Zhang, Fa-Lei, Yang, Hui-Xiang, Wu, Xing, Li, Jia-Yi, Wang, Shi-Qin, He, Juan, Li, Zheng-Hui, Feng, Tao, and Liu, Ji-Kai
Two undescribed triterpenes, tricholimbrins A and B, three undescribed steroids, tricholimbrins C‒E, one undescribed 4-chromanone derivative, along with 27 known compounds were isolated from fruiting bodies of the mushroom Tricholoma imbricatum. Tricholimbrins A and B are two polycyclic triterpenoids with a carbon degradation, while tricholimbrin C is a ring-rearranged steroid containing an aromatic moiety that might be derived from an ergosterol. Isocyathisterol, 3 β ,15 α -dihydroxyl-(22 E ,24 R)-ergosta-5,8(14),22-trien-7-one, demethylincisterol A 3 , and volemolide showed cytotoxicities to six human cancer cell lines. 3 β -Hydroxyl-(22 E ,24 R)-ergosta-5,8,22-trien-7,15-dione and 3 β -hydroxyl-(22 E ,24 R)-ergosta-5,8,22-trien-7-one showed preferable cytotoxicities against HL-60 while chaxine C and volemolide showed preferable cytotoxicities against A-549, with IC 50 values less than 10 μ M. Triterpenoids and ergosterols from fruiting bodies of Tricholoma imbricatum. Image 1 • A total of 33 compounds have been obtained from mushroom Tricholoma imbricatum. • Compounds 1–3 are rare natural triterpenoids or ergosterol derivatives. • Many compounds possess certain cytotoxicities to human cancer cell lines. [ABSTRACT FROM AUTHOR] more...