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To explore the diverse profiles of adverse reactions caused by oxaliplatin between colon and rectal cancer, we investigated the toxicity of oxaliplatin in patients with colon and rectal cancer. From January 2017 to December 2021, 200 cases of sporadic CRC patients with adverse reactions after oxaliplatin were collected from Harbin Medical University Cancer Hospital, Harbin, China. All patients received a chemotherapy regimen containing oxaliplatin (100 colon cancer and 100 rectal cancer). We reviewed the adverse reactions induced by oxaliplatin in patients with colon and rectal cancer. We found there was no significant difference in gastrointestinal toxicity, hematotoxicity, neurotoxicity, hepatotoxicity, respiratory toxicity, and cardiotoxicity caused by oxaliplatin between patients with colon cancer and patients with rectal cancer, but patients with rectal cancer were more prone to allergic reactions than patients with colon cancer after oxaliplatin. In addition, we found neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) were higher in patients with colon cancer than in patients with rectal cancer. This may reflect differences in immune status and inflammatory responses between colon cancer and rectal cancer, which might be the reason for more allergic reactions caused by oxaliplatin in colon cancer patients compared to rectal cancer patients. Except for a higher incidence of allergic reactions in patients with rectal cancer, no significant difference in the incidence of adverse drug reactions associated with oxaliplatin was noted between patients with colon cancer and rectal cancer. Our results suggested more attention should be paid to the allergic reaction caused by oxaliplatin in patients with colon cancer. [ABSTRACT FROM AUTHOR]

Porous tantalum (Ta) implants have important clinical application prospects due to their appropriate elastic modulus, and their excellent bone growth and bone conduction ability. However, porous Ta microstructure designs generally mimic titanium (Ti) implants commonly used in the clinic, and there is a lack of research on the influence of the microstructure on the mechanical properties and penetration characteristics, which will greatly affect bone integration performance. This study explored the effects of different microstructure parameters, including the fillet radius of the middle plane and top planes, on the mechanics and permeability properties of porous Ta diamond cells through simulation, and put forward an optimization design with a 0.5 mm midplane fillet radius and 0.3 mm top-plane fillet radius in order to significantly decrease the stress concentration effect and improve permeability. On this basis, the porous Ta structures were prepared by Laser Powder Bed Fusion (LPBF) technology and evaluated before and after microstructural optimization. The elastic modulus and the yield strength were increased by 2.31% and 10.39%, respectively. At the same time, the permeability of the optimized structure was also increased by 8.25%. The optimized microstructure design of porous Ta has important medical application value. [ABSTRACT FROM AUTHOR]

In the context of “the world is undergoing great development, transformations, and adjustments,” the new trends in the world economy deserve more attention. This article gives a brief review of changes in international trade growth, current account balances, international investment flow, effective interest rates, and relative growth rates of both developed and developing economies. It argues that the slowdown in external demands will continue for a long time, that countries may attach more importance to external markets and competition will intensify. In the course of economic globalization, China needs to focus on developing its domestic markets, devote itself to creating favorable social and economic institutional conditions to increase efficiency and constantly progress in endogenetic technology, and explore an upgraded system for international multilateral trade and investment

To improve the performance of porous tantalum (Ta) manufactured by laser powder bed fusion (L-PBF) and meet its application requirements in medicine, the authors of this paper studied the influence of L-PBF process parameters on the strut surface morphology and mechanical performance. It was found that the powder layer thickness had a significant influence on the microstructure and mechanical properties based on statistical analysis. We proposed optimal process parameters of laser power of 150 W, scanning speed of 270 mm/s, thickness of 0.05 mm, and scanning spacing of 0.07 mm. After parameter optimization, we successfully obtained Ta samples with an elastic modulus of 1.352 ± 0.007 GPa and yield strength of 53.217 ± 0.114 MPa. The results show that the elastic modulus and yield strength of porous Ta samples with a porosity of 80% under the optimal process parameters are significantly superior to previous studies. The porous Ta scaffolds with higher mechanical properties fabricated with the optimized process parameters of L-PBF have significant value for applications in medicine. [ABSTRACT FROM AUTHOR]

Numerical simulation is an effective approach to analyze the selective laser melting (SLM) process and reduce the production development cost. Based on the finite difference method (FDM), the nonuniform grid algorithm (NUGA) is developed to simulate the thermal behavior in SLM process concerning the variable thermophysical parameters of materials with different status. The NUGA can effectively improve computing efficiency, and the calculation speed using NUGA is 6 – 10 times than that without using NUGA. Different heat transfer strategies are used on each side of the two critical scanning speeds, 68.95 mm/s and 6895 mm/s, respectively, and the results of temperature calculations are highly consistent. The correctness of the heat transfer strategy under different speeds is analyzed using the NUGA. The effects of processing parameters (laser power, scanning speed and building height) on the shape and volume of the molten pool are investigated. As the scanning speed ranged from 100 mm/s to 500 mm/s, the width and depth of the molten pool decrease, while the length increases. As the laser power ranged from 100 W to 500 W, the length, width and depth of molten pool all increase. The length of the molten pool increases 11.68% from 264.94 μ m of layer 1 to 295.88 μ m of layer 5. The molten pool volume decreases, then increases and decreases finally from the start to the end of single molten path. The molten pool volume increases with increasing laser power and building height, while decreases with increasing scanning speed in general. The NUGA is an effective method for temperature simulation of large-size parts, which expands the application range of temperature simulation in SLM process. [ABSTRACT FROM AUTHOR]

According to the characteristics of resources and environment in Mudanjiang City, four factors, i.e. and resources, water resources, environment and hazard are selected as evaluation indexes to establish a three-level evaluation index system of resources and environment carrying capacity in Mudanjiang City. In virtue of GIS spatial analysis technology, the carrying capacity of resources and environment in Mudanjiang City was evaluated through integrated evaluation of agricultural and urban function direction on the basis of the single evaluation of each factor. The results show that the areas with higher agricultural production carrying capacity are mainly distributed in Ning'an City and Dongning city, accounting for 48.87% of the total area, and the areas with higher urban construction carrying capacity are mainly distributed in the north of Ning'an City, the south of Hailin City and the urban area, accounting for 44.99%, 68.34% of the current cultivated and has higher agricultural production carrying capacity and 79.73% of the construction and has higher urban construction carrying capacity. The evaluation results are in line with the reality of Mudanjiang City, and can provide reference for resource development and utilization, ecological environment protection and land space planning of Mudanjiang City. [ABSTRACT FROM AUTHOR]

A nitrogen‐doped MnO nanoparticles/ porous carbon nanosheets (N−MnO/PCS) composite was synthesized by the room‐temperature redox reaction between KMnO4 and PCS followed by a facile carbothermal reduction, and a subsequent coating process of urea onto MnO/PCS and heat treatment. N−MnO nanoparticles with a grain size of about 30 nm are homogenously embedded on the surface of the N−PCS, corresponding to a high loading of 50.09 wt.% in the resulting composite. Benefiting from the enhanced reaction kinetics as well as electrical conductivity and continuous transport pathways of Li+/electron resulting from the N‐doping and hybridization of the cross‐linked porous carbon substrate, the as‐synthesized N−MnO/PCS‐1 electrode delivers a large reversible specific capacity (1497.2 mA h g−1 at 100 mA g−1 after 160 cycles), outstanding rate capacities (710.6 mA h g−1 at 1 A g−1 and 640.1 mA h g−1 at 2 A g−1) and long‐term cycling stability with specific capacity (976 mA h g−1 at 0.5 A g−1 after cycling 300 cycles). The simple and green synthesis and electronic properties of this composite mean that it has great potential as a high‐capacity anode material for practical application in large‐scale energy storage devices. [ABSTRACT FROM AUTHOR]

Highlights • Hybrid pooling is proposed for improving the generalization ability of convolutional neural networks. • The performance of the hybrid pooling is presented in image classification tasks. • The hybrid pooling combined with the dropout technique is competitive to other methods. • Layer-wise control of feature extraction can be realized by the hybrid pooling. Abstract Convolutional neural networks (CNNs) have attracted considerable attention in many application fields for their great ability to deal with image recognition and object detection tasks. A pooling process is an important process in CNNs, which serves to decrease the dimensionality of processed data for reducing computational cost as well as for enhancing tolerance to translation and noise. Although standard pooling methods, such as the max pooling and the average pooling, are typically adopted in many studies, a newly devised pooling method could improve the generalization ability of CNNs. In this study, we propose a hybrid pooling method which stochastically chooses the max pooling or the average pooling in each pooling layer. A characteristic of the hybrid pooling is that the probability for choosing one of the two pooling methods can be controlled for each convolutional layer. In image classification tasks with benchmark datasets, we show that the hybrid pooling is effective for increasing the generalization ability of CNNs. Moreover, we demonstrate that the hybrid pooling combined with the dropout is competitive with other existing methods in classification performance. [ABSTRACT FROM AUTHOR]

As the cathode ternary activated materials with high content of nickel have been widely used in lithium-ion batteries, the recycling of the spent cathode materials has been paid worthy attention. In this work, the sulfate solution with Li, Ni, Co and Mn elements was formed by dissolving the spent LiNi 0.5 Co 0.2 Mn 0.3 O 2 cathode materials in 20% sulfuric acid and 30% H 2 O 2 , assisted with reflux at 90 °C for 1 h. Based on the above solution, the precursor (Ni 0.5 Co 0.2 Mn 0.3 (OH) 2), along with the lithium and sodium sulfates mixture solutions were prepared by co-precipitation at 55 °C. Then Li 2 CO 3 powders and sodium sulfate solution were obtained through evaporating filtered solution separated from the preparation of the precursor and added an amount of Na 2 CO 3 , with the removal of 30% water and separation at about 70 °C. The purity of recovered Li 2 CO 3 is about 99.5%. The residual concentrations of Ni, Co and Mn in the filtered solution separated from the preparation of precursor are only 0.041, 0.025, 0.038 ppm left, respectively. The prepared cathode material LiNi 0.5 Co 0.2 Mn 0.3 O 2 from the precursor exhibits good cycle performance and shows a stable discharge capacity of 140 mAh g−1 at a current rate of 100 mA g−1 between 2.8 and 4.2 V. Image 1 • The facile strategy of entire recovery is proposed from spent LiNi 0.5 Co 0.2 Mn 0.3 O 2 cathode material. • The products of new LiNi 0.5 Co 0.2 Mn 0.3 O 2 , Li 2 CO 3 and Na 2 SO 4 were obtained. • No ammonia is introduced throughout the recovery process. • The filtered solution contains ultra-trace residual concentration of Ni, Co and Mn elements. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficacy of combining polyene phosphatidylcholine (PPC) with liraglutide in the treatment of nonalcoholic fatty liver disease (NAFLD) and investigate its impact on adipokine expression, specifically omentin-1 and vaspin., Methods: One hundred twenty NAFLD patients were randomly assigned to either the observation group (n = 60) or the control group (n = 60). The control group received single-dose PPC treatment, while the observation group received a combination of PPC and liraglutide for 12 weeks. Clinical efficacy, adipose-related factors (omentin-1, vaspin, serum fibroblast growth factor 21 (FGF21)), liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamyl transpeptidase (GGT)), and adverse reaction rates were compared between the two groups before and after treatment., Results: In the observation group, the clinical effectiveness rate (95.00%) was significantly higher than that in the control group (83.33%) (P < .05). Before treatment, there were no significant differences in omentin-1, vaspin, FGF21, ALT, AST, and GGT between the two groups (P > .05). After treatment, both groups showed decreased levels of vaspin, FGF21, ALT, AST, and GGT, along with increased omentin-1 levels. However, levels of vaspin, FGF21, ALT, AST, and GGT were lower in the observation group compared to the control group, while omentin-1 levels were higher (P < .05). Adverse reaction rates did not significantly differ between the two groups (10.00% vs. 6.67%) (P > .05)., Conclusions: The combination therapy of PPC and liraglutide demonstrates efficacy in treating NAFLD, improving adipose-related factors, and reducing liver enzyme activity with high safety. This approach warrants broader clinical implementation.