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42 results on '"Swan, Timothy"'

3. Rare genetic variants impact muscle strength.

Author

Huang, Yunfeng, Bodnar, Dora, Chen, Chia-Yen, Sanchez-Andrade, Gabriela, Sanderson, Mark, Whelan, Christopher D., Bronson, Paola, Sexton, David, John, Sally, Marshall, Eric, Patel, Mehool, Duraisamy, Saranya, Swan, Timothy, Baird, Denis, Eaton, Susan, Gagnon, Jake, Gao, Feng, Gubbels, Cynthia, Kupelian, Varant, and Li, Kejie

Subjects
MUSCLE strength, GENETIC variation, IMPACT strength, MISSENSE mutation, CONNECTIN, GRIP strength
Abstract

Muscle strength is highly heritable and predictive for multiple adverse health outcomes including mortality. Here, we present a rare protein-coding variant association study in 340,319 individuals for hand grip strength, a proxy measure of muscle strength. We show that the exome-wide burden of rare protein-truncating and damaging missense variants is associated with a reduction in hand grip strength. We identify six significant hand grip strength genes, KDM5B, OBSCN, GIGYF1, TTN, RB1CC1, and EIF3J. In the example of the titin (TTN) locus we demonstrate a convergence of rare with common variant association signals and uncover genetic relationships between reduced hand grip strength and disease. Finally, we identify shared mechanisms between brain and muscle function and uncover additive effects between rare and common genetic variation on muscle strength. Here, the authors provide an exome study of hand grip strength, a proxy of generalized muscle strength. They identify six exome-wide significant genes, with links to disease, and additivity of rare and common genetic variant effects on muscle strength. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Joint Practice Guideline for Sterile Technique during Vascular and Interventional Radiology Procedures: From the Society of Interventional Radiology, Association of periOperative Registered Nurses, and Association for Radiologic and Imaging Nursing, for the Society of Interventional Radiology (Wael Saad, MD, Chair), Standards of Practice Committee, and Endorsed by the Cardiovascular Interventional Radiological Society of Europe and the Canadian Interventional Radiology Association

Author

Chan, Danny, Downing, Denise, Keough, Christine E., Saad, Wael A., Annamalai, Ganesh, d'Othee, B. Janne, Ganguli, Suvranu, Itkin, Maxim, Kalva, Sanjeeva P., Khan, Arshad Ahmed, Krishnamurthy, Venkataramu, Nikolic, Boris, Owens, Charles A., Postoak, Darren, Roberts, Anne C., Rose, Steven C., Sacks, David, Siddiqi, Nasir H., Swan, Timothy L., Thornton, Raymond H., Towbin, Richard, Wallace, Michael J., Walker, T. Gregory, Wojak, Joan C., Wardrope, Ronald R., and Cardella, John F.

Published
2012
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5. Quality Improvement Guidelines for Preventing Wrong Site, Wrong Procedure, and Wrong Person Errors: Application of the Joint Commission “Universal Protocol for Preventing Wrong Site, Wrong Procedure, Wrong Person Surgery” to the Practice of Interventional Radiology

Author

Angle, John F., Nemcek, Albert A., Jr, Cohen, Alan M., Miller, Donald L., Grassi, Clement J., D'Agostino, Horacio R., Khan, Arshad Ahmed, Kundu, Sanjoy, Osnis, Robert B., Rajan, Dheeraj K., Schwartzberg, Marc S., Swan, Timothy L., Vedantham, Suresh, Wallace, Michael J., and Cardella, John F.

Published
2009
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6. Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal

Author

Vedantham, Suresh, Thorpe, Patricia E., Cardella, John F., Grassi, Clement J., Patel, Nilesh H., Ferral, Hector, Hofmann, Lawrence V., Janne d'Othée, Bertrand M., Antonaci, Vittorio P., Brountzos, Elias N., Brown, Daniel B., Martin, Louis G., Matsumoto, Alan H., Meranze, Steven G., Miller, Donald L., Millward, Steven F., Min, Robert J., Neithamer, Calvin D., Jr., Rajan, Dheeraj K., Rholl, Kenneth S., Schwartzberg, Marc S., Swan, Timothy L., Towbin, Richard B., Wiechmann, Bret N., and Sacks, David

Published
2009
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9. Genetic map of regional sulcal morphology in the human brain from UK biobank data.

Author

Sun, Benjamin B., Loomis, Stephanie J., Pizzagalli, Fabrizio, Shatokhina, Natalia, Painter, Jodie N., Foley, Christopher N., Biogen Biobank Team, Sun, Benjamin, Tsai, Ellen, Bronson, Paola, Sexton, David, John, Sally, Marshall, Eric, Patel, Mehool, Duraisamy, Saranya, Swan, Timothy, Baird, Dennis, Chen, Chia-Yen, Eaton, Susan, and Gagnon, Jake

Subjects
GENETIC correlations, MORPHOLOGY, GENE mapping, MAGNETIC resonance imaging, NEURAL development
Abstract

Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted large-scale genome- and exome-wide associations of regional cortical sulcal measures derived from magnetic resonance imaging scans of 40,169 individuals in UK Biobank. We discovered 388 regional brain folding associations across 77 genetic loci, with genes in associated loci enriched for expression in the cerebral cortex, neuronal development processes, and differential regulation during early brain development. We integrated brain eQTLs to refine genes for various loci, implicated several genes involved in neurodevelopmental disorders, and highlighted global genetic correlations with neuropsychiatric phenotypes. We provide an interactive 3D visualisation of our summary associations, emphasising added resolution of regional analyses. Our results offer new insights into the genetic architecture of brain folding and provide a resource for future studies of sulcal morphology in health and disease. Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans, revealing insights into the processes guiding cortical development and genetic correlations with neuropsychiatric phenotypes. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal

Author

Vedantham, Suresh, Thorpe, Patricia E., Cardella, John F., Grassi, Clement J., Patel, Nilesh H., Ferral, Hector, Hofmann, Lawrence V., Janne d'Othée, Bertrand M., Antonaci, Vittorio P., Brountzos, Elias N., Brown, Daniel B., Martin, Louis G., Matsumoto, Alan H., Meranze, Steven G., Miller, Donald L., Millward, Steven F., Min, Robert J., Neithamer, Calvin D., Jr., Rajan, Dheeraj K., Rholl, Kenneth S., Schwartzberg, Marc S., Swan, Timothy L., Towbin, Richard B., Wiechmann, Bret N., and Sacks, David

Published
2006
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11. Design and testing of a winglet airfoil for low-speed aircraft

Author

Maughmer, Mark D., Swan, Timothy S., and Willits, Steven M.

Subjects
Gliders (Aeronautics) -- Testing, Gliders (Aeronautics) -- Design and construction, Wind tunnels -- Usage, Turbulence -- Research, Aerofoils -- Design and construction, Aerofoils -- Testing, Mechanics -- Research, Aerospace and defense industries, Business, Science and technology
Abstract

The Pennsylvania State University (PSU) 94-097 airfoil has been designed for use on winglets of high-performance sailplanes. The design problem is difficult because the airfoil must operate over a wide range of Reynolds numbers, and this range includes values that are relatively low. To validate the design tools, as well as the design itself, the airfoil was tested in the Penn State Low-Speed, Low-Turbulence Wind Tunnel from Reynolds numbers of 2.4 x [10.sup.5] to 1.0 x [10.sup.6]. In addition to free-transition measurements, potential drag reductions using artificial turbulators were explored, although the benefits were found to be limited for this application. Finally, performance predictions from two well-known computer codes are compared to the data obtained experimentally, and both are found to generate results that are in good agreement with the wind-tunnel measurements.

Published
2002

21. Quality Improvement Guidelines for Percutaneous Management of the Thrombosed or Dysfunctional Dialysis Access

Author

Aruny, John E., Lewis, Curtis A., Cardella, John F., Cole, Patricia E., Davis, Andrew, Drooz, Alain T., Grassi, Clement J., Gray, Richard J., Husted, James W., Jones, Michael Todd, McCowan, Timothy C., Meranze, Steven G., Van Moore, A., Neithamer, Calvin D., Oglevie, Steven B., Omary, Reed A., Patel, Nilesh H., Rholl, Kenneth S., Roberts, Anne C., Sacks, David, Sanchez, Orestes, Silverstein, Mark I., Singh, Harjit, Swan, Timothy L., Towbin, Richard B., Trerotola, Scott O., and Bakal, Curtis W.

Published
2003
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26. Quality Improvement Guidelines for Percutaneous Management of the Thrombosed or Dysfunctional Dialysis Access

Author

Aruny, John E., Lewis, Curtis A., Cardella, John F., Cole, Patricia E., Davis, Andrew, Drooz, Alain T., Grassi, Clement J., Gray, Richard J., Husted, James W., Jones, Michael Todd, McCowan, Timothy C., Meranze, Steven G., Van Moore, A., Neithamer, Calvin D., Oglevie, Steven B., Omary, Reed A., Patel, Nilesh H., Rholl, Kenneth S., Roberts, Anne C., Sacks, David, Sanchez, Orestes, Silverstein, Mark I., Singh, Harjit, Swan, Timothy L., Towbin, Richard B., Trerotola, Scott O., and Bakal, Curtis W.

Published
1999
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28. 2017 ACR Annual Meeting Open-Microphone Session: Navigating the Landscape of Changing Practice Models: Private Practice, Corporate Radiology, and Enterprise Systems.

Author

Stern, Eric J., Everett, Catherine, Friedberg, Eric B., Kotsenas, Amy L., Glover, McKinley, Lightfoote, Johnson B., Lall, Neil, and Swan, Timothy L.

Abstract

Many practice groups are considering adopting new practice models, primarily to secure their practices by adapting to new payment models, government compliance and regulation, and increasing IT and infrastructure costs. As we move toward value-based care and capitation, the value equation (value = quality/cost) will lead us to also compete on cost to improve value. No matter what payment models ultimately dominate, we need to be prepared to lead in a value-based care environment. Measures of value will either be defined by radiologists or imposed by outside entities. It is critical to our continued success that practices and practice leaders continue to fully and strongly support the ACR to avoid the possibility of a decline in membership that may accompany a lack of practice engagement. Consolidation appears inevitable, but with the help of the ACR, radiologists should have a vibrant future if investments are made now in determining appropriate radiology-specific value measures that are meaningful in consolidated health care environments. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Multi-society Consensus Quality Improvement Guidelines for the Treatment of Lower-extremity Superficial Venous Insufficiency with Endovenous Thermal Ablation from the Society of Interventional Radiology, Cardiovascular Interventional Radiological Society of Europe, American College of Phlebology, and Canadian Interventional Radiology Association

Author

Khilnani, Neil M., Grassi, Clement J., Kundu, Sanjoy, D'Agostino, Horacio R., Khan, Arshad Ahmed, McGraw, J. Kevin, Miller, Donald L., Millward, Steven F., Osnis, Robert B., Postoak, Darren, Saiter, Cindy Kaiser, Schwartzberg, Marc S., Swan, Timothy L., Vedantham, Suresh, Wiechmann, Bret N., Crocetti, Laura, Cardella, John F., and Min, Robert J.

Published
2010
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32. Quality Improvement Guidelines for Preventing Wrong Site, Wrong Procedure, and Wrong Person Errors: Application of the Joint Commission “Universal Protocol for Preventing Wrong Site, Wrong Procedure, Wrong Person Surgery” to the Practice of Interventional Radiology

Author

Angle, John F., Nemcek, Albert A., Jr, Cohen, Alan M., Miller, Donald L., Grassi, Clement J., D'Agostino, Horacio R., Khan, Arshad Ahmed, Kundu, Sanjoy, Osnis, Robert B., Rajan, Dheeraj K., Schwartzberg, Marc S., Swan, Timothy L., Vedantham, Suresh, Wallace, Michael J., and Cardella, John F.

Published
2008
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34. Joint Practice Guideline for Sterile Technique during Vascular and Interventional Radiology Procedures: From the Society of Interventional Radiology, Association of periOperative Registered Nurses, and Association for Radiologic and Imaging Nursing, ...

Author

Chan, Danny, Downing, Denise, Keough, Christine E., Saad, Wael A., Annamalai, Ganesh, Janne d’Othee, B., Ganguli, Suvranu, Itkin, Maxim, Kalva, Sanjeeva P., Khan, Arshad Ahmed, Krishnamurthy, Venkataramu, Nikolic, Boris, Owens, Charles A., Postoak, Darren, Roberts, Anne C., Rose, Steven C., Sacks, David, Siddiqi, Nasir H., Swan, Timothy L., and Thornton, Raymond H.

Published
2012
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35. Multidisciplinary Practical Guidelines for Gastrointestinal Access for Enteral Nutrition and Decompression From the Society of Interventional Radiology and American Gastroenterological Association (AGA) Institute, With Endorsement by Canadian ...

Author

Itkin, Maxim, DeLegge, Mark H., Fang, John C., McClave, Stephen A., Kundu, Sanjoy, Janne d'Othee, Bertrand, Martinez-Salazar, Gloria M., Sacks, David, Swan, Timothy L., Towbin, Richard B., Walker, T. Gregory, Wojak, Joan C., Zuckerman, Darryl A., and Cardella, John F.

Published
2011
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41. Multidisciplinary practical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association (AGA) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

Author

Itkin M, DeLegge MH, Fang JC, McClave SA, Kundu S, d'Othee BJ, Martinez-Salazar GM, Sacks D, Swan TL, Towbin RB, Walker TG, Wojak JC, Zuckerman DA, and Cardella JF

Subjects
Cecostomy standards, Contraindications, Decompression, Surgical adverse effects, Enteral Nutrition adverse effects, Enteral Nutrition economics, Gastrostomy standards, Humans, Intubation, Gastrointestinal adverse effects, Jejunostomy standards, Decompression, Surgical methods, Decompression, Surgical standards, Enteral Nutrition methods, Enteral Nutrition standards, Gastrointestinal Diseases therapy, Intubation, Gastrointestinal standards
Published
2011
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42. Quality improvement guidelines for transhepatic arterial chemoembolization, embolization, and chemotherapeutic infusion for hepatic malignancy.

Author

Brown DB, Cardella JF, Sacks D, Goldberg SN, Gervais DA, Rajan DK, Vedantham S, Miller DL, Brountzos EN, Grassi CJ, Towbin RB, Angle JF, Balter S, Clark TW, Cole PE, Drescher P, Freeman NJ, Georgia JD, Haskal Z, Hovsepian DM, Kilnani NM, Kundu S, Malloy PC, Martin LG, McGraw JK, Meranze SG, Meyers PM, Millward SF, Murphy K, Neithamer CD Jr, Omary RA, Patel NH, Roberts AC, Schwartzberg MS, Siskin GP, Smouse HR, Swan TL, Thorpe PE, Vesely TM, Wagner LK, Wiechmann BN, Bakal CW, Lewis CA, Nemcek AA Jr, and Rholl KS

Published
2009
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