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Structure and intramolecular transformations of N-phenyl, N′-(diisopropoxythiophosphoryl)thiourea has been studied by NMR spectroscopy and the AM1 quantum-chemical simulation. It has been shown that several forms, including two amide forms ( EZ and ZE) and two prototropic forms, coexist in a dynamic equilibrium. [ABSTRACT FROM AUTHOR]

Structure and intramolecular transformations of N3-phenyl-N1-(diisopropoxythiophosphoryl)-thiosemicarbazide in CD2Cl2 were studied by one- and two-dimensional 1H, 13C and 31P NMR spectroscopy. The combined analysis of the data of NMR spectroscopy and calculation simulation confirmed a high lability of the studied compounds resulting in the formation of various conformational and tautomeric forms in solutions. The preference of Z,E-conformation of the amide form with cis- and trans-location of two N-H groups and the C=S group relatively to the two C-N bonds was revealed. [ABSTRACT FROM AUTHOR]

Aim: Assessment of the prevalence and prognostic value of gastroenterological manifestations in patients with COVID-19., Materials and Methods: A single-center retrospective cohort study was carried out. Only cases with laboratory confirmed detection of SARS-CoV-2 virus RNA using polymerase chain reaction in oro-/nasopharyngeal smear samples were subject to analysis. Patients with documented (according to anamnestic data and/or according to examination data during hospitalization) organic pathology of the gastrointestinal tract (GIT) and/or hepatobiliary system, malignant neoplasms of any localization, as well as pregnant patients were excluded from the general register of retrospective data. The final cohort was divided into two groups depending on the presence of gastrointestinal symptoms: COVID-19 with gastrointestinal symptoms (cases) and COVID-19 without gastrointestinal symptoms (control)., Results: The final sample consisted of 3764 patients, including 2108 (56%) women and 1656 (44%) men. The average age of the subjects included in the analysis was 58.0 years (95% confidence interval CI 48.663.0). In the study cohort, gastroenterological manifestations (alone or in combination) were recorded in 885 (23.51%) patients. Calculation of the odds ratio (OR) of unfavorable and lethal outcomes between the analyzed groups showed that the presence of gastroenterological symptoms significantly increases the chances of lethal outcome in a cohort of elderly and senile patients (OR 1.6817, 95% CI 1.03352.7364; p=0.0364), determines a higher risk of hospitalization or transfer to the intensive care unit (OR 1.2959, 95% CI 1.05471.5922; p=0.0136), development of acute respiratory distress syndrome (OR 1.5952, 95% CI 1.31641.9329; p0.0001), as well as the need for mechanical ventilation (OR 1.2849, 95% CI 1.0771.5329; p=0.0054)., Conclusion: The present study has demonstrated that gastroenterological symptoms are detected in about one in four patients infected with the SARS-CoV-2 virus and multiply the risk of adverse and life-threatening complications of COVID-19.