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The work-readiness of Project Management (PM) graduates has been highly discussed topic during the last decade. Employers consistently seek graduates capable of thriving in the ever-changing, intricate, and challenging project environment. Computer-based games offer the potential to replicate real-life project environment, allowing students to learn how to navigate the challenges posed by projects. PM higher education has started to utilise computer-based games in the curriculum to improve highly sought after technical and soft skills of students. While significant studies have been conducted on gamification within PM, the review of their contributions and key characteristics has been missing, hence, necessitating this study. This study explores the research trends and contributions of publications related to computer-based games in PM higher education. As a result, it provides valuable insights and recommendations for educators, game designers and researchers to effectively integrate computer-based games within PM higher education. The findings of this review hold value for educators aiming to use computer-based games as an integrated learning concept, game developers striving to create more effective games and researchers interested in indulging deeper into the realm of computer-based games for PM.

Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-specific gene expression in mammalian cells. Aberrations in this intricate landscape drive substantial changes in gene function, emerging as a linchpin in cancer etiology and progression. While cancer was conventionally perceived as solely a genetic disorder, its contemporary definition encompasses genetic alterations intertwined with disruptive epigenetic abnormalities. This review explores the profound impact of DNA methylation, histone modifications, and noncoding RNAs on fundamental cellular processes. When these pivotal epigenetic mechanisms undergo disruption, they intricately guide the acquisition of the 6 hallmark characteristics of cancer within seemingly normal cells. Leveraging the latest advancements in decoding these epigenetic intricacies holds immense promise, heralding a new era in developing targeted and more efficacious treatment modalities against cancers driven by aberrant epigenetic modifications.

Construction Engineering and Management (CEM) is a critically important discipline that provides a scientific and management-oriented perspective for building and construction projects. Owing to the contingent nature of this industry, CEM research is highly context-specific and is governed by socio-economic needs, environmental challenges, and industry-specific issues. Australia is home to several universities engaged in CEM-related research and training. In terms of the CEM research volume, Australia occupies fourth place, globally. Considering the importance of Australia-based CEM research, the aim of this study was to investigate how CEM research in Australia has developed temporally and across different institutions, how research collaborations in this area materialized, and which topics and research domains are typically being explored. Accordingly, this study conducted a systematic review of 4318 publications from 158 Australia-based CEM academics, primarily based in eight Australian universities. Based on Scientometric and critical review techniques, this study provides insights into research topics, research growth, publication volume, and collaboration in the CEM research discipline in Australia. Similar to global CEM research, Australia-based CEM research places a high emphasis on topics such as risk, sustainability, decision-making, cost, design, and BIM. However, unlike global research trends, Australia-based CEM research places a much higher emphasis on safety and stakeholder management. Australian institutions have high collaboration among themselves and with Chinese and Hong Kong-based institutions. Recommendations for research development in Australia are provided to facilitate a discussion on how Australian institutions can set the future agenda for CEM research.

Green building (GB) projects, although being developed and operated for more than two decades, may still be regarded as innovative. To address the socio-environmental challenges of the built environment, GBs need to continuously innovate. A comprehensive account of the innovation frontiers and factors affecting GB project innovation is missing in previous studies. In this study, for an in-depth understanding of what makes these projects innovative and how to create an enabling environment for their innovation, semi-structured interviews with 45 GB experts from six regions were conducted. Innovation in GBs was found to be a function of the GB idea, constituent building technologies, potential performance, and the project development process. Key frontiers where innovation in GB projects is needed include environmental performance, health and well-being, and the resolution of mutually contradicting project aspirations. The study also identified some factors contributing to innovation in GBs, which are primarily related to support from the government, client, and project team; availability of time and budget; scalability of innovative solutions; and nature of the construction industry. A nexus between green certifications, sustainability, and innovation is also explained. The awareness and understanding of industry experts regarding GB project innovation will add to the theory of GB projects and green innovation, and will help stakeholders to create a more enabling environment for innovation.

Building materials with a low environmental impact are critical to the sustainability of the built environment. The environmental impact of materials can be determined by a Life Cycle Impact Assessment (LCIA), which constitutes multiple parameters such as the water used in a material’s life cycle. To use the LCIA approach for building material selection, its parameters need to be assigned different weights, which is the primary objective of this study. Building Information Modelling (BIM) can play an influential role when using LCIA during the building design process. With this consideration, we study the attention given to environmental sustainability in buildings and the responsiveness of BIM in this case. A multi-regional survey of 120 experts from academia and industry was conducted. The results show the relative importance of LCIA parameters and the focus of the building sector on environmental sustainability. The current and the future responsiveness of BIM towards environmental sustainability is also indicated. To promote the integration of LCIA in building design and performance assessment, the future role of BIM applications is explored. The results will contribute to research and practice in the sustainable built environment by helping select environment-friendly building materials.

Background: To compare interlocking intramedullary nails vs minimally invasive percutaneous plate osteosynthesis with locking compression plates for the treatment of diaphyseal tibial fractures, in terms of good functional outcome with reference to wound infections as rate of complications. Methods: In this descriptive study, 140 patients with diaphyseal tibia fractures, were included. The patients included were adults with closed tibial shaft fractures which were less than 2 weeks old, located at 7 cm below the knee joint and 7 cm above the ankle joint. Fractures which were open and of pathological nature were not included in our study. Random allocation into two equal groups was done and 70 patients in group 1 were operated with interlocking nail and remaining 70 in group 2 were operated with Minimally Invasive Percutaneous Plate Osteosynthesis (MIPPO) with a locking compression plate. Follow up of all patients was done uptil 6 weeks. Results: Among all the patients included in the study right tibial fracture involvement was found in 57.9% and that of left side was found in 42.1%. Lesser complications in terms of implant irritation, pain and infection (superficial and deep) were seen in MIPPO group (4.3%) as compared to interlocking group (10%). Conclusion: Due to less infection, less irritability, early union of the fracture and decreased implant related problems, minimally invasive percutaneous plate osteosynthesis, with locking compression plate is preferable in the treatment of tibial shaft fractures over the closed intramedullary interlocking nailing technique.

Background: Psoriasis is a chronic inflammatory, immune mediated, provocative and challenging skin condition. It is a non-contagious but debilitating disease and a leading cause of socioeconomic burden on the health system. Objective: To evaluate the role of antioxidant levels, lipid peroxidation status and lipid profile in the etiology and degree of severity of psoriatic illness among psoriasis patients presenting in Dermatology department. Study Design: This study was carried out as a retrospective case control study. Place and duration of Study: It was carried out by the Department of Biochemistry, Basic Medical Sciences Institute (BMSI) in collaboration with Departmnt of Biochemistry, Khyber Medical College, Peshawar and Department of Skin and Venereal disease, Jinnah Post Graduate Medical Centre (JPMC) Karachi. Material and Methods: One hundred and twenty cases (n=130) of already diagnosed psoriasis patients were randommely and fifty healthy matched controls (n=50) of the same age and gender were included from the general population for comparison. Lipid profile including serum total cholesterol, TG, HDL-c and LDL-c levels were measured by enzyme colorimetric analysis on Micro Lab 300 (Merck & Germany). Antioxidant status SOD and lipid peroxidation status MDA were measured by ELISA technique. Statistical analysis was performed using SPSS software Version 16. In this analysis, a “p” value of less than 0.05 was considered to be significant. Results: The study showed significantly elevated levels of MDA, serum TG, total cholesterol and LDL-c levels in psoriatic patients in comparison with controls, whereas SOD levels and HDL-c levels were found to be significantly lower in psoriatic patients as compared to normal healthy matched controls. Conclusion: The findings of this study support the hypothesis that an imbalance in oxidant-antioxidant system may play a role in the etiology of psoriasis and the degree of severity of its presentation. The study also concluded that dyslipidemia was an observed risk factor for the development of cardiovascular diseases in psoriatic patients..

Primary adrenal lymphoma (PAL) often occurs bilaterally and is a rare malignancy of old age. Workup for primary adrenal insufficiency often unmasks this underlying grave pathology. In this article, we present a case of a 73-yearold patient who presented with features of primary adrenal insufficiency and renal colic. Diagnostic abdominal imaging revealed bilateral suprarenal masses as the cause of adrenal gland destruction and the patient's symptoms. FDG PET-CT scan and histopathology confirmed the diagnosis of mature bilateral B-cell primary adrenal lymphomas. Though the patient showed an excellent initial response to the first four chemotherapy cycles, a relapse resulted in metastatic disease. This article highlights the PAL's disease course, imaging features, and management dilemma due to Chemotherapy's side effects and a higher recurrence rate. Keywords: Primary adrenal lymphoma, Primary adrenal insufficiency, R-CHOP, Role of imaging.

Background Chorionic bump is a rare condition defined as a bulge or protrusion from the choriodecidual surface into the gestational sac. The limited literature on this infrequent entity suggests that the pregnancies with multiple chorionic bumps mostly result in fetal demise. Aims To review the available literature and the patients from our institute having sonographic findings of chorionic bump and making the sonographers and radiologists aware of this known cause of first-trimester pregnancy loss. Study design A retrospective review of the cases diagnosed at our institute during the last four years. Methods and materials Single-center institutional data for four years (January 2016-December 2019) was accessed using ICD codes. IRB approval was waived owing to the anonymized use of patient data. Results Six female patients diagnosed with chorionic bump were included, with a mean age of 29.83±12 years. The average gestational age at the time of diagnosis was 8.16±3 weeks. The most common sonographic findings were a protrusion from the chorionic wall into the gestational sac cavity, having a central hypoechoic region with peripheral hyperechoic rim (isoechoic to the chorion) and having no vascularity (n=5), and the less common finding was a hyperechoic protrusion with no vascularity (n=1). n=5 had a single lesion, and n=1 had two lesions. The average diameter of the lesion in the largest dimension was 18±11 mm. n=3 pregnancies resulted in a first-trimester miscarriage, and n=3 pregnancies delivered healthy babies at term.  Conclusions A chorionic bump significantly increases the risk of a first-trimester miscarriage., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Yousaf et al.)

A chemical investigation of the MeOH extract of a marine sponge Haliclona (Reniera) sp., collected off the coast of Ulleung Island, Korea, led to the isolation of thirteen new cerebrosides (1--3, 5--14), along with a known analogue (4). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy, MS spectrometry, and chemical method. The major new features of these glucocerebrosides are C15 and C19 acyl chains, long (C24-C28) acyl chains, or the S-configuration of the acyl chains. It is noteworthy that both R- and S-configurations of the acyl chains were observed in the same specimen.