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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.techfore.2008.07.001 Byline: Yuya Kajikawa, Junta Yoshikawa, Yoshiyuki Takeda, Katsumori Matsushima Author Affiliation: Institute of Engineering Innovation, School of Engineering, the University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-8656, Japan

Academic landscape of innovation research was analyzed by citation network analysis, which was divided into three main clusters; with "technological innovation" as the central core together with "innovation fundamentals" and "innovation management". Historically, research on innovation started from innovation management, such as innovational organization research, but research in the other two cluster areas is currently more active. With this background, we prepared a historical overview of national innovation system policy in Japan and the United States. Finally, we compared the trend of global innovation research with that of the national innovation systems in Japan and the United States. [ABSTRACT FROM AUTHOR]

We analyze a topological structure of networks formed according to the entries and trackbacks in the blogosphere, which is a collection of weblog articles. The analysis is performed based on community extraction, network visualization and keyword analysis. It is shown that the large-scale structure of the blogosphere has a globally sparse, but locally dense structure. The entries in a community yield a dense structure while the trackbacks that interconnect communities are sparse. The visualized results show sparkling-firework-like patterns. We then attempt to characterize the communities using a tf-idf technique. It is found that specific topics are discussed in each community. These results will help us to identify the communities in which certain specific topics discussed and to detect trends in the blogosphere. [ABSTRACT FROM AUTHOR]

In this article, we performed a comparative study to investigate the performance of methods for detecting emerging research fronts. Three types of citation network, co-citation, bibliographic coupling, and direct citation, were tested in three research domains, gallium nitride (GaN), complex network (CNW), and carbon nanotube (CNT). Three types of citation network were constructed for each research domain, and the papers in those domains were divided into clusters to detect the research front. We evaluated the performance of each type of citation network in detecting a research front by using the following measures of papers in the cluster: visibility, measured by normalized cluster size, speed, measured by average publication year, and topological relevance, measured by density. Direct citation, which could detect large and young emerging clusters earlier, shows the best performance in detecting a research front, and co-citation shows the worst. Additionally, in direct citation networks, the clustering coefficient was the largest, which suggests that the content similarity of papers connected by direct citations is the greatest and that direct citation networks have the least risk of missing emerging research domains because core papers are included in the largest component. [ABSTRACT FROM AUTHOR]

Abstract: Here, we report a three-component coupling reaction approach between an aldehyde, an allyloxyamine, and a maleimide toward isoquinoline derivatives. At first, an oxime O-allylic ether, prepared by dehydrative condensation of the aldehyde and the allyloxyamine, was reacted with the maleimide in the presence of a Pd2+ species. The cycloadduct obtained was then subjected to the Heck cyclization employing a Pd0 species to give thermodynamically stable diastereomer of isoquinoline derivatives selectively in 25–78% yields. [Copyright &y& Elsevier]

Recently, the requirement of the printed wiring boards (PWBs) of environmental harmony type has risen rapidly. We have developed the core technologies of halogen-free. They consist of resin system technology and high filler content technology. The point of the resin technology is the development of a new resin system (RO resin) which takes nitrogen into the molecule frame in a large quantity. The point of the high filler content technology is the development of a new filler interphase control system (FICS) which enables the high dispersion of fillers. A variety of halogen-free substrates which can be applied to the diversified needs have been developed by combining these technologies. They are MCL-RO-67G, thin laminate for the multi-layer PWBs, MCF-4000G, build-up material for high density interconnect (HDI) , and MCL-E-679F(G), high Tg laminate for the advanced plastic IC packages (PKGs) and PWBs. These materials have excellent heat-resistance, and are suitable for lead-free solder as well. The robustness towards temperature, humidity and frequency of those materials is better than that of current materials. The synthetic board design of the environmental harmony type is facilitated by combined use of these materials. We are also developing several multi-layer and build-up materials, HDI for high frequency, high speed and high reliability application to meet the requirement of PWBs and advanced PKGs for the near future. [ABSTRACT FROM AUTHOR]

Goniodomin A is a phycotoxin produced by the dinoflagellates Alexandrium hiranoi (formerly Goniodoma pseudogoniaulax ) and Alexandrium monilatum. This polyether macrolide exerts a potent antifungal effect and disturbs the actomyosin ATPase activity and the F-actin meshwork in diverse cell types. Goniodomin B is a fused acetal isomer isolated with goniodomin A with unknown activity. Histopathological changes induced by goniodomin A postulated hepatocytes as target cells. In this study both compounds induce a time and concentration dependent fall in the viability of Clone 9 rat hepatocytes. Furthermore, for both compounds, primary rat hepatocytes are almost 10 folds less sensitive than Clone 9 cells. Goniodomin A is highly effective in the nanomolar range while micromolar concentrations of goniodomin B are necessary to observe cytoxicity. Additionally, goniodomin A induced a significant increase in the F-actin and decrease in the G-actin content of Clone 9 cells but did not change the actin of primary cultured hepatocytes. However, goniodomin B could not exert significant alterations in the cytoskeleton of neither cell type. Futhermore goniodomin A as well as goniodomin B are cytotoxic to excitable cells. Both analogues triggered a time dependent decrease on viability in BE(2)-M17 human neuroblastoma cells. In this cell model goniodomin A increased the intracellular calcium and depolarized cells. We conclude that goniodomins A and B are biologically active molecules in hepatocytes and also in excitable cells BE(2)-M17. However, the analogue goniodomin B, whose activity is described in this work for the first time, is a much less potent compound. [ABSTRACT FROM AUTHOR]

A convergent synthesis of the C1-C16 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved via a 2-fold application of palladium-catalyzed organostannane-thioester coupling.

The complete absolute configuration of goniodomin A, an actin-targeting polyether macrolide isolated from the marine dinoflagellate Alexandrium hiranoi, was established from analysis of ROESY experiments and coupling constants, synthesis of suitable model compounds for NMR spectroscopic comparisons, degradation experiments, and correlation with synthetic reference compounds.