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Your search keyword '"Ura, Nobuyuki"' showing total 219 results
Start Over Author "Ura, Nobuyuki" Publication Type Academic Journals
219 results on '"Ura, Nobuyuki"'

1. Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia.

Author

Morimoto, Satoshi, Sasaki, Haruki, Suda, Chikahito, Ichihara, Atsuhiro, Ura, Nobuyuki, and Falhammar, Henrik

Abstract

Purpose. Sarcopenia is an advancing and widespread skeletal muscle condition characterized by the depletion of skeletal muscle mass. The (pro)renin receptor ((P)RR) is a multifaceted protein with both pathophysiological and physiological functions. (P)RR is cleaved to generate soluble (P)RR, whose blood concentration may reflect the expression level of tissue (P)RR. We have discovered that the expression of (P)RR was elevated in the atrophied skeletal muscles of aged mice and humans. Methods. In this study, we examined the correlation between muscle atrophy and serum soluble (P)RR levels in bedridden patients with sarcopenia. Results. In total, 45 subjects were enrolled. Their ages were 81 (59–89) y.o., and serum soluble (P)RR levels were 30.5 ± 7.3 ng/ml. Lean body mass ratio (lean body mass/body weight), an index of muscle mass, was independently significantly and negatively correlated with serum soluble (P)RR concentrations in all patients. In addition, the lean body mass ratio was independently significantly and negatively correlated with serum soluble (P)RR concentrations in older patients (≥82 y.o.) but not in younger patients (<82 y.o.). Conclusion. These data suggested that patients with sarcopenia, especially in elderly patients, may be associated with increased (P)RR expression. The serum soluble (P)RR level could be a biomarker of sarcopenia although this issue should be investigated by future studies. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Nationwide prospective and retrospective surveys for hepatitis B virus reactivation during immunosuppressive therapies

Author

Mochida, Satoshi, Nakao, Masamitsu, Nakayama, Nobuaki, Uchida, Yoshihito, Nagoshi, Sumiko, Ido, Akio, Mimura, Toshihide, Harigai, Masayoshi, Kaneko, Hiroshi, Kobayashi, Hiroko, Tsuchida, Tetsuya, Suzuki, Hiromichi, Ura, Nobuyuki, Nakamura, Yuichi, Bessho, Masami, Dan, Kazuo, Kusumoto, Shigeru, Sasaki, Yasutsuna, Fujii, Hirofumi, Suzuki, Fumitaka, Ikeda, Kenji, Yamamoto, Kazuhiko, Takikawa, Hajime, Tsubouchi, Hirohito, and Mizokami, Masashi

Published
2016
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12. Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient

Author

Imai, Enyu, Horio, Masaru, Iseki, Kunitoshi, Yamagata, Kunihiro, Watanabe, Tsuyoshi, Hara, Shigeko, Ura, Nobuyuki, Kiyohara, Yutaka, Hirakata, Hideki, Moriyama, Toshiki, Ando, Yasuhiro, Nitta, Kosaku, Inaguma, Daijo, Narita, Ichiei, Iso, Hiroyasu, Wakai, Kenji, Yasuda, Yoshinari, Tsukamoto, Yusuke, Ito, Sadayoshi, Makino, Hirofumi, Hishida, Akira, and Matsuo, Seiichi

Published
2007
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13. Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease

Author

Imai, Enyu, Horio, Masaru, Nitta, Kosaku, Yamagata, Kunihiro, Iseki, Kunitoshi, Hara, Shigeko, Ura, Nobuyuki, Kiyohara, Yutaka, Hirakata, Hideki, Watanabe, Tsuyoshi, Moriyama, Toshiki, Ando, Yasuhiro, Inaguma, Daiki, Narita, Ichiei, Iso, Hiroyasu, Wakai, Kenji, Yasuda, Yoshinari, Tsukamoto, Yusuke, Ito, Sadayoshi, Makino, Hirofumi, Hishida, Akira, and Matsuo, Seiichi

Published
2007
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36. Potential prescribing omissions may have no influence on cause of death in care‐dependent older adults with percutaneous endoscopic gastrostomy tube.

Author

Hattori, Yukari, Abe, Takayuki, Kojima, Taro, Hamada, Shota, Ogawa, Sumito, Ura, Nobuyuki, and Akishita, Masahiro

Subjects
AGE distribution, ELDER care, ANTICOAGULANTS, CREATININE, CAUSES of death, DRUG prescribing, MEDICAL records, SERUM albumin, SEX distribution, SURVIVAL, PHYSICIAN practice patterns, LOGISTIC regression analysis, BODY mass index, RETROSPECTIVE studies, POLYPHARMACY, PLATELET aggregation inhibitors, FEEDING tubes, DESCRIPTIVE statistics, DIGESTIVE system endoscopic surgery, ACQUISITION of data methodology
Abstract

Aim: Studies of medication use in patients with a percutaneous endoscopic gastrostomy (PEG) tube have not been conducted adequately. The aim of this study was to describe medication use of care‐dependent older adults with PEG and evaluate whether potential prescribing omissions (PPO) would affect the cause of death or acute illness. Methods: In a geriatric long‐term care hospital, 116 inpatients aged ≥65 years with insertion of a PEG tube because of dysphagia were enrolled and followed for 2 years: 2016–2018. The patients were divided into two groups, i.e., group A (who died between 2016 and 2018) and group B (who continued to be hospitalized in 2018). Clinical data and prescribed medications were recorded. Logistic regression models were conducted to assess the associations between survival and variables: age, gender, serum albumin level, serum creatinine level, body mass index (BMI), number of drugs and PPO. Results: The patients' mean age was 85.3 ± 10.2 years, 57.8% were women and the mean number of drugs was 6.8 ± 3.5. Medications for managing symptoms, such as constipation and gastrointestinal symptoms, were commonly prescribed. The most common PPO medications were antiplatelet agents and anticoagulants. On logistic regression analysis, PPO had no influence on the cause of death or acute illness. Lower age, higher serum albumin level and body mass index were associated with survival in both univariate and multivariate models. Conclusions: Polypharmacy was prevalent in patients with PEG. Given the finding that PPO had no influence on health outcome, rational deprescribing could be warranted. Geriatr Gerontol Int 2020; 20: 961–966. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Optimal blood pressure in patients with peripheral artery disease following endovascular therapy.

Author

Sasaki, Haruki, Ura, Nobuyuki, Hata, Shinya, Moniwa, Norihito, Hasegawa, Koichi, Takizawa, Hideki, and Tanaka, Shigemichi

Subjects
*BLOOD pressure, *CARDIOVASCULAR diseases risk factors, *ENDOVASCULAR surgery, *CORONARY restenosis, *GLYCOSYLATED hemoglobin, *METFORMIN
Abstract

This study examined the associations between blood pressure (BP) and event incidence to define optimal BP after endovascular therapy (EVT) in patients who underwent EVT. BP was monitored every 6 months for 5 years, and the patients were divided into two groups by average BP: ≥ 140/90 mmHg and < 140/90 mmHg. The association of BP with several events was examined. Although no significant differences in total mortality were observed between the groups, restenosis rates were significantly higher among patients who did not achieve target BP (36.2%) than among those who did (18.2%) (p < 0.01). The percentage of patients with glycosylated haemoglobin > 7.0% was significantly higher among those who did not achieve target BP in the restenosis group (42.9%) than in the other group (10.8%) (p < 0.01). In the restenosis group, there was a significantly higher percentage of patients taking metformin (p < 0.01) than in the other group. Metformin seemed to be administered to patients with more severe diabetes mellitus. In conclusion, it is important to manage hypertension and diabetes to prevent restenosis after EVT. [ABSTRACT FROM PUBLISHER]

Published
2016
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42. Urinary Angiotensin-Converting Enzyme 2 in Hypertensive Patients May Be Increased by Olmesartan, an Angiotensin II Receptor Blocker.

Author

Furuhashi, Masato, Moniwa, Norihito, Mita, Tomohiro, Fuseya, Takahiro, Ishimura, Shutaro, Ohno, Kohei, Shibata, Satoru, Tanaka, Marenao, Watanabe, Yuki, Akasaka, Hiroshi, Ohnishi, Hirofumi, Yoshida, Hideaki, Takizawa, Hideki, Saitoh, Shigeyuki, Ura, Nobuyuki, Shimamoto, Kazuaki, and Miura, Tetsuji

Subjects
ANGIOTENSIN converting enzyme, PEPTIDES, KIDNEY diseases, ANTIHYPERTENSIVE agents, ALBUMIN genetics, PATIENTS
Abstract

BACKGROUND Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney and converts angiotensin (Ang) II to Ang-(1–7), a renoprotective peptide. Urinary ACE2 has been shown to be elevated in patients with chronic kidney disease. However, the effects of antihypertensive agents on urinary ACE2 remain unclear. METHODS Of participants in the Tanno-Sobetsu cohort study in 2011 (n = 617), subjects on no medication (n = 101) and hypertensive patients treated with antihypertensive agents, including the calcium channel blockers amlodipine and long-acting nifedipine; the ACE inhibitor enalapril; and the Ang II receptor blockers losartan, candesartan, valsartan, telmisartan, and olmesartan, for more than 1 year (n = 100) were enrolled, and urinary ACE2 level was measured. RESULTS Glucose and hemoglobin A1c were significantly higher in patients treated with enalapril, telmisartan or olmesartan than in the control subjects. Urinary albumin-to-creatinine ratio (UACR) was significantly higher in patients treated with enalapril than in the control subjects. Urinary ACE2 level was higher in the olmesartan-treated group, but not the other treatment groups, than in the control group. Urinary ACE2 level was positively correlated with systolic blood pressure (r = 0.211; P = 0.003), UACR (r = 0.367; P < 0.001), and estimated salt intake (r = 0.260; P < 0.001). Multivariable regression analysis after adjustment of age, sex, and the correlated indices showed that the use of olmesartan was an independent predictor of urinary ACE2 level. CONCLUSIONS In contrast with other antihypertensive drugs, olmesartan may uniquely increase urinary ACE2 level, which could potentially offer additional renoprotective effects. [ABSTRACT FROM PUBLISHER]

Published
2015
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43. Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial.

Author

Ogihara, Toshio, Saruta, Takao, Rakugi, Hiromi, Saito, Ikuo, Shimamoto, Kazuaki, Matsuoka, Hiroaki, Shimada, Kazuyuki, Ito, Sadayoshi, Horiuchi, Masatsugu, Imaizumi, Tsutomu, Takishita, Shuichi, Higaki, Jitsuo, Katayama, Shigehiro, Kimura, Genjiroh, Umemura, Satoshi, Ura, Nobuyuki, Hayashi, Koichi, Odawara, Masato, Tanahashi, Norio, and Ishimitsu, Toshihiko

Published
2014
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48. Mechanisms of Insulin Resistance in Hypertensive Rats.

Author

Shimamoto, Kazuaki and Ura, Nobuyuki

Subjects
*INSULIN resistance, *ESSENTIAL hypertension, *OBESITY, *CARDIOVASCULAR diseases, *RATS
Abstract

Insulin resistance and hyperinsulinemia are common findings in patients with essential hypertension. Recent evidence indicates that these impairments in glucose metabolism may play a role not only in the development of type 2 diabetes, but also in the onset and persistence of hypertension, dyslipidemia, and abdominal obesity. The accumulation of these risk factors constitutes a high-risk group of cardiovascular diseases, the so-called metabolic syndrome. Insulin resistance has also been reported in several animal models for hypertension, including the spontaneously hypertensive rat (SHR) and the fructose-fed rat (FFR). SHRs and FFRs have been employed in many studies to investigate the mechanisms and pathophysiology of insulin resistance and hypertension, but the precise mechanism of insulin resistance remains to be clarified. In this review, the possible mechanisms of insulin resistance in SHRs and FFRs are summarized. [ABSTRACT FROM AUTHOR]

Published
2006
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49. Association between senescence-related uncoupling protein 2 gene polymorphisms and abdominal obesity in Japanese subjects: The Tanno and Sobetsu study.

Author

Rui Xu, Ishikawa, Kazuhiko, Katsuya, Tomohiro, Yuxiao Fu, Akasaka, Hiroshi, Ikushima, Masashi, Chihara, Yukana, Ura, Nobuyuki, Shimamoto, Kazuaki, Rakugi, Hiromi, and Ogihara, Toshio

Subjects
BODY weight, INSULIN, PROTEINS, OXIDATIVE stress, OBESITY
Abstract

Background: Uncoupling protein 2 ( UCP2) plays an important role in regulating body weight, energy expenditure and insulin secretion. UCP2 is upregulated in white fat in response to fat feeding, and negatively controls insulin secretion. UCP2 also has a function that protects cells from apoptosis and oxidative stress, which shows UCP2 might be a senescence-related gene. Previously, UCP2-866G/A polymorphism in the promoter region has been reported to alter adipose tissue mRNA expression and is associated with obesity in Caucasians. Methods: In this study, we investigated the association between this polymorphism and obesity, insulin secretion and hypertension in the general Japanese population. Results: The allele frequency of UCP2-866G/A polymorphism was significantly higher in Japanese subjects compared to Caucasians. It revealed that subjects only in the obese group with the AA type of UCP2-866G/A polymorphism had significantly higher levels of body mass index (BMI) and waist circumference. Multiple logistic regression analysis showed that this polymorphism was independently associated with waist circumference. This positive association remained in the analysis of the subgroup younger than 65 years, but not in the older group. This polymorphism did not affect levels of insulin and homeostasis model assessment ratio (HOMA-R). Conclusions: These results suggest that the AA type of UCP2-866G/A polymorphism is related to abdominal obesity, which indicates the possible role of this polymorphism in causing metabolic syndromes. [ABSTRACT FROM AUTHOR]

Published
2006
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