181 results on '"Van Remoortel, Hans"'
Search Results
2. Cost-Effectiveness of Thrombopoietin Mimetics in Patients with Thrombocytopenia: A Systematic Review
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Van Remoortel, Hans, Scheers, Hans, Avau, Bert, Georgsen, Jørgen, Nahirniak, Susan, Shehata, Nadine, Stanworth, Simon J., De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
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- 2023
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3. Adverse events of iron and/or erythropoiesis-stimulating agent therapy in preoperatively anemic elective surgery patients: a systematic review
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Laermans, Jorien, Van Remoortel, Hans, Avau, Bert, Bekkering, Geertruida, Georgsen, Jørgen, Manzini, Paola Maria, Meybohm, Patrick, Ozier, Yves, De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
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- 2022
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4. Predicting medical usage rate at mass gathering events in Belgium: development and validation of a nonlinear multivariable regression model
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Scheers, Hans, Van Remoortel, Hans, Lauwers, Karen, Gillebeert, Johan, Stroobants, Stijn, Vranckx, Pascal, De Buck, Emmy, and Vandekerckhove, Philippe
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- 2022
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5. Lack of Cost-Effectiveness of Preoperative Erythropoiesis-Stimulating Agents and/or Iron Therapy in Anaemic, Elective Surgery Patients: A Systematic Review and Updated Analysis
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Avau, Bert, Van Remoortel, Hans, Laermans, Jorien, Bekkering, Geertruida, Fergusson, Dean, Georgsen, Jørgen, Manzini, Paola Maria, Ozier, Yves, De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
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- 2021
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6. High-Intensity Training for 6 Months Safely, but Only Temporarily, Improves Exercise Capacity in Selected Solid Organ Transplant Recipients
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Cappelle, Marie, Masschelein, Evi, Vos, Robin, Van Remoortel, Hans, Smets, Sven, Vanbekbergen, Jonas, Verreydt, Joris, Troosters, Thierry, Goetschalckx, Kaatje, Gosselink, Rik, and Monbaliu, Diethard
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- 2021
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7. The effect of hand hygiene promotion programs during epidemics and pandemics of respiratory droplet-transmissible infections on health outcomes: a rapid systematic review
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Veys, Koen, Dockx, Kim, Van Remoortel, Hans, Vandekerckhove, Philippe, and De Buck, Emmy
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- 2021
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8. Authors’ Response to “Preoperative Intravenous Iron for Iron Deficiency is Cost-Effective Prior to Major Elective Surgery”
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Avau, Bert, Van Remoortel, Hans, De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
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- 2022
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9. Effects of plasmapheresis frequency on health status and exercise performance in men: A randomized controlled trial.
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Mortier, Alexandre, Khoudary, Jina, van Dooslaer de Ten Ryen, Sophie, Lannoy, Camille, Benoit, Nicolas, Antoine, Nancy, Copine, Sylvie, Van Remoortel, Hans, Vandekerckhove, Philippe, Compernolle, Veerle, and Deldicque, Louise
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RANDOMIZED controlled trials ,SERUM albumin ,IMMUNOGLOBULIN M ,BODY composition ,PLASMAPHERESIS - Abstract
Background and Objectives: Most research studies on the effects of repeated plasma donation are observational with different study limitations, resulting in high uncertainty on the link between repeated plasma donation and health consequences. Here, we prospectively investigated the safety of intensive or less intensive plasma donation protocols. Materials and Methods: Sixty‐three male subjects participated in this randomized controlled trial and were divided into low‐frequency (LF, once/month, n = 16), high‐frequency (HF, three times/month, n = 16), very high‐frequency (VHF, two times/week, n = 16) and a placebo (P, once/month, n = 15) groups. Biochemical, haematological, clinical, physiological and exercise‐related data were collected before (D0), after 1½ months (D42) and after 3 months (D84) of donation. Results: In VHF, red blood cells, haemoglobin and haematocrit levels decreased while reticulocyte levels increased from D0 to D84. In both HF and VHF, plasma ferritin levels were lower at D42 and D84 compared to D0. In VHF, plasma levels of albumin, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) dropped from D0 to D42 and remained lower at D84 than at D0. In HF, plasma IgG, IgA and IgM were lower at D42, and IgG and IgM were lower at D84, compared to D0. Few adverse events were reported in HF and VHF. Repeated plasma donation had no effect on blood pressure, body composition or exercise performance. Conclusion: VHF plasmapheresis may result in a large reduction in ferritin and IgG levels. HF and VHF plasmapheresis may result in little to no difference in other biochemical, haematological, clinical, physiological and exercise‐related parameters. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Safety and protection of plasma donors: A scoping review and evidence gap map.
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Schroyens, Natalie, D'aes, Tine, De Buck, Emmy, Mikkelsen, Susan, Tiberghien, Pierre, van den Hurk, Katja, Erikstrup, Christian, Compernolle, Veerle, and Van Remoortel, Hans
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EVIDENCE gaps ,PLASMAPHERESIS ,CONVALESCENT plasma ,PLASMA devices ,RESEARCH personnel ,DATABASE searching - Abstract
Background and Objectives: As part of a large‐scale project to safely increase plasma collection in Europe, the current scoping review identifies the existing evidence (gaps) on adverse events (AEs) and other health effects in plasmapheresis donors, as well as factors that may be associated with such events/effects. Materials and Methods: We searched six databases and three registries. Study characteristics (publication type, language, study design, population, outcomes, associated factors, time of assessment, duration of follow‐up, number and frequency of donations, convalescent plasma [y/n], setting and location) were synthesized narratively and in an interactive evidence gap map (EGM). Results: Ninety‐four research articles and five registrations were identified. Around 90% were observational studies (57 controlled and 33 uncontrolled), and most of them were performed in Europe (55%) or the United States (20%). Factors studied in association with donor health included donor characteristics (e.g., sex, age) (n = 27), cumulative number of donations (n = 21), donation frequency (n = 11), plasma collection device or programme (n = 11), donor status (first time vs. repeat) (n = 10), donation volume per session (n = 8), time in donation programme (n = 3), preventive measures (n = 2) or other (n = 9). Conclusion: The current scoping review provides an accessible tool for researchers and policymakers to identify the available evidence (gaps) concerning plasmapheresis donation safety. Controlled prospective studies with long‐term donor follow‐up are scarce. Furthermore, additional experimental studies comparing the health effects of different donation frequencies are required to inform a safe upper limit for donation frequency. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Very‐high frequency plasmapheresis and donor health–absence of evidence is not equal to evidence of absence.
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Van Remoortel, Hans, van den Hurk, Katja, Compernolle, Veerle, O'Leary, Peter, Tiberghien, Pierre, and Erikstrup, Christian
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PLASMAPHERESIS , *RANDOMIZED controlled trials , *TRUST - Abstract
The article discusses the growing utilization of Plasma-Derived Medicinal Products (PDMPs) and the importance of ensuring the safety of plasma donors. It critiques two studies that concluded that repeated plasmapheresis (plasma donation) is safe for donors, pointing out methodological shortcomings and selection biases in the studies. The authors argue that more robust evidence, such as randomized controlled trials (RCTs) and real-world data analysis, is needed to determine the long-term impact of repeated plasmapheresis on donor health. They emphasize the need for trustworthy evidence syntheses and transparent criteria for evaluating the quality of evidence. Until more conclusive evidence is available, blood establishments will continue to prioritize donor safety. [Extracted from the article]
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- 2023
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12. Health status deterioration in subjects with mild to moderate airflow obstruction, a six years observational study
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Rodrigues, Fernanda Machado, Demeyer, Heleen, Loeckx, Matthias, Hornikx, Miek, Van Remoortel, Hans, Janssens, Wim, and Troosters, Thierry
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- 2019
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13. Evidence-based educational pathway for the integration of first aid training in school curricula
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De Buck, Emmy, Van Remoortel, Hans, Dieltjens, Tessa, Verstraeten, Hans, Clarysse, Matthieu, Moens, Olaf, and Vandekerckhove, Philippe
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- 2015
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14. Is an endoscopic examination associated with transfusion‐transmissible infections? A systematic review and meta‐analysis
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Van Remoortel, Hans, Borra, Vere, De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
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- 2018
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15. The effect of a standard whole blood donation on oxygen uptake and exercise capacity: a systematic review and meta‐analysis
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Van Remoortel, Hans, De Buck, Emmy, Compernolle, Veerle, Deldicque, Louise, and Vandekerckhove, Philippe
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- 2017
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16. Evidence-Based Medicine: Principles and Values as Illustrated by the Case of Patient Blood Management.
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Van Remoortel, Hans, De Buck, Emmy, Seifried, Erhard, and Vandekerckhove, Philippe
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- 2023
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17. Development of an Evidence-Based First Aid Guideline for First Responders in Sub-Saharan Africa.
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AVAU, BERT, SOMMEN, JOOST, LAERMANS, JORIEN, VAN REMOORTEL, HANS, VANHOVE, ANNE-CATHERINE, VANDEKERCKHOVE, PHILIPPE, DE BUCK, EMMY, GEDULD, HEIKE, and NAIDOO, NAVINDHRA
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ONLINE information services ,MEDICAL databases ,CONFIDENCE intervals ,MEDICAL information storage & retrieval systems ,SYSTEMATIC reviews ,EVIDENCE-based medicine ,FIRST aid in illness & injury ,MEDICAL protocols ,RESEARCH funding ,DESCRIPTIVE statistics ,EMERGENCY medical personnel ,MEDLINE ,ODDS ratio - Abstract
Copyright of International Journal of First Aid Education is the property of International Journal of First Aid Education and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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18. Systematic reviews on platelet transfusions: Is there unnecessary duplication of effort? A scoping review.
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Avau, Bert, O, Dorien, Veys, Koen, Georgsen, Jørgen, Nahirniak, Susan, Shehata, Nadine, Stanworth, Simon J., Van Remoortel, Hans, De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
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BLOOD platelet transfusion ,BLOOD products ,CONCEPT mapping - Abstract
Background and Objectives: Platelet transfusions are used across multiple patient populations to prevent and correct bleeding. This scoping review aimed to map the currently available systematic reviews (SRs) and evidence‐based guidelines in the field of platelet transfusion. Materials and Methods: A systematic literature search was conducted in seven databases for SRs on effectiveness (including dose and timing, transfusion trigger and ratio to other blood products), production modalities and decision support related to platelet transfusion. The following data were charted: methodological features of the SR, population, concept and context features, outcomes reported, study design and number of studies included. Results were synthesized in interactive evidence maps. Results: We identified 110 SRs. The majority focused on clinical effectiveness, including prophylactic or therapeutic transfusions compared to no platelet transfusion (34 SRs), prophylactic compared to therapeutic‐only transfusion (8 SRs), dose, timing (11 SRs) and threshold for platelet transfusion (15 SRs) and the ratio of platelet transfusion to other blood products in massive transfusion (14 SRs). Furthermore, we included 34 SRs on decision support, of which 26 evaluated viscoelastic testing. Finally, we identified 22 SRs on platelet production modalities, including derivation (4 SRs), pathogen inactivation (6 SRs), leucodepletion (4 SRs) and ABO/human leucocyte antigen matching (5 SRs). The SRs were mapped according to concept and clinical context. Conclusion: An interactive evidence map of SRs and evidence‐based guidelines in the field of platelet transfusion has been developed and identified multiple reviews. This work serves as a tool for researchers looking for evidence gaps, thereby both supporting research and avoiding unnecessary duplication. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Methodologic quality assessment of red blood cell transfusion guidelines and the evidence base of more restrictive transfusion thresholds
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Van Remoortel, Hans, De Buck, Emmy, Dieltjens, Tessa, Pauwels, Nele S., Compernolle, Veerle, and Vandekerckhove, Philippe
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- 2016
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20. L04-3 Effets de la fréquence des plasmaphérèses : un essai contrôlé randomisé
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Khoudary, Jina, Van Remoortel, Hans, Compernolle, Veerle, and Deldicque, Louise
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- 2023
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21. Effectiveness of insecticide-treated and untreated nets to prevent malaria in India*
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Van Remoortel, Hans, De Buck, Emmy, Singhal, Maneesh, Vandekerckhove, Philippe, and Agarwal, Satya P.
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- 2015
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22. Mass gathering events: a retrospective analysis of the triage categories, type of injury or medical complaint and medical usage rates.
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Van Remoortel, Hans, Scheers, Hans, Lauwers, Karen, Gillebeert, Johan, Stroobants, Stijn, Vranckx, Pascal, De Buck, Emmy, and Vandekerckhove, Philippe
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- 2022
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23. Standardizing the Analysis of Physical Activity in Patients With COPD Following a Pulmonary Rehabilitation Program
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Demeyer, Heleen, Burtin, Chris, Van Remoortel, Hans, Hornikx, Miek, Langer, Daniel, Decramer, Marc, Gosselink, Rik, Janssens, Wim, and Troosters, Thierry
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- 2014
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24. Determinants and outcomes of physical activity in patients with COPD: a systematic review
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Gimeno-Santos, Elena, Frei, Anja, Steurer-Stey, Claudia, de Batlle, Jordi, Rabinovich, Roberto A, Raste, Yogini, Hopkinson, Nicholas S, Polkey, Michael I, van Remoortel, Hans, Troosters, Thierry, Kulich, Karoly, Karlsson, Niklas, Puhan, Milo A, and Garcia-Aymerich, Judith
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- 2014
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25. Risk Factors and Comorbidities in the Preclinical Stages of Chronic Obstructive Pulmonary Disease
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Van Remoortel, Hans, Hornikx, Miek, Langer, Daniel, Burtin, Chris, Everaerts, Stephanie, Verhamme, Peter, Boonen, Steven, Gosselink, Rik, Decramer, Marc, Troosters, Thierry, and Janssens, Wim
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- 2014
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26. Prevalence and associated risk factors of HIV infections in a representative transgender and non-binary population in Flanders and Brussels (Belgium): Protocol for a community-based, cross-sectional study using time-location sampling.
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De Brier, Niels, Van Schuylenbergh, Judith, Van Remoortel, Hans, Van den Bossche, Dorien, Fieuws, Steffen, Molenberghs, Geert, De Buck, Emmy, T'Sjoen, Guy, Compernolle, Veerle, Platteau, Tom, and Motmans, Joz
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GENDER identity ,TRANS women ,TRANS men ,TRANSGENDER people ,STATISTICAL sampling ,HIV antibodies ,HIV infections ,FEMININE identity - Abstract
Introduction: HIV prevalence and sexual risk have been estimated very high for transgender people. However, the limited sampling and data collection methods used in current research on transgender people potentially led to overrepresentation and generalisation of people at risk for HIV. Current HIV prevalence estimates in transgender populations are generalised from studies mainly focusing on transgender women engaging in sex work. Moreover, studies focusing on non-binary people, who identify with a broad range of identities beyond the traditional male and female gender identities, are scarce. Objectives: To estimate the HIV prevalence rate in the Flemish and Brussels (Belgium) transgender population, including transgender women, transgender men and non-binary people, and to identify the associated risk factors. Methods: In this community-based cross-sectional study, self-identified transgender and non-binary (TGNB) people will be recruited through a two-stage time-location sampling approach. First, community settings in which TGNB people gather will be mapped to develop an accurate sampling frame. Secondly, a multistage sampling design is applied involving a stratification based on setting type (healthcare facilities vs outreach events), a selection of clusters by systematic sampling and a simple random selection of TGNB people within each cluster. Participants will complete an electronic self-reported survey to measure sociological, sexual and drug-using behaviors (risk factors) and oral fluid aliquots will be collected and tested for HIV antibodies. Logistic regression models will be used to evaluate risk factors independently associated with HIV infection. The presented study is registered at ClinicalTrials.gov (NCT04930614). Discussion: This study will be the first to investigate the HIV prevalence rates and associated risk behaviors in an accurate representation of the TGNB population in a Western European country. The findings will globally serve as a knowledge base for identifying subgroups at risk for becoming infected with HIV within TGNB people and to set up targeted prevention programs. [ABSTRACT FROM AUTHOR]
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- 2022
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27. Daily physical activity in subjects with newly diagnosed COPD
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Van Remoortel, Hans, Hornikx, Miek, Demeyer, Heleen, Langer, Daniel, Burtin, Chris, Decramer, Marc, Gosselink, Rik, Janssens, Wim, and Troosters, Thierry
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- 2013
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28. Pulmonary Rehabilitation and Cardiovascular Disease
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Troosters, Thierry and Van Remoortel, Hans
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- 2009
29. Translation and validation of PubMed and Embase search filters for identification of systematic reviews, intervention studies, and observational studies in the field of first aid.
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Avau, Bert, Van Remoortel, Hans, and De Buck, Emmy
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EXPERIMENTAL design , *ONLINE information services , *SCIENTIFIC observation , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *BIBLIOGRAPHIC databases , *FIRST aid in illness & injury , *HEALTH , *DESCRIPTIVE statistics , *INFORMATION retrieval , *INFORMATION storage & retrieval systems , *MEDLINE - Abstract
Objective: The aim of this project was to validate search filters for systematic reviews, intervention studies, and observational studies translated from Ovid MEDLINE and Embase syntax and used for searches in PubMed and Embase.com during the development of evidence summaries supporting first aid guidelines. We aimed to achieve a balance among recall, specificity, precision, and number needed to read (NNR). Methods: Reference gold standards were constructed per study type derived from existing evidence summaries. Search filter performance was assessed through retrospective searches and measurement of relative recall, specificity, precision, and NNR when using the translated search filters. Where necessary, search filters were optimized. Adapted filters were validated in separate validation gold standards. Results: Search filters for systematic reviews and observational studies reached recall of ≥85% in both PubMed and Embase. Corresponding specificities for systematic review filters were ≥96% in both databases, with a precision of 9.7% (NNR 10) in PubMed and 5.4% (NNR 19) in Embase. For observational study filters, specificity, precision, and NNR were 68%, 2%, and 51 in PubMed and 47%, 0.8%, and 123 in Embase, respectively. These filters were considered sufficiently effective. Search filters for intervention studies reached a recall of 85% and 83% in PubMed and Embase, respectively. Optimization led to recall of ≥95% with specificity, precision, and NNR of 49%, 1.3%, and 79 in PubMed and 56%, 0.74%, and 136 in Embase, respectively. Conclusions: We report validated filters to search for systematic reviews, observational studies, and intervention studies in guideline projects in PubMed and Embase.com. [ABSTRACT FROM AUTHOR]
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- 2021
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30. Patient blood management – recommendations from the International Consensus Conference, Frankfurt/Main, Germany.
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Mueller, Markus M., Van Remoortel, Hans, Meybohm, Patrick, Aranko, Kari, Murphy, Michael F., Carson, Jeffrey L., Wood, Erica, Vandekerckhove, Philippe, and Seifried, Erhard
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RED blood cell transfusion , *MEDICAL research , *ADULTS , *ERYTHROCYTES , *INTENSIVE care patients , *CONFERENCES & conventions - Abstract
An International Consensus Conference (ICC) on PBM was held in 2018 to develop evidence‐based clinical and research recommendations for preoperative anaemia, red blood cell (RBC) transfusion thresholds for adults and implementation of PBM programmes. An international scientific committee (SC) defined 17 Population‐Intervention‐Comparison‐Outcome (PICO) questions for the three topics preoperative anaemia, red blood cell (RBC) transfusion thresholds for adults and PBM implementation. Based on these questions, an extensive literature search was conducted in four biomedical databases. The GRADE framework (= grading of recommendations, assessment, development and evaluation) was used to develop a systematic approach to the presentation of evidence summaries and for making clinical recommendations. Three expert panels (EP) consisting of clinicians, scientists, nurses, patient representatives and methodologists were established and used these methods to develop recommendations driven by published evidence. Out of more than 17 500 literature citations, data from 145 studies were incorporated. The expert panel for preoperative anaemia developed 4 clinical and 3 research recommendations. A strong recommendation advices early detection and management of preoperative anaemia before major elective surgery. For RBC transfusion thresholds, 4 clinical and 6 research recommendations have been formulated. Two strong clinical recommendations for RBC transfusion thresholds comprise a haemoglobin concentration of <7 g/dl for critically ill, but clinical stable adult intensive care patients independent of septic shock and <7·5 g/dl for adults undergoing cardiac surgery. For the implementation of PBM programmes, 2 clinical and 3 research recommendations were developed. Research recommendations were formulated as encouragement of new studies to answer open questions. Due to the relative paucity of strong evidence‐based answers in current publications to the 17 PICO questions, additional research, an international consensus for accepted definitions and Hb thresholds as well as clinically meaningful end‐points for clinical studies are necessary. The 2018 PBM ICC defined the current status of PBM evidence and established 10 clinical and 12 research recommendations for preoperative anaemia, RBC transfusion thresholds for adults and implementation of PBM programmes. [ABSTRACT FROM AUTHOR]
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- 2021
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31. Hepatitis B virus prevalence in first‐time blood donors in Flanders, Belgium: Impact of universal vaccination and migration.
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De Brier, Niels, Koc, Özgür M., De Buck, Emmy, Muylaert, An, Nevens, Frederik, Vanbrabant, Miek, Vandeloo, Judith, Van Remoortel, Hans, Robaeys, Geert, and Compernolle, Veerle
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HEPATITIS B virus ,HEPATITIS associated antigen ,HEPATITIS B ,HEPATITIS C virus ,VACCINATION - Abstract
Background: Transfusion‐transmissible infections such as hepatitis B virus (HBV) remain a major concern for the safety of blood transfusion. This cross‐sectional study aimed to assess the trend of HBV prevalence and associated risk factors among a first‐time donor population in a low endemic country. Study Design and Methods: Between 2010 and 2018, blood samples were collected from first‐time donors presented at donor collection sites of Belgian Red Cross‐Flanders. They were tested for hepatitis B surface antigen (HBsAg), hepatitis B core antibodies (anti‐HBc), and HBV DNA, HIV and hepatitis virus C (HCV) antibodies and RNA, and syphilis antibodies. Results: A total of 211,331 first‐time blood donors (43.7% males, median age 25 years) were analyzed. HBsAg prevalence decreased from 0.06% in 2010 to 0.05% in 2018 (p =.004) and this declining trend was accompanied by an increased number of donors in the HBV vaccinated birth cohort (p <.001). HBsAg prevalence was 0.33% in foreign‐born donors and 0.02% in Belgian natives (p <.001). Multivariate risk profiling showed that anti‐HBc positivity was significantly associated with mainly foreign‐born donors (odds ratio [OR] = 9.24) but also with older age (OR = 1.06), male gender (OR = 1.32), year of blood donation (OR = 0.94), and co‐infections with HCV (OR = 4.31) or syphilis (OR = 4.91). Discussion: The decreasing trend in HBV prevalence could mainly be explained by the introduction of the universal HBV vaccination. Being born in endemic areas was the most important predictor for HBV infection while the co‐infections with syphilis suggest unreported sexual risk contacts. [ABSTRACT FROM AUTHOR]
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- 2021
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32. Effectiveness of Iron Supplementation With or Without Erythropoiesis-Stimulating Agents on Red Blood Cell Utilization in Patients With Preoperative Anaemia Undergoing Elective Surgery: A Systematic Review and Meta-Analysis.
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Van Remoortel, Hans, Laermans, Jorien, Avau, Bert, Bekkering, Geertruida, Georgsen, Jørgen, Manzini, Paola Maria, Meybohm, Patrick, Ozier, Yves, De Buck, Emmy, Compernolle, Veerle, and Vandekerckhove, Philippe
- Abstract
• IV Iron monotherapy may not reduce the number of patients transfused. • Iron monotherapy may not reduce the number of red blood cell (RBC) units transfused. • It is unclear if IV and oral iron monotherapy differentially impact RBC utilization. • Oral iron + ESAs probably reduce the number of patients and RBC units transfused. • IV Iron + ESAs may reduce the number of patients transfused. Patient Blood Management (PBM) is an evidence-based, multidisciplinary, patient-centred approach to optimizing the care of patients who might need a blood transfusion. This systematic review aimed to collect the best available evidence on the effectiveness of preoperative iron supplementation with or without erythropoiesis-stimulating agents (ESAs) on red blood cell (RBC) utilization in all-cause anaemic patients scheduled for elective surgery. Five databases and two trial registries were screened. Primary outcomes were the number of patients and the number of RBC units transfused. Effect estimates were synthesized by conducting meta-analyses. GRADE (Grades of Recommendation, Assessment, Development and Evaluation) was used to assess the certainty of evidence. We identified 29 randomized controlled trials (RCTs) and 2 non-RCTs comparing the effectiveness of preoperative iron monotherapy, or iron + ESAs, to control (no treatment, usual care, placebo). We found that: (1) IV and/or oral iron monotherapy may not result in a reduced number of units transfused and IV iron may not reduce the number of patients transfused (low-certainty evidence); (2) uncertainty exists whether the administration route of iron therapy (IV vs oral) differentially affects RBC utilization (very low-certainty evidence); (3) IV ferric carboxymaltose monotherapy may not result in a different number of patients transfused compared to IV iron sucrose monotherapy (low-certainty evidence); (4) oral iron + ESAs probably results in a reduced number of patients transfused and number of units transfused (moderate-certainty evidence); (5) IV iron + ESAs may result in a reduced number of patients transfused (low-certainty evidence); (6) oral and/or IV iron + ESAs probably results in a reduced number of RBC units transfused in transfused patients (moderate-certainty evidence); (7) uncertainty exists about the effect of oral and/or IV iron + ESAs on the number of patients requiring transfusion of multiple units (very low-certainty evidence). Effect estimates of different haematological parameters and length of stay were synthesized as secondary outcomes. In conclusion, in patients with anaemia of any cause scheduled for elective surgery, the preoperative administration of iron monotherapy may not result in a reduced number of patients or units transfused (low-certainty evidence). Iron supplementation in addition to ESAs probably results in a reduced RBC utilization (moderate-certainty evidence). [ABSTRACT FROM AUTHOR]
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- 2021
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33. Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
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Hornikx Miek, Van Remoortel Hans, Lehouck An, Mathieu Chantal, Maes Karen, Gayan-Ramirez Ghislaine, Decramer Marc, Troosters Thierry, and Janssens Wim
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Chronic obstructive pulmonary disease ,Exercise capacity ,Skeletal muscle ,Systemic consequences ,Vitamin D ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Rationale Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease. Material and methods This study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation. Results Vitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11±12 cmH2O vs 0±14 cmH2O; p = 0.004) and maximal oxygen uptake (110±211 ml/min vs -20±187 ml/min; p = 0.029). Improvements in quadriceps strength (15±16 Nm) or six minutes walking distance (40±55 meter) were not significantly different from the effects in the placebo group (7±19 Nm and 11±74 meter; p>0.050). Conclusion High dose vitamin D supplementation during rehabilitation may have mild additional benefits to training.
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- 2012
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34. Validity of activity monitors in health and chronic disease: a systematic review
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Van Remoortel Hans, Giavedoni Santiago, Raste Yogini, Burtin Chris, Louvaris Zafeiris, Gimeno-Santos Elena, Langer Daniel, Glendenning Alastair, Hopkinson Nicholas S, Vogiatzis Ioannis, Peterson Barry T, Wilson Frederick, Mann Bridget, Rabinovich Roberto, Puhan Milo A, and Troosters Thierry
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Chronic diseases ,Doubly labelled water ,Indirect calorimetry ,Activity monitoring ,Physical activity ,Validation study ,Systematic review ,Nutritional diseases. Deficiency diseases ,RC620-627 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract The assessment of physical activity in healthy populations and in those with chronic diseases is challenging. The aim of this systematic review was to identify whether available activity monitors (AM) have been appropriately validated for use in assessing physical activity in these groups. Following a systematic literature search we found 134 papers meeting the inclusion criteria; 40 conducted in a field setting (validation against doubly labelled water), 86 in a laboratory setting (validation against a metabolic cart, metabolic chamber) and 8 in a field and laboratory setting. Correlation coefficients between AM outcomes and energy expenditure (EE) by the criterion method (doubly labelled water and metabolic cart/chamber) and percentage mean differences between EE estimation from the monitor and EE measurement by the criterion method were extracted. Random-effects meta-analyses were performed to pool the results across studies where possible. Types of devices were compared using meta-regression analyses. Most validation studies had been performed in healthy adults (n = 118), with few carried out in patients with chronic diseases (n = 16). For total EE, correlation coefficients were statistically significantly lower in uniaxial compared to multisensor devices. For active EE, correlations were slightly but not significantly lower in uniaxial compared to triaxial and multisensor devices. Uniaxial devices tended to underestimate TEE (−12.07 (95%CI; -18.28 to −5.85) %) compared to triaxial (−6.85 (95%CI; -18.20 to 4.49) %, p = 0.37) and were statistically significantly less accurate than multisensor devices (−3.64 (95%CI; -8.97 to 1.70) %, p
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- 2012
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35. Prediction modelling studies for medical usage rates in mass gatherings: A systematic review.
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Van Remoortel, Hans, Scheers, Hans, De Buck, Emmy, Haenen, Winne, and Vandekerckhove, Philippe
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META-analysis , *PREDICTION models , *WATER supply , *STATISTICAL models , *RATINGS of hospitals , *MULTIVARIABLE testing - Abstract
Background: Mass gathering manifestations attended by large crowds are an increasingly common feature of society. In parallel, an increased number of studies have been conducted that developed and/or validated a model to predict medical usage rates at these manifestations. Aims: To conduct a systematic review to screen, analyse and critically appraise those studies that developed or validated a multivariable statistical model to predict medical usage rates at mass gatherings. To identify those biomedical, psychosocial and environmental predictors that are associated with increased medical usage rates and to summarise the predictive performance of the models. Method: We searched for relevant prediction modelling studies in six databases. The predictors from multivariable regression models were listed for each medical usage rate outcome (i.e. patient presentation rate (PPR), transfer to hospital rate (TTHR) and the incidence of new injuries). The GRADE methodology (Grades of Recommendation, Assessment, Development and Evaluation) was used to assess the certainty of evidence. Results: We identified 7,036 references and finally included 16 prediction models which were developed (n = 13) or validated (n = 3) in the USA (n = 8), Australia (n = 4), Japan (n = 1), Singapore (n = 1), South Africa (n = 1) and The Netherlands (n = 1), with a combined audience of >48 million people in >1700 mass gatherings. Variables to predict medical usage rates were biomedical (i.e. age, gender, level of competition, training characteristics and type of injury) and environmental predictors (i.e. crowd size, accommodation, weather, free water availability, time of the manifestation and type of the manifestation) (low-certainty evidence). Evidence from 3 studies indicated that using Arbon's or Zeitz' model in other contexts significantly over- or underestimated medical usage rates (from 22% overestimation to 81% underestimation). Conclusions: This systematic review identified multivariable models with biomedical and environmental predictors for medical usage rates at mass gatherings. Since the overall certainty of the evidence is low and the predictive performance is generally poor, proper development and validation of a context-specific model is recommended. [ABSTRACT FROM AUTHOR]
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- 2020
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36. Is sexual risk behaviour associated with an increased risk of transfusion‐transmissible infections in blood donors from Western and Pacific countries? A systematic review and meta‐analysis.
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Van Remoortel, Hans, Matthysen, Wout, Avau, Bert, Compernolle, Veerle, Vandekerckhove, Philippe, and De Buck, Emmy
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META-analysis , *BLOOD donors , *ANAL sex , *BEHAVIOR ,WESTERN countries - Abstract
Background and Objectives: The donor medical questionnaire is designed to aid blood establishments in supporting a safe blood supply. According to blood donor deferral policies, sexual risk behaviour (SRB) leads to a (temporary) deferral from blood donation. This systematic review aimed to scientifically underpin these policies by identifying the best available evidence on the association between SRB and the risk of transfusion transmissible infections (TTIs). Materials & Methods: Studies from three databases investigating the link between SRB (excluding men who have sex with men (MSM)) and TTIs (HBV, HCV, HIV, Treponema pallidum) in donors from Western and Pacific countries were obtained and assessed on eligibility by two reviewers independently. The association between SRB and TTIs was expressed by calculating pooled effect measures via meta‐analyses. The GRADE methodology (Grades of Recommendation, Assessment, Development and Evaluation) was used to assess the quality of evidence. Results: We identified 3750 references and finally included 15 observational studies. Meta‐analyses showed that there is a significant (P < 0·05) positive association between the following SRB and HBV and/or HCV infection: having sex with an intravenous drug user (high‐certainty evidence), receiving money or goods for sex (moderate‐high certainty evidence), having a sex partner with hepatitis/HIV (moderate‐certainty evidence) and paid for sex or anal sex (low‐certainty evidence). Conclusion: Sexual risk behaviour (including having sex with an intravenous drug user, receiving money or goods for sex or having a sex partner with hepatitis/HIV) is probably associated with an increased risk of HBV/HCV infection in blood donors from Western and Pacific countries. [ABSTRACT FROM AUTHOR]
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- 2020
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37. The systematic use of evidence‐based methodologies and technologies enhances shared decision‐making in the 2018 International Consensus Conference on Patient Blood Management.
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Van Remoortel, Hans, Aranko, Kari, Mueller, Markus M., De Buck, Emmy, Devine, Dana, Folléa, Gilles, Meybohm, Patrick, Tiberghien, Pierre, Wood, Erica M., Vandekerckhove, Philippe, and Seifried, Erhard
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RED blood cell transfusion , *CONFERENCES & conventions , *BLOOD groups , *BLOOD transfusion , *BLOOD - Abstract
Background and objectives: Patient Blood Management (PBM) aims to optimize the care of patients who might need a blood transfusion. The International Consensus Conference on PBM (ICC‐PBM) aimed to develop evidence‐based recommendations on three topics: preoperative anaemia, red blood cell transfusion thresholds and implementation of PBM programmes. This paper reports how evidence‐based methodologies and technologies were used to enhance shared decision‐making in formulating recommendations during the ICC‐PBM. Materials & Methods: Systematic reviews on 17 PICO (Population, Intervention, Comparison, Outcomes) questions were conducted by a Scientific Committee (22 international topic experts and one methodologist) according to GRADE (Grades of Recommendation, Assessment, Development and Evaluation) methodology. Evidence‐based recommendations were formulated using Consensus Development Conference methodology. Results: We screened 17 607 references and included 145 studies. The overall certainty in the evidence of effect estimates was generally low or very low. During the ICC, plenary sessions (100–200 stakeholders from a range of clinical disciplines and community representatives) were followed by closed sessions where multidisciplinary decision‐making panels (>50 experts and patient organizations) formulated recommendations. Two chairs (content‐expert and methodologist) moderated each session and two rapporteurs documented the discussions. The Evidence‐to‐Decision template (GRADEpro software) was used as the central basis in the process of formulating recommendations. Conclusion: This ICC‐PBM resulted in 10 clinical and 12 research recommendations supported by an international stakeholder group of experts in blood transfusion. Systematic, rigorous and transparent evidence‐based methodology in a formal consensus format should be the new standard to evaluate (cost‐) effectiveness of medical treatments, such as blood transfusion. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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38. 2018 Evidence Base of Patient Blood Management - Recommendations from the First International Consensus Conference, Frankfurt/Main, Germany
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Mueller, Markus M., van Remoortel, Hans, Meybohm, Patrick, Aranko, Kari, Murphy, Mike, Carson, Jeffrey L., and Seifried, Erhard
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- 2019
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39. Is there a risk of transfusion‐transmissible infections after percutaneous needle treatments in blood donors? A systematic review and meta‐analysis.
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Van Remoortel, Hans, Moorkens, Dorien, Avau, Bert, Compernolle, Veerle, Vandekerckhove, Philippe, and De Buck, Emmy
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BLOOD donors , *THERAPEUTICS , *META-analysis , *HIV infections , *NEEDLES & pins - Abstract
Background and objectives: The donor medical questionnaire identifies a blood donor's history of known blood safety risks. Current Australian, Canadian, European and USA legislation temporarily defers blood donors who received different percutaneous needle treatments (i.e. tattooing, acupuncture and piercing) from blood donation. This systematic review aimed to scientifically underpin these deferrals by identifying the best available evidence on the association between percutaneous needle treatments and the risk of transfusion‐transmissible infections (TTIs). Materials and methods: Studies from three databases investigating the link between percutaneous needle treatments and TTIs (HBV, HCV and HIV infection) in blood donors were retained and assessed on eligibility by two reviewers independently. The association between percutaneous needle treatments and TTIs was expressed by conducting meta‐analyses and calculating pooled effect measures (odds ratios (ORs) and 95% CIs). The GRADE methodology (Grades of Recommendation, Assessment, Development and Evaluation) was used to assess the quality of evidence. Results: We identified 1242 references and finally included 21 observational studies. Twenty studies assessed the link between percutaneous needle treatments and HCV infection and found that blood donors receiving these treatments had an increased risk of HCV infection (tattooing: pooled OR 5·28, 95% CI [4·33, 6·44], P < 0·00001 (low‐quality evidence); acupuncture: pooled OR 1·56, 95% CI [1·17, 2·08], P = 0·03 (very low‐quality evidence); and piercing: pooled OR 3·25, 95% CI [1·68, 6·30], P = 0·0005 (low‐quality evidence)). Conclusion: Percutaneous needle treatments may be associated with an increased HCV infection risk. Further high‐quality studies are required to formulate stronger evidence‐based recommendations on percutaneous needle treatments as a blood donor deferral criterion. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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40. Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference.
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Mueller, Markus M., Van Remoortel, Hans, Meybohm, Patrick, Aranko, Kari, Aubron, Cécile, Burger, Reinhard, Carson, Jeffrey L., Cichutek, Klaus, De Buck, Emmy, Devine, Dana, Fergusson, Dean, Folléa, Gilles, French, Craig, Frey, Kathrine P., Gammon, Richard, Levy, Jerrold H., Murphy, Michael F., Ozier, Yves, Pavenski, Katerina, and So-Osman, Cynthia
- Subjects
- *
GASTROINTESTINAL hemorrhage , *PREOPERATIVE education , *CRITICALLY ill children , *BLOOD , *ANEMIA diagnosis , *GASTROINTESTINAL hemorrhage treatment , *IRON deficiency anemia diagnosis , *THERAPEUTIC use of iron , *HEMATOPOIETIC agents , *SURGICAL blood loss , *BLOOD transfusion , *CRITICAL care medicine , *RED blood cell transfusion , *BONE fractures , *CARDIAC surgery , *HEMOGLOBINS , *HIP joint injuries , *IRON deficiency anemia , *PREOPERATIVE care , *SYSTEMATIC reviews , *PREVENTION , *THERAPEUTICS - Abstract
Importance: Blood transfusion is one of the most frequently used therapies worldwide and is associated with benefits, risks, and costs.Objective: To develop a set of evidence-based recommendations for patient blood management (PBM) and for research.Evidence Review: The scientific committee developed 17 Population/Intervention/Comparison/Outcome (PICO) questions for red blood cell (RBC) transfusion in adult patients in 3 areas: preoperative anemia (3 questions), RBC transfusion thresholds (11 questions), and implementation of PBM programs (3 questions). These questions guided the literature search in 4 biomedical databases (MEDLINE, EMBASE, Cochrane Library, Transfusion Evidence Library), searched from inception to January 2018. Meta-analyses were conducted with the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) methodology and the Evidence-to-Decision framework by 3 panels including clinical and scientific experts, nurses, patient representatives, and methodologists, to develop clinical recommendations during a consensus conference in Frankfurt/Main, Germany, in April 2018.Findings: From 17 607 literature citations associated with the 17 PICO questions, 145 studies, including 63 randomized clinical trials with 23 143 patients and 82 observational studies with more than 4 million patients, were analyzed. For preoperative anemia, 4 clinical and 3 research recommendations were developed, including the strong recommendation to detect and manage anemia sufficiently early before major elective surgery. For RBC transfusion thresholds, 4 clinical and 6 research recommendations were developed, including 2 strong clinical recommendations for critically ill but clinically stable intensive care patients with or without septic shock (recommended threshold for RBC transfusion, hemoglobin concentration <7 g/dL) as well as for patients undergoing cardiac surgery (recommended threshold for RBC transfusion, hemoglobin concentration <7.5 g/dL). For implementation of PBM programs, 2 clinical and 3 research recommendations were developed, including recommendations to implement comprehensive PBM programs and to use electronic decision support systems (both conditional recommendations) to improve appropriate RBC utilization.Conclusions and Relevance: The 2018 PBM International Consensus Conference defined the current status of the PBM evidence base for practice and research purposes and established 10 clinical recommendations and 12 research recommendations for preoperative anemia, RBC transfusion thresholds for adults, and implementation of PBM programs. The relative paucity of strong evidence to answer many of the PICO questions supports the need for additional research and an international consensus for accepted definitions and hemoglobin thresholds, as well as clinically meaningful end points for multicenter trials. [ABSTRACT FROM AUTHOR]- Published
- 2019
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41. Six years progression of exercise capacity in subjects with mild to moderate airflow obstruction, smoking and never smoking controls.
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Rodrigues, Fernanda Machado, Loeckx, Matthias, Hornikx, Miek, Van Remoortel, Hans, Louvaris, Zafeiris, Demeyer, Heleen, Janssens, Wim, and Troosters, Thierry
- Subjects
EXERCISE physiology ,RESPIRATORY obstructions ,SMOKING ,AEROBIC capacity ,VENTILATION - Abstract
Background: Exercise capacity is an important feature in patients with COPD. Its impairment drives disability and dependency for daily activities performance. This study evaluated the six years change in exercise capacity in subjects with airflow obstruction and compared this to subjects without airflow obstruction, with and without a smoking history. Methods: Cardiopulmonary exercise tests (CPET) were repeatedly performed during a six years follow up period. Peak oxygen uptake (VO
2 peak), work rate (WRpeak), heart rate (HRpeak), minute ventilation (VEpeak), respiratory exchange ratio (RERpeak) and ventilatory reserve (VE/MVV) were collected as effort dependent outcomes. The slopes of oxygen uptake, ventilatory and mechanical efficiency (OUES, ΔVE/ΔVCO2 and ΔVO2 /ΔWR) were collected as effort independent outcomes. Results: One hundred and thirty-eight subjects were included. Thirty-eight presented airflow obstruction (63±6 years, 74% men, FEV1 90±15%pred ), 44 had a smoking history but no airflow obstruction (61±5 years, 61% men, FEV1 105±15%pred ) and 56 had never smoked (61±7 years, 57% men, FEV1 117±18%pred ). At baseline, the airflow obstruction group had slightly worse exercise capacity in comparison to the never smoking control group, in absolute terms and expressed as percentage of the predicted value (VO2 peak = 27±5 versus 32±8 ml/min/kg, p<0.01; 112±29 versus 130±33%pred , p = 0.04). Most exercise variables showed a statistically significant yearly deterioration, with exception of VE/MVV, ΔVE/ΔVCO2 and ΔVO2 /ΔWR. The yearly decline in VO2 peak and OUES was not faster in subjects with airflow obstruction than in smoking and never smoking controls (VO2 peak -67 (9) versus -76 (9) ml/min, p = 0.44 and versus -58 (9), p = 0.47; OUES -32 (11) versus -68 (10), p = 0.03 and versus -68 (13), p = 0.03). Conclusions: With exception of VO2 peak, effort dependent variables deteriorated faster in subjects with airflow obstruction compared to never smoking controls. The deterioration of effort independent variables, however, was not accelerated in the airflow obstruction group compared to controls. [ABSTRACT FROM AUTHOR]- Published
- 2018
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42. Engagement of stakeholders in the development of a Theory of Change for handwashing and sanitation behaviour change.
- Author
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De Buck, Emmy, Hannes, Karin, Cargo, Margaret, Van Remoortel, Hans, Vande veegaete, Axel, Mosler, Hans-Joachim, Govender, Thashlin, Vandekerckhove, Philippe, and Young, Taryn
- Subjects
HAND washing ,HEALTH behavior ,HEALTH promotion ,HYGIENE ,RESEARCH methodology ,PUBLIC health ,SANITATION ,SOCIAL change ,THEORY ,HUMAN services programs ,MIDDLE-income countries ,LOW-income countries - Abstract
A Theory of Change (ToC) is an approach to map programmes aimed at inducing change in a specific context, with the goal of increasing their impact. We applied this approach to the specific case of handwashing and sanitation practices in low- and middle-income countries and developed a ToC as part of a systematic review exercise. Different existing sources of information were used to inform the initial draft of the ToC. In addition, stakeholder involvement occurred and peer review took place. Our stakeholders included methodological (ToC/quantitative and qualitative research) and content experts (WASH (Water, Sanitation, Hygiene)/behaviour change), as well as end-users/practitioners, policy-makers and donors. In conclusion, the development of a ToC, and the involvement of stakeholders in its development, was critical in terms of understanding the context in which the promotional programmes are being implemented. We recommend ToC developers to work with stakeholders to create a ToC relevant for practice. [ABSTRACT FROM PUBLISHER]
- Published
- 2018
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43. The Minimal Important Difference in Physical Activity in Patients with COPD.
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Demeyer, Heleen, Burtin, Chris, Hornikx, Miek, Camillo, Carlos Augusto, Van Remoortel, Hans, Langer, Daniel, Janssens, Wim, and Troosters, Thierry
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OBSTRUCTIVE lung disease treatment ,PHYSICAL activity ,HOSPITAL admission & discharge ,MEDICAL rehabilitation ,DISEASE exacerbation - Abstract
Background: Changes in physical activity (PA) are difficult to interpret because no framework of minimal important difference (MID) exists. We aimed to determine the minimal important difference (MID) in physical activity (PA) in patients with Chronic Obstructive Pulmonary Disease and to clinically validate this MID by evaluating its impact on time to first COPD-related hospitalization. Methods: PA was objectively measured for one week in 74 patients before and after three months of rehabilitation (rehabilitation sample). In addition the intraclass correlation coefficient was measured in 30 patients (test-retest sample), by measuring PA for two consecutive weeks. Daily number of steps was chosen as outcome measurement. Different distribution and anchor based methods were chosen to calculate the MID. Time to first hospitalization due to an exacerbation was compared between patients exceeding the MID and those who did not. Results: Calculation of the MID resulted in 599 (Standard Error of Measurement), 1029 (empirical rule effect size), 1072 (Cohen's effect size) and 1131 (0.5SD) steps.day
-1 . An anchor based estimation could not be obtained because of the lack of a sufficiently related anchor. The time to the first hospital admission was significantly different between patients exceeding the MID and patients who did not, using the Standard Error of Measurement as cutoff. Conclusions: The MID after pulmonary rehabilitation lies between 600 and 1100 steps.day-1 . The clinical importance of this change is supported by a reduced risk for hospital admission in those patients with more than 600 steps improvement. [ABSTRACT FROM AUTHOR]- Published
- 2016
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44. Physical Activity Counselling during Pulmonary Rehabilitation in Patients with COPD: A Randomised Controlled Trial.
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Burtin, Chris, Langer, Daniel, van Remoortel, Hans, Demeyer, Heleen, Gosselink, Rik, Decramer, Marc, Dobbels, Fabienne, Janssens, Wim, and Troosters, Thierry
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OBSTRUCTIVE lung diseases patients ,MEDICAL rehabilitation ,PHYSICAL activity ,RANDOMIZED controlled trials ,HEALTH programs - Abstract
Background: Pulmonary rehabilitation programs only modestly enhance daily physical activity levels in patients with chronic obstructive pulmonary disease (COPD). This randomised controlled trial investigates the additional effect of an individual activity counselling program during pulmonary rehabilitation on physical activity levels in patients with moderate to very severe COPD. Methods: Eighty patients (66±7 years, 81% male, forced expiratory volume in 1 second 45±16% of predicted) referred for a six‐month multidisciplinary pulmonary rehabilitation program were randomised. The intervention group was offered an additional eight-session activity counselling program. The primary outcomes were daily walking time and time spent in at least moderate intense activities. Results: Baseline daily walking time was similar in the intervention and control group (median 33 [interquartile range 16–47] vs 29 [17–44]) whereas daily time spent in at least moderate intensity was somewhat higher in the intervention group (17[4–50] vs 12[2–26] min). No significant intervention*time interaction effects were observed in daily physical activity levels. In the whole group, daily walking time and time spent in at least moderate intense activities did not significantly change over time. Conclusions: The present study identified no additional effect of eight individual activity counselling sessions during pulmonary rehabilitation to enhance physical activity levels in patients with COPD. Trial Registration: clinicaltrials.gov [ABSTRACT FROM AUTHOR]
- Published
- 2015
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45. Physiological responses during downhill walking: A new exercise modality for subjects with chronic obstructive pulmonary disease?
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Camillo, Carlos Augusto, Burtin, Chris, Hornikx, Miek, Demeyer, Heleen, De Bent, Kristien, van Remoortel, Hans, Osadnik, Christian R, Janssens, Wim, and Troosters, Thierry
- Abstract
Skeletal muscle quadriceps low-frequency fatigue (LFF) during exercise promotes improvements in exercise capacity with exercise training. In healthy subjects, eccentric muscle work induced by downhill walking (DW) generates higher muscular stress, whilst metabolic cost is lower compared to level walking (LW). We investigated quadriceps LFF and metabolic cost of DW in patients with chronic obstructive pulmonary disease. Ten participants (67 ± 7 years, FEV1 51 ± 15% predicted) performed DW, DW carrying a load (DWL) of 10% body weight via vest and LW, in random order. Quadriceps potentiated twitch force (TWqpot) was assessed before and after each walk, and muscle damage was assessed before and 24 hours after each walk via serum creatine kinase (CK) levels. Ventilation (VE) and oxygen consumption (VO2) were measured via breath-by-breath analysis during each walk. DW and DWL resulted in a greater decrease in TWqpot (−30 ± 14 N in DW, p < 0.05; and −22 ± 16 N in DWL, p < 0.05) compared to LW (−3 ± 21 N, p > 0.05). CK levels only increased 24 hours following DW and DWL (p < 0.05). DW and DWL showed lower VE and VO2 than LW (p < 0.05). DW is associated with enhanced quadriceps LFF and lower cardiorespiratory costs than LW. The addition of a chest load to DW does not seem to enhance these effects. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
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46. Evidence-based first aid and prevention guidelines for laypeople in India.
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De Buck, Emmy, Van Remoortel, Hans, Geuvens, Hugo, Veegaete, Axel Vande, Singhal, Maneesh, Vandekerckhove, Philippe, and Agarwal, Satya Paul
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DIARRHEA , *THERAPEUTICS , *FIRST aid in illness & injury , *HEALTH education , *INFORMATION storage & retrieval systems , *MEDICAL databases , *MEDICAL information storage & retrieval systems , *MEDICAL protocols , *MEDLINE , *ONLINE information services , *RED Cross & Red Crescent , *SYSTEMATIC reviews , *EVIDENCE-based medicine , *PROFESSIONAL practice , *PSYCHOLOGY ,RESPIRATORY infection treatment - Abstract
Background: Training first medical responders is considered an extremely cost-effective intervention for frequently occurring diseases and injuries in low and middle-income countries. Aims & Objectives: The Belgian Red Cross-Flanders together with the Indian Red Cross Society, aimed to develop evidence-based guidelines to train lay people on how to manage and prevent emergency situations in India. Methods: Evidence-based guidelines were developed adhering to the principles of AGREE II. The reporting of the systematic literature reviews was done according to the PRISMA statements. We identified evidence on the effectiveness of various first aid and preventive procedures from Indian studies and on alternative interventions that have been used by Indian laypeople. The quality of the scientific evidence was determined using the GRADE methodology. Values and preferences from the target group were collected and inputs from a multidisciplinary panel of 12 Indian experts were taken. Result: After developing 77 specific search strategies in PubMed, 10055 references were screened and 90 relevant studies were included as a basis for the recommendations in the guidelines. Examples of effective interventions include rice water for diarrhoea, and gargling to prevent respiratory infections. Conclusion: Evidence-based first aid and prevention guidelines for Indian laypeople were developed. These guidelines will increase the capacity of the Indian Red Cross Society in providing appropriate first aid training and first aid information to the public, and in delivering first aid assistance in case of disasters, disease outbreaks, emergencies, and road accidents in India. [ABSTRACT FROM AUTHOR]
- Published
- 2015
47. RISK FACTORS AND COMORBIDITIES IN THE PRE-CLINICAL STAGES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.
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Van Remoortel, Hans, Hornikx, Miek, Langer, Daniel, Burtin, Chris, Everaerts, Stephanie, Verhamme, Peter, Boonen, Steven, Gosselink, Rik, Decramer, Marc, Troosters, Thierry, and Janssens, Wim
- Published
- 2014
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48. The minimal important difference of the pulmonary functional status and dyspnea questionnaire in patients with severe chronic obstructive pulmonary disease.
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Regueiro, Eloisa M. G., Burtin, Chris, Baten, Paul, Langer, Daniel, Van Remoortel, Hans, Di Lorenzo, Valéria A. Pires, Costa, Dirceu, Janssens, Wim, Decramer, Marc, Gosselink, Rik, and Troosters, Thierry
- Subjects
OBSTRUCTIVE lung diseases patients ,PULMONARY function tests ,DYSPNEA ,MEDICAL rehabilitation ,REGRESSION analysis - Abstract
Background: The modified version of the Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ-M) is used in patients with COPD to obtain information about their functional status. It consists of 3 components (change in activities, dyspnea and fatigue) ranging from 0 to 100 and has been shown to be responsive following pulmonary rehabilitation (PR). The interpretation of changes in PFSDQ-M score after an intervention is difficult in the absence of the minimal important difference (MID) of the PFSDQ-M. This study aims at investigating the MID of the PFSDQ-M. Methods: We enrolled 301 patients with COPD (FEV
1 42 ± 15%pred) that completed the PFSDQ-M before and after a 3-month PR program (ΔChronic Respiratory Disease Questionnaire (CRDQ) +16 ± 12 points, ΔSix-minute walking distance (6MWD) +47 ± 89 m, both p < 0.001). An anchor-based approach consisted of calculating the correlation between the ΔPFSDQ-M and anchors with an established MID (ΔCRDQ and Δ6MWD). Linear regression analyses were performed to predict the MID from these anchors. Secondly several distribution-based approaches (Cohen's effect size, empirical rule effect size and standard error of measurement method) were used. Results: Anchor-based estimates for the different PFSDQ-M-components were between -3 and -5 points based on CRDQ score and -6 (only calculated for change in activities) based on 6MWD. Using the distribution-based methods, the estimates of MID ranged from -3 to -5 points for the different components. Conclusions: We concluded that the estimate of MID of the PFSDQ-M after pulmonary rehabilitation corresponds to a change of 5 points (range - 3 to -6) in each component in patients with severe COPD. [ABSTRACT FROM AUTHOR]- Published
- 2013
49. Impact of exacerbations of cystic fibrosis on muscle strength.
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Burtin, Chris, Van Remoortel, Hans, Vrijsen, Bart, Langer, Daniel, Colpaert, Kristine, Gosselink, Rik, Decramer, Marc, Dupont, Lieven, and Troosters, Thierry
- Subjects
- *
CYSTIC fibrosis , *MUSCLE strength , *INTRAVENOUS therapy , *ANTIBIOTICS , *DISEASE exacerbation , *HOSPITAL care - Abstract
Background: Adult patients with cystic fibrosis have peripheral muscle weakness, which is related to exercise intolerance and poor prognosis. The influence of acute exacerbations on muscle strength has been poorly studied. This study aimed to investigate whether quadriceps force (QF), as assessed with an involuntary technique, changes during intravenous antibiotics therapy (IVAT) for an exacerbation. Methods: QF was measured in 20 patients using twitch stimulation of the femoral nerve at the day of hospitalization (day 1) and at termination (day 14) of the IVAT. Physical activity was monitored during IVAT using a SenseWear armband. Ten stable patients served as control subjects. Results: QF did not change during exacerbation (potentiated twitch force at day 1: 140 ± 42 N, at day 14: 140 ± 47 N), but a decrease was observed in individual patients. Changes in twitch force during exacerbation were correlated with time spent in activities of at least moderate intensity (r = 0.61, p = 0.007). Conclusions: QF does not systematically decrease during exacerbations of cystic fibrosis. Individual changes in QF are well correlated with daily time spent in activities of at least moderate intensity. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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- View/download PDF
50. The Influence of Comorbidities on Outcomes of Pulmonary Rehabilitation Programs in Patients with COPD: A Systematic Review.
- Author
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Hornikx, Miek, Van Remoortel, Hans, Demeyer, Heleen, Camillo, Carlos Augusto Marcal, Decramer, Marc, Janssens, Wim, and Troosters, Thierry
- Abstract
Introduction. Chronic obstructive pulmonary disease (COPD) is associated with comorbidities such as cardiovascular disease, metabolic disease, osteoporosis, and anxiety and/or depression. Although pulmonary rehabilitation programs are proven to be beneficial in patients with COPD, it is unclear whether comorbidities influence pulmonary rehabilitation outcomes. The aim of the present review was to investigate to what extent the presence of comorbidities can affect pulmonary rehabilitation outcomes. Methods. The systematic literature search (Pubmed, EMBASE, and PEDro) resulted in 4 articles meeting the inclusion criteria. The odds ratios (95% confidence intervals) of the logistic regression analyses, with comorbidities as independent variables and pulmonary rehabilitation outcomes (dyspnea, functional exercise capacity, and quality of life) as dependent variables, were used for data extraction. Results. Patients with anxiety and/or depression less likely improve in dyspnea. Osteoporosis is associated with less improvements in functional exercise capacity, while cardiovascular disease does not seem to negatively impact on this outcome. Patients with cardiovascular comorbidity will experience less positive changes in quality of life. Conclusion. Evidence from literature suggests that comorbidities can have a negative influence on pulmonary rehabilitation outcomes. Screening for comorbidities in pulmonary rehabilitation settings seems useful to readdress the right patients for individually tailored pulmonary rehabilitation. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
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