31 results on '"Troupis J."'
Search Results
2. 2.3.24 Mesenchymal precursor cell mediated disc regeneration at the time of microdiscectomy.
- Author
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Goldschlager, T., Oehme, D., Ghosh, P., Shimon, S., Ghosh, I., Wu, J., Rosenfeld, J.V., Danks, A., Troupis, J., McDonald, C., and Jenkin, G.
- Published
- 2013
3. Dynamic motion analysis of dart throwers motion visualized through computerized tomography and calculation of the axis of rotation.
- Author
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Edirisinghe, Y., Troupis, J. M., Patel, M., Smith, J., and Crossett, M.
- Abstract
We used a dynamic three-dimensional (3D) mapping method to model the wrist in dynamic unrestricted dart throwers motion in three men and four women. With the aid of precision landmark identification, a 3D coordinate system was applied to the distal radius and the movement of the carpus was described. Subsequently, with dynamic 3D reconstructions and freedom to position the camera viewpoint anywhere in space, we observed the motion pathways of all carpal bones in dart throwers motion and calculated its axis of rotation. This was calculated to lie in 27° of anteversion from the coronal plane and 44° of varus angulation relative to the transverse plane. This technique is a safe and a feasible carpal imaging method to gain key information for decision making in future hand surgical and rehabilitative practices. [ABSTRACT FROM PUBLISHER]
- Published
- 2014
- Full Text
- View/download PDF
4. Superior CT Coronary Angiography Image Quality at Lower Radiation Exposure with Second Generation 320-Detector-Row CT in Patients with Elevated Heart Rate – A Comparison with First Generation 320-Detector-Row CT
- Author
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Soh, S., Wong, D., Ko, B., Cameron, J., Nasis, A., Nerlekar, N., Troupis, J., Meredith, I., and Seneviratne, S.
- Published
- 2013
- Full Text
- View/download PDF
5. Impact of Increased Rotation Speed on Image Quality and Radiation Dose in 320 Multidetector Row Cardiac CT
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Tung, M., Nerlekar, N., Cameron, J., Troupis, J., Meredith, I., and Seneviratne, S.
- Published
- 2013
- Full Text
- View/download PDF
6. 320 Detector Row CT Coronary Angiography Predicts Freedom from Revascularisation and Acts as a Gatekeeper to Defer Referrals for Invasive Angiography in Stable Coronary Artery Disease—A Fractional Flow Reserve Correlated Study
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Ko, B., Cameron, J., Wong, D., Leong, D., Leung, M., Meredith, I., Nerlekar, N., Antonis, P., Crossett, M., Troupis, J., Harper, R., Malaiapan, Y., and Seneviratne, S.
- Published
- 2013
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7. Transluminal Attenuation Gradient on 320-Detector Row CT (TAG320) Compared to Contrast Opacification Mean Difference (CO-Mean-Difference) for Detection of Functionally Significant Stenosis Assessed by Fractional Flow Reserve (FFR)
- Author
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Wong, D., Ko, B., Cameron, J., Nerlekar, N., Leung, M., Malaiapan, Y., Crossett, M., Leong, D., Worthley, S., Troupis, J., Meredith, I., and Seneviratne, S.
- Published
- 2013
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8. B001 CT Stress Myocardial Perfusion Imaging – A Comparison with Quantitative Coronary Angiography and Fractional Flow Reserve
- Author
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Ko, B., Cameron, J.D., Meredith, I.T., Leung, M., Hope, S., Antonis, P., Lehman, S., Nasis, A., Crossett, M., Troupis, J., DeFrance, T., and Seneviratne, S.
- Published
- 2011
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9. Discharging Chest Pain Patients from ED after a Single Troponin and Normal 320-Slice CCTA Significantly Reduces Length of Stay
- Author
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Nasis, A., Meredith, I., Nerlekar, N., Cameron, J., Antonis, P., Mottram, P., Troupis, J., Kambourakis, T., Braitberg, G., and Seneviratne, S.
- Published
- 2010
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10. Comparison of hamate versus second or third toe osteochondral graft using magnetic resonance imaging for reconstruction of proximal interphalangeal fracture-dislocations.
- Author
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Hamilton S, Troupis C, Hong T, Tran A, Troupis J, and Leong JCS
- Subjects
- Humans, Male, Adult, Female, Prospective Studies, Middle Aged, Finger Injuries surgery, Finger Injuries diagnostic imaging, Toes transplantation, Toes diagnostic imaging, Toes surgery, Young Adult, Bone Transplantation methods, Magnetic Resonance Imaging, Fracture Dislocation surgery, Fracture Dislocation diagnostic imaging, Finger Joint surgery, Finger Joint diagnostic imaging, Hamate Bone diagnostic imaging, Hamate Bone injuries, Hamate Bone transplantation
- Abstract
Hemi-hamate arthroplasty is a method used to reconstruct complex fracture-dislocations of the proximal interphalangeal joint of the fingers. Other graft sites, including the toe second and third phalanges, have been proposed as alternatives to hemi-hamate arthroplasty due to variable clinical outcomes and anatomy. Through a prospective magnetic resonance imaging (MRI)-based study in asymptomatic individuals, we aimed to characterize the anatomy of the proximal interphalangeal joint and compare this with the hamate, second and third toes to determine the closest anatomical match using pre-determined measurements. Our results show that the second and third toes have greater anatomical similarity to the proximal interphalangeal joint of the fingers compared to the hamate. High-resolution MRI is a reliable method of characterizing the anatomy of these structures and could be a useful clinical tool in determining reconstructive options in the management of this challenging injury. Level of evidence: II., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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11. No Difference in Functional, Radiographic, and Survivorship Outcomes Between Direct Anterior or Posterior Approach THA: 5-Year Results of a Randomized Trial.
- Author
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Nambiar M, Cheng TE, Onggo JR, Maingard J, Troupis J, Pope A, Armstrong MS, and Singh PJ
- Subjects
- Aged, Female, Follow-Up Studies, Functional Status, Humans, Male, Middle Aged, Patient Reported Outcome Measures, Postoperative Complications etiology, Postoperative Period, Quality of Life, Radiography, Survival Analysis, Survivorship, Treatment Outcome, Walk Test, Arthroplasty, Replacement, Hip methods, Postoperative Complications epidemiology
- Abstract
Background: Both the direct anterior approach (DAA) and posterior approach (PA) to THA have known advantages and disadvantages. The comparison between DAA and PA THA has been widely explored during the early postoperative period. However, few randomized trials have compared these approaches at a minimum follow-up of 5 years; doing so would be important to establish any differences in mid-term outcomes or complications., Questions/purposes: We performed a randomized trial comparing DAA and PA in THA in terms of (1) patient-reported outcome scores, (2) quality of life and functional outcomes assessed by the EQ-5D and 10-meter walk test results, (3) radiographic analysis, and (4) survivorship and surgical complications at a minimum of 5 years follow-up., Methods: Two hip specialist surgeons performed both DAA and PA THA using the same THA components at two hospital sites. One hundred twelve patients on the elective THA surgical waitlist were invited to participate in the study. Thirty-four patients did not meet the study's inclusion criteria and were excluded, and three patients declined to participate in the study. The remaining 75 patients who were eligible were randomized into DAA and PA groups. Thirty-seven patients were initially randomized to receive DAA THA, but two did not and were excluded, resulting in 48% (35 of 73) of patients who received DAA THA; 52% (38 of 73) of patients were randomized into and received PA THA. Over a minimum 5 years of follow-up, 3% (1 of 35) of DAA patients were lost to follow-up, and none of the patients undergoing PA THA were lost. A per-protocol analysis was adopted, resulting in further patients being excluded from analysis. Of the 73 study patients, 99% (72; DAA: 35, PA: 37) were analyzed at 1 year, 95% (69; DAA: 34, PA: 35) were analyzed at 2 years, and 72% (52; DAA: 23, PA: 29) were analyzed at 5 years. The primary outcome was the Oxford Hip Score (OHS) and WOMAC score. Secondary outcomes included the EQ-5D and EQ-5D VAS scores, 10-meter walk test results, radiographic evidence of loosening (femoral: lucency > 2 mm at the implant-bone interface, subsidence > 2 mm; acetabular: migration or change in inclination), 5-year survivorship analysis from all-cause revisions, and surgical complications. The study was powered to detect a 10-point difference in the WOMAC score, which is equivalent to the minimum clinically important difference (MCID)., Results: There were no differences in primary outcomes (OHS and WOMAC scores) or secondary outcomes (EQ-5D scores, EQ-5D VAS scores, and 10-meter walk test result) between the DAA and PA groups at the 5-year follow-up interval. The median (range) OHS at 5 years was 46 (16 to 48) for DAA and 47 (18 to 48) for PA groups (p = 0.93), and the median WOMAC score was 6 (0 to 81) for DAA and 7 (0 to 59) for PA groups (p = 0.96). The median EQ-5D score was 1 (0.1 to 1) for DAA and 1 (0.5 to 1) for PA groups (p = 0.45), and the median EQ-5D VAS score was 85 (60 to 100) for DAA and 95 (70 to 100) for PA groups (p = 0.29). There were no cases of component loosening on radiographs. There was no difference in component survival between the two approaches at 5 years (DAA: 97% [95% CI 85% to 100%] versus PA: 97% [95% CI 87% to 100%]). Eight of 23 patients in the DAA group reported decreased sensation in the lateral femoral cutaneous nerve distribution., Conclusion: DAA and PA are both effective approaches in performing primary THA. Each approach has its associated risks and complications. The choice of THA should be based on individual patient factors, surgeon experience, and shared decision-making. Early registry data indicate DAA and PA THA are comparable, but longer-term data with larger numbers of patients will be required before one can safely conclude equal survivorship between both approaches., Level of Evidence: Level I, therapeutic study., Competing Interests: Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request., (Copyright © 2021 by the Association of Bone and Joint Surgeons.)
- Published
- 2021
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12. Computed tomography guided lung biopsy under general anaesthesia with apnoea: Preliminary experience.
- Author
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Deb S, Malkoutzis E, and Troupis J
- Subjects
- Anesthesia, General, Apnea, Humans, Image-Guided Biopsy, Lung diagnostic imaging, Radiography, Interventional, Retrospective Studies, Tomography, X-Ray Computed, Lung Neoplasms diagnostic imaging, Pneumothorax
- Abstract
Certain pulmonary lesions may be challenging to biopsy with conventional computed tomography percutaneous lung biopsy (CTPLB) under local anaesthesia (LA) which requires consistent patient breath holding to minimise complications. We aim to describe and evaluate the feasibility of CTPLB under general anaesthesia (GA) with apnoea, comparing results to patients undergoing biopsy under LA. This was a retrospective analysis of CTPLB with 18 GA and 137 LA patients. All biopsies were performed using a co-axial needle system in the radiology department on a multi-detector CT scanner with patient positioning determined by assessing shortest distance to target lesion. GA cases were performed under relaxant anaesthesia with intermittent positive pressure ventilation. Lower lobar lesion location and a combination of size and location (including proximity to critical structures) were indications for GA biopsy in >90% of patients. Mean lesion size for GA biopsies was 18 mm and control group 30 mm (P < 0.006) and mean pleura to lesion distance 29 and 11 mm, respectively (P < 0.0009). Pneumothorax rates were lower in our GA biopsy group (11%) compared to control group (42%) (P < 0.05). No anaesthetic complications were encountered. All GA samples were diagnostic. Based on a small number of patients, CTPLB under GA with apnoea seems a safe, feasible alternative to conventional CTPLB under LA for technically challenging lesions. This technique is routinely employed at our centre allowing access to lesions previously deemed unsafe to biopsy., (© 2021 The Royal Australian and New Zealand College of Radiologists.)
- Published
- 2021
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13. Structural integrity of rotator cuff at 16 years following repair: good long-term outcomes despite recurrent tears.
- Author
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Elliott RSJ, Lim YJ, Coghlan J, Troupis J, and Bell S
- Abstract
Background: There are few studies reporting long-term rotator cuff integrity following repair. The present study reports a case series of surgically repaired supraspinatus tendons followed up with clinical outcomes and ultrasound imaging after an average of 16 years., Methods: The prospectively studied clinical outcomes at short-, medium- and long-term follow-up in 27 shoulders in 25 patients treated with arthroscopic subacromial decompression and mini-open rotator cuff repair have been reported previously. The functional outcomes scores recorded were the University of California Los Angeles (UCLA), American Shoulder and Elbow Surgeons (ASES) and Simple Shoulder Test (SST) measures. These patients then underwent an ultrasound scan with respect to the long-term assessment of the shoulder and the integrity of the repair., Results: A recurrent tear was noted in 37% of patients at 16.25 years after surgery, of which 50% were small. Two patients required repeat surgery. Patients had a mean UCLA score of 30, an ASES score of 91.3 and a SST score of 9.5 with a 85% level of satisfaction with surgery. Patients with a recurrent tear had outcome scores equivalent to those with an intact cuff with no significant pain. No independent risk factors were identified as predictors for recurrent tear., Conclusions: Patients showed sustained benefit and satisfaction at long-term follow-up despite a 37% recurrence of full-thickness supraspinatus tear.
- Published
- 2019
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14. Noninvasive CT-Derived FFR Based on Structural and Fluid Analysis: A Comparison With Invasive FFR for Detection of Functionally Significant Stenosis.
- Author
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Ko BS, Cameron JD, Munnur RK, Wong DTL, Fujisawa Y, Sakaguchi T, Hirohata K, Hislop-Jambrich J, Fujimoto S, Takamura K, Crossett M, Leung M, Kuganesan A, Malaiapan Y, Nasis A, Troupis J, Meredith IT, and Seneviratne SK
- Subjects
- Adult, Aged, Aged, 80 and over, Area Under Curve, Coronary Stenosis physiopathology, Coronary Vessels physiopathology, Feasibility Studies, Female, Humans, Male, Middle Aged, Models, Cardiovascular, Observer Variation, Patient-Specific Modeling, Predictive Value of Tests, Prognosis, Prospective Studies, ROC Curve, Reproducibility of Results, Severity of Illness Index, Computed Tomography Angiography methods, Coronary Angiography methods, Coronary Stenosis diagnostic imaging, Coronary Vessels diagnostic imaging, Fractional Flow Reserve, Myocardial, Multidetector Computed Tomography methods, Radiographic Image Interpretation, Computer-Assisted methods
- Abstract
Objectives: This study describes the feasibility and accuracy of a novel computed tomography (CT) fractional flow reserve (FFR) technique based on alternative boundary conditions., Background: Techniques used to compute FFR based on images acquired from coronary computed tomography angiography (CTA) are described. Boundary conditions were typically determined by allometric scaling laws and assumptions regarding microvascular resistance. Alternatively, boundary conditions can be derived from the structural deformation of coronary lumen and aorta, although its accuracy remains unknown., Methods: Forty-two patients (78 vessels) in a single institution prospectively underwent 320-detector coronary CTA and FFR. Deformation of coronary cross-sectional lumen and aorta, computed from coronary CTA images acquired over diastole, was used to determine the boundary conditions based on hierarchical Bayes modeling. CT-FFR was derived using a reduced order model performed using a standard desktop computer and dedicated software. First, 12 patients (20 vessels) formed the derivation cohort to determine optimal CT-FFR threshold with which to detect functional stenosis, defined as FFR of ≤0.8, which was validated in the subsequent 30 patients (58 vessels)., Results: Derivation cohort results demonstrated optimal threshold for CT-FFR was 0.8 with 67% sensitivity and 91% specificity. In the validation cohort, CT-FFR was successfully computed in 56 of 58 vessels (97%). Compared with coronary CTA, CT-FFR at ≤0.8 demonstrated a higher specificity (87% vs. 74%, respectively) and positive predictive value (74% vs. 60%, respectively), with comparable sensitivity (78% vs. 79%, respectively), negative predictive value (89% vs. 88%, respectively), and accuracy (area under the curve: 0.88 vs. 0.77, respectively; p = 0.22). Based on Bland-Altman analysis, mean intraobserver and interobserver variability values for CT-FFR were, respectively, -0.02 ± 0.05 (95% limits of agreement: -0.12 to 0.08) and 0.03 ± 0.06 (95% limits: 0.07 to 0.19). Mean time per patient for CT-FFR analysis was 27.07 ± 7.54 min., Conclusions: CT-FFR based on alternative boundary conditions and reduced-order fluid model is feasible, highly reproducible, and may be accurate in detecting FFR ≤ 0.8. It requires a short processing time and can be completed at point-of-care. Further validation is required in large prospective multicenter settings., (Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
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15. Diffusion-weighted imaging and the skeletal system: a literature review.
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Yao K and Troupis JM
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- Bone Neoplasms diagnostic imaging, Bone and Bones diagnostic imaging, Humans, Bone Diseases diagnostic imaging, Diffusion Magnetic Resonance Imaging methods
- Abstract
Diffusion-weighted imaging (DWI) is a magnetic resonance imaging (MRI) sequence that has a well-established role in neuroimaging, and is increasingly being utilised in other clinical contexts, including the assessment of various skeletal disorders. It utilises the variability of Brownian motion of water molecules; the differing patterns of water molecular diffusion in various biological tissues help determine the contrast obtained in DWI. Although early research on the clinical role of DWI focused mainly on the field of neuroimaging, there are now more studies demonstrating the promising role DWI has in the diagnosis and monitoring of various osseous diseases. DWI has been shown to be useful in assessing a patient's skeletal tumour burden, monitoring the post-chemotherapy response of various bony malignancies, detecting hip ischaemia in patients with Legg-Calvé-Perthes disease, as well as determining the quality of repaired articular cartilage. Despite its relative successes, DWI has several limitations, including its limited clinical value in differentiating chondrosarcomas from benign bone lesions, as well as osteoporotic vertebral compression fractures from compression fractures due to malignancy. This literature review aims to provide an overview of the recent developments in the use of DWI in imaging the skeletal system, and to clarify the role of DWI in assessing various osseous diseases., (Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2016
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16. Giant Aortic Mural Thrombus.
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Lok SY, Bhagwat K, Smith JA, Troupis J, and Joshi P
- Subjects
- Aortic Diseases therapy, Blood Vessel Prosthesis Implantation methods, Female, Humans, Middle Aged, Thrombosis therapy, Tomography, X-Ray Computed, Aorta, Thoracic, Aortic Diseases diagnosis, Thrombolytic Therapy methods, Thrombosis diagnosis
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- 2016
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17. Cardiac CT imaging in the context of left atrial appendage occlusion.
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Kwong Y and Troupis J
- Subjects
- Atrial Appendage diagnostic imaging, Atrial Appendage surgery, Atrial Fibrillation complications, Cardiac-Gated Imaging Techniques methods, Humans, Preoperative Care methods, Stroke etiology, Treatment Outcome, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery, Septal Occluder Device, Stroke prevention & control, Tomography, X-Ray Computed methods
- Abstract
Left atrial occlusion devices are a recognized treatment option in patients with difficult to treat atrial fibrillation or intolerance to warfarin therapy. There are an increasing number of devices on the market, and good quality preoperative imaging is crucial to assess the feasibility of the procedure and help plan the occlusion. Electrocardiography-gated cardiac CT is ideal for this purpose as the high spatial and temporal resolution allow accurate measurements and reformats in multiple planes. As the imaging specialist reporting the CT may not necessarily be the interventionalist performing the implantation, this review will illustrate the important points in reporting the preimplant CT. The expected postoperative appearances and potential complications will also be described., (Copyright © 2015 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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18. Superior CT coronary angiography image quality at lower radiation exposure with second generation 320-detector row CT in patients with elevated heart rate: a comparison with first generation 320-detector row CT.
- Author
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Wong DT, Soh SY, Ko BS, Cameron JD, Crossett M, Nasis A, Troupis J, Meredith IT, and Seneviratne SK
- Abstract
Background: This study aims to compare the image quality of second generation versus first generation 320-computed tomography coronary angiography (CTCA) in patients with heart rate ≥65 bpm as it has not been specifically reported., Methods: Consecutive patients who underwent CTCA using second-generation-320-detector-row-CT were prospectively enrolled. A total of 50 patients with elevated (≥65 bpm) heart rate and 50 patients with controlled (<65 bpm) heart rate were included. Age and gender matched patients who were scanned with the first-generation-320-detector-row-CT were retrospectively identified. Image quality in each coronary artery segment was assessed by two blinded CT angiographers using the five-point Likert scale., Results: In the elevated heart rate cohorts, while there was no significant difference in heart rate during scan-acquisition (66 vs. 69 bpm, P=0.308), or body mass index (28.5 vs. 29.6, P=0.464), the second generation scanner was associated with better image quality (3.94±0.6 vs. 3.45±0.8, P=0.001), and with lower radiation (2.8 vs. 4.3 mSv, P=0.009). There was no difference in scan image quality for the controlled heart rate cohorts., Conclusions: The second generation CT scanner provides better image quality at lower radiation dose in patients with elevated heart rate (≥65 bpm) compared to first generation CT scanner.
- Published
- 2014
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19. Comparison of diagnostic accuracy of combined assessment using adenosine stress computed tomography perfusion + computed tomography angiography with transluminal attenuation gradient + computed tomography angiography against invasive fractional flow reserve.
- Author
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Wong DT, Ko BS, Cameron JD, Leong DP, Leung MC, Malaiapan Y, Nerlekar N, Crossett M, Troupis J, Meredith IT, and Seneviratne SK
- Subjects
- Aged, Cohort Studies, Coronary Stenosis physiopathology, Female, Humans, Male, Middle Aged, Perfusion Imaging, Retrospective Studies, Adenosine, Coronary Angiography standards, Coronary Stenosis diagnostic imaging, Exercise Test standards, Fractional Flow Reserve, Myocardial physiology, Multidetector Computed Tomography standards
- Abstract
Objectives: The goal of this study was to compare the diagnostic accuracy of combined computed tomography perfusion (CTP) + computed tomography angiography (CTA), transluminal attenuation gradient by 320-detector row computed tomography (TAG320) + CTA, and CTP + TAG320 + CTA (multidetector computed tomography-integrated protocol [MDCT-IP]) assessment in predicting significant fractional flow reserve (FFR)., Background: CTA has limited specificity for predicting functionally significant stenoses. Novel CT techniques, including adenosine stress CTP and TAG320, may improve the diagnostic accuracy of CTA., Methods: CTA, CTP, and TAG320 were assessed using 320-detector row MDCT. Patients who underwent CTA, CTP, and FFR assessment on invasive coronary angiography were included. CTP was assessed using the visual perfusion assessment. TAG320 was defined as the linear regression coefficient between luminal attenuation and axial distance. A TAG320 cutoff value of -15.1 HU/10 mm as previously described was defined as significant. Functionally significant coronary stenosis was defined as FFR ≤0.8., Results: The cohort included 75 patients (age 64.1 ± 10.8 years, 52 men) and 44 (35%) FFR-significant vessels. In 127 vessels, CTA predicted FFR-significant stenosis with 89% sensitivity and 65% specificity compared with MDCT-IP, which showed 88% sensitivity and 83% specificity. In 97 vessels in which the results of all techniques were available, TAG320 + CTA (area under the curve [AUC] = 0.844) and CTP + CTA (AUC = 0.845) had comparable per-vessel diagnostic accuracy (p = 0.98). The diagnostic accuracy of MDCT-IP (AUC = 0.91) was superior to TAG320 + CTA or CTP + CTA (p = 0.01)., Conclusions: In vessels without significant calcification or artefact, TAG320 + CTA and CTP + CTA provide comparable diagnostic accuracy for functional assessment of coronary artery stenosis. MDCT-IP may provide the best diagnostic accuracy for functional assessment of coronary artery stenosis., (Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
20. Dynamic motion analysis of dart throwers motion visualized through computerized tomography and calculation of the axis of rotation.
- Author
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Edirisinghe Y, Troupis JM, Patel M, Smith J, and Crossett M
- Subjects
- Biomechanical Phenomena, Carpal Joints physiology, Female, Humans, Male, Movement physiology, Rotation, Wrist Joint anatomy & histology, Wrist Joint diagnostic imaging, Wrist Joint physiology, Carpal Bones anatomy & histology, Carpal Bones diagnostic imaging, Carpal Joints anatomy & histology, Carpal Joints diagnostic imaging, Four-Dimensional Computed Tomography methods
- Abstract
We used a dynamic three-dimensional (3D) mapping method to model the wrist in dynamic unrestricted dart throwers motion in three men and four women. With the aid of precision landmark identification, a 3D coordinate system was applied to the distal radius and the movement of the carpus was described. Subsequently, with dynamic 3D reconstructions and freedom to position the camera viewpoint anywhere in space, we observed the motion pathways of all carpal bones in dart throwers motion and calculated its axis of rotation. This was calculated to lie in 27° of anteversion from the coronal plane and 44° of varus angulation relative to the transverse plane. This technique is a safe and a feasible carpal imaging method to gain key information for decision making in future hand surgical and rehabilitative practices.
- Published
- 2014
- Full Text
- View/download PDF
21. 320-row CT coronary angiography predicts freedom from revascularisation and acts as a gatekeeper to defer invasive angiography in stable coronary artery disease: a fractional flow reserve-correlated study.
- Author
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Ko BS, Wong DT, Cameron JD, Leong DP, Leung M, Meredith IT, Nerlekar N, Antonis P, Crossett M, Troupis J, Harper R, Malaiapan Y, and Seneviratne SK
- Subjects
- Aged, Angina Pectoris diagnostic imaging, Area Under Curve, Coronary Angiography instrumentation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, ROC Curve, Reference Standards, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, Coronary Angiography standards, Coronary Artery Disease diagnostic imaging, Coronary Stenosis diagnostic imaging, Fractional Flow Reserve, Myocardial, Multidetector Computed Tomography standards
- Abstract
Objectives: To determine the accuracy of 320-row multidetector coronary computed tomography angiography (M320-CCTA) to detect functional stenoses using fractional flow reserve (FFR) as the reference standard and to predict revascularisation in stable coronary artery disease., Methods: One hundred and fifteen patients (230 vessels) underwent M320-CCTA and FFR assessment and were followed for 18 months. Diameter stenosis on invasive angiography (ICA) and M320-CCTA were assessed by consensus by two observers and significant stenosis was defined as ≥50%. FFR ≤0.8 indicated functionally significant stenoses., Results: M320-CCTA had 94% sensitivity and 94% negative predictive value (NPV) for FFR ≤0.8. Overall accuracy was 70%, specificity 54% and positive predictive value 65%. On receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) for CCTA to predict FFR ≤0.8 was 0.74 which was comparable with ICA. The absence of a significant stenosis on M320-CCTA was associated with a 6% revascularisation rate. M320-CCTA predicted revascularisation with an AUC of 0.71 which was comparable with ICA., Conclusions: M320-CCTA has excellent sensitivity and NPV for functional stenoses and therefore may act as an effective gatekeeper to defer ICA and revascularisation. Like ICA, M320-CCTA lacks specificity for functional stenoses and only has moderate accuracy to predict the need for revascularisation., Key Points: • Important information about the heart is provided by 320-row multidetector CT coronary angiography (M320-CCTA). • M320-CCTA accurately detects and excludes functional stenoses determined by fractional flow reserve (FFR). • Non-significant stenoses on M320-CCTA associated with fewer cardiac events and less revascularisation. • M320-CCTA may act as a gatekeeper for invasive angiography and inappropriate revascularisation. • Like ICA, M320-CCTA only has moderate accuracy to predict vessels requiring revascularisation.
- Published
- 2014
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22. Review of cardiomyopathy imaging.
- Author
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Gunaratnam K, Wong LH, Nasis A, Ellims A, Nandurkar D, Soo G, Cameron J, and Troupis J
- Subjects
- Humans, Cardiomyopathies diagnosis, Echocardiography methods, Image Enhancement methods, Magnetic Resonance Imaging, Cine methods, Tomography, X-Ray Computed methods
- Abstract
Cardiomyopathies are increasingly being detected on both routine and non-routine imaging. Furthermore, the diagnosis of cardiomyopathy is changing from the traditional method of clinical presentation and cardiac morphology to a quantifiable method based on both cardiac morphology and function. With cardiac magnetic resonance imaging, coronary computed tomography and nuclear medicine increasingly being utilized along with echocardiography in the diagnostic process, it is important for the radiologist to be aware of the relevant criteria in formulating a diagnosis. We aim to provide an overview of the imaging characteristics of the most commonly encountered cardiomyopathies., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
- Full Text
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23. Transluminal attenuation gradient in coronary computed tomography angiography is a novel noninvasive approach to the identification of functionally significant coronary artery stenosis: a comparison with fractional flow reserve.
- Author
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Wong DT, Ko BS, Cameron JD, Nerlekar N, Leung MC, Malaiapan Y, Crossett M, Leong DP, Worthley SG, Troupis J, Meredith IT, and Seneviratne SK
- Subjects
- Aged, Blood Flow Velocity physiology, Cohort Studies, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Female, Humans, Linear Models, Male, Middle Aged, ROC Curve, Retrospective Studies, Sensitivity and Specificity, Coronary Angiography methods, Coronary Stenosis diagnostic imaging, Coronary Stenosis physiopathology, Fractional Flow Reserve, Myocardial physiology, Image Interpretation, Computer-Assisted methods, Multidetector Computed Tomography methods
- Abstract
Objective: The purpose of this study was to assess the diagnostic accuracy of TAG320 in predicting functional stenosis severity evaluated by fractional flow reserve (FFR)., Background: Coronary computed tomography angiography (CCTA) has limited specificity for predicting functionally significant stenoses. Recent studies suggest that contrast gradient attenuation along an arterial lesion, or transluminal attenuation gradient (TAG), may provide assessment of functional significance of coronary stenosis. The use of 320-detector row computed tomography (CT), enabling near isophasic, single-beat imaging of the entire coronary tree, may be ideal for TAG functional assessment of a coronary arterial stenosis., Methods: We assessed the diagnostic accuracy of TAG320 using 320-row CCTA with FFR for the evaluation of functional stenosis severity in consecutive patients undergoing invasive coronary angiography and FFR for stable chest pain. The luminal radiological contrast attenuation (Hounsfield units [HU]) was measured at 5-mm intervals along the artery from ostium to a distal level where the cross-sectional area decreased to <2.0 mm(2). TAG320 was defined as the linear regression coefficient between luminal attenuation and axial distance. Functionally significant coronary stenosis was defined as ≤0.8 on FFR., Results: In our cohort of 54 patients (age 62.7 ± 8.7 years, 35 men, 78 vessels), TAG320 in FFR-significant vessels was significantly lower when compared with FFR nonsignificant vessels (-21 [-27; -16] vs. -11 [-16; -3] HU/10 mm, p < 0.001). On receiver-operating characteristic analysis, a retrospectively determined TAG320 cutoff of -15.1 HU/10 mm predicted FFR ≤0.8 with (a bootstrapped resampled) a sensitivity of 77%, specificity of 74%, positive predictive value of 67%, and negative predictive value of 86%. The combined TAG320 and CCTA assessment had an area under the curve of 0.88. There was incremental value of adding TAG320 to CCTA assessment for detection of significant FFR by Wald test (p = 0.0001) and integrated discrimination improvement index (0.11, p = 0.002)., Conclusions: Assessment of TAG320 with a 320-detector row CT provides acceptable prediction of invasive FFR and may provide a noninvasive modality for detecting functionally significant coronary stenoses. Combined TAG320 and CCTA assessment may have incremental predictive value over CCTA alone for detecting functionally significant coronary arterial stenoses; however, larger studies are required to determine the benefit of combined TAG320 and CCTA assessment., (Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2013
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24. Cardiomyopathy and cardiac computed tomography: what the radiologist needs to know.
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Troupis JM, Singh Pasricha S, Gunaratnam K, Nasis A, Cameron J, and Seneviratne S
- Subjects
- Cardiomyopathies etiology, Cardiomyopathies pathology, Coronary Stenosis diagnostic imaging, Humans, Hypertension complications, Hypertension diagnostic imaging, Hypertension pathology, Prognosis, Survival Rate, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left pathology, Cardiomyopathies diagnostic imaging, Coronary Angiography methods, Tomography, X-Ray Computed methods
- Abstract
Coronary computed tomographic angiography (CCTA) is an established tool for the investigation of shortness of breath and chest pain. Although CCTA is performed to assess vessels that could well be diseased, one must review the study for evidence of cardiomyopathy, which can provoke similar symptoms. Cardiomyopathies can coexist with various causes of chest pain including obstructive coronary artery disease and may, therefore, be identifiable at CCTA. Furthermore, symptoms such as shortness of breath and chest pain that the clinician may suspect are secondary to coronary disease leading to investigation with CCTA, may be secondary to cardiomyopathy. We review several important causes of cardiomyopathy that may be detected by CCTA, which are important for radiologists to identify given the implications for further management and prognosis., (Copyright © 2012 The Royal College of Radiologists. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
25. Combined CT coronary angiography and stress myocardial perfusion imaging for hemodynamically significant stenoses in patients with suspected coronary artery disease: a comparison with fractional flow reserve.
- Author
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Ko BS, Cameron JD, Leung M, Meredith IT, Leong DP, Antonis PR, Crossett M, Troupis J, Harper R, Malaiapan Y, and Seneviratne SK
- Subjects
- Aged, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Coronary Stenosis diagnostic imaging, Coronary Stenosis physiopathology, Female, Humans, Male, Middle Aged, Observer Variation, Predictive Value of Tests, Prospective Studies, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Cardiac Catheterization, Coronary Angiography methods, Coronary Artery Disease diagnosis, Coronary Stenosis diagnosis, Fractional Flow Reserve, Myocardial, Hemodynamics, Multidetector Computed Tomography, Myocardial Perfusion Imaging methods
- Abstract
Objectives: We sought to determine the accuracy of combined coronary computed tomography angiography (CTA) and computed tomography stress myocardial perfusion imaging (CTP) in the detection of hemodynamically significant stenoses using fractional flow reserve (FFR) as a reference standard in patients with suspected coronary artery disease., Background: CTP can be qualitatively assessed by visual interpretation or quantified by the transmural perfusion ratio determined as the ratio of subendocardial to subepicardial contrast attenuation. The incremental value of each technique in addition to coronary CTA to detect hemodynamically significant stenoses is not known., Methods: Forty symptomatic patients underwent FFR and 320-detector computed tomography assessment including coronary CTA and CTP. Myocardial perfusion was assessed using the transmural perfusion ratio and visual perfusion assessment. Computed tomography images were assessed by consensus of 2 observers. Transmural perfusion ratio <0.99 was used as the threshold for abnormal perfusion. FFR ≤0.8 indicated hemodynamically significant stenoses., Results: Coronary CTA detected FFR-significant stenoses with 95% sensitivity and 78% specificity. The additional use of visual perfusion assessment and the transmural perfusion ratio both increased the specificity to 95%, with sensitivity of 87% and 71%, respectively. The area under the receiver-operating characteristic curve for coronary CTA + visual perfusion assessment was significantly higher than both coronary CTA (0.93 vs. 0.85, p = 0.0003) and coronary CTA + the transmural perfusion ratio (0.93 vs. 0.79, p = 0.0003). Per-vessel and per-patient accuracy for coronary CTA, coronary CTA + the transmural perfusion ratio, and coronary CTA + visual perfusion assessment was 83% and 83%, 87% and 92%, and 92% and 95%, respectively., Conclusions: In suspected coronary artery disease, combined coronary CTA + CTP identifies patients with hemodynamically significant stenoses with >90% accuracy compared with FFR. When interpreted with coronary CTA, visual perfusion assessment provided superior incremental value in the detection of FFR-significant stenoses compared with the quantitative transmural perfusion ratio assessment., (Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
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26. Are extra-labral MR findings useful in the diagnosis of a labral tear?
- Author
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Saddik D, Tran P, Troupis J, Tirman P, O'donnell J, Howells R, Farish S, and Tartaglia C
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- Adult, Female, Humans, Male, Reproducibility of Results, Sensitivity and Specificity, Acetabulum pathology, Edema complications, Edema pathology, Fractures, Cartilage complications, Fractures, Cartilage pathology, Magnetic Resonance Imaging methods
- Abstract
Objective: To determine diagnostic performance statistics of extra-labral magnetic resonance (MR) findings for detection of labral tears in a population of patients with clinical suspicion of this diagnosis., Materials and Methods: Seventy-nine patients clinically suspected of having a labral tear (who underwent arthroscopy) had their MR studies retrospectively reviewed to determine the presence of lateral acetabular oedema-like marrow signal, ganglia, dysplastic femoral bumps, synovial herniation pits and geodes. These findings were then correlated with the arthroscopic presence (or absence) of a labral tear., Results: All findings (lateral acetabular oedema-like marrow signal, ganglia, dysplastic femoral bumps, synovial herniation pits and geodes) had a specificity and positive predictive value (PPV) of 100%. Lateral acetabular oedema-like marrow signal had a sensitivity of 35% and 20% negative predictive value (NPV). This was the only statistically significant finding (P < 0.05). The sensitivity and NPV of ganglia were 12% and 16%, dysplastic femoral bumps (12%, 16%), synovial herniation pits (4%, 14%) and geodes (6%, 15%) respectively, (P > 0.05)., Conclusion: Lateral acetabular oedema-like marrow signal is a useful sign (100% PPV) in the MR diagnosis of a labral tear, if one is clinically suspected. The other findings (ganglia, dysplastic femoral bumps, synovial herniation pits and geodes) were not statistically significant. Further studies are required to evaluate these., (© 2012 The Authors. Journal of Medical Imaging and Radiation Oncology © 2012 The Royal Australian and New Zealand College of Radiologists.)
- Published
- 2012
- Full Text
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27. Presence of accessory left atrial appendage/diverticula in a population with atrial fibrillation compared with those in sinus rhythm: a retrospective review.
- Author
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Troupis J, Crossett M, Scneider-Kolsky M, and Nandurkar D
- Subjects
- Adult, Aged, Aged, 80 and over, Atrial Appendage diagnostic imaging, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation pathology, Chi-Square Distribution, Coronary Angiography methods, Diverticulum diagnostic imaging, Diverticulum pathology, Female, Heart Diseases diagnostic imaging, Heart Diseases pathology, Humans, Male, Middle Aged, Predictive Value of Tests, Prevalence, Retrospective Studies, Tomography, X-Ray Computed, Victoria epidemiology, Young Adult, Atrial Appendage pathology, Atrial Fibrillation epidemiology, Diverticulum epidemiology, Heart Diseases epidemiology
- Abstract
Accessory left atrial appendages and atrial diverticula have an incidence of 10-27%. Their association with atrial fibrillation needs to be confirmed. This study determined the prevalence, number, size, location and morphology of accessory left atrial appendages/atrial diverticula in patients with atrial fibrillation compared with those in sinus rhythm. A retrospective analysis of 47 consecutive patients with atrial fibrillation who underwent 320 multidetector Coronary CT angiography (CCTA) was performed. A random group of 47 CCTA patients with sinus rhythm formed the control group. The presence, number, size, location and morphology of accessory left atrial appendages and atrial diverticula in each group were analysed. Twenty one patients had a total of 25 accessory left atrial appendages and atrial diverticula in the atrial fibrillation group and 22 patients had a total of 24 accessory left atrial appendages and atrial diverticula in the sinus rhythm group. Twenty-one atrial diverticula were identified in 19 patients in the atrial fibrillation group and 19 atrial diverticula in 17 patients in the sinus rhythm group. The mean length and width of accessory left atrial appendage was 6.9 and 4.7 mm, respectively in the atrial fibrillation group and 12 and 4.6 mm, respectively, in the sinus rhythm group, P = ns (not significant). The mean length and width of atrial diverticulum was 4.7 and 3.6 mm, respectively in the atrial fibrillation group and 6.2 and 5 mm, respectively in the sinus rhythm group (P = ns). Eighty-four % and 96% of the accessory left atrial appendages/atrial diverticula in the atrial fibrillation and sinus rhythm groups were located along the right anterosuperior left atrial wall. Accessory left atrial appendages and atrial diverticula are common structures with similar prevalence in patients with atrial fibrillation and sinus rhythm.
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- 2012
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28. Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve.
- Author
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Ko BS, Cameron JD, Meredith IT, Leung M, Antonis PR, Nasis A, Crossett M, Hope SA, Lehman SJ, Troupis J, DeFrance T, and Seneviratne SK
- Subjects
- Adenosine, Aged, Coronary Angiography methods, Coronary Stenosis diagnosis, Female, Humans, Male, Middle Aged, Myocardial Ischemia physiopathology, Myocardial Revascularization methods, Observer Variation, Prospective Studies, Sensitivity and Specificity, Vasodilator Agents, Fractional Flow Reserve, Myocardial physiology, Myocardial Ischemia diagnosis, Myocardial Perfusion Imaging methods, Tomography, X-Ray Computed methods
- Abstract
Aims: Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting myocardial ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, is unknown. Our aim was to determine the diagnostic accuracy of CTP and its incremental value when used with computed tomography coronary angiography (CTA) for detecting ischaemia compared with FFR., Methods and Results: Forty-two patients (126 vessel territories), who had at least one ≥50% angiographic stenosis on invasive angiography considered for non-urgent revascularization, were included and underwent FFR and CT assessment, including CTP, delayed contrast enhancement scan and CTA all acquired using 320-detector row CT, and prospective ECG gating. Fractional flow reserve was determined in 86 territories subtended by vessels with ≥50% stenosis upon visual assessment. Fractional flow reserve ≤0.8 was considered to indicate significant ischaemia. Computed tomography myocardial perfusion imaging correctly identified 31/41 (76%) ischaemic territories and 38/45 (84%) non-ischaemic territories. Per-vessel territory sensitivity, specificity, positive, and negative predictive values of CTP were 76, 84, 82, and 79%, respectively. The combination of a ≥50% stenosis on CTA and perfusion defect on CTP was 98% specific for ischaemia, while the presence of <50% stenosis on CTA and normal perfusion on CTP was 100% specific for exclusion of ischaemia. Mean radiation for CTP and combined CT was 5.3 and 11.3 mSv, respectively., Conclusion: Computed tomography myocardial perfusion imaging is moderately accurate in identifying perfusion defects associated with ischaemia as assessed by FFR in patients considered for revascularization. In territories, where CTA and CTP are concordant, CTA/CTP is highly accurate in the detection and exclusion of ischaemia. This is achievable with acceptable radiation exposure using 320-detector row CT and prospective ECG gating.
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- 2012
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29. Normal perfusion of the left ventricular myocardium using 320 MDCT.
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Crossett MP, Schneider-Kolsky M, and Troupis J
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- Adult, Coronary Angiography, Female, Hemodynamics, Humans, Male, Middle Aged, Predictive Value of Tests, Reference Values, Retrospective Studies, Victoria, Coronary Circulation, Heart Ventricles diagnostic imaging, Myocardial Perfusion Imaging methods, Tomography, X-Ray Computed
- Abstract
Background: CT myocardial perfusion imaging is an emerging CT application using density measurements of contrast-enhanced left ventricular (LV) myocardium., Objective: Using a 320-MDCT we have consistently observed lower Hounsfield unit (HU) values in the lateral LV myocardium, potentially mimicking perfusion defects. This study aimed to evaluate contrast-enhancement patterns of the LV myocardium in normal studies., Methods: Twenty-one clinical cases with normal coronary MDCT-based angiography findings, as determined by 2 qualified readers, were selected for retrospective evaluation. Using 8 identically sized and positioned ROIs, the HU measurements were recorded from short axis axial reconstructions through the LV myocardium in middle, apical, and basal locations. Scans were acquired on a 320-slice MDCT unit., Results: The middle short axis location demonstrated HU densities of 79.4 (range 42.3-162.7) in the lateral myocardial wall (regions 2, 3, and 4) compared with 103.9 (range 11.4-159.6) in the inferior, septal, and anterior walls (regions 1, 5, 6, 7, and 8; P < 0.001). HU densities for the basal slice were 82.3 (range 51.5-168.4) in the lateral wall compared with 94.9 (range 35.3-144) in the inferior, septal, and anterior walls (P < 0.001). In the apical location, HU densities were 79.9 (range 42.3-139.3) in the lateral wall compared with 100.9 (range 69.0-170.5) in the inferior, septal, and anterior walls (P < 0.001)., Conclusion: Normal LV myocardial enhancement using a 320-slice MDCT demonstrates significantly lower densities in the lateral wall when compared with the anterior, septal, and inferior walls in patients with normal coronary vascular anatomy. Assessment of CT myocardial perfusion studies should therefore be undertaken with caution, to prevent misrepresenting these lower-density values in the LV lateral wall., (Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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30. Prevalence and location of acetabular sublabral sulci at hip arthroscopy with retrospective MRI review.
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Saddik D, Troupis J, Tirman P, O'Donnell J, and Howells R
- Subjects
- Acetabulum injuries, Adolescent, Adult, Aged, Cartilage, Articular pathology, Contrast Media, Female, Gadolinium DTPA, Hip Joint pathology, Humans, Male, Middle Aged, Acetabulum pathology, Arthroscopy, Magnetic Resonance Imaging
- Abstract
Objective: The objective of this prospective study was to determine the prevalence and location of acetabular sublabral sulci diagnosed as variants at hip arthroscopy and to provide a retrospective MRI review., Subjects and Methods: Two experienced hip arthroscopists noted the prevalence and location of acetabular labral sulci in 121 patients. The study population consisted of 57 males and 64 females with an average age of 43 years (range, 16-70 years). Of the 121 hip arthroscopies that showed sulci (22% of patients), correlation with the relevant MR studies (n = 27) was performed. Two radiologists who were aware of the arthroscopic findings reviewed the MR studies retrospectively, and agreement on imaging appearances was reached by consensus., Results: Arthroscopy revealed 30 sulci (25%) in 27 of the 121 patients. In those who had a single sulcus (25 patients), 11 (44%) were located anterosuperiorly, 12 (48%) posteroinferiorly, one (4%) anteroinferiorly, and one (4%) posterosuperiorly. The other two patients had more than one sulcus: one patient had one posterosuperior sulcus and one posteroinferior sulcus; and the other patient had one anterosuperior sulcus, one anteroinferior sulcus, and one posteroinferior sulcus. In total, of the 121 patients, the number and position of the sulci were 12 anterosuperior (10%), 14 posteroinferior (12%), two anteroinferior (2%), and two posterosuperior (2%). Of the 27 MR examinations, 24 were unenhanced and three studies were performed after intraarticular injection of gadolinium. In these 27 patients, a total of 30 sulci were detected at arthroscopy. On retrospective MR review of both the conventional and gadolinium-enhanced studies, nine (75%) of the 12 anterosuperior sulci could be visualized. Ten (71%) of the 14 posteroinferior sulci were also identified. Neither of the two anteroinferior sulci could be seen. Both of the posterosuperior sulci were evident. Of the conventional MR studies, of a potential of 27, 18 (70%) were identified on conventional imaging., Conclusion: Sulci of the hip exist (22% of patients) and can be found at all anatomic positions (i.e., anterosuperior, anteroinferior, posterosuperior, and posteroinferior) of the hip. These sulci can be visualized on MRI with an accuracy of 70% using a nongadolinium technique.
- Published
- 2006
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31. Medical care. Antitrust laws emerging exemption.
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Troupis JR
- Subjects
- Economic Competition legislation & jurisprudence, Guidelines as Topic, Health Maintenance Organizations economics, Health Maintenance Organizations legislation & jurisprudence, Institutional Practice legislation & jurisprudence, Practice Management, Medical legislation & jurisprudence, Rate Setting and Review, United States, Antitrust Laws, Health Care Sector legislation & jurisprudence
- Published
- 1997
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