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Your search keyword '"Tarko, Laura"' showing total 23 results
Start Over Author "Tarko, Laura" Publication Type Academic Journals
23 results on '"Tarko, Laura"'

19. Abstract 14867: Predictors of Statin Initiation for Primary Prevention of Cardiovascular Disease in Familial Hypercholesterolemia Phenotype: A Veterans Health Administration Study.

Author

Qazi, Saadia, Tarko, Laura M, Ho, Yuk-Lam, Orkaby, Ariela R, Sun, Yan V, Assimes, Themistocles L, Gagnon, David R, Cho, Kelly, Djousse, Luc, Gaziano, J. Michael, O'Donnell, Christopher J, and Wilson, Peter W

Subjects
*FAMILIAL hypercholesterolemia, *HEALTH services administration, *GENETIC disorders, *CARDIOVASCULAR diseases, *VETERANS' health, *PREVENTIVE medicine
Abstract

Introduction: Familial hypercholesterolemia (FH) phenotype is defined in part by LDL-Cholesterol (LDL-C) ≥190mg/dL, a strong risk factor for cardiovascular disease (CVD). The 2013 AHA/ACC guidelines recommend high intensity statins for primary prevention irrespective of global risk assessment. We sought to determine predictors of any statin initiation in patients with the FH phenotype within the Veteran's Health Administration (VHA). Methods: Inclusion criteria consisted of care at the VHA (2002-2014), age ≥21 years, absence of prevalent CVD, baseline LDL-C of ≥190 mg/dL, and no prior evidence of statin use. Baseline characteristics were ascertained from electronic health records for new cases of FH phenotype. We define baseline LDL-C quartiles as Q1=190-195, Q2=196-202, Q3=203-215, and Q4 >215 (mg/dL). We constructed multivariable logistic regression models to determine the odds of the initiation of any statin within 90 days of maximum LDL-C. Results: Over 12 years, we identified a cohort of 165,110 Veterans (age=53±12, men=91%; white race=74%). Statins were initiated in 88,878 (in 2002-2013=53%, in 2014=62%) of these patients. Comorbidities included smoking history (80%), hypertension (37%), diabetes (6%), chronic kidney disease (3%), and cancer (15%). In multivariable adjusted logistic regression models, significant predictors of statin initiation were older age, diabetes, hypertension, white race, smoking, baseline LDL-C quartile, and recent calendar year. Veterans with kidney disease, thyroid disease, cancer, and black race had lower odds of statin initiation (Table 1). Conclusions: A majority (62%) of the Veteran population with an LDL phenotype consistent with FH initiate statins, and they are more likely to be older, white, have a high baseline LDL-C, have hypertension and have diabetes. The odds of statin initiation have increased in recent years and this may reflect VHA changes in practice concordant with the ACC/AHA guidelines. [ABSTRACT FROM AUTHOR]

Published
2018

20. Abstract 14288: Effect of Pre-Stroke Body Mass Index on Post-Stroke Mortality in the United States Veteran Population.

Author

Costa, Lauren, Tarko, Laura, Ho, Yuk-Lam, Posner, Daniel, Demissie, Serkalem, Gagnon, David R, Cho, Kello, Djousse, Luc, Seshadri, Sudha, Wilson, Peter W, and Aparicio, Hugo J

Subjects
*BODY mass index, *OBESITY, *STROKE, *HEALTH services administration, *MORTALITY, *VETERANS' health
Abstract

Introduction: Previous studies relating weight to post-stroke mortality have shown conflicting results, with some showing lower risk of mortality among overweight or obese individuals. We studied the association between BMI and post-stroke mortality in the U. S. Veteran population. Methods: We used a nationwide sample of hospitalizations in the Veteran's Health Administration (VHA) system (2002-2009) with admission ICD-9 codes for ischemic stroke in patients without a history of stroke. BMI (kg/m2) was calculated as the average of all BMI measurements 1-18 months prior to stroke. All-cause mortality was obtained from the National Death Index (NDI). Hazard ratios (HR) of mortality for standard BMI categories were estimated from Cox models with high normal weight (BMI 22.5-25) as reference. Analyses were adjusted for age, sex, vascular risk factors, PAD, cancer, dementia, COPD, smoking, CKD, and heart disease. Sensitivity analyses were performed on a subgroup without conditions that might affect weight and survival including smoking, cancer, dementia, or heart disease. The effect of BMI as a continuous measure on all-cause mortality was analyzed using splines, with BMI=23 as the reference point. Results: Of 19,409 incident stroke cases, mean age was 68±12 years, 97% were male, and average BMI was 28.8±5.9. There were 1,321 patients included in sensitivity analyses (age 64±12 years, 96% male). In the overall sample, underweight (BMI <18.5) was associated with higher risk of mortality (HR 2.17, 95% CI 1.7-2.8, p<0.001). Obesity (30

Published
2018

22. PROGNOSTIC SIGNIFICANCE OF NEW-ONSET ATRIAL FIBRILLATION IN COVID-19.

Author

Ko, Darae, Treu, Timothy, Tarko, Laura, Ho, Yuk-Lam, Galloway, Ashley, Preis, Sarah, Trinquart, Ludovic, Gagnon, David, Monahan, Kevin M., Helm, Robert, Orkaby, Ariela R., Lubitz, Steven, Walkey, Allan, Cho, Kelly, Wilson, Peter W., and Benjamin, Emelia J.

Subjects
*ATRIAL fibrillation, *COVID-19, *ATRIAL flutter
Published
2022
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