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Every power system is vulnerable to fault occurrences. Under permanent fault conditions, maintenance crew has the duty to detect the problem, repair the defect and recover the power supply system. If the fault is previously located, the repair can be performed faster. The common methods to locate the fault in electrical distribution systems use the final user information or some heuristics with fuse coordination and the loss of loads. In this paper, a new algorithm for fault location in distribution power systems is presented. Using computational simulations, travelling waves theory, wavelet transform, a new data preprocessing feature, and artificial neural networks, this new algorithm tries to approximate the fault location using data provided by only one measurement point at the beginning of the feeder.

The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite the availability of vaccines, the virus continues to spread, and there is a need for alternative strategies to alleviate its impact. Vitamin D, a secosteroid hormone best known for its role in bone health, exhibits immunomodulatory effects in certain viral infections. Here, we have shown that bioactive vitamin D (calcitriol) limits in vitro replication of SARS-CoV-2 and murine coronaviruses MHV-3 and MHV-A59. Comparative studies involving wild-type mice intranasally infected with MHV-3, a model for studying β-CoV respiratory infections, confirmed the protective effect of vitamin D in vivo. Accordingly, mice fed a standard diet rapidly succumbed to MHV-3 infection, whereas those on a vitamin D-rich diet (10,000 IU of Vitamin D3/kg) displayed increased resistance to acute respiratory damage and systemic complications. Consistent with these findings, the vitamin D-supplemented group exhibited lower viral titers in their lungs and reduced levels of TNF, IL-6, IL-1β, and IFN-γ, alongside an enhanced type I interferon response. Altogether, our findings suggest vitamin D supplementation ameliorates β-CoV-triggered respiratory illness and systemic complications in mice, likely via modulation of the host’s immune response to the virus.

The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite the availability of vaccines, the virus continues to spread, and there is a need for alternative strategies to alleviate its impact. Vitamin D, a secosteroid hormone best known for its role in bone health, exhibits immunomodulatory effects in certain viral infections. Here, we have shown that bioactive vitamin D (calcitriol) limits in vitro replication of SARS-CoV-2 and murine coronaviruses MHV-3 and MHV-A59. Comparative studies involving wild-type mice intranasally infected with MHV-3, a model for studying β-CoV respiratory infections, confirmed the protective effect of vitamin D in vivo. Accordingly, mice fed a standard diet rapidly succumbed to MHV-3 infection, whereas those on a vitamin D-rich diet (10,000 IU of Vitamin D3/kg) displayed increased resistance to acute respiratory damage and systemic complications. Consistent with these findings, the vitamin D-supplemented group exhibited lower viral titers in their lungs and reduced levels of TNF, IL-6, IL-1β, and IFN-γ, alongside an enhanced type I interferon response. Altogether, our findings suggest vitamin D supplementation ameliorates β-CoV-triggered respiratory illness and systemic complications in mice, likely via modulation of the host's immune response to the virus. [ABSTRACT FROM AUTHOR]

ABSTRACT Pompe disease (PD) is a potentially lethal illness involving irreversible muscle damage resulting from glycogen storage in muscle fiber and activation of autophagic pathways. A promising therapeutic perspective for PD is enzyme replacement therapy (ERT) with the human recombinant enzyme acid alpha-glucosidase (Myozyme®). The need to organize a diagnostic flowchart, systematize clinical follow-up, and establish new therapeutic recommendations has become vital, as ERT ensures greater patient longevity. A task force of experienced clinicians outlined a protocol for diagnosis, monitoring, treatment, genetic counseling, and rehabilitation for PD patients. The study was conducted under the coordination of REBREPOM, the Brazilian Network for Studies of PD. The meeting of these experts took place in October 2013, at L’Hotel Port Bay in São Paulo, Brazil. In August 2014, the text was reassessed and updated. Given the rarity of PD and limited high-impact publications, experts submitted their views.

Renewable energy sources have been growing worldwide and solar energy is a significant part of such sources. An essential step in planning studies, including the problem of optimal location and sizing of photovoltaic (PV) generators, is estimating how much energy the panels will generate over time. For that, two aspects must be considered: the stochastic nature of the input variables and the way to calculate the generator's output power. A brief literature review identified 12 approaches to determine the PV output power. Therefore, this article compares such methods through actual meteorological data and generated energy over 1 year by a solar power plant located in a specific site in the Brazilian Northeast. An analysis is carried out on the influence of correlations between meteorological variables in estimating the generated energy. There is no comparative work in the literature on the analytical models for calculating the PV output power in conjunction with the correlation analysis. As expected, models that consider the influence of ambient temperature on output power performed better than those that do not. How the energy generated by the PV panel is estimated can influence the economic viability of a project since oversizing the PV system entails unnecessary additional costs. Monte Carlo simulations generate data samples used by the studied models for power output calculation. According to our findings, considering the correlation between meteorological variables reduces the error in estimating the generated energy by PV panels. [ABSTRACT FROM AUTHOR]

A fim de descrever a clientela atendida nos Centros de Atenção Psicossocial (CAPS) da Cidade de Santos foi realizado um censo de pacientes atendidos nos CAPS no período 1º de junho de 2001 a 30 de junho de 2001. O primeiro contato do paciente com o serviço foi registrado e seus dados foram preenchidos em ficha padronizada utilizando o prontuário médico como fonte de informação. Foram atendidos 1.673 usuários, com idade média de 46 anos, mulheres (59,0%), morando com a família (78,0%) e tempo médio de três anos em tratamento no serviço. Atenderam 38,0% de esquizofrênicos, esquizotípicos e delirantes, 31,0% com transtorno de humor e 17,0% de neuróticos, nas modalidades de ambulatório médico-psiquiátrico (81,0%), individual (23,0%), grupal (13,0%) e reabilitação psicossocial (4,3%). Os CAPS de Santos atendem todas as categorias de transtornos mentais, sendo os mais freqüentes aqueles considerados mais graves, o que é esperado para este tipo de serviço. O modelo de tratamento oferecido tem características ambulatorial e médico-psiquiátrica.To report on the clientele treated at community mental health services (CAPS) in the city of Santos, São Paulo, Brazil, a census was conducted of the patients examined at the services from June 1, 2001, to June 30, 2001. The patient's initial contact with the service was registered, and data were recorded on a standardized form, using the medical case history as a source of information. Among the 1,673 patients, average age was 46 years, 59.0% were female, 58.0% lived with their families, and mean duration of treatment was three years. Some 38.0% were schizophrenic, schizotypical, or in acute delusional states, 31.0% presented mood disorders, and 17.0% were neurotic. Treatment modalities included out-patient psychiatric (81.0%), individual (23.0%), group (13.0%), and psychosocial rehabilitation (4.3%). In Santos, CAPS treat all categories of mental disorders (and frequently those considered the most severe cases) expected at this type of service. The treatment model is that of an out-patient psychiatric clinic.

A fim de descrever a clientela atendida nos Centros de Atenção Psicossocial (CAPS) da Cidade de Santos foi realizado um censo de pacientes atendidos nos CAPS no período 1º de junho de 2001 a 30 de junho de 2001. O primeiro contato do paciente com o serviço foi registrado e seus dados foram preenchidos em ficha padronizada utilizando o prontuário médico como fonte de informação. Foram atendidos 1.673 usuários, com idade média de 46 anos, mulheres (59,0%), morando com a família (78,0%) e tempo médio de três anos em tratamento no serviço. Atenderam 38,0% de esquizofrênicos, esquizotípicos e delirantes, 31,0% com transtorno de humor e 17,0% de neuróticos, nas modalidades de ambulatório médico-psiquiátrico (81,0%), individual (23,0%), grupal (13,0%) e reabilitação psicossocial (4,3%). Os CAPS de Santos atendem todas as categorias de transtornos mentais, sendo os mais freqüentes aqueles considerados mais graves, o que é esperado para este tipo de serviço. O modelo de tratamento oferecido tem características ambulatorial e médico-psiquiátrica.

In this contribution to PSAS08 we report on the research activities developed in our Toulouse group in the framework of the BMV project, concerning the search for photon oscillations into massive particles, such as axion-like particles, in the presence of a strong transverse magnetic field. We recall our main result obtained in collaboration with LULI at Ecole Polytechnique (Palaiseau, France). We also present the very preliminary results obtained with the BMV experiment which is set up at LNCMI (Toulouse, France). PACS Nos: 12.20.Fv, 14.80.-j Dans cette contribution a PSAS08, nous presentons les activites de recherche developpees dans notre groupe a Toulouse, dans le cadre du projet BMV, concemant la recherche d'oscillations entre photons et particules massiques telles que les pseudo-axions en presence d'un champ magnetique transverse intense. Nous rappelons notre principal resultat obtenu en collaboration avec le LULI a l'Ecole Polytechnique (Palaiseau, France). Nous presentons egalement les resultats tres preliminaires obtenus sur l'experience BMV, installee an LNCMI (Toulouse, France). [Traduit par la Redaction], 1. Introduction Since 2001 in Toulouse (France), we have been conducting research activities in the framework of the BMV (Birefringence Magnetique du Vide) project [1] to study the propagation of [...]