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Your search keyword '"Thayer, Sarah P"' showing total 269 results
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269 results on '"Thayer, Sarah P"'

3. Early detection of sporadic pancreatic cancer: summative review.

Author

Chari, Suresh T, Kelly, Kimberly, Hollingsworth, Michael A, Thayer, Sarah P, Ahlquist, David A, Andersen, Dana K, Batra, Surinder K, Brentnall, Teresa A, Canto, Marcia, Cleeter, Deborah F, Firpo, Matthew A, Gambhir, Sanjiv Sam, Go, Vay Liang W, Hines, O Joe, Kenner, Barbara J, Klimstra, David S, Lerch, Markus M, Levy, Michael J, Maitra, Anirban, Mulvihill, Sean J, Petersen, Gloria M, Rhim, Andrew D, Simeone, Diane M, Srivastava, Sudhir, Tanaka, Masao, Vinik, Aaron I, and Wong, David

Subjects
Humans, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Diagnostic Imaging, Biopsy, Prognosis, Molecular Diagnostic Techniques, Survival Analysis, Predictive Value of Tests, Interdisciplinary Communication, Cooperative Behavior, Biomedical Research, International Cooperation, Diffusion of Innovation, Congresses as Topic, Early Detection of Cancer, Biomarkers, Tumor, biomarker, diabetes, screening, familial, imaging, pancreatic ductal adenocarcinoma, Rare Diseases, Pancreatic Cancer, Cancer, Prevention, Digestive Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Clinical Sciences, Gastroenterology & Hepatology
Abstract

Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field. An in-depth summary of current efforts in the field, analysis of gaps in specific areas of expertise, and challenges that exist in early detection is presented within distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. In addition, an overview of efforts in familial PC is presented in an addendum to this article. It is clear from the summit deliberations that only strategically designed collaboration among investigators, institutions, and funders will lead to significant progress in early detection of sporadic PC.

Published
2015

4. Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.

Author

Tempero, Margaret A, Arnoletti, J Pablo, Behrman, Stephen W, Ben-Josef, Edgar, Benson, Al B, Casper, Ephraim S, Cohen, Steven J, Czito, Brian, Ellenhorn, Joshua DI, Hawkins, William G, Herman, Joseph, Hoffman, John P, Ko, Andrew, Komanduri, Srinadh, Koong, Albert, Ma, Wen Wee, Malafa, Mokenge P, Merchant, Nipun B, Mulvihill, Sean J, Muscarella, Peter, Nakakura, Eric K, Obando, Jorge, Pitman, Martha B, Sasson, Aaron R, Tally, Anitra, Thayer, Sarah P, Whiting, Samuel, Wolff, Robert A, Wolpin, Brian M, Freedman-Cass, Deborah A, and Shead, Dorothy A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Pancreatic Cancer, Clinical Research, Rare Diseases, Digestive Diseases, Adenocarcinoma, Antineoplastic Combined Chemotherapy Protocols, Diagnostic Imaging, Humans, Neoplasm Staging, Pancreatic Neoplasms, National Comprehensive Cancer Networks, Oncology & Carcinogenesis, Oncology and carcinogenesis, Health services and systems
Abstract

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pancreatic Adenocarcinoma discuss the workup and management of tumors of the exocrine pancreas. These NCCN Guidelines Insights provide a summary and explanation of major changes to the 2012 NCCN Guidelines for Pancreatic Adenocarcinoma. The panel made 3 significant updates to the guidelines: 1) more detail was added regarding multiphase CT techniques for diagnosis and staging of pancreatic cancer, and pancreas protocol MRI was added as an emerging alternative to CT; 2) the use of a fluoropyrimidine plus oxaliplatin (e.g., 5-FU/leucovorin/oxaliplatin or capecitabine/oxaliplatin) was added as an acceptable chemotherapy combination for patients with advanced or metastatic disease and good performance status as a category 2B recommendation; and 3) the panel developed new recommendations concerning surgical technique and pathologic analysis and reporting.

Published
2012

5. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Author

Geller, Leore T., Barzily-Rokni, Michal, Danino, Tal, Jonas, Oliver H., Shental, Noam, Nejman, Deborah, Gavert, Nancy, Zwang, Yaara, Cooper, Zachary A., Shee, Kevin, Thaiss, Christoph A., Reuben, Alexandre, Livny, Jonathan, Avraham, Roi, Frederick, Dennie T., Ligorio, Matteo, Chatman, Kelly, Johnston, Stephen E., Mosher, Carrie M., Brandis, Alexander, Fuks, Garold, Gurbatri, Candice, Gopalakrishnan, Vancheswaran, Kim, Michael, Hurd, Mark W., Katz, Matthew, Fleming, Jason, Maitra, Anirban, Smith, David A., Skalak, Matt, Bu, Jeffrey, Michaud, Monia, Trauger, Sunia A., Barshack, Iris, Golan, Talia, Sandbank, Judith, Flaherty, Keith T., Mandinova, Anna, Garrett, Wendy S., Thayer, Sarah P., Ferrone, Cristina R., Huttenhower, Curtis, Bhatia, Sangeeta N., Gevers, Dirk, Wargo, Jennifer A., Golub, Todd R., and Straussman, Ravid

Published
2017

39. Isolation and characterization of centroacinar/ terminal ductal progenitor cells in adult mouse pancreas

Author

Rovira, Meritxell, Scott, Sherri-Gae, Liss, Andrew S., Jensen, Jan, Thayer, Sarah P., and Leach, Steven D.

Subjects
Homeostasis -- Research, Pancreas -- Physiological aspects, Pancreas -- Genetic aspects, Pancreas -- Research, Stem cells -- Physiological aspects, Stem cells -- Genetic aspects, Science and technology
Abstract

The question of whether dedicated progenitor cells exist in adult vertebrate pancreas remains controversial. Centroacinar cells and terminal duct (CA/TD) cells lie at the junction between peripheral acinar cells and the adjacent ductal epithelium, and are frequently included among cell types proposed as candidate pancreatic progenitors. However these cells have not previously been isolated in a manner that allows formal assessment of their progenitor capacities. We have found that a subset of adult CA/TD cells are characterized by high levels of ALDH1 enzymatic activity, related to high-level expression of both Aldh1a1 and Aldh1a7. This allows their isolation by FACS using a fluorogenic ALDH1 substrate. FACS-isolated CA/TD cells are relatively depleted of transcripts associated with differentiated pancreatic cell types. In contrast, they are markedly enriched for transcripts encoding Sca1, Sdf1, c-Met, Nestin, and Sox9, markers previously associated with progenitor populations in embryonic pancreas and other tissues. FACS-sorted CA/TD cells are uniquely able to form self-renewing 'pancreatospheres' in suspension culture, even when plated at clonal density. These spheres display a capacity for spontaneous endocrine and exocrine differentiation, as well as glucose-responsive insulin secretion. In addition, when injected into cultured embryonic dorsal pancreatic buds, these adult cells display a unique capacity to contribute to both the embryonic endocrine and exocrine lineages. Finally, these cells demonstrate dramatic expansion in the setting of chronic epithelial injury. These findings suggest that CA/TD cells are indeed capable of progenitor function and may contribute to the maintenance of tissue homeostasis in adult mouse pancreas. ALDH1 | CD133 | pancreatic | pancreatosphere | stem cell www.pnas.org/cgi/doi/10.1073/pnas.0912589107

Published
2010

42. [beta] cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo

Author

Strobel, Oliver, Dor, Yuval, Stirman, Amy, Trainor, Amanda, Fernandez-del Castillo, Carlos, Warshaw, Andrew L., and Thayer, Sarah P.

Subjects
Transdifferentiation -- Research, Pancreatitis -- Research, Pancreatic beta cells -- Structure, Pancreatic beta cells -- Research, Science and technology
Abstract

Inflammatory injury to the pancreas results in regeneration of normal tissue and formation of metaplastic lesions of a ductal phenotype. These metaplastic ductal lesions (MDL) are called tubular complexes (TC), mucinous metaplasia, or pancreatic intraepithelial neoplasia. Because they are regularly found in chronic pancreatitis and pancreatic cancer, their formation is thought to represent a step in inflammation-mediated carcinogenesis. Despite these lesions' ductal character, their origin is controversial. All known pancreatic cell lineages have been suggested as the origin. In vitro studies suggest that differentiated cells in the pancreas remain highly plastic and can transdifferentiate as a mechanism of regeneration and metaplasia. In vivo studies suggest that islets, specifically [beta] cells, may be the cell of origin. However, in vitro studies are subject to ductal cell contamination, and previous in vivo studies interpret static data rather than direct evidence. Using genetic lineage tracing in vivo, we investigate whether transdifferentiation of [beta] cells contributes to regeneration or metaplasia in pancreatitis. RIP-CreER;Z/AP mice were used to heritably tag [beta] cells in the adult pancreas. Injury by cerulein pancreatitis resulted in regeneration of normal tissue and metaplasia with formation of two distinct types of TC and mucinous lesions. Lineage tracing revealed that none of these MDL are of [beta] cell origin; nor do [beta] cells contribute to regeneration of normal acinar and ductal tissue, which indicates that the plasticity of differentiated pancreatic islet cells, suggested by earlier static and in vitro studies, plays no role in regeneration, metaplasia, and carcinogenesis in vivo. metaplasia | pancreatitis | pancreatic intraepithelial neoplasia

Published
2007

47. Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010

Author

Cai, Sophie, Hong, Theodore S., Goldberg, Saveli I., Fernandez-del Castillo, Carlos, Thayer, Sarah P., Ferrone, Cristina R., Ryan, David P., Blaszkowsky, Lawrence S., Kwak, Eunice L., Willett, Christopher G., Lillemoe, Keith D., Warshaw, Andrew L., and Wo, Jennifer Y.

Published
2013
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48. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Author

Thayer, Sarah P., di Magliano, Marina Pasca, Heiser, Patrick W., Nielsen, Corinne M., Roberts, Drucilla J., Lauwers, Gregory Y., Qi, Yan Ping, Gysin, Stephan, Castillo, Carlos Fernandez-del, Yajnik, Vijay, Antoniu, Bozena, McMahon, Martin, Warshaw, Andrew L., and Hebrok, Matthias

Abstract

Author(s): Sarah P. Thayer (corresponding author) [1, 6]; Marina Pasca di Magliano [4, 6]; Patrick W. Heiser [4]; Corinne M. Nielsen [1, 2]; Drucilla J. Roberts [2]; Gregory Y. Lauwers [...]

Published
2003
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49. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes

Author

Mino-Kenudson, Mari, Fernández-del Castillo, Carlos, Baba, Yoshifumi, Valsangkar, Nakul P, Liss, Andrew S, Hsu, Maylee, Correa-Gallego, Camilo, Ingkakul, Thun, Perez Johnston, Rocio, Turner, Brian G, Androutsopoulos, Vasiliki, Deshpande, Vikram, McGrath, Deborah, Sahani, Dushyant V, Brugge, William R, Ogino, Shuji, Pitman, Martha B, Warshaw, Andrew L, and Thayer, Sarah P

Published
2011
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