Search

Your search keyword '"Wang, Qingyang"' showing total 426 results
Start Over Author "Wang, Qingyang" Publication Type Academic Journals
426 results on '"Wang, Qingyang"'

2. Prediction and Analysis of Earth Pressure Balance Shield Machine Advancing Speed in Limestone Stratum

Author

LIU Hao, CUI Jianbo, YANG Xia, and WANG Qingyang

Subjects
urban rail transit, earth pressure balance shield machine, advancing speed, limestone stratum, Transportation engineering, TA1001-1280
Abstract

Objective The advancing speed of shield machine is crucial not only for the tunnel excavation pace but also for the predicting construction schedule and cost. Therefore, it is necessary to predict and analyze the advancing speed of the shield machine. Method Taking the full-section limestone stratum of Longao Station-Olympic Sports Center West Station interval on Jinan Metro Line 3 as research object, data from shield machine excavation are collected and preprocessed using methods such as zero-push value, outlier removal, and data denoising. To improve prediction accuracy, the dataset is divided into training and validation sets. A model for predicting thrust speed is established from linear regression based on cutterhead torque and total thrust, and the influence law of excavation load on advancing speed is analyzed. Result & Conclusion In limestone stratum, the linear regression prediction accuracy of three advancing speed prediction models all exceeds 0.70, indicating that advancing speed can be accurately predicted based on cutterhead torque and total thrust. During excavation with the earth pressure balance shield machine, fluctuations in cutterhead rotation speed and advancing speed are minimal. As the cutterhead rotation speed increases, the cutterhead torque gradually decreases. Cutterhead torque positively influences the advancing speed; the greater the cutterhead torque, the higher the advancing speed. Under the same stratum and excavation conditions, due to the soil extrusion action of cutterhead, merely increasing the total thrust is not conducive to improving advancing speed, calling for the necessity of simultaneously increasing cutterhead rotation speed.

Published
2024
Full Text
View/download PDF

8. scDesign3 generates realistic in silico data for multimodal single-cell and spatial omics

Author

Song, Dongyuan, Wang, Qingyang, Yan, Guanao, Liu, Tianyang, Sun, Tianyi, and Li, Jingyi Jessica

Subjects
Bioengineering, Generic health relevance
Abstract

We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories and spatial locations; and generates in silico negative and positive controls for benchmarking computational tools.

Published
2023

12. Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection.

Author

Seo, Goo-Young, Takahashi, Daisuke, Wang, Qingyang, Mikulski, Zbigniew, Chen, Angeline, Chou, Ting-Fang, Marcovecchio, Paola, McArdle, Sara, Sethi, Ashu, Shui, Jr-Wen, Takahashi, Masumi, Surh, Charles, Cheroutre, Hilde, and Kronenberg, Mitchell

Subjects
Animals, Collagen, Epithelial Cells, Integrins, Intraepithelial Lymphocytes, Ligands, Mice
Abstract

Intraepithelial T cells (IETs) are in close contact with intestinal epithelial cells and the underlying basement membrane, and they detect invasive pathogens. How intestinal epithelial cells and basement membrane influence IET survival and function, at steady state or after infection, is unclear. The herpes virus entry mediator (HVEM), a member of the TNF receptor superfamily, is constitutively expressed by intestinal epithelial cells and is important for protection from pathogenic bacteria. Here, we showed that at steady-state LIGHT, an HVEM ligand, binding to epithelial HVEM promoted the survival of small intestine IETs. RNA-seq and addition of HVEM ligands to epithelial organoids indicated that HVEM increased epithelial synthesis of basement membrane proteins, including collagen IV, which bound to β1 integrins expressed by IETs. Therefore, we proposed that IET survival depended on β1 integrin binding to collagen IV and showed that β1 integrin-collagen IV interactions supported IET survival in vitro. Moreover, the absence of β1 integrin expression by T lymphocytes decreased TCR αβ+ IETs in vivo. Intravital microscopy showed that the patrolling movement of IETs was reduced without epithelial HVEM. As likely consequences of decreased number and movement, protective responses to Salmonella enterica were reduced in mice lacking either epithelial HVEM, HVEM ligands, or β1 integrins. Therefore, IETs, at steady state and after infection, depended on HVEM expressed by epithelial cells for the synthesis of collagen IV by epithelial cells. Collagen IV engaged β1 integrins on IETs that were important for their maintenance and for their protective function in mucosal immunity.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results