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1. Comparison of total body irradiation versus non-total body irradiation containing regimens for de novo acute myeloid leukemia in children

Author

Christopher E. Dandoy, Stella M. Davies, Kwang Woo Ahn, Yizeng He, Anders E. Kolb, John Levine, Stephanie Bo-Subait, Hisham Abdel-Azim, Neel Bhatt, Joseph Chewning, Shahinaz Gadalla, Nicholas Gloude, Robert Hayashi, Nahal R. Lalefar, Jason Law, Margaret MacMillan, Tracy O'Brien, Timothy Prestidge, Akshay Sharma, Peter Shaw, Lena Winestone, and Mary Eapen

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

With limited data comparing hematopoietic cell transplant outcomes between myeloablative total body irradiation (TBI) containing and non-TBI regimens in children with de novo acute myeloid leukemia, the aim of this study was to compare transplant-outcomes between these regimens. Cox regression models were used to compare transplant-outcomes after TBI and non-TBI regimens in 624 children transplanted between 2008 and 2016. Thirty two percent (n=199) received TBI regimens whereas 68% (n=425) received non-TBI regimens. Five-year non-relapse mortality was higher with TBI regimens (22% vs. 11%, p

Published
2020
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