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522 results on '"Tomiyama, Hirofumi"'

2. Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author

Bruin, Willem B, Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L, Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C, Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan AJP, Echevarria, Marco AN, Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D, Grazioplene, Rachael G, Gruner, Patricia, Guo, Joyce Y, Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M, Moreira, Pedro S, Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, Zorrilla, Jose C Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan YC, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R, Evelyn Stewart, S, Szeszko, Philip R, Tang, Jinsong, Thomopoulos, Sophia I, Thorsen, Anders L, Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M, Venkatasubramanian, Ganesan, Vetter, Nora C, Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A, van Marle, Hein JF, van de Mortel, Laurens A, van der Straten, Anouk, van der Werf, Ysbrand D, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and van Wingen, Guido A

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical and Health Psychology, Clinical Sciences, Psychology, Machine Learning and Artificial Intelligence, Mental Illness, Serious Mental Illness, Brain Disorders, Anxiety Disorders, Mental Health, Good Health and Well Being, ENIGMA-OCD Working Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Correction to: Molecular Psychiatry, published online 2 May 2023 In this article Honami Arai, Irene Bollettini, Rosa Calvo Escalona, Ana Coelho, Federica Colombo, Leila Darwich, Martine Fontaine, Toshikazu Ikuta, Jonathan C. Ipser, Asier Juaneda-Seguí, Hitomi Kitagawa, Gerd Kvale, Mafalda Machado-Sousa, Astrid Morer, Takashi Nakamae, Jin Narumoto, Joseph O’Neill, Sho Okawa, Eva Real, Veit Roessner, Joao R. Sato, Cinto Segalàs, Roseli G. Shavitt, Dick J. Veltman, Kei Yamada were missing from the author list indexed under the ENIGMA-OCD Working Group. Additionally, there was an error regarding Tokiko Yoshida’s name, where the first name and last name were written in the wrong order. The original article has been corrected.

Published
2023

3. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.

Author

Bruin, Willem, Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea, Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo, Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan, Echevarria, Marco, Eng, Goi, Ferreira, Sónia, Feusner, Jamie, Grazioplene, Rachael, Gruner, Patricia, Guo, Joyce, Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo, Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun, Lazaro, Luisa, Li, Chiang-Shan, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose, Moreira, Pedro, Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan, Nurmi, Erika, Zorrilla, Jose, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily, Evelyn Stewart, S, Szeszko, Philip, Tang, Jinsong, Thomopoulos, Sophia, Thorsen, Anders, Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya, Venkatasubramanian, Ganesan, Vetter, Nora, Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke, van Marle, Hein, van de Mortel, Laurens, van der Straten, Anouk, van der Werf, Ysbrand, Thompson, Paul, Stein, Dan, van den Heuvel, Odile, van Wingen, Guido, and Piacentini, John

Subjects
Humans, Connectome, Brain Mapping, Magnetic Resonance Imaging, Brain, Obsessive-Compulsive Disorder, Biomarkers, Neural Pathways
Abstract

Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohens d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohens d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.

Published
2023

4. An evidence review project for food with function claims ~Challenges of the Japan society for vascular failure for the promotion of adequate evidences for food with function claims

Author

Matsumoto, Chisa, Tomiyama, Hirofumi, Takahashi, Osamu, Maruhashi, Tatsuya, Matsuzawa, Yasushi, Masaki, Nobuyuki, Muraki, Isao, Yano, Yuichiro, Sugimoto, Tadafumi, Kabutoya, Tomoyuki, Sawami, Kosuke, Tanaka, Atsushi, Arima, Hisatomi, Sata, Masataka, and Node, Koichi

Published
2024
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6. Intermittent hypoxia by obstructive sleep apnea is significantly associated with electro-anatomical remodeling of the left atrium preceding structural remodeling in patients with atrial fibrillation

Author

Takada, Yasuyuki, Shiina, Kazuki, Orihara, Shunichiro, Takata, Yoshifumi, Takahashi, Takamichi, Kani, Junya, Kusume, Takahiro, Terasawa, Muryo, Nakano, Hiroki, Saitoh, Yukio, Yazaki, Yoshinao, Tomiyama, Hirofumi, Chikamori, Taishiro, and Satomi, Kazuhiro

Published
2024
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9. Expert Consensus on the Clinical Use of Pulse Wave Velocity in Asia

Author

Park, Jeong Bae, Sharman, James E, Li, Yan, Munakata, Masanori, Shirai, Kohji, Chen, Chen-Huan, Jae, Sae Young, Tomiyama, Hirofumi, Kosuge, Hisanori, Bruno, Rosa Maria, Spronck, Bart, Kario, Kazuomi, Lee, Hae Young, Cheng, Hao-Min, Wang, Jiguang, Budoff, Matthew, Townsend, Raymond, and Avolio, Alberto P

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Aging, Bioengineering, Heart Disease, Prevention, Cardiovascular, Clinical Research, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Arterial stiffness, Pulse wave velocity, Cardiovascular disease, Asia, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Arterial stiffness is a progressive aging process that predicts cardiovascular disease. Pulse wave velocity (PWV) has emerged as a noninvasive, valid, and reliable measure of arterial stiffness and an independent risk predictor for adverse outcomes. However, up to now, PWV measurement has mostly been used as a tool for risk prediction and has not been widely used in clinical practice. This consensus paper aims to discuss multiple PWV measurements currently available in Asia and to provide evidence-based assessment together with recommendations on the clinical use of PWV. For the methodology, PWV measurement including the central elastic artery is essential and measurements including both the central elastic and peripheral muscular arteries, such as brachial-ankle PWV and cardio-ankle vascular index, can be a good alternative. As Asian populations are rapidly aging, timely detection and intervention of "early vascular aging" in terms of abnormally high PWV values are recommended. More evidence is needed to determine if a PWV-guided therapeutic approach will be beneficial to the prevention of cardiovascular diseases beyond current strategies. Large-scale randomized controlled intervention studies are needed to guide clinicians.

Published
2022

12. Association of arterial stiffness with kidney function among adults without chronic kidney disease

Author

Itano, Seiji, Yano, Yuichiro, Nagasu, Hajime, Tomiyama, Hirofumi, Kanegae, Hiroshi, Makino, Hirofumi, Higashi, Yukihito, Kobayashi, Yusuke, Sogawa, Yuji, Satoh, Minoru, Suzuki, Kenji, Townsend, Raymond R, Budoff, Matthew, Bakris, George, and Kashihara, Naoki

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Kidney Disease, Clinical Research, Renal and urogenital, Ankle Brachial Index, Disease Progression, Female, Glomerular Filtration Rate, Humans, Hypertension, Japan, Kidney, Kidney Function Tests, Male, Medical Records, Problem-Oriented, Middle Aged, Prognosis, Renal Insufficiency, Chronic, Retrospective Studies, Risk Assessment, Vascular Stiffness, arterial stiffness, blood pressure, cardio-ankle vascular index, chronic kidney disease, hypertension, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundOur aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD).MethodsWe analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR)

Published
2020

22. Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension

Author

Tomiyama, Hirofumi, Vlachopoulos, Charalambos, Xaplanteris, Panagiotis, Nakano, Hiroki, Shiina, Kazuki, Ishizu, Tomoko, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Tanaka, Atsushi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ohkuma, Toshiaki, Ninomiya, Toshiharu, Chikamori, Taishiro, Yamashina, Akira, and Ueda, Shin-ichiro

Published
2020
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25. Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension

Author

Tanaka, Atsushi, Kawaguchi, Atsushi, Tomiyama, Hirofumi, Ishizu, Tomoko, Matsumoto, Chisa, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Yamashina, Akira, and Node, Koichi

Published
2018
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27. Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis

Author

Ohkuma, Toshiaki, Ninomiya, Toshiharu, Tomiyama, Hirofumi, Kario, Kazuomi, Hoshide, Satoshi, Kita, Yoshikuni, Inoguchi, Toyoshi, Maeda, Yasutaka, Kohara, Katsuhiko, Tabara, Yasuharu, Nakamura, Motoyuki, Ohkubo, Takayoshi, Watada, Hirotaka, Munakata, Masanori, Ohishi, Mitsuru, Ito, Norihisa, Nakamura, Michinari, Shoji, Tetsuo, Vlachopoulos, Charalambos, Aboyans, Victor, and Yamashina, Akira

Published
2018
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28. Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension

Author

Tomiyama, Hirofumi, Ishizu, Tomoko, Kohro, Takahide, Matsumoto, Chisa, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, and Yamashina, Akira

Published
2018
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29. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Author

Maruhashi, Tatsuya, Soga, Junko, Fujimura, Noritaka, Idei, Naomi, Mikami, Shinsuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Kajikawa, Masato, Matsumoto, Takeshi, Oda, Nozomu, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Aibara, Yoshiki, Yusoff, Farina Mohamad, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Noma, Kensuke, Nakashima, Ayumu, Goto, Chikara, Tomiyama, Hirofumi, Takase, Bonpei, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, Yamashina, Akira, and Higashi, Yukihito

Published
2018
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31. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Author

Umemura, Satoshi, Arima, Hisatomi, Arima, Shuji, Asayama, Kei, Dohi, Yasuaki, Hirooka, Yoshitaka, Horio, Takeshi, Hoshide, Satoshi, Ikeda, Shunya, Ishimitsu, Toshihiko, Ito, Masaaki, Ito, Sadayoshi, Iwashima, Yoshio, Kai, Hisashi, Kamide, Kei, Kanno, Yoshihiko, Kashihara, Naoki, Kawano, Yuhei, Kikuchi, Toru, Kitamura, Kazuo, Kitazono, Takanari, Kohara, Katsuhiko, Kudo, Masataka, Kumagai, Hiroo, Matsumura, Kiyoshi, Matsuura, Hideo, Miura, Katsuyuki, Mukoyama, Masashi, Nakamura, Satoko, Ohkubo, Takayoshi, Ohya, Yusuke, Okura, Takafumi, Rakugi, Hiromi, Saitoh, Shigeyuki, Shibata, Hirotaka, Shimosawa, Tatsuo, Suzuki, Hiromichi, Takahashi, Shori, Tamura, Kouichi, Tomiyama, Hirofumi, Tsuchihashi, Takuya, Ueda, Shinichiro, Uehara, Yoshinari, Urata, Hidenori, and Hirawa, Nobuhito

Published
2019
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32. Validation of non-invasive central blood pressure devices: Artery society task force (abridged) consensus statement on protocol standardization

Author

Sharman, James E., Avolio, Alberto P., Baulmann, Johannes, Benetos, Athanase, Blacher, Jacques, Blizzard, C. Leigh, Boutouyrie, Pierre, Chen, Chen-Huan, Chowienczyk, Phil, Cockcroft, John R., Cruickshank, J. Kennedy, Ferreira, Isabel, Ghiadoni, Lorenzo, Hughes, Alun, Jankowski, Piotr, Laurent, Stephane, McDonnell, Barry J., McEniery, Carmel, Millasseau, Sandrine C., Papaioannou, Theodoros G., Parati, Gianfranco, Park, Jeong Bae, Protogerou, Athanase D., Roman, Mary J., Schillaci, Giuseppe, Segers, Patrick, Stergiou, George S., Tomiyama, Hirofumi, Townsend, Raymond R., Van Bortel, Luc M., Wang, Jiguang, Wassertheurer, Siegfried, Weber, Thomas, Wilkinson, Ian B., and Vlachopoulos, Charalambos

Published
2017
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34. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study

Author

Oda, Nozomu, Kajikawa, Masato, Maruhashi, Tatsuya, Iwamoto, Yumiko, Kishimoto, Shinji, Matsui, Shogo, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Goto, Chikara, Aibara, Yoshiki, Nakashima, Ayumu, Noma, Kensuke, Tomiyama, Hirofumi, Takase, Bonpei, Yamashina, Akira, and Higashi, Yukihito

Published
2017
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36. Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention

Author

Tomiyama, Hirofumi, Ohkuma, Toshiaki, Ninomiya, Toshiharu, Mastumoto, Chisa, Kario, Kazuomi, Hoshide, Satoshi, Kita, Yoshikuni, Inoguchi, Toyoshi, Maeda, Yasutaka, Kohara, Katsuhiko, Tabara, Yasuharu, Nakamura, Motoyuki, Ohkubo, Takayoshi, Watada, Hirotaka, Munakata, Masanori, Ohishi, Mitsuru, Ito, Norihisa, Nakamura, Michinari, Shoji, Tetsuo, Vlachopoulos, Charalambos, Aboyans, Victor, and Yamashina, Akira

Published
2019
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38. High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study

Author

Eguchi, Kazuo, Miyashita, Hiroshi, Takenaka, Tsuneo, Tabara, Yasuharu, Tomiyama, Hirofumi, Dohi, Yasuaki, Hashimoto, Junichiro, Ohkubo, Takayoshi, Ohta, Yuko, Hirooka, Yoshitaka, Kohara, Katsuhiko, Ito, Sadayoshi, Kawano, Yuhei, Sunagawa, Kenji, Suzuki, Hiromichi, Imai, Yutaka, Kario, Kazuomi, Takazawa, Kenji, Yamashina, Akira, Shimada, Kazuyuki, and the ABC-J II Investigator Group

Published
2018
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41. Physiological Diagnostic Criteria for Vascular Failure

Author

Tanaka, Atsushi, Tomiyama, Hirofumi, Maruhashi, Tatsuya, Matsuzawa, Yasushi, Miyoshi, Toru, Kabutoya, Tomoyuki, Kario, Kazuomi, Sugiyama, Seigo, Munakata, Masanori, Ito, Hiroshi, Ueda, Shinichiro, Vlachopoulos, Charalambos, Higashi, Yukihito, Inoue, Teruo, and Node, Koichi

Published
2018
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43. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Author

Kajikawa, Masato, Maruhashi, Tatsuya, Hidaka, Takayuki, Matsui, Shogo, Hashimoto, Haruki, Takaeko, Yuji, Nakano, Yukiko, Kurisu, Satoshi, Kihara, Yasuki, Yusoff, Farina Mohamad, Kishimoto, Shinji, Chayama, Kazuaki, Goto, Chikara, Noma, Kensuke, Nakashima, Ayumu, Hiro, Takafumi, Hirayama, Atsushi, Shiina, Kazuki, Tomiyama, Hirofumi, Yagi, Shusuke, Amano, Rie, Yamada, Hirotsugu, Sata, Masataka, and Higashi, Yukihito

Published
2019
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44. Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness.

Author

Tomiyama, Hirofumi, Imai, Takumi, Shiina, Kazuki, Higashi, Yukihito, Nakano, Hiroki, Takahashi, Takamichi, Fujii, Masatsune, Matsumoto, Chisa, Yamashina, Akira, and Chikamori, Taishiro

Abstract

Background: Although some cardiovascular risk factors (CVRFs) are known to be associated with increased arterial stiffness, increased arterial stiffness does not mediate the cardiovascular risk associated with all CVRFs. Here, based on long-term repeated-measurement data, we examined the association of the lifelong status of each CVRF with the rate of progression of arterial stiffness. Methods: We utilized the data from annual health checkups with the brachial-ankle pulse wave velocity measurements over a 16-year period in middle-aged Japanese occupational cohort. Results: Totally, 29 090 brachial-ankle pulse wave velocity data were obtained during the follow-up of 3763 subjects ranging in age from around 30 to 70 years. Smoking, heavy alcohol intake, hypertension, diabetes, hypertriglyceridemia, and hyperuricemia were independently associated with the fast progression of arterial stiffness. Also, lower values in nondisease range in blood pressure, glycosylated hemoglobin A1c, triglyceride, and uric acid were independently associated with the slow progression of arterial stiffness. For body mass index and low-density lipoprotein cholesterol, no clear associations with the progression of arterial stiffness were observed. Conclusions: The present prospective study provided more robust epidemiological evidence for the heterogeneity of the significance of contribution of lifelong status of each CVRF to the slow and fast rate of progression of arterial stiffness. These findings suggest the important need to examine, in further studies, the effects of global early interventions to control the levels of the culprit CVRFs, even from middle age, not only to prevent a fast progression of the arterial stiffness but also to maintain a relatively slow progression of arterial stiffness. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Nutritional Status and Sleep Quality Are Associated with Atrial Fibrillation in Patients with Obstructive Sleep Apnea: Results from Tokyo Sleep Heart Study.

Author

Shiina, Kazuki, Takata, Yoshifumi, Takahashi, Takamichi, Kani, Junya, Nakano, Hiroki, Takada, Yasuyuki, Yazaki, Yoshinao, Satomi, Kazuhiro, and Tomiyama, Hirofumi

Abstract

The prevalence of obstructive sleep apnea (OSA) in patients with atrial fibrillation (AF) has been observed to be much higher than in control participants without AF. Limited data exist regarding the prevalence of AF in patients with OSA. The clinical characteristics, nutritional status, and sleep parameters associated with AF in patients with OSA remain unclear. In this study, we aimed to determine the prevalence and factors associated with AF in patients with OSA from a large Japanese sleep cohort (Tokyo Sleep Heart Study). This was a single-center explorative cross-sectional study. Between November 2004 and June 2018, we consecutively recruited 2569 patients with OSA who underwent an overnight full polysomnography at our hospital. They were assessed using a 12-lead ECG and echocardiography. The clinical characteristics, sleep parameters, and medical history were also determined. Of the OSA patients, 169 (6.6%) had AF. Compared with the non-AF patients, OSA patients with AF were older and male, and they had higher prevalence of a history of alcohol consumption, hypertension, chronic kidney disease, and undernutrition, as well as a reduced ejection fraction. With regard to the sleep study parameters, OSA patients with AF had reduced slow-wave sleep and sleep efficiency, as well as higher periodic limb movements. There were no significant differences in the apnea–hypopnea index or hypoxia index between the two groups. The logistic regression analysis demonstrated that age (OR = 4.020; 95% CI: 1.895–8.527; p < 0.001), a history of alcohol consumption (OR = 2.718; 95% CI: 1.461–5.057; p = 0.002), a high CONUT score (OR = 2.129; 95% CI: 1.077–4.209; p = 0.030), and reduced slow-wave sleep (OR = 5.361; 95% CI: 1.505–19.104; p = 0.010) were factors significantly related to AF. The prevalence of AF in patients with OSA was 6.6%. Age, a history of alcohol consumption, undernutrition, and reduced sleep quality were independent risk factors for the presence of AF in patients with OSA, regardless of the severity of OSA. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese

Author

Tomiyama, Hirofumi, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Watanabe, Kentaro, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Ikeda, Hisao, and Yamashina, Akira

Published
2015
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48. Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study.

Author

Masaki, Nobuyuki, Adachi, Takeshi, Tomiyama, Hirofumi, Kohro, Takahide, Suzuki, Toru, Ishizu, Tomoko, Ueda, Shinichiro, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, and Furukawa, Taiji

Subjects
BRACHIAL artery, TYPE 2 diabetes, PEOPLE with diabetes, HYPEREMIA, MICROCIRCULATION disorders
Abstract

Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non‐T2DM]; women, n = 107 [T2DM] and n = 313 [non‐T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5‐year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age‐adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia. [ABSTRACT FROM AUTHOR]

Published
2023
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