.20% and 0.285%±0.010%, respectively. Two components of Cd and Hg in GPFe-2 had reference values, and other 23 components had certified values and uncertainties. The contents of iron and phosphorus in GPFe-2 were 41.46%±0.20% and 0.735%±0.020%, respectively. Two components of FeO and Hg in GPFe-3 had reference values, while other 23 components had certified values and uncertainties. The contents of iron and phosphorus in GPFe-3 were 51.44%±0.13% and 1.73%±0.05%, respectively. CONCLUSIONS The developed high-phosphorus iron ore reference materials meet the requirements for exploration, evaluation, and comprehensive utilization of high-phosphorus iron ore.

The necessity of integrated energy-saving reform of boiler feed water pump is explained， the improved scheme of planetary hydraulic speed regulating device is put forward， and its working principle and energy saving characteristic is expounded. Taking a power plant in Xinjiang as an example， the renovation project of feed water pump unit replacing hydraulic coupling with the original size of planetary hydraulic speed regulating device from mechanical system， lubricating oil system and electrical system is carried out. A detailed comparative analysis of the feasibility， economy and effect of the comprehensive energy saving reform of the feed water pump is carried out. It is concluded that the advantages of planetary hydraulic speed regulating device can reduce the power consumption rate of power plant by 0.41%， and at the same time have the characteristics of safety， stability， high efficiency and energy saving.

Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy. Industry and academia have substantially invested in developing substances, which can efficiently and specifically block the WNT signaling pathway. However, a clear clinical proof of the efficacy of this approach is still missing. Studies on the metabolomics dysregulation of cancer cells have led to innovations in oncological diagnostics. In addition, modulation of cancer cell metabolome is at the base of promising clinical oncology trials currently underway. While onco-protein activation can have profound metabolic outcomes, the involvement of stem cell signals, such as the WNT pathway, in tumor cell metabolomics is yet insufficiently characterized. Material and methods: We determined live cell metabolism and bioenergetics in pathophysiological relevant, WNT-dependent glioblastoma stem cell (GSC) models. We quantified those parameters in cells with canonical WNT activity and in isogenic cells where WNT activity had been inhibited by short hairpin RNA against β-catenin. Furthermore, we applied computational analysis of RNA sequencing to verify our functional findings in independent GSCs cohorts. Results: The investigated collection of disease models allows the separation in tumors with low, moderate and high base line metabolic activity. Suppression of canonical WNT signaling led to significant reduction of total, mitochondrial, and glycolytic ATP production rates. Elevated canonical WNT transcription signature in GSCs positively correlated with transcription levels of mitochondrial ATP synthesis, whereas non-canonical WNT gene expression signature did not. Conclusion: The applied disease modeling technology allows the recapitulation of inter-tumoral heterogeneous metabolic properties of glioblastoma. Our data show for the first time that inhibition of canonical WNT signaling in alive GSCs functionally correlates with energy inhibition and glucose homeostasis. As this correlation occurs in GSCs from different transcriptional or epigenetic transcriptional subtypes, our results suggest that developing therapies directed against glycolysis/ATP-synthesis may be a promising strategy to overcome therapy resistance due to inter-tumoral heterogeneity and offers starting point to impair downstream signal WNT.

Optical metasurfaces are judicously engineered electromagnetic interfaces that can control and manipulate many of light’s quintessential properties, such as amplitude, phase, and polarization. These artificial surfaces are composed of subwavelength arrays of optical antennas that experience resonant light-matter interaction with incoming electromagnetic radiation. Their ability to arbitrarily engineer optical interactions has generated considerable excitement and interest in recent years and is a promising methodology for miniaturizing optical components for applications in optical communication systems, imaging, sensing, and optical manipulation. However, development of optical metasurfaces requires progress and solutions to inherent challenges, namely large losses often associated with the resonant structures; large-scale, complementary metal-oxide-semiconductor-compatible nanofabrication techniques; and incorporation of active control elements. Furthermore, practical metasurface devices require robust operation in high-temperature environments, caustic chemicals, and intense electromagnetic fields. Although these challenges are substantial, optical metasurfaces remain in their infancy, and novel material platforms that offer resilient, low-loss, and tunable metasurface designs are driving new and promising routes for overcoming these hurdles. In this review, we discuss the different material platforms in the literature for various applications of metasurfaces, including refractory plasmonic materials, epitaxial noble metal, silicon, graphene, phase change materials, and metal oxides. We identify the key advantages of each material platform and review the breakthrough devices that were made possible with each material. Finally, we provide an outlook for emerging metasurface devices and the new material platforms that are enabling such devices.

The aim of the study is to investigate a variation in the gene SLC6A19 in a female patient with Hartnup disorder manifested only by seizure.

Graphene doped tin oxide composites were prepared with SnCIZ·2HZ 0 and graphene oxide as raw materials with sol-gel method and then spincoated on the quartz glass to manufacture a new transparent conductive film. The composite film was characterized with X-ray diffraction(XRD)and scanning electron microscopy(SEM) analysis. XRD results show that the graphene oxide was successfully prepared with Hummers method. The graphene layers and particulate SnOZ can be clearly observed in SEM photos. The transmittance and conductivity of the thin films were tested with ultraviolet visible spectrophotometer and Hall effect measurement. The results show that the transmittivity of composite film in visible region is more than 90% and surface square resistance is 41 S2/口.The graphene/ SnOZ film exhibits a higher performance in transparence and conductivity than commercial FTO glass.

C30H24CoN6O6S, monoclinic, P21/c (no. 14), a = 11.892(6) Å, b = 11.206(6) Å, c = 20.694(11) Å, β = 93.558(13)°, V = 2752(3) Å3, Z = 4, Rgt(F) = 0.0413, wRref(F2) = 0.1030, T = 293(2) K.

Inspired by the ultraviolet induced properties of biological materials, we developed fluorescent wood as a new type of functional material which can be applied to anti-counterfeit label technology and wood-emitting artwork. This study discusses the influence of temperature, time, ligand ratio, and reactant concentration on the structure and properties of fluorescent wood with europium(III) ternary complexes. The surface morphology and fluorescent properties of the modified wood were characterized by scanning electron microscopy (SEM) and fluorescence spectrometry. The results showed that a high reaction temperature of 75 ºC was beneficial in obtaining stronger fluorescent wood; a reaction time of 8 h exerted a significant influence on fluorescent wood when the reactant concentration of the sample was 0.03 mol/L. In addition, the results of infrared spectroscopy, X-ray photoelectron spectroscopy, and energy-dispersive X-ray analysis showed that modification of wood takes place through the Si-OH groups of the silane coupling agent, which link to the surface of wood. After 120 hours of UV light irradiation, the surface fluorescence intensity of the modified wood can reach 500 arb. units. It can be considered that the modified wood has better anti-ultraviolet aging properties, thereby prolonging the life of poplar.