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359 results on '"St. Guily"'

1. « Certains lieux de la peinture », comme expérience ontologique, de révélation chez María Zambrano

Author

Camille Lacau St Guily

Subjects
María Zambrano, revelation, painting, ontological experience, History of Spain, DP1-402
Abstract

Through painting, as she testifies in several of her writings, among others in Algunos lugares de la pintura, through her autobiographical essay, Delirio y destino, or in her text entitled “El idiota” and in all her essays dedicated to Velázquez’s “Niño de Vallecas”, María Zambrano lives personal and “privileged” experiences, with the being. Painting offers her “revelations”. Some masterful works can put her in the presence of the soul of things and of any being, in the event of an encounter, which arises or can be woven in the duration, in a form of metanoïa of the heart and the intelligence, of the eyes and the ears, leading Zambrano to perceive the sublime in the non-being, in the damaged, the despised, the smallest, the simple, humble things, to be astonished in front of a face without apparent brilliance, that humanity rejects.

Published
2024
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2. Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy

Author

Roth, Fanny, Dhiab, Jamila, Boulinguiez, Alexis, Mouigni, Hadidja-Rose, Lassche, Saskia, Negroni, Elisa, Muraine, Laura, Marhic, Alix, Oliver, Alison, Lainé, Jeanne, Rouche, Andrée, O’Ferrall, Erin K., van Engelen, Baziel, Ottenheijm, Coen, Greif, Hagar, Blumen, Sergiu, Lacau St Guily, Jean, Perie, Sophie, Butler-Browne, Gillian, Mouly, Vincent, and Trollet, Capucine

Published
2022
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4. A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

Author

Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perié, Jean Lacau St‐Guily, Aurélien Corneau, Gillian Butler‐Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, and Capucine Trollet

Subjects
Human, FAPs, Skeletal muscle, Pharyngeal muscle, Fibrosis, ECM, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695
Abstract

Abstract Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to trauma, aging, or dystrophies and impairs muscle function. Fibrosis represents a hurdle for the treatment of human muscular dystrophies. While data on the mechanisms of fibrosis have mostly been investigated in mice, dystrophic mouse models often do not recapitulate fibrosis as observed in human patients. Consequently, the cellular and molecular mechanisms that lead to fibrosis in human muscle still need to be identified. Methods Combining mass cytometry, transcriptome profiling, in vitro co‐culture experiments, and in vivo transplantation in immunodeficient mice, we investigated the role and nature of nonmyogenic cells (fibroadipogenic progenitors, FAPs) from human fibrotic muscles of healthy individuals (FibMCT) and individuals with oculopharyngeal muscular dystrophy (OPMD; FibMOP), as compared with nonmyogenic cells from human nonfibrotic muscle (MCT). Results We found that the proliferation rate of FAPs from fibrotic muscle is 3–4 times higher than those of FAPs from nonfibrotic muscle (population doubling per day: MCT 0.2 ± 0.1, FibMCT 0.7 ± 0.1, and FibMOP 0.8 ± 0.3). When cocultured with muscle cells, FAPs from fibrotic muscle impair the fusion index unlike MCT FAPs (myoblasts alone 57.3 ± 11.1%, coculture with MCT 43.1 ± 8.9%, with FibMCT 31.7 ± 8.2%, and with FibMOP 36.06 ± 10.29%). We also observed an increased proliferation of FAPs from fibrotic muscles in these co‐cultures in differentiation conditions (FibMCT +17.4%, P

Published
2022
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5. History of tonsillectomy and risk of oropharyngeal cancer

Author

Combes, Jean-Damien, Voisin, Nicolas, Périé, Sophie, Malard, Olivier, Jegoux, Franck, Nadjingar, Ritoungarte, Buiret, Guillaume, Philouze, Pierre, Garrel, Renaud, Vergez, Sébastien, Fakhry, Nicolas, Righini, Christian, Mirghani, Haitham, Lerat, Justine, Saroul, Nicolas, Verillaud, Benjamin, Bartaire, Emmanuel, Céruse, Philippe, Clifford, Gary M., Franceschi, Silvia, and Lacau St Guily, Jean

Published
2021
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6. Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France

Author

Albert, S., Andry, G., Babin, E., Bach, C., Badet, J.-M., Badoual, C., Baglin, A.C., Banal, A., Barry, B., Baudin, E., Baujat, B., Bensadoun, R.J., Bertolus, C., Bessède, J.-P., Blanchard, D., Borel, C., Bozorg-Grayeli, A., Breheret, R., Breton, P., Brugel, L., Calais, G., Casiraghi, O., Cassagnau, E., Castillo, L., Ceruse, P., Chabolle, F., Chevalier, D., Chobaut, J.C., Choussy, O., Cosmidis, A., Coste, A., Costes, V., Crampette, L., Darrouzet, V., Demez, P., Dessi, P., Devauchelle, B., Digue, L., Dolivet, G., Dubrulle, F., Duflo, S., Dufour, X., Even, C., Faivre, S., Fakhry, N., Ferron, C., Floret, F., de Gabory, L., Garrel, R., Geoffrois, L., Gilain, L., Giovanni, A., Girod, A., Guerrier, B., Hans, S., Herman, P., Hofman, P., Housset, M., Jankowski, R., Jegoux, F., Juliéron, M., Kaminsky, M.-C., Kolb, F., Lacau St Guily, J., Laccoureye, L., Lallemant, B., Lang, P., Lartigau, E., Lavieille, J.-P., Lefevre, M., Leroy, X., Malard, O., Massip, F., Mauvais, O., Merol, J.-C., Michel, J., Mom, T., Morinière, S., de Monès, E., Moulin, G., Moya-Plana, A., Noel, G., Poissonnet, G., Prades, J.-M., de Raucourt, D., Reyt, E., Righini, C., Marie Robin, Y., Rolland, F., Ruhin, B., Sarroul, N., Schultz, P., Serrano, E., Sterkers, O., Strunski, V., Sudaka, A., Tassart, M., Testelin, S., Thariat, J., Timochenko, A., Toussaint, B., Uro Coste, E., Valette, G., Van den Abbeele, T., Varoquaux, A., Veillon, F., Vergez, S., Vérillaud, B., Wassef, M., Aupérin, A., Obongo, R., Baglin, A., Ferrand, F.R., Saroul, N., and Janot, F.

Published
2019
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17. Estimation of the overall burden of cancers, precancerous lesions, and genital warts attributable to 9-valent HPV vaccine types in women and men in Europe

Author

Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany, and Silvia de Sanjosé

Subjects
Human papillomavirus, Burden of disease, Cancer, Precancerous lesions, Genital warts, Head and neck, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital warts. We estimated the annual number of new cases of these diseases attributable to 9-valent HPV vaccine types in women and men in Europe. Methods The annual number of new cancers of the cervix, vulva, vagina, anus, penis, and selected head and neck sites in the population of the European Medicines Agency territory was estimated based on age-specific incidence rates extracted from Cancer Incidence in 5 Continents, Volume X and Eurostat population data for 2015. The annual number of new cancers attributable to 9-valent HPV vaccine types was estimated by applying the HPV attributable fraction from reference publications based on a large European multicenter study. For non-cervical cancers, HPV attributable fractions were based on oncogenically-active HPV infections only (i.e., detection of HPV DNA and either mRNA and/or p16 positivity). For precancerous lesions of the cervix, vulva, vagina, and anus, and for genital warts, previously published estimations were updated for the 2015 population. Results The annual number of new cancers attributable to 9-valent HPV vaccine types was estimated at 47,992 (95% bound: 39,785-58,511). Cervical cancer showed the highest burden (31,130 cases), followed by head and neck cancer (6,786 cases), anal cancer (6,137 cases), vulvar cancer (1,466 cases), vaginal cancer (1,360 cases), and penile cancer (1,113 cases). About 81% were estimated to occur in women and 19% in men. The annual number of new precancerous lesions (CIN2+, VIN2/3, VaIN2/3, and AIN2/3) and genital warts attributable to 9-valent HPV vaccine types was estimated at 232,103 to 442,347 and 680,344 to 844,391, respectively. Conclusions The burden of cancers associated with 9-valent HPV vaccine types in Europe is substantial in both sexes. Head and neck cancers constitute a heavy burden, particularly in men. Overall, about 90% of HPV-related cancers, 80% of precancerous lesions, and 90% of genital warts are expected to be attributable to 9-valent HPV vaccine types each year, demonstrating the important preventive potential of the 9-valent HPV vaccine in Europe.

Published
2017
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21. PABPN1 gene therapy for oculopharyngeal muscular dystrophy

Author

A. Malerba, P. Klein, H. Bachtarzi, S. A. Jarmin, G. Cordova, A. Ferry, V. Strings, M. Polay Espinoza, K. Mamchaoui, S. C. Blumen, J. Lacau St Guily, V. Mouly, M. Graham, G. Butler-Browne, D. A. Suhy, C. Trollet, and G. Dickson

Subjects
Science
Abstract

Oculopharyngeal muscular dystrophy is caused by trinucleotide repeat expansions in thePABPN1gene. Here the authors use AAV-based gene therapy to knockdown the mutant gene and replace it with a wild-type allele, and show effectiveness in mice and in patient cells.

Published
2017
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22. Guidelines (short version) of the French Otorhinolaryngology – Head and Neck Surgery Society (SFORL) on patient pathway organization in ENT: The therapeutic decision-making process

Author

Deneuve, S., Babin, E., Lacau-St-Guily, J., Baujat, B., Bensadoun, R.-J., Bozec, A., Chevalier, D., Choussy, O., Cuny, F., Fakhry, N., Guigay, J., Makeieff, M., Merol, J.-C., Mouawad, F., Pavillet, J., Rebiere, C., Righini, C.-A., Sostras, M.-C., Tournaille, M., and Vergez, S.

Published
2015
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26. La philosophie en Espagne, en « crise perpétuelle » (1850-1940) ?

Author

Camille Lacau St Guily

Subjects
philosophie, Espagne xixe / xxe, désert philosophique espagnol, Language and Literature
Abstract

L’(in)existence de la philosophie et de la figure du philosophe dans la « cité » espagnole est une problématique constante, dans l’histoire des idées en Espagne. Cette discipline entre même, pour de multiples motifs, dans une crise aiguë, lors du xixe s., qui, certes, s’apaise grâce à l’institutionnalisation par José Ortega y Gasset de l’École de Madrid, quelques années plus tard, dès 1910, mais qui se déchaîne pour des raisons conjoncturelles nouvelles, dès l’instauration de la dictature franquiste, en 1936 ; la plupart des « philosophes » espagnols désertent alors leur pays. Comment donc interpréter l’existence critique de la philosophie en Espagne, particulièrement lors de la seconde moitié du xixe et de la première moitié du xxe ? Entre-t-elle alors en crise, s’y enlise-t-elle ou se trouve-t-elle dans une « crise perpétuelle » depuis des siècles ? Faut-il l’expliquer par une « nature » aphilosophique, un rejet essentiel de la contemplation, par une préférence pour l’action dès lors qu’elle doit résoudre des conflits existentiels, pour la poésie comme langue de la métaphysique, ou par des causes extrinsèques ? Pourquoi le philosophe n’occupe-t-il pas une place majeure dans la république des intellectuels espagnols ? Pourquoi la philosophie est-elle à cette période, notamment, désynchronisée des formes de la modernité philosophique ? C’est à ces questions que nous aimerions tenter de répondre, dans les circonstances propres qu’impose le pays, entre 1850 et 1940.

Published
2015
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42. La philosophie espagnole des années 1900-1930, une philosophie poétique ?

Author

Camille Lacau St Guily

Subjects
María Zambrano, Spanish philosophy, poetic philosophy, Henri Bergson, poetic anthropology, Miguel de Unamuno, History of Spain, DP1-402
Abstract

Even though it had never been recognized as such, a philosophical tradition did exist in Spain in the 1900-1930's, but was represented by men who were not perceived as philosophers. This article points out that Spain has known a strong philosophical tradition provided we open the universal philosophical Republic to the hybrid profile of « poet-philosophers ». In the 1900-1930's, the Spanish philosophy was a poetic philosophy, a poetic anthropology, driven by, among others, men such as Miguel de Unamuno, but also Gabriel Alomar, Victoriano García Martí, María Zambrano, Federico García Lorca.

Published
2015
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50. A New Animal Model of Laryngeal Transplantation.

Author

Philouze, Pierre, Malard, Olivier, Albert, Sébastien, Badet, Lionel, Baujat, Bertrand, Faure, Frédéric, Fuchsmann, Carine, Jegoux, Franck, Lacau-St-Guily, Jean, Marie, Jean-Paul, Ramade, Antoine, Vergez, Sebastien, Ceruse, Philippe, and Gauthier, Olivier J.

Subjects
ANIMAL models in research, TRANSPLANTATION of organs, tissues, etc., SWINE, LARYNX, ISCHEMIA
Abstract

Only three laryngeal transplants have been described in the literature to date, and none of the techniques has enabled a completely satisfactory functional result to be obtained. This article presents a new model of laryngeal transplantation, with quality of revascularisation of the transplant being the principal objective and optimisation of the various steps of the procedure, with the integration of a new reinnervation technique as a secondary objective. We present a preclinical animal study. Three pig larynges removed in vivo underwent allotransplantation according to the same protocol. The quality of the revascularisation was examined immediately after the surgery as well as by endoscopy for one animal on the fourth day after the operation. The mean time of cold ischaemia was 3 h 15 min. The anaesthetic tolerance of the pigs was excellent. Revascularisation was achieved and judged to be excellent for the three transplants immediately after the operation and the endoscopy performed for one pig on the fourth day after the operation confirmed this result. The anatomical similarities also enabled the application and integration of an innovative technique of laryngeal reinnervation into the various phases of the operation. We describe a reliable and reproducible animal model for laryngeal transplantation. Its application in humans can be envisaged. [ABSTRACT FROM AUTHOR]

Published
2022
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