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Your search keyword '"Valls‐Solé, Josep"' showing total 525 results
Start Over Author "Valls‐Solé, Josep" Publication Type Academic Journals
525 results on '"Valls‐Solé, Josep"'

5. Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory

Author

Barbosa, Joao, Stein, Heike, Martinez, Rebecca L, Galan-Gadea, Adrià, Li, Sihai, Dalmau, Josep, Adam, Kirsten CS, Valls-Solé, Josep, Constantinidis, Christos, and Compte, Albert

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Cognitive and Computational Psychology, Neurosciences, Psychology, Brain Disorders, 1.1 Normal biological development and functioning, Underpinning research, 1.2 Psychological and socioeconomic processes, Neurological, Adolescent, Adult, Animals, Electroencephalography, Female, Humans, Macaca mulatta, Male, Memory, Short-Term, Neurons, Prefrontal Cortex, Reaction Time, Saccades, Spatial Memory, Transcranial Magnetic Stimulation, Young Adult, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Persistent neuronal spiking has long been considered the mechanism underlying working memory, but recent proposals argue for alternative 'activity-silent' substrates. Using monkey and human electrophysiology data, we show here that attractor dynamics that control neural spiking during mnemonic periods interact with activity-silent mechanisms in the prefrontal cortex (PFC). This interaction allows memory reactivations, which enhance serial biases in spatial working memory. Stimulus information was not decodable between trials, but remained present in activity-silent traces inferred from spiking synchrony in the PFC. Just before the new stimulus, this latent trace was reignited into activity that recapitulated the previous stimulus representation. Importantly, the reactivation strength correlated with the strength of serial biases in both monkeys and humans, as predicted by a computational model that integrates activity-based and activity-silent mechanisms. Finally, single-pulse transcranial magnetic stimulation applied to the human PFC between successive trials enhanced serial biases, thus demonstrating the causal role of prefrontal reactivations in determining working-memory behavior.

Published
2020

31. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)

Author

Lefaucheur, Jean-Pascal, André-Obadia, Nathalie, Antal, Andrea, Ayache, Samar S., Baeken, Chris, Benninger, David H., Cantello, Roberto M., Cincotta, Massimo, de Carvalho, Mamede, De Ridder, Dirk, Devanne, Hervé, Di Lazzaro, Vincenzo, Filipović, Saša R., Hummel, Friedhelm C., Jääskeläinen, Satu K., Kimiskidis, Vasilios K., Koch, Giacomo, Langguth, Berthold, Nyffeler, Thomas, Oliviero, Antonio, Padberg, Frank, Poulet, Emmanuel, Rossi, Simone, Rossini, Paolo Maria, Rothwell, John C., Schönfeldt-Lecuona, Carlos, Siebner, Hartwig R., Slotema, Christina W., Stagg, Charlotte J., Valls-Sole, Josep, Ziemann, Ulf, Paulus, Walter, and Garcia-Larrea, Luis

Published
2014
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37. Multifocal Transcranial Direct Current Stimulation in Primary Progressive Aphasia Does Not Provide a Clinical Benefit Over Speech Therapy.

Author

Borrego-Écija, Sergi, Montagut, Nuria, Martín-Trias, Pablo, Vaqué-Alcázar, Lídia, Illán-Gala, Ignacio, Balasa, Mircea, Lladó, Albert, Casanova-Mollà, Jordi, Bargalló, Nuria, Valls-Solé, Josep, Lleó, Alberto, Bartrés-Faz, David, and Sánchez-Valle, Raquel

Subjects
TRANSCRANIAL direct current stimulation, SPEECH therapy, ALZHEIMER'S disease, APHASIA, PARIETAL lobe, FRONTOTEMPORAL dementia
Abstract

Background: Primary progressive aphasia (PPA) is a group of neurodegenerative disorders including Alzheimer's disease and frontotemporal dementia characterized by language deterioration. Transcranial direct current stimulation (tDCS) is a non-invasive intervention for brain dysfunction. Objective: To evaluate the tolerability and efficacy of tDCS combined with speech therapy in the three variants of PPA. We evaluate changes in fMRI activity in a subset of patients. Methods: Double-blinded, randomized, cross-over, and sham-controlled tDCS study. 15 patients with PPA were included. Each patient underwent two interventions: a) speech therapy + active tDCS and b) speech therapy + sham tDCS stimulation. A multifocal strategy with anodes placed in the left frontal and parietal regions was used to stimulate the entire language network. Efficacy was evaluated by comparing the results of two independent sets of neuropsychological assessments administered at baseline, immediately after the intervention, and at 1 month and 3 months after the intervention. In a subsample, fMRI scanning was performed before and after each intervention. Results: The interventions were well tolerated. Participants in both arms showed clinical improvement, but no differences were found between active and sham tDCS interventions in any of the evaluations. There were trends toward better outcomes in the active tDCS group for semantic association and reading skills. fMRI identified an activity increase in the right frontal medial cortex and the bilateral paracingulate gyrus after the active tDCS intervention. Conclusion: We did not find differences between active and sham tDCS stimulation in clinical scores of language function in PPA patients. [ABSTRACT FROM AUTHOR]

Published
2023
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