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This paper gives a detailed account of the Gravity Probe B cryogenic payload comprised of a unique Dewar and Probe. The design, fabrication, assembly, and ground and on-orbit performance will be discussed, culminating in a 17 month 9 day on-orbit liquid helium lifetime. [ABSTRACT FROM AUTHOR]

The results of the Gravity Probe B relativity science mission published in Everitt et al (2011 Phys. Rev. Lett.106 221101) required a rather sophisticated analysis of experimental data due to several unexpected complications discovered on-orbit. We give a detailed description of the Gravity Probe B data reduction. In the first paper (Silbergleit et al Class. Quantum Grav.22 224018) we derived the measurement models, i.e., mathematical expressions for all the signals to analyze. In the third paper (Conklin et al Class. Quantum Grav.22 224020) we explain the estimation algorithms and their program implementation, and discuss the experiment results obtained through data reduction. This paper deals with the science data preparation for the main analysis yielding the relativistic drift estimates. [ABSTRACT FROM AUTHOR]

Gravity Probe B (GP-B) is a landmark physics experiment in space designed to yield precise tests of two fundamental predictions of Einstein's theory of general relativity, the geodetic and frame-dragging effects, by means of cryogenic gyroscopes in Earth orbit. Launched on 20 April 2004, data collection began on 28 August 2004 and science operations were completed on 29 September 2005 upon liquid helium depletion. During the course of the experiment, two unexpected and mutually-reinforcing complications were discovered: (1) larger than expected 'misalignment' torques on the gyroscopes producing classical drifts larger than the relativity effects under study and (2) a damped polhode oscillation that complicated the calibration of the instrument's scale factor against the aberration of starlight. Steady progress through 2006 and 2007 established the methods for treating both problems; in particular, an extended effort from January 2007 on 'trapped flux mapping' led in August 2007 to a dramatic breakthrough, resulting in a factor of [?]20 reduction in data scatter. This paper reports results up to November 2007. Detailed investigation of a central 85-day segment of the data has yielded robust measurements of both relativity effects. Expansion to the complete science data set, along with anticipated improvements in modeling and in the treatment of systematic errors may be expected to yield a 3-6% determination of the frame-dragging effect. [ABSTRACT FROM AUTHOR]

Gravity Probe B, launched 20 April 2004, is a space experiment testing two fundamental predictions of Einstein's theory of general relativity (GR), the geodetic and frame-dragging effects, by means of cryogenic gyroscopes in Earth orbit. Data collection started 28 August 2004 and ended 14 August 2005. Analysis of the data from all four gyroscopes results in a geodetic drift rate of -6601.8±18.3  mas/yr and a frame-dragging drift rate of -37.2±7.2  mas/yr, to be compared with the GR predictions of -6606.1  mas/yr and -39.2  mas/yr, respectively ("mas" is milliarcsecond; 1  mas=4.848×10(-9)  rad).

GABA level and the activity of L-glutamate-1-decarboxylase (GAD) (EC 4.1.1.15) were studied in brains of mice treated with beta-vinyllactic acid, a new, selective and pyridoxal phosphate-independent GAD inhibitor. Valproate and diazepam protected mice against convulsions caused by beta-vinyllactic acid although both anti-epileptic drugs antagonized neither the decrease in GABA concentrations nor the inhibition of GAD observed after treatment with beta-vinyllactic acid alone. Assuming that the anticonvulsant effect measured with both antiepileptics is GABA mediated, these results support the hypothesis of a postsynaptic enhancement of GABAergic transmission by diazepam and valproate.